Andrew P Ambrosy, Alex J Chang, Beth Davison, Adriaan Voors, Alain Cohen-Solal, Albertino Damasceno, Antoine Kimmoun, Carolyn S P Lam, Christopher Edwards, Daniela Tomasoni, Etienne Gayat, Gerasimos Filippatos, Hadiza Saidu, Jan Biegus, Jelena Celutkiene, Jozine M Ter Maaten, Kamilė Čerlinskaitė-Bajorė, Karen Sliwa, Koji Takagi, Marco Metra, Maria Novosadova, Marianela Barros, Marianna Adamo, Matteo Pagnesi, Mattia Arrigo, Ovidiu Chioncel, Rafael Diaz, Peter S Pang, Piotr Ponikowski, Gad Cotter, Alexandre Mebazaa
BACKGROUND: Guideline-directed medical therapy decisions may be less affected by single patient variables such as blood pressure or kidney function and more by overall risk profile. In STRONG-HF, high intensity care (HIC) in the form of rapid uptitration of heart failure (HF) guideline-directed medical therapy (GDMT) was effective overall, but the safety, tolerability and efficacy of HIC across the spectrum of HF severity is unknown. Evaluating this with a simple risk-based framework offers an alternative and more clinically translatable approach than traditional subgroup analyses...
April 30, 2024: JACC. Heart Failure