Flávio Duarte Faria, Cristiane Cantiga-Silva, Carolina de Barros Morais Cardoso, Nathália Evelyn da Silva Machado, Pedro Henrique Chaves de Oliveira, Mariana Pagliusi Justo, Juliana Goto, Rogério de Castilho Jacinto, Gustavo Sivieri-Araújo, Luciano Tavares Angelo Cintra
The aim of this study was to investigate the influence of systemic antibiotic therapy on the development and progression of induced apical periodontitis (AP) in Wistar rats. Fifty-six rats were submitted to pulp exposure of the lower left first molar for the induction of AP. On the same day, intraperitoneal antibiotic therapy was administered once a day, for 15 days, until euthanasia. The groups were formed according to the different treatments (n = 8): C-control; GEN-treated with gentamicin (10 mg/Kg); AC-treated with amoxicillin (100 mg/Kg); MZ-treated with metronidazole (40 mg/Kg); AMP-treated with ampicillin (100 mg/Kg); AMC group-treated with amoxicillin + clavulanic acid (100 mg/kg); CLI-treated with clindamycin (60 mg/kg)...
March 8, 2024: Odontology