Lichen planopilaris

M Kinoshita-Ise
No abstract text is available yet for this article.
March 20, 2020: British Journal of Dermatology
Alexander C Katoulis, Despina Mortaki, Dimitrios Sgouros, Aikaterini I Liakou, Evangelia Bozi, Dimitra Koumaki, Korina Tzima, Ioannis Panayiotides
Sebaceous nevus (SN), is a skin hamartoma, combining a variety of epidermal, follicular, sebaceous, and apocrine abnormalities. Although usually present at birth, it may become apparent later in life appearing as a yellowish-brown, verrucous plaque with alopecia. SN is implicated with secondary tumors arising on the hairless plaque during the adulthood. Lichen planopilaris is a common, primary lymphocytic scarring alopecia of unknown etiology, characterized by lichenoid/interface perifollicular lymphocytic infiltrate occurring at the level of the infundibulum and the isthmus...
March 2020: Indian Journal of Dermatology
Chih-Lung Chen, Wen-Yen Huang, Eddy Hsi Chun Wang, Kang-Yu Tai, Sung-Jan Lin
Stem cell activity is subject to non-cell-autonomous regulation from the local microenvironment, or niche. In adaption to varying physiological conditions and the ever-changing external environment, the stem cell niche has evolved with multifunctionality that enables stem cells to detect these changes and to communicate with remote cells/tissues to tailor their activity for organismal needs. The cyclic growth of hair follicles is powered by hair follicle stem cells (HFSCs). Using HFSCs as a model, we categorize niche cells into 3 functional modules, including signaling, sensing and message-relaying...
March 14, 2020: Journal of Biomedical Science
Maryam Shayesteh Alam, Brittanie LaBelle
No abstract text is available yet for this article.
March 2020: JAAD Case Reports
Meghan L McPhie, Ami Wang, Sonja Molin, Thomas Herzinger
Infliximab is a tumor necrosis factor-alpha inhibitor used to treat a range of inflammatory diseases. Most reports of cutaneous eruptions from tumor necrosis factor-alpha inhibitors have described the paradoxical development of psoriasis or psoriasiform drug reaction. In our report, we present a 31-year-old female with inflammatory bowel disease who developed an unusual lichenoid drug reaction to infliximab involving the hair follicles, resulting in progressive global alopecia. Clinical features and histopathological findings were consistent with drug-induced lichen planopilaris with eosinophils and lichenoid dermatitis...
2020: SAGE Open Medical Case Reports
Michael J Randolph, Waleed Al Salhi, Antonella Tosti
Lichen planopilaris (LPP) is a cell-mediated scarring alopecia that causes inflammation of the scalp and the eventual destruction of hair follicles in affected areas. Current literature on treatment of LPP remains limited with no definitive treatment approach being recognized, although a combination of topical/intralesional steroids and orally administered hydroxychloroquine remains the most utilized option. Low-level light therapy (LLLT) is an expanding technology shown to be effective in a variety of dermatologic conditions...
February 14, 2020: Dermatology and Therapy
Joshua A Lee, Dylan A Levy, Krishna G Patel, Emily Brennan, Samuel L Oyer
OBJECTIVE: Evolving hair transplantation (HT) techniques have offered new possibilities for hair restoration. However, the role of HT in patients with frontal fibrosing alopecia (FFA) and lichen planopilaris (LPP) remains unclear. This study aims to evaluate the outcomes and temporal relationship of HT in this population. METHODS: A literature search of three databases was conducted. We reviewed 1) literature reporting outcomes of patients with LPP or FFA who received HT, and 2) studies reporting the development of LPP or FFA resulting from HT...
February 11, 2020: Laryngoscope
Jacob Griggs, Ralph M Trüeb, Maria Fernanda Reis Gavazzoni Dias, Maria Hordinsky, Antonella Tosti
BACKGROUND/OBJECTIVES: Fibrosing alopecia in a pattern distribution (FAPD) is a newly recognized form of scarring alopecia sharing characteristics of both androgenetic alopecia (AGA) and lichen planopilaris (LPP). The existing literature on FAPD and current understanding of the epidemiology, pathogenesis, clinical features, diagnosis, and treatment of this disease are reviewed. METHODS: PubMed searches were performed to identify all articles discussing FAPD. The references of articles were used to identify additional articles...
January 8, 2020: Journal of the American Academy of Dermatology
Jodie Raffi, Raagini Suresh, Oma Agbai
Certain types of alopecia, such as traction alopecia, discoid lupus erythematosus, and central centrifugal cicatricial alopecia, occur more commonly in African-American individuals than in those of other ethnicities. Both intrinsic hair qualities and hair care practices play a role. Lower baseline tensile strength, hair density, and growth rates, as well as the use of high-tension hairstyles and chemical relaxers may contribute to alopecia in this group. Alopecia can also occur as a result of discoid lupus erythematosus, which involves chronic lymphocytic infiltration and eventual scarring of the hair follicle...
December 2019: International Journal of Women's Dermatology
M Harries, J Hardman, I Chaudhry, E Poblet, R Paus
BACKGROUND: Frontal fibrosing alopecia (FFA) is traditionally regarded as a variant of lichen planopilaris (LPP) based on histological features. Distinct clinical presentation, demographics and epidemiology suggest differing pathogenic factors determine the final phenotype. OBJECTIVES: To map the hair follicle immune system (HIS) in LPP and FFA by systematically comparing key inflammatory markers in defined hair follicle compartments. METHODS: Lesional scalp biopsies from LPP, FFA and healthy controls were stained with the following immunohistochemical markers: CD1a and CD209, CD4, CD8, CD56, CD68, CD123, CXCR3, FOXP3, mast cell tryptase and cKit...
December 28, 2019: British Journal of Dermatology
Erik L. Peterson, Daniel Gutierrez, Nooshin K. Brinster, Kristen I. Lo Sicco, Jerry Shapiro
Lichen planopilaris (LPP) is a cicatricial alopecia that often causes permanent hair loss. Pioglitazone, a peroxisome proliferator activated receptor-gamma (PPAR- γ) agonist, has demonstrated immunomodulatory properties that may offer an effective treatment modality. This retrospective analysis describes 23 patients with LPP treated with adjunctive pioglitazone. Most (18/25) demonstrated significant reduction in patient-reported symptoms and clinical signs of inflammation. No adverse effects were reported...
December 1, 2019: Journal of Drugs in Dermatology: JDD
Andjela Egger, Olivera Stojadinovic, Mariya Miteva
BACKGROUND: Folliculitis decalvans (FD) and lichen planopilaris (LPP) are classified as neutrophilic and lymphocytic cicatricial alopecias according to the North American Hair Research Society. Recently, a clinical phenotype combining concomitant or sequential features for both was described as a FD LPP phenotypic spectrum (FDLPPPS). OBJECTIVES: To review the most common phenotypic presentation of FDLPPPS with a main focus on histopathology. METHODS: We reviewed retrospectively series of 7 patients with a similar phenotypic presentation with special focus on the histologic pattern...
March 2020: American Journal of Dermatopathology
Dustin H Marks, Dina Hagigeorges, Athena J Manatis-Lornell, Ruth K Foreman, Maryanne M Senna
Background: We report a case of acute and severe lichen planopilaris (LPP)-like alopecia in a 35-year-old male construction worker following occupational exposure to trichloroethylene (TCE) and tetrachloroethylene (PCE). Case Report: Two weeks after initiating ground-intrusive construction at a previous dry-cleaning facility site, the patient developed sudden scalp pruritus and associated patchy hair loss. As subsequent scalp biopsies revealed LPP, he was started on hydroxychloroquine at 200 mg twice daily and clobetasol solution once daily...
November 2019: Skin Appendage Disorders
Yuval Ramot, Marta Bertolini, Maria Boboljova, Yoshikazu Uchida, Ralf Paus
Peroxisome proliferator-activated receptors (PPARs) are abundantly expressed in human skin, with PPAR-γ being the most intensively investigated isoform. In various ex vivo and in vivo models, PPAR-γ-mediated signalling has recently surfaced as an essential element of hair follicle (HF) development, growth and stem cell biology. Moreover, the availability of novel, topically applicable PPAR-γ modulators with a favourable toxicological profile has extended the range of potential applications in clinical dermatology...
November 26, 2019: Experimental Dermatology
Timothy L Tan, Kristina Doytcheva, Joan Guitart, Pedram Gerami, Pedram Yazdan
BACKGROUND: Eccrine duct dilation (EDD) was recently described to occur more frequently in cicatricial alopecias than noncicatricial alopecias. Because single EDD can be useful in the evaluation of alopecias, we aimed to determine whether dilation of multiple eccrine duct units, or "multiple eccrine duct dilation (MEDD)," could more specifically discriminate between cicatricial and noncicatricial alopecias. METHODS: We retrospectively evaluated 611 scalp biopsies (342 cicatricial alopecias and 269 noncicatricial alopecias)...
December 2019: American Journal of Dermatopathology
Korn Triyangkulsri, Ploychompoo Srisuwanwattana, Tueboon Sriphojanart, Poonkiat Suchonwanit
Fibrosing alopecia in a pattern distribution (FAPD) is a relatively new entity in the family of cicatricial alopecia. It has been categorized as a member of the lichen planopilaris (LPP) group due to its similarity in clinical and histopathological presentation. Nonetheless, the disease earns its own entity due to its lichenoid inflammation exclusively involving miniaturized hair and area of involvement mimicking pattern hair loss which differentiates itself from other types of LPP or pattern hair loss. Since its first introduction by Zinkernagel and Trüeb in 2000, there have been only few case reports and series of FAPD...
September 2019: Case Reports in Dermatology
Michela Starace, Gloria Orlando, Aurora Alessandrini, Carlotta Baraldi, Francesca Bruni, Bianca Maria Piraccini
BACKGROUND: Fibrosing Alopecia in a Pattern Distribution (FAPD) and Cicatricial Pattern Hair Loss (CPHL) are poorly recognized diffuse variants of Lichen Planopilaris (LPP). OBJECTIVES: The medical features of 40 patients affected by a diffuse hair thinning associated with a long-lasting history of pruritus and erythema of the scalp and a histopathological diagnosis of LPP were reviewed. METHODS: Clinical, trichoscopy, histopathology, response to treatment and follow-up were analyzed...
November 7, 2019: Journal of the American Academy of Dermatology
Pedro Secchin, Danielle Carvalho Quintella, Nathalia Ávila de Oliveira Paula, Luana Cristina da Silva Andrade, Celso Tavares Sodré
BACKGROUND: Frontal fibrosing alopecia is a condition of unknown origin, histologically similar to classic lichen planopilaris and generally observed in postmenopausal women with alopecia of the frontal-temporal hairline. OBJECTIVES: To describe the clinical, dermatoscopic, and histopathological characteristics and the treatment used in patients who have frontal fibrosing alopecia at the Alopecia Outpatient Clinic in a university hospital. METHODS: Retrospective descriptive study performed by reviewing medical charts and biopsies of the scalp...
2019: Anais Brasileiros de Dermatologia
Christian S Jordan, Cindi Chapman, Athanassios Kolivras, Janet L Roberts, Nathaniel B Thompson, Curtis T Thompson
BACKGROUND: The purpose of the study was to compare the histopathologic and immunophenotypic features of central centrifugal cicatricial alopecia (CCCA) and lichen planopilaris (LPP) to better characterize and differentiate these two clinical entities. CCCA remains an ill-defined and still-unsettled histologic entity and many hair loss experts regard CCCA to be histologically indistinguishable from LPP. Given the overlapping histologic features of these two lymphocyte-predominant cicatricial alopecias, and the lack of consensus regarding the significance of proposed distinctions, dermatopathologists face difficulty in providing clinicians and patients certainty with a definitive diagnosis of CCCA vs LPP...
February 2020: Journal of Cutaneous Pathology
Sergio Vañó-Galván, David Saceda-Corralo, Ulrike Blume-Peytavi, Jose Cucchía, Ncoza C Dlova, Maria Fernanda Reis Gavazzoni Dias, Ramon Grimalt, Daniela Guzmán-Sánchez, Matthew Harries, Anthony Ho, Susan Holmes, Jorge Larrondo, Anisa Mosam, Rui Oliveira-Soares, Giselle M Pinto, Bianca M Piraccini, Rodrigo Pirmez, Daniel De la Rosa Carrillo, Lidia Rudnicka, Jerry Shapiro, Rodney Sinclair, Antonella Tosti, Ralph M Trüeb, Annika Vogt, Mariya Miteva
Background: The frequency of different types of alopecia is not clearly reported in recent studies. Objective: To analyze the frequency of the types of alopecia in patients consulting at specialist hair clinics (SHC) and to assess for global variations. Methods: Multicenter retrospective study including data from patients evaluated at referral SHC in Europe, America, Africa and Australia. Results: A total of 2,835 patients (72...
August 2019: Skin Appendage Disorders
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