Anja Schulz-Kuhnt, Katharina Rühle, Asal Javidmehr, Michael Döbrönti, Jana Biwank, Selina Knittel, Peter Neidlinger, Jannik Leupold, Li-Juan Liu, Mark Dedden, Regina Verena Taudte, Arne Gessner, Martin F Fromm, Dirk Mielenz, Lucas Kreiss, Maximilian J Waldner, Sebastian Schürmann, Oliver Friedrich, Barbara Dietel, Rocío López-Posadas, Christina Plattner, Sebastian Zundler, Christoph Becker, Raja Atreya, Markus F Neurath, Imke Atreya
OBJECTIVE: Mucosal T cells play a major role in inflammatory bowel disease (IBD). However, their immunometabolism during intestinal inflammation is poorly understood. Due to its impact on cellular metabolism and proinflammatory immune cell function, we here focus on the enzyme ATP citrate lyase (ACLY) in mucosal T cell immunometabolism and its relevance for IBD. DESIGN: ACLY expression and its immunometabolic impact on colitogenic T cell function were analysed in mucosal T cells from patients with IBD and in two experimental colitis models...
January 4, 2024: Gut