Kimberly Huerth, Chesahna Kindred
Frontal fibrosing alopecia (FFA) is a primary lymphocytic cicatricial alopecia that is currently regarded as a variant of lichen planopilaris. FFA has historically been considered rare in black patients, in whom traction alopecia, central centrifugal cicatricial alopecia, and androgenetic alopecia are frequently assumed to be more common. We describe a case of FFA in a black woman that both clinically resembled androgenetic alopecia and lacked many of the physical exam and dermoscopic findings associated with FFA...
July 1, 2020: Journal of Drugs in Dermatology: JDD
Ratchathorn Panchaprateep, Pariya Ruxrungtham, Bussabong Chancheewa, Pravit Asawanonda
Frontal fibrosing alopecia (FFA) is a distinctive lymphocytic scarring alopecia with rapid increase in prevalence. Most FFA series are retrospectively reported from Caucasians with only few from Asians. The objective of this study was to characterize the clinical, trichoscopic and histopathological findings as well as treatment outcomes. This was a retro-prospective cohort study of patients diagnosed with FFA from 1 January 2010 to 1 November 2019. All patients were asked to present for re-examination. Clinical, trichoscopic, histopathological and laboratory data were recorded...
July 24, 2020: Journal of Dermatology
Fatemeh Sari Aslani, Mozhdeh Sepaskhah, Zahra Bagheri, Mojgan Akbarzadeh-Jahromi
Background: Differentiating scarring alopecia secondary to lichen planopilaris (LPP) and discoid lupus erythematosus (DLE) has always been a challenge clinically and pathologically. Plasmacytoid dendritic cells (PDCs) have been reported in the cutaneous lupus erythematosus by CD123 immunostaining. This study assesses CD123 marker positivity and patterns of elastic fiber loss in scalp biopsy to differentiate DLE from LLP. Patients and Methods: Forty-three cases with clinical and pathological diagnosis of LPP and DLE were selected, and CD123 immunohistochemistry staining and elastic staining were performed on them...
March 2020: International Journal of Trichology
Farahnaz Fatemi Naeini, Fatemeh Mohaghegh, Minoo Jelvan, Ali Asilian, Mina Saber
BACKGROUND: Lichen Planopilaris (LPP) is a primary scarring alopecia with unknown etiology and its management is a challenge for dermatologists. We aimed to compare the safety and efficacy of methotrexate and cyclosporine in LPP patients. METHODS: In a randomized clinical trials, 33 patients were randomly allocated to receive either 15-mg oral methotrexate per week or 3-5-mg/kg/day cyclosporine for six months. During the treatment course, side effects, signs/symptoms and laboratory test were assessed periodically...
September 2020: International Immunopharmacology
Michael Randolph, Antonella Tosti
BACKGROUND: Although topical minoxidil is an effective treatment option for hair loss, many patients are poorly compliant due to the necessity to apply the medication twice a day, undesirable hair texture, and scalp irritation. OBJECTIVE: In recent years, oral minoxidil at low dose has been proposed as a safe alternative. This study reviewed articles in which oral minoxidil was utilized to treat hair loss to determine its efficacy and safety as an alternative to topical minoxidil...
July 1, 2020: Journal of the American Academy of Dermatology
Sahar Dadkhahfar, Farnaz Araghi, Mohammadreza Tabary, Hamideh Moravvej
No abstract text is available yet for this article.
June 1, 2020: Journal of Drugs in Dermatology: JDD
Katerina Svigos, Lu Yin, Katharina Shaw, Daniel Gutierrez, Erik Peterson, Kristen Lo Sicco, Jerry Shapiro
No abstract text is available yet for this article.
November 2020: Journal of the American Academy of Dermatology
Mariachiara Arisi, Alessandra Gelmetti, Arianna Zanca, Mariateresa Rossi, Luisa Lorenzi, Paolo Incardona, Piergiacomo Calzavara-Pinton, Marina Venturini
Graham Little-Piccardi-Lassueur syndrome (GLPLS) is a rare variant of lichen planopilaris, characterized by a triad of clinical signs including follicular spinous papules on the body area, scarring alopecia of the scalp and non-scarring alopecia of the groin and/or axilla. To date, fewer than 50 cases have been described in the literature. We first report a case of GLPLS investigated with non-invasive techniques such as dermoscopy and in vivo reflectance confocal microscopy (RCM) and successfully treated with narrowband-UVB (NB-UVB) phototherapy...
June 12, 2020: Dermatology and Therapy
John Plante, Chelsea Eason, Alan Snyder, Dirk Elston
No abstract text is available yet for this article.
November 2020: Journal of the American Academy of Dermatology
Sean Dreyer, Chandra Smart, Carolyn Goh
No abstract text is available yet for this article.
April 2020: Cutis; Cutaneous Medicine for the Practitioner
Lara Trindade de Carvalho, Nekma Meah, Dmitri Wall, Rodney Sinclair
Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are lymphocytic, cicatricial alopecias. Clinically, LPP presents with multifocal patchy alopecia, while FFA, considered a variant of LPP, results in hairline recession. Frontal recession in FFA may progress as far as the mid-scalp and infrequently beyond. Treatment to arrest the inflammatory process can be challenging and response variable. We report a case of recalcitrant lichen planopilaris and frontal fibrosing alopecia demonstrating significant clinical improvement after four doses of the interleukin-23 monoclonal antibody tildrakizumab...
July 2020: Dermatologic Therapy
Vahideh Lajevardi, Fereshteh Salarvand, Maryam Ghiasi, Maryam Nasimi, Mohammad Taraz
Background and objectives: Lichen planopilaris (LPP) is one of the important causes of cicatricial alopecia. We aimed to evaluate the efficacy and safety of low-dose naltrexone (LDN) in the setting of a clinical trial in patients with LPP. Methods: We included patients with LPP between 2018 and 2020. Patients were allocated to two groups. The first group received topical clobetasol plus oral low dose naltrexone (3 mg) while the second received topical clobetasol plus placebo. The assessment was made for the disease severity by lichen planopilaris activity index (LPPAI) instrument and the safety of the drug in 2-month intervals up to 6 months...
June 8, 2020: Journal of Dermatological Treatment
Daniela Pinto, Francesco Maria Calabrese, Maria De Angelis, Giuseppe Celano, Giammaria Giuliani, Marco Gobbetti, Fabio Rinaldi
Involvement of the microbiome in many different scalp conditions has been investigated over the years. Studies on the role of the scalp microbiome in specific diseases, such as those involving hair growth alterations like non-cicatricial [androgenetic alopecia (AGA), alopecia areata (AA)] and cicatricial alopecia lichen planopilaris, are of major importance. In the present work, we highlighted the differences in microbial populations inhabiting the scalp of AA subjects and a healthy sample cohort by using an integrated approach relying on metagenomic targeted 16S sequencing analysis, urine metabolomics, and human marker gene expression...
2020: Frontiers in Cellular and Infection Microbiology
Xufeng Du, Yuqian Li, Qilin Zhu, Jing Zhu, Wengrong Xu, Zhongming Li, Dirk M Elston
No abstract text is available yet for this article.
May 2020: JAAD Case Reports
X Bosch-Amate, C Riquelme-McLoughlin, D Morgado-Carrasco, L Rojano-Fritz, P Iranzo-Fernández
Lichen planus pemphigoides (LPP) is a rare autoimmune subepidermal blistering disease characterized by the coexistence of both lichen planus and either bullous pemphigoid or mucous membrane pemphigoid (MMP) features. Frontal fibrosing alopecia (FFA) is a scarring alopecia, generally considered a form of lichen planopilaris. We report two patients with concomitant FFA and MPP. Patient 1 was a 73-year-old woman with the clinical and histological diagnosis of oral lichen planus. In addition, she presented alopecic plaques in the parietal area with blisters, immunohistologically compatible with Brunsting-Perry pemphigoid, a variant of MMP...
April 20, 2020: Clinical and Experimental Dermatology
Azadeh Rakhshan, Parviz Toossi, Maliheh Amani, Sahar Dadkhahfar, Arash Bagheri Hamidi
BACKGROUND: Clinical and histological features may overlap between lichen planopilaris-associated and discoid lupus erythematosus-associated scarring alopecia. OBJECTIVES: The aim of this study was to demonstrate the cutaneous infiltration of plasmacytoid dendritic cells and to compare their distribution pattern in discoid lupus erythematosus and lichen planopilaris. METHODS: Twenty-four cases of discoid lupus erythematosus and 30 cases of lichen planopilaris were examined for immunostaining of the CD123 marker...
March 20, 2020: Anais Brasileiros de Dermatologia
Sergio Vano-Galvan, Lara Trindade de Carvalho, David Saceda-Corralo, Rita Rodrigues-Barata, Karolina L Kerkemeyer, Rodney D Sinclair, Ángela Hermosa-Gelbard, Óscar M Moreno-Arrones, Juan Jimenez-Cauhe, Bevin Bhoyrul
No abstract text is available yet for this article.
April 11, 2020: Journal of the American Academy of Dermatology
Niyaz Mostafa, Kevin Phan, Saxon Smith
Background: For severe cases of lichen planopilaris (LPP), unresponsive to first line therapy, systemic or potent agents may be required for disease control. There have been several reports of the off-label use of mycophenolate mofetil (MMF) in patients with LPP or have developed adverse effects to initial agents. Methods: A systematic review and meta-analysis was performed according to recommended Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies with ≥5 cases reporting the outcomes of MMF in LPP were pooled and a meta-analysis of proportion was performed...
April 23, 2020: Journal of Dermatological Treatment
Alfredo Rossi, Francesca Magri, Gemma Caro, Alessandro Federico, Maria Caterina Fortuna, Giuseppe Soda, Ludovica De Vincentiis, Marta Carlesimo
BACKGROUND: Immune checkpoint inhibitors are monoclonal antibodies which target immune "checkpoints" enhancing T cell-mediated cytotoxic and antitumor responses. Together to the amazing results, these drugs are associated with some peculiar adverse events called immune-related adverse events. Alopecia is one of these. It is usually reported to be clinically and histologically similar to alopecia areata. AIMS: We report a case of eosinophilic folliculitis of the scalp occurred during nivolumab therapy, its management and some pathogenetic hypotheses...
April 12, 2020: Journal of Cosmetic Dermatology
Raevti Bole, Saranya Wyles, Sydney Larkin, Reese Imhof, Rochelle R Torgerson
Background: Cicatricial alopecia is a type of permanent hair loss in which the hair follicle is replaced by scar tissue. Given its relatively low incidence, limited information is available regarding baseline hair characteristics, onset, and other disease-associated factors. Objective: We sought to further elucidate this information in our lichen planopilaris (LPP) patients. Methods: Between 1993 and 2016, 505 patients were diagnosed with biopsy-proven LPP...
March 2020: International Journal of Women's Dermatology
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