Lichen planopilaris | Page 3

Hojat Eftekhari, Seyyede Zeinab Azimi, Rana Rafiei, Abbas Darjani, Narges Alizadeh, Elahe Rafiei, Reyhaneh Ghadarjani, Kaveh Gharaei Nejad
BACKGROUND: Dermoscopy can be helpful in assessing nonpigmented lesions and inflammatory processes like lichen planopilaris (LPP). MATERIAL & METHODS: In this observational prospective study, 81 patients with a cicatricial alopecic patch on their scalp were included and underwent dermatologic examination. A biopsy was taken from the active part of the lesion based on dermoscopy evaluation. RESULTS: Analysis of 44 patients with definite diagnosis of LPP revealed that the mean age at the time of presentation was 44...
August 1, 2019: International Journal of Dermatology
Athena Manatis-Lornell, Jean-Phillip Okhovat, Dustin H Marks, Dina Hagigeorges, Maryanne M Senna
No abstract text is available yet for this article.
July 2020: Journal of the American Academy of Dermatology
Özlem Karadag Köse, A Tülin Güleç
INTRODUCTION: Clinical diagnosis of primary cicatricial alopecias presents difficulties. Studies regarding their trichoscopic features are scarce and mostly not comprehensive. The aim of this study is to evaluate the potential benefit of a handheld dermatoscope in clinical diagnosis of primary cicatricial alopecias. METHODS: In all, 69 patients with primary cicatricial alopecias were included in this prospective study. Preliminary diagnoses were established clinically, and confirmed by scalp biopsy in all cases...
June 12, 2019: Dermatology and Therapy
V Kanti, A Constantinou, P Reygagne, A Vogt, J Kottner, U Blume-Peytavi
BACKGROUND: Frontal fibrosing alopecia (FFA) is a cicatricial alopecia mostly affecting the frontotemporal hairline. Its aetiology and associated factors remain unclear. OBJECTIVE AND METHODS: An observational, cross-sectional and descriptive study was conducted in France and Germany to identify demographic and health characteristics associated with the severity of FFA. RESULTS: Of 490 included patients, 95% were female, of which 84% were postmenopausal...
June 9, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
Manao Kinoshita, Youichi Ogawa, Saori Yamamoto, Shinji Simada, Kazutoshi Harada, Tatsuyoshi Kawamura
Primary cicatricial alopecia (PCA) is a group of poorly understood mechanisms in which the destruction of hair follicles leads to permanent hair loss. Lichen planopilaris (LPP) is a type of lymphocytic PCA and it has been known for epidermal Langerhans cells (LC) to disappear in the scar of LPP. We also found that epidermal LC also disappeared in the scar of folliculitis decalvans (FD), a type of neutrophilic PCA. Of note was that epidermal LC did not disappear in the scar of discoid lupus erythematosus, another type of lymphocytic PCA, suggesting that LC disappearance in the scar was not always a common feature of PCA...
June 5, 2019: Journal of Dermatology
L Yip, T H Barrett, M J Harries
We present a series of 13 patients with clinical and histological features of both folliculitis decalvans (FD) and lichen planopilaris (LPP), either concomitantly, or sequentially as the clinical phenotype changed over time. This biphasic presentation of FD-LPP is not as uncommon as would be expected from the lack of description in the literature. We discuss current theories about the pathogenesis of both LPP and FD, and speculate how abnormal immune responses may either predispose to secondary bacterial infection or be influenced by dysbiosis of the skin/hair follicle microbiome, resulting in inflammation and permanent hair follicle damage...
April 24, 2019: Clinical and Experimental Dermatology
Soheil Tavakolpour, HamidReza Mahmoudi, Robabeh Abedini, Kambiz Kamyab Hesari, Amin Kiani, Maryam Daneshpazhooh
Frontal fibrosing alopecia (FFA) is a relatively new scarring alopecia that is considered a variant of lichen planopilaris (LPP) with no recognized promising treatments. In this study, we tried to clarify the underlying signaling pathways and their roles in the pathogenesis and progression of FFA. Because of several differences in clinical manifestations, response to treatments, and pathological findings, these two conditions could be differentiated from each other. Taking into account the already discussed signaling pathways and involved players such as T cells, mast cells, and sebaceous glands, different possible therapeutic options could be suggested...
June 2019: International Journal of Women's Dermatology
Pedram Alirezaei, Mohammad Ahmadpanah, Aliasghar Rezanejad, Alireza Soltanian, Dena Sadeghi Bahmani, Serge Brand
BACKGROUND: Individuals with lichen planopilaris (LPP) typically present with hair loss and an irritated scalp, with signs and symptoms such as itching, erythema, scaling, and burning. Both hair loss and reddened skin may be visible also for other people. Therefore, it is conceivable that individuals with LPP might report a lower mental health status. Accordingly, in the present study, we compared dimensions of mental health between individuals with LPP and healthy controls. METHOD: A total of 38 individuals with LPP (mean age: 38...
April 10, 2019: Neuropsychobiology
Vahide Lajevardi, Hamidreza Mahmoudi, Samane Moghanlou, Mahsa Ansari, Amir Teimourpour, Maryam Daneshpazhooh
BACKGROUND/OBJECTIVES: Videodermoscopy is a valuable tool for the diagnosis of cicatricial alopecias such as lichen planopilaris. Lichen planopilaris activity index is used for evaluating lichen planopilaris severity. Our aim was to examine the utility of videodermoscopy in the assessment of lichen planopilaris severity. METHODS: One hundred and seventeen histopathologically confirmed lichen planopilaris patients under went videodermoscopy. Lichen planopilaris activity index was calculated according to cicatricial alopecia standardised flowchart...
August 2019: Australasian Journal of Dermatology
David Arnold, Melissa B Hoffman, Oluwakemi Onajin, Omar P Sangueza, Amy McMichael
Lichen planus (LP) is an idiopathic inflammatory disease of the skin, hair, nails, and mucous membranes. Classic cutaneous LP is characterized by violaceous flat-topped papules that typically favor the extremities. LP on the scalp, otherwise known as lichen planopilaris, classically presents with scarring alopecia, perifollicular erythema and follicular prominence. Although LP pigmentosus presents primarily as hyperpigmentation, there is only one previous report of hypopigmented LP. In this report, the authors report 2 cases of LP that presented primarily as hypopigmented macules in 2 African American men...
March 18, 2019: American Journal of Dermatopathology
Joanna Jaros, Peter Lio
Low-dose naltrexone (LDN) has been successfully studied as an immunomodulatory and anti-inflammatory therapy in a wide range of conditions including Crohn’s disease, fibromyalgia, major depressive disorder, cancer, chronic regional pain syndrome, Charcot-Marie-Tooth, and multiple sclerosis.1-5 Recently, off label LDN has been shown to improve dermatologic conditions such as systemic sclerosis, Hailey-Hailey Disease, lichen planopilaris, and guttate psoriasis.6-9 In this article, we examine the existing evidence for use of LDN in skin disease and discuss its potential application in the treatment of atopic dermatitis (AD)...
March 1, 2019: Journal of Drugs in Dermatology: JDD
Mariusz Sikora, Adriana Rakowska, Małgorzata Olszewska, Lidia Rudnicka
Naltrexone is a competitive opioid receptor antagonist approved as supportive treatment in alcohol dependence and opioid addiction. At a dose of 50-100 mg daily, naltrexone is used off-label in dermatology for the treatment of trichotillomania and different types of pruritus. At a dose as low as 1- 5 mg per day, naltrexone demonstrates immunomodulatory action i.e. modulates Toll-like receptors signaling, decreases release of proinflammatory cytokines (tumor necrosis factor, interleukin-6, interleukin- 12), inhibits T lymphocyte proliferation, down-regulates the expression of chemokine receptors and adhesion molecules...
2019: Current Drug Targets
Theresa N Canavan, Sarah F McClees, James Robert Duncan, Boni E Elewski
Lichen planopilaris (LPP) is a scarring alopecia seen classically in older Caucasian women. Frontal fibrosing alopecia (FFA) is a distinct disease that shares the histologic and trichoscopic features of LPP but differs in its clinical presentation in that it involves the frontal scalp and occasionally the eyelashes and eyebrows of older Caucasian women. Several recent studies have described a link between FFA and the use of sunscreen. Here we report a case of LPP arising in the part line of the scalp of a woman with a history of long-term daily application of spray-on sunscreen to the hair part line...
February 2019: Skin Appendage Disorders
Chloe Ekelem, Christine Pham, Natasha Atanaskova Mesinkovska
Importance: Hair loss, or alopecia, is one of the most commonly presented problems in dermatology. Scarring alopecias are considered particularly damaging due to limited success in slowing permanent disease progression, and current treatment methods, such as intralesional and topical steroids and topical minoxidil, are largely ineffective. Objective: Hair transplantation is a debated treatment option for advanced cases of primary scarring alopecia. This study reviews the efficacy of hair transplantation as a treatment option for primary scarring alopecia...
February 2019: Skin Appendage Disorders
Agata Kłosowicz, Karolina Englert, Karolina Pełka, Maciej Pastuszczak, Anna Pastuszczak
Lichen planopilaris (LPP) is a rare, scarring form of alopecia with lymphocytic pattern. Due to the destruction of epithelial hair follicle stem cells in the bulge, it represents an irreversible condition. Antinuclear antibodies have been used for decades as diagnostic biomarkers of several rheumatological diseases. AIM: The aim of study was to determine the frequency of anti-nuclear antibodies positivity and subsequently analyze the presence of specific antibodies in LPP patients. MATERIALS AND METHODS: 57 patients (aged 28-79, female 96%) were included in the study...
January 28, 2019: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Mankul Goyal, Sujay Khandpur, M Ramam, Vinod Kumar Sharma, Manoj Kumar Singh
Background: Transverse sections of scalp biopsies are performed for the assessment of alopecias and are considered advantageous over vertical sections. Aim: The aim was to study the histopathological features of alopecias on transverse sections of scalp biopsies. Methods: It was a descriptive study. Clinically confirmed cases of noncicatricial and cicatricial alopecias were subjected to 4 mm scalp biopsies, which were sectioned transversely and analyzed...
January 2019: Indian Journal of Dermatology
Radhika Agarwal, Meeta Singh, Reema Dahiya, Vishal Singh, Dimple Chaudhary, Nita Khurana, Vijay Kumar Garg
Objectives: To study the direct immunofluorescence (DIF) in cicatricial alopecia (CA) patients. Materials and Methods: Approximately, 155 skin biopsies from CA patients examined over 7 years (2009-2015). Special stains and Hematoxylin and Eosin were performed, and final histopathological diagnosis was made. DIF (against anti-IgG, IgM, C3, IgA, and fibrinogen) on all these cases and patterns were noted. The descriptive statistics were applied along with ANOVA test...
January 2019: Indian Journal of Pathology & Microbiology
Allison C Hu, Lance W Chapman, Natasha A Mesinkovska
BACKGROUND: Physicians are beginning to use finasteride as treatment for hair loss, hirsutism, and various other dermatologic conditions in women. However, the reported efficacy and use of finasteride in the female population varies widely. The purpose of this study is therefore to better define the efficacy and use of finasteride in women and identify research gaps that require further investigation. METHODS: A systematic review of the current literature describing finasteride use in women...
July 2019: International Journal of Dermatology
Brigette Lee, Dirk M Elston
BACKGROUND: Naltrexone in standard and reduced doses is efficacious in many inflammatory and acantholytic disorders. OBJECTIVE: We summarized the current data of naltrexone that are relevant to dermatologic practice. METHODS: An English language PubMed literature search was performed using the terms naltrexone, low-dose naltrexone, Hailey-Hailey, psoriasis, lichen planopilaris, alopecia, opioid, opioid receptor, treatment, dermatology, monitoring, side effect, skin, pruritus, cutaneous, acantholytic, and Darier...
June 2019: Journal of the American Academy of Dermatology
Loren Krueger, Katerina Svigos, Nooshin Brinster, Nada Elbuluk
Frontal fibrosing alopecia (FFA) was first described as a progressive recession of the frontal hairline in postmenopausal women. Since its initial description, recognition and understanding of FFA has expanded. The condition is now defined as a patterned, symmetric, frontotemporal scarring alopecia that is considered to be histopathologically indistinguishable from lichen planopilaris. Numerous case reports and series have suggested clinical variants of and associations with FFA. In addition to reviewing the literature on FFA's associations, this article includes a case series of 5 women with skin of color (Hispanic and black) who presented with various cutaneous findings in association with FFA, including lichen planus pigmentosus (LPP), facial papules, and eyebrow loss...
November 2018: Cutis; Cutaneous Medicine for the Practitioner
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