Shiva Kargar, Alireza Ansari-Moghaddam
BACKGROUND: Smoking is an important risk factor for various diseases, especially cancer. AIMS: To estimate the prevalence of cigarette and waterpipe smoking and its association with cancer incidence in Middle Eastern countries. METHODS: We searched Medline, Google Scholar, and PubMed for original articles published between 2000 and 2020 using a combination of the terms smoking, cigarettes, waterpipe, hookah, tobacco, prevalence, Middle East, and the names of countries in the Middle East...
September 9, 2023: Eastern Mediterranean Health Journal
Keren Jia, Yang Chen, Yu Sun, Yajie Hu, Lei Jiao, Jie Ma, Jiajia Yuan, Changsong Qi, Yanyan Li, Jifang Gong, Jing Gao, Xiaotian Zhang, Jian Li, Cheng Zhang, Lin Shen
No abstract text is available yet for this article.
September 29, 2023: BMC Medicine
H Htet, T T Win, S T Wong, N H Shamsudin, P Kandasami
INTRODUCTION: Gastric cancer (GC) is one of the leading causes of all new cancer cases globally. Although it is no longer reported in the top 10th most common cancer in Malaysia, geographical distribution and ethnic influences still obviously exist. MATERIALS AND METHODS: This is a retrospective analysis of histopathological records in a public tertiary health care centre in Malaysia. The computerised laboratory information system from the histopathology department of the hospital was retrieved for the period of 2005-2018...
September 2023: Medical Journal of Malaysia
Yakai Huang, Yingjing Zhang, Yu Zhang, Wenping Liu, Yantian Fang, Masoud Motlagh
An environmentally friendly strategy was used in this study to synthesize gold nanoparticles decorated on sepiolite clay (GNPs-SC) using Heracleum persicum grass extract. The physicochemical characters of the prepared composite were characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), and X-ray diffraction (XRD). A GNPs-SC modified carbon pate electrode (CPE) was used to study the electrochemical oxidation of nitrite. The proposed nitrite sensor exhibits excellent performance, including a broad linear range (1...
September 27, 2023: Environmental Research
Ying Yu, Chao Tan, Li Ding, Zhen Zhu, Gong Zhang, Cong Long
In the digestive system, gastric cancer (GC) is one of the most usual pernicious tumors. Despite great improvement has been created in treatment, it is still the second major reason of cancer-relevant death. Thus, further researches are required to explicate the latent molecular mechanisms and look for novel biomarkers. ZIC2 has been confirmed to be a facilitator in diversified cancers. However, the particular regulatory of ZIC2 in GC needs further investigation. In this work, it was notarized that ZIC2 expression was up-regulated in GC, and ZIC2 knockdown weakened GC cell proliferation...
September 19, 2023: Tissue & Cell
Zahra Abedi Cham Heidari, Parizad Ghanbarikondori, Elham Mortazavi Mamaghani, Ali Hheidari, Elham Saberian, Elaheh Mozaffari, Mohsen Alizadeh, Mohammad Allahyartorkaman
OBJECTIVE: Addressing both the initial treatment response and subsequent paclitaxel resistance is a pivotal concern. Nano drug delivery, an emerging approach, presents a cutting-edge alternative to conventional chemotherapy. METHODS: This investigation synthesized PEGylated nanoparticles (NPs) via the Reverse Phase Evaporation technique for liposomal NPs. Characteristics such as zeta potential, size, drug release and polydispersity index (PDI) were subjected to evaluation...
September 1, 2023: Asian Pacific Journal of Cancer Prevention: APJCP
Fang Huang, Meihua Fang
Liver was the most common site of distant metastasis in patients with gastric cancer (GC). The prediction model of the risk of liver metastasis was rarely proposed. Therefore, we aimed to establish a prediction model for liver metastasis in patients with GC. In this retrospective cohort study, we extracted demographic and clinical data of all the GC patients from the Surveillance, Epidemiology, and End Results registration database from 2010 to 2015. Patients were divided into training set (n = 1691) for model development and testing set (n = 3943) for validation...
September 29, 2023: Medicine (Baltimore)
Zhi-Yang Liu, Lin Xin
The basement membrane is an essential defense against cancer progression and is intimately linked to the tumor immune microenvironment. However, there is limited research comprehensively discussing the potential application of basement membrane-related genes (BMRGs) in the prognosis evaluation and immunotherapy of gastric cancer (GC). The RNA-seq data and clinical information of GC patients were collected from the TCGA and GEO database. Prognosis-associated BMRGs were filtered via univariate Cox regression analysis...
September 29, 2023: Medicine (Baltimore)
Hongmei He, Fang Yu, Fang Wang, Qian Liu
OBJECTIVE: To analyze the application of enteral nutrition support in perioperative gastric cancer patients based on multiform Internet education mode, and to explore the effects of this mode on nutritional indexes such as body weight, total protein (TP), albumin (ALB), prealbumin (PA) and hemoglobin (Hb), and quality of life after intervention. METHODS: The data of 80 patients with gastric cancer admitted to our hospital from January 2018 to January 2020 were retrospectively analyzed...
September 29, 2023: Alternative Therapies in Health and Medicine
Xiaowen Zhang, Xiao-Fei Chen, Wen-Jia Chen, Haibo Ding, Bao-Xia Zhang
This study employs network pharmacology to uncover the pharmacological mechanisms underlying Shen-qi-di-huang decoction's efficacy in treating uremia. We identified a total of 927 differentially expressed genes (DEGs) through differential expression analysis and the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database and analysis platform, of which 607 were downregulated and 320 were upregulated. We also obtained the effective biological components and related target gene information of Chinese herbal medicines such as Renshen, Huangqi, shudihuang, Shanyao, Fuling, Mudanpi, and Shanzhuyu in Shen-qi-di-huang decoction and constructed a regulatory relationship network between molecular components and target genes in Shen-qi-di-huang decoction...
September 29, 2023: Alternative Therapies in Health and Medicine
Yuna Kim, Yoo Jin Bae, Jie-Hyun Kim, Hyunki Kim, Su-Jin Shin, Da Hyun Jung, Hyojin Park
BACKGROUND: Trastuzumab is the only approved target agent for the first-line treatment of human epidermal growth factor receptor-2 (HER-2) positive gastric cancer; however, trastuzumab resistance is a major problem in clinical practice. To comprehend the mechanism of trastuzumab resistance, we focused on the Wnt/β-catenin signaling pathway and its influence on the phenotypes and behavior of trastuzumab-resistant gastric cancer cells. METHODS: Trastuzumab-resistant NCI-N87R cells were established in vitro from the human gastric cancer cell line NCI-N87 by dose-escalating repeated trastuzumab treatment...
September 29, 2023: BMC Cancer
Yi-Wen Chen, Cheng-Yen Chuang, Shyh-Sheng Yang, Sen-Ei Shai, Ming-Ching Lee, Hao-Yun Chen, Chih-Hung Lin
BACKGROUND: Gastric conduit is most widely used method for esophageal reconstruction. Despite its popularity, certain complications, such as anastomotic leakage and strictures remain to be resolved. In the present study, we reviewed the outcomes of narrow gastric conduit compared with wide gastric conduit reconstruction. METHODS: We retrospectively reviewed 493 patients with esophageal cancer who received esophagectomy with reconstruction in Taichung Veteran General Hospital, Taiwan between January 2010 and December 2019...
September 29, 2023: Journal of the Chinese Medical Association: JCMA
Abdelrahman A Nimeri
No abstract text is available yet for this article.
September 29, 2023: Journal of the American College of Surgeons
Gen Tsujio, Masakazu Yashiro, Takashi Sakuma, Rika Aoyama, Koji Maruo, Yurie Yamamoto, Kiyoshi Maeda
BACKGROUND/AIM: Intra-tumoral heterogeneity, which is frequently found in various types of cancers, has been suggested to play an important role in cancer progression and metastasis. The findings of our previous study suggested that p-SMAD2 and c-MET signaling might play important roles in the progression to lymph node metastasis of HER2-positive gastric cancer. In this study, we confirmed the effect of SMAD2/MET signaling in the progression of HER2-positive gastric cancer in an animal model...
October 2023: Anticancer Research
Yi-Qiang Zhang, Shuai-Shuai Shi, Yun-Fei Li, Yang Yang, Peng Bai, Chu-Han Qiao
BACKGROUND/AIM: In addition to its established role in regulating circadian rhythms and reducing inflammation, melatonin has been demonstrated to possess anti-cancer properties. In this study, we investigated the effects of exosomal miRNAs released by melatonin-treated GC cells on gastric cancer. MATERIALS AND METHODS: To identify the potential exosomal miRNAs involved in the treatment of gastric cancer, we performed exosome small RNA sequencing (sRNA-seq) to screen significant changes in 34 exosomal miRNAs in AGS cells before and after melatonin treatment...
October 2023: Anticancer Research
Linlin DU, Fei Xie, Haibo Han, Lianhai Zhang
BACKGROUND/AIM: Spalt-like transcription factor 4 (SALL4), as a proto-oncogene, is expressed in various tumors and correlates with poor prognosis of patients. Entinostat, a histone deacetylase (HDAC) inhibitor, has emerged as a potentially promising anti-cancer drug. This study aims to explore the biological role and underlying mechanism of SALL4 targeting by entinostat in gastric cancer. MATERIALS AND METHODS: Online databases were used to exam the link between SALL4 and prognosis...
October 2023: Anticancer Research
Zhening Zhang, Yiyi Yu, Tong Xie, Changsong Qi, Xiaotian Zhang, Lin Shen, Zhi Peng
BACKGROUND: The clinicopathological features of MET-amplified gastric cancer (GC) and real-world data on the efficacy of MET-targeted therapies remain unknown. Pulmonary lymphangitis carcinomatosis (PLC) is a peculiar manifestation of GC, whose management has not been thoroughly described. METHODS: This study analyzed patients diagnosed with MET-amplified GC or GC with PLC at any time point of the disease course from 2011 to 2021 in two centers. Clinicopathological features and survival outcomes of MET-amplified GC were analyzed...
September 29, 2023: Cancer Medicine
Yan-Cui Gong, Guo-Liang Ren, Bo Liu, Feng Li, Hong-Peng Zhao, Jing-Bo Chen, Yu-Peng Li, Hai-Hua Yu
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the colony formation assay data shown in Figs. 2, 4 and 8 were strikingly similar to data that had already appeared in another article written by different authors at different research institutes [Chen W, Wang J, Liu S, Wang S, Cheng Y, Zhou W, Duan C and Zhang C: MicroRNA‑361‑3p suppresses tumor cell proliferation and metastasis by directly targeting SH2B1 in NSCLC. J Exp Clin Cancer Res 35: 76, 732516, 2016]...
November 2023: Oncology Reports
Mariana Belén Velásquez Sotomayor, Anthony Vladimir Campos Segura, Ricardo José Asurza Montalva, Obert Marín-Sánchez, Alexis Germán Murillo Carrasco, César Alexander Ortiz Rojas
Gastric cancer (GC) ranks fifth in incidence and fourth in mortality worldwide. The high death rate in patients with GC requires new biomarkers for improving survival estimation. In this study, we performed a transcriptome-based analysis of five publicly available cohorts to identify genes consistently associated with prognosis in GC. Based on the ROC curve, patients were categorized into high and low-expression groups for each gene using the best cutoff point. Genes associated with survival (AUC > 0.5; univariate and multivariate Cox regressions, p < 0...
2023: Frontiers in Genetics
Journal Of Healthcare Engineering
[This retracts the article DOI: 10.1155/2022/7897274.].
2023: Journal of Healthcare Engineering
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