Lichen planopilaris

John Plante, Chelsea Eason, Alan Snyder, Dirk Elston
No abstract text is available yet for this article.
May 28, 2020: Journal of the American Academy of Dermatology
Sean Dreyer, Chandra Smart, Carolyn Goh
No abstract text is available yet for this article.
April 2020: Cutis; Cutaneous Medicine for the Practitioner
Lara Trindade de Carvalho, Nekma Meah, Dmitri Wall, Rodney Sinclair
Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are lymphocytic, cicatricial alopecias. Clinically, LPP presents with multifocal patchy alopecia, while FFA, considered a variant of LPP, results in hairline recession. Frontal recession in FFA may progress as far as the mid-scalp and infrequently beyond. Treatment to arrest the inflammatory process can be challenging and response variable. We report a case of recalcitrant lichen planopilaris and frontal fibrosing alopecia demonstrating significant clinical improvement after four doses of the interleukin-23 (IL-23) monoclonal antibody tildrakizumab...
May 26, 2020: Dermatologic Therapy
Vahideh Lajevardi, Fereshteh Salarvand, Maryam Ghiasi, Maryam Nasimi, Mohammad Taraz
Background and Objectives: Lichen planopilaris (LPP) is one of the important causes of cicatricial alopecia. We aimed to evaluate the efficacy and safety of low-dose naltrexone (LDN) in the setting of a clinical trial in patients with LPP. Methods: We included patients with LPP between 2018 and 2020. Patients were allocated to two groups. The first group received topical clobetasol plus oral low dose naltrexone (3mg) while the second received topical clobetasol plus placebo. The assessment was made for the disease severity by lichen planopilaris activity index (LPPAI) instrument and the safety of the drug in 2-month intervals up to 6 months...
May 23, 2020: Journal of Dermatological Treatment
Daniela Pinto, Francesco Maria Calabrese, Maria De Angelis, Giuseppe Celano, Giammaria Giuliani, Marco Gobbetti, Fabio Rinaldi
Involvement of the microbiome in many different scalp conditions has been investigated over the years. Studies on the role of the scalp microbiome in specific diseases, such as those involving hair growth alterations like non-cicatricial [androgenetic alopecia (AGA), alopecia areata (AA)] and cicatricial alopecia lichen planopilaris, are of major importance. In the present work, we highlighted the differences in microbial populations inhabiting the scalp of AA subjects and a healthy sample cohort by using an integrated approach relying on metagenomic targeted 16S sequencing analysis, urine metabolomics, and human marker gene expression...
2020: Frontiers in Cellular and Infection Microbiology
Xufeng Du, Yuqian Li, Qilin Zhu, Jing Zhu, Wengrong Xu, Zhongming Li, Dirk M Elston
No abstract text is available yet for this article.
May 2020: JAAD Case Reports
X Bosch-Amate, C Riquelme-Mc Loughlin, D Morgado-Carrasco, L Rojano-Fritz, P Iranzo-Fernández
Lichen planus pemphigoides (LPP) is a rare autoimmune subepidermal blistering disease characterized by the coexistence of both lichen planus and bullous pemphigoid or mucous membrane pemphigoid (MMP) features. Frontal fibrosing alopecia (FFA) is a scarring alopecia, generally considered as a form of lichen planopilaris. Case 1 was a 70-year-old woman with clinical and histological diagnosis of oral lichen planus. In addition, she presented alopecic plaques in the parietal area with blisters, immunohistologically compatible with Brunsting-Perry pemphigoid, a MMP variant...
April 20, 2020: Clinical and Experimental Dermatology
Azadeh Rakhshan, Parviz Toossi, Maliheh Amani, Sahar Dadkhahfar, Arash Bagheri Hamidi
BACKGROUND: Clinical and histological features may overlap between lichen planopilaris-associated and discoid lupus erythematosus-associated scarring alopecia. OBJECTIVES: The aim of this study was to demonstrate the cutaneous infiltration of plasmacytoid dendritic cells and to compare their distribution pattern in discoid lupus erythematosus and lichen planopilaris. METHODS: Twenty-four cases of discoid lupus erythematosus and 30 cases of lichen planopilaris were examined for immunostaining of the CD123 marker...
March 20, 2020: Anais Brasileiros de Dermatologia
Sergio Vano-Galvan, Lara Trindade de Carvalho, David Saceda-Corralo, Rita Rodrigues-Barata, Karolina L Kerkemeyer, Rodney D Sinclair, Ángela Hermosa-Gelbard, Óscar M Moreno-Arrones, Juan Jimenez-Cauhe, Bevin Bhoyrul
No abstract text is available yet for this article.
April 11, 2020: Journal of the American Academy of Dermatology
Niyaz Mostafa, Kevin Phan, Saxon D Smith
Background: For severe cases of lichen planopilaris, unresponsive to first line therapy, systemic or potent agents may be required for disease control. There have been several reports of the off label use of mycophenolate mofetil (MMF) in patients with lichen planopilaris or have developed adverse effects to initial agents. Methods: A systematic review and meta-analysis was performed according to recommended PRISMA guidelines. Studies with ≥5 cases reporting the outcomes of MMF in LPP were pooled and a meta-analysis of proportion was performed...
April 11, 2020: Journal of Dermatological Treatment
Alfredo Rossi, Francesca Magri, Gemma Caro, Alessandro Federico, Maria Caterina Fortuna, Giuseppe Soda, Ludovica De Vincentiis, Marta Carlesimo
BACKGROUND: Immune checkpoint inhibitors are monoclonal antibodies which target immune "checkpoints" enhancing T cell-mediated cytotoxic and antitumor responses. Together to the amazing results, these drugs are associated with some peculiar adverse events called immune-related adverse events. Alopecia is one of these. It is usually reported to be clinically and histologically similar to alopecia areata. AIMS: We report a case of eosinophilic folliculitis of the scalp occurred during nivolumab therapy, its management and some pathogenetic hypotheses...
April 12, 2020: Journal of Cosmetic Dermatology
Raevti Bole, Saranya Wyles, Sydney Larkin, Reese Imhof, Rochelle R Torgerson
Background: Cicatricial alopecia is a type of permanent hair loss in which the hair follicle is replaced by scar tissue. Given its relatively low incidence, limited information is available regarding baseline hair characteristics, onset, and other disease-associated factors. Objective: We sought to further elucidate this information in our lichen planopilaris (LPP) patients. Methods: Between 1993 and 2016, 505 patients were diagnosed with biopsy-proven LPP...
March 2020: International Journal of Women's Dermatology
Prag Batra, Kumar Sukhdeo, Jerry Shapiro
Introduction: We present 2 cases in which typically irreversible lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) showed signs of reversal. Case Presentation: A 27-year-old Caucasian man presented with hair loss and intense pruritus on the vertex scalp for 4 years with biopsy-proven LPP and having failed multiple pharmacologic modalities. Six months after adding oral tofacitinib and later dapsone, he demonstrated reduced scalp visibility, evidence of crown and vertex hair regrowth, and elimination of itch...
March 2020: Skin Appendage Disorders
M Kinoshita-Ise
No abstract text is available yet for this article.
March 20, 2020: British Journal of Dermatology
Alexander C Katoulis, Despina Mortaki, Dimitrios Sgouros, Aikaterini I Liakou, Evangelia Bozi, Dimitra Koumaki, Korina Tzima, Ioannis Panayiotides
Sebaceous nevus (SN), is a skin hamartoma, combining a variety of epidermal, follicular, sebaceous, and apocrine abnormalities. Although usually present at birth, it may become apparent later in life appearing as a yellowish-brown, verrucous plaque with alopecia. SN is implicated with secondary tumors arising on the hairless plaque during the adulthood. Lichen planopilaris is a common, primary lymphocytic scarring alopecia of unknown etiology, characterized by lichenoid/interface perifollicular lymphocytic infiltrate occurring at the level of the infundibulum and the isthmus...
March 2020: Indian Journal of Dermatology
Chih-Lung Chen, Wen-Yen Huang, Eddy Hsi Chun Wang, Kang-Yu Tai, Sung-Jan Lin
Stem cell activity is subject to non-cell-autonomous regulation from the local microenvironment, or niche. In adaption to varying physiological conditions and the ever-changing external environment, the stem cell niche has evolved with multifunctionality that enables stem cells to detect these changes and to communicate with remote cells/tissues to tailor their activity for organismal needs. The cyclic growth of hair follicles is powered by hair follicle stem cells (HFSCs). Using HFSCs as a model, we categorize niche cells into 3 functional modules, including signaling, sensing and message-relaying...
March 14, 2020: Journal of Biomedical Science
Maryam Shayesteh Alam, Brittanie LaBelle
No abstract text is available yet for this article.
March 2020: JAAD Case Reports
Meghan L McPhie, Ami Wang, Sonja Molin, Thomas Herzinger
Infliximab is a tumor necrosis factor-alpha inhibitor used to treat a range of inflammatory diseases. Most reports of cutaneous eruptions from tumor necrosis factor-alpha inhibitors have described the paradoxical development of psoriasis or psoriasiform drug reaction. In our report, we present a 31-year-old female with inflammatory bowel disease who developed an unusual lichenoid drug reaction to infliximab involving the hair follicles, resulting in progressive global alopecia. Clinical features and histopathological findings were consistent with drug-induced lichen planopilaris with eosinophils and lichenoid dermatitis...
2020: SAGE Open Medical Case Reports
Michael J Randolph, Waleed Al Salhi, Antonella Tosti
Lichen planopilaris (LPP) is a cell-mediated scarring alopecia that causes inflammation of the scalp and the eventual destruction of hair follicles in affected areas. Current literature on treatment of LPP remains limited with no definitive treatment approach being recognized, although a combination of topical/intralesional steroids and orally administered hydroxychloroquine remains the most utilized option. Low-level light therapy (LLLT) is an expanding technology shown to be effective in a variety of dermatologic conditions...
April 2020: Dermatology and Therapy
Joshua A Lee, Dylan A Levy, Krishna G Patel, Emily Brennan, Samuel L Oyer
OBJECTIVE: Evolving hair transplantation (HT) techniques have offered new possibilities for hair restoration. However, the role of HT in patients with frontal fibrosing alopecia (FFA) and lichen planopilaris (LPP) remains unclear. This study aims to evaluate the outcomes and temporal relationship of HT in this population. METHODS: A literature search of three databases was conducted. We reviewed 1) literature reporting outcomes of patients with LPP or FFA who received HT, and 2) studies reporting the development of LPP or FFA resulting from HT...
February 11, 2020: Laryngoscope
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