Han Wu, Jinfa Ye, Minjie Zhang, Lingyu Zhang, Sijie Lin, Qingjian Li, Yanbo Liu, Yun Han, Caihong Huang, Yiming Wu, Yuhang Cheng, Shundong Cai, Lang Ke, Gang Liu, Wei Li, Chengchao Chu
Corneal neovascularization (CNV) is one of the common blinding factors worldwide, leading to reduced vision or even blindness. However, current treatments such as surgical intervention and anti-VEGF agent therapy still have some shortcomings or evoke some adverse effects. Recently, SU6668, an inhibitor targeting angiogenic tyrosine kinases, has demonstrated growth inhibition of neovascularization. But the hydrophobicity and low ocular bioavailability limit its application in cornea. Hereby, we proposed the preparation of SU6668 pure nanoparticles (NanoSU6668; size ~135 nm) using a super-stable pure-nanomedicine formulation technology (SPFT), which possessed uniform particle size and excellent aqueous dispersion at 1 mg/mL...
May 27, 2024: Journal of Nanobiotechnology