Yahiya Y Syed
Futibatinib (Lytgobi® ) is an oral, covalently binding, irreversible inhibitor of fibroblast growth factor receptor (FGFR)1-4 that is being developed by Taiho Oncology and Taiho Pharmaceutical for the treatment of cancers, including cholangiocarcinoma, breast cancer, gastric cancer, urothelial cancer, oesophageal cancer and non-small cell lung cancer. Futibatinib was approved in the USA on 30 September 2022 for the treatment of adult patients with previously treated, unresectable, locally advanced or metastatic intrahepatic cholangiocarcinoma harbouring FGFR2 gene fusions or other rearrangements...
November 28, 2022: Drugs
Loganathan Chandramani Priya Dharshini, Rajan Radha Rasmi, Chinnadurai Kathirvelan, Kalavathi Murugan Kumar, K M Saradhadevi, Kunnathur Murugesan Sakthivel
Cancer progression is closely linked to oxidative stress (OS) inflammation. OS is caused by an imbalance between the amount of reactive oxygen species produced and antioxidants present in the body. Excess ROS either oxidizes biomolecules or activates the signaling cascade, resulting in inflammation. Immune cells secrete cytokines and chemokines when inflammation is activated. These signaling molecules attract a wide range of immune cells to the site of infection or oxidative stress. Similarly, increased ROS production by immune cells at the inflamed site causes oxidative stress in the affected area...
November 28, 2022: Applied Biochemistry and Biotechnology
Qianqian Gao, Yufang Chen, Lingping Yue, Ziyan Li, Meihua Wang
Transmembrane protein 132 A (TMEM132A) has been recently reported to be a novel regulator of the Wnt signaling pathway, which is a cancer-associated cascade. However, the role of TMEM132A in cancer is not well characterized. Here, we used bioinformatics analysis to analyze the differential expression of TMEM132A in gastric cancer (GC) tissues and determine its diagnostic and prognostic value. Results showed that TMEM132A expression was upregulated in GC tissues. TMEM132A was also found to have diagnostic and prognostic roles in patient with GC...
November 28, 2022: Nucleosides, Nucleotides & Nucleic Acids
Azusa Kawasaki, Naohiro Yoshida, Hiroyoshi Nakanishi, Shigetsugu Tsuji, Kenichi Takemura, Hisashi Doyama
OBJECTIVES: Overlooking early gastric cancer (EGC) during endoscopy is an issue to be resolved. Image-enhanced endoscopy is expected to improve EGC detection. This study investigated the usefulness of third-generation narrow band imaging (3G-NBI) and texture and color enhancement imaging (TXI) in improving the visibility of EGC using the color difference between EGC and its surrounding gastric mucosa. METHODS: In this retrospective observational study, we examined 51 superficial EGCs that underwent endoscopic submucosal dissection and were observed by all three methods: 3G-NBI, TXI, and white light imaging (WLI)...
April 2023: DEN Open
Junchang Zhang, Han Wang, Jing Wu, Cheng Yuan, Songyao Chen, Shuhao Liu, Mingyu Huo, Changhua Zhang, Yulong He
O-glycosylation is a widespread post-translational modification of proteins. Aberrant O-glycosylation is a hallmark of cancer. Here, we show that the polypeptide N-acetylgalactosamine-transferase 1 ( GALNT1 ) is frequently upregulated in gastric cancer and is correlated with poor survival. Overexpression of GALNT1 promoted, whereas knockdown suppressed proliferation, migration, and invasion of gastric cancer cells in vitro and in vivo . Mechanistically, GALNT1 enhances aberrant initiation of O-glycosylation and results in CD44 glycoproteins modified with abundant Tn antigens, thereby activating the Wnt/β-catenin signaling pathway...
2022: International Journal of Biological Sciences
Amar Kumar Behera, Manasa Ranjan Dash, Dhirendra Nath Soren, Kedar Nath Nayak, Deba Prasad Rath, Sudhansu Behera
Introduction Gastric cancer is the fourth most common type of cancer and the second leading cause of cancer-related death in the world. The etiology of gastric cancer includes Helicobacter pylori infection, diet, lifestyle, tobacco, alcohol, and genetic susceptibility. Upper gastrointestinal endoscopy (UGIE) is the most effective method for examining the upper gastrointestinal tract as compared to the other examination tools. Objective To study the histopathological finding of upper gastrointestinal endoscopic biopsies and its association with H...
October 2022: Curēus
Yiran Chen, Yanyan Chen, Liping Wen, Laizhen Tou, Haiyong Wang, Lisong Teng
BACKGROUND: The clinicopathological features and surgical treatment strategies of Borrmann type IV gastric cancer (GC) remain controversial. Peritoneal metastasis is the most common recurrence pattern in patients with Borrmann type IV GC. METHODS: Among 2026 gastric cancer between January 2009 and August 2019, 159 cases of Borrmann type IV GC were included in this study (7.8%). We retrospectively analyzed the clinicopathological characteristics and prognosis of these patients...
2022: Frontiers in Surgery
Liang Wang, Yingfang Deng, Su Yan, Xinfu Ma, Cheng Wang, Wei Miao, Xiaoqian Chen
[This corrects the article DOI: 10.3389/fsurg.2022.995194.].
2022: Frontiers in Surgery
Hua Lu, Tingliang Han, Fangcun Li, Jiali Yang, Zhaomeng Hou
BACKGROUND: With the development of robotic surgery in the field of oncology, an increasing number of relevant research papers have been published. In order to explore the research hotspots and trends in this field, a bibliometric and visual analysis was performed for the first time. METHODS: The literature records related to oncology robotic surgery were obtained from the Web of Science Core Collection database and imported into the software VOSviewer 1.6.18, CiteSpace 6...
2022: Frontiers in Oncology
Junyang Wang, Tong Liu, Tao Huang, Mei Shang, Xudong Wang
The immune system and the tumor have been at each other's throats for so long that the neoplasm has learned to avoid detection and avoid being attacked, which is called immune evasion. Malignant tumors, such as gastric cancer (GC), share the ability to evade the body's immune system as a defining feature. Immune evasion includes alterations to tumor-associated antigens (TAAs), antigen presentation mechanisms (APMs), and the tumor microenvironment (TME). While TAA and APM are simpler in nature, they both involve mutations or epigenetic regulation of genes...
2022: Frontiers in Oncology
Difeng Li, Xin Zhang, Lili Jiang
Gastric cancer (GC) is characterized by high invasion and poor prognosis. The occurrence of liver metastasis seriously affects advanced GC prognosis. In recent years, great progress has been made in the field of GC liver metastasis. The abnormal expression of related genes leads to the occurrence of GC liver metastasis through metastasis cascades. The changes in the liver microenvironment provide a pre-metastasis condition for GC cells to colonize and grow. The development of several potential therapeutic targets might provide new therapeutic strategies for its treatment...
2022: Frontiers in Oncology
Jung Hyun Kwak, Chan Hyuk Park, Chang Soo Eun, Dong Soo Han, Yong Sung Kim, Kyu Sang Song, Bo Youl Choi, Hyun Ja Kim
PURPOSE: Current evidence regarding the association between zinc intake and gastric cancer (GC)-specific survival in patients with intestinal-type GC is lacking. Therefore, this cohort study investigated the association between zinc intake and GC mortality through follow-up on GC death among patients with intestinal-type GC and whether these effects differ according to the source of zinc intake. METHODS: A total of 185 patients with intestinal-type GC were enrolled from two hospitals between 2002 and 2006...
2022: Frontiers in Oncology
Renjie Xu, Jiahui Yu, Shangjin Song, Dazhi Sun, Lijuan Xiu, Jinyu Xu, Jing Zhao, Xuan Liu, Qing Ji, Xiaoqiang Yue
Objective: To determine the effect and mechanism of the long non-coding RNA (lncRNA) ncRuPAR (non-protein coding RNA, upstream of coagulation factor II thrombin receptor [F2R]/protease-activated receptor-1 [PAR-1]) in human gastric cancer. Methods: HGC-27-ncRuPAR overexpression and MGC-803-ncRuPAR-RNAi knockdown gastric cancer cell lines were established. We assessed the effect of ncRuPAR on cell proliferation, apoptosis, migration, and invasion using Cell Counting Kit 8, flow cytometry, scratch and transwell assays, respectively...
2022: International Journal of Medical Sciences
Maoyuan Zhao, Feng Wei, Guangwei Sun, Yueqiang Wen, Juyi Xiang, Fangting Su, Lu Zhan, Qing Nian, Yu Chen, Jinhao Zeng
Gastric cancer, a common malignant disease, seriously endangers human health and life. The high mortality rate due to gastric cancer can be attributed to a lack of effective therapeutic drugs. Cancer cells utilize the glycolytic pathway to produce energy even under aerobic conditions, commonly referred to as the Warburg effect, which is a characteristic of gastric cancer. The identification of new targets based on the glycolytic pathway for the treatment of gastric cancer is a viable option, and accumulating evidence has shown that phytochemicals have extensive anti-glycolytic properties...
2022: Frontiers in Pharmacology
Huan-Fu Hu, Zheng Wang, Wen-Li Tang, Xue-Ming Fu, Xiang-Jun Kong, Ying-Kun Qiu, Sheng-Yan Xi
Background: Sophora flavescens aiton (SFA) and its main bioactive metabolite matrine are widely used in traditional Chinese medicine (TCM) preparations and have achieved good curative effects for the treatment of various tumors. However, the mechanisms underlying SFA and matrine individually and in combination with chemotherapeutic drugs for treatment of gastric cancer (GC) remain unclear. Aim of the study: To elucidate the mechanisms underlying the ability of SFA and matrine individually and in combination with chemotherapeutic drugs to inhibit proliferation and promote apoptosis of human GC cells...
2022: Frontiers in Pharmacology
Hao Sun, Li Chen, Rong Huang, Hongming Pan, Yanjiao Zuo, Ruihu Zhao, Yingwei Xue, Hongjiang Song
OBJECTIVE: Although the application of immunotherapy in gastric cancer has achieved satisfactory clinical effects, many patients have no response. The aim of this retrospective study is to investigate the predictive ability of the prognostic nutrition index (PNI) to the prognosis of patients with gastric cancer who received immune checkpoint inhibitors (ICIs). MATERIALS AND METHODS: Participants were 146 gastric cancer patients with ICIs (PD-1/PD-L1 inhibitors) or chemotherapy...
2022: Frontiers in Nutrition
Wei Mi, Zhi Zheng, Jiong-Di Lu, Shu-Quan Duan, Jie Zhang, Hai-Qiao Zhang, Yi-Xuan Ding, Jie Yin, Feng Cao, Jun Zhang, Fei Li
BACKGROUND: Pancreatic adenocarcinoma (PAAD) is a cancerous tumor with an extremely poor 5-year survival rate. The exploration of biomarkers for the diagnosis and treatment of PAAD is crucial in clinical practice. Krüppel-like factors (KLFs) are involved in a variety of biological functions in cells. According to multiple studies, KLF16 behave as an oncogene in prostate, breast and gastric cancers. However, no research has been done on the significance of KLF16 in PAAD. AIM: To explore the molecular mechanisms of KLF16 in PAAD...
November 15, 2022: World Journal of Gastrointestinal Oncology
Li-Hua Zhang, Hui-Qin Zhuo, Jing-Jing Hou, Yang Zhou, Jia Cheng, Jian-Chun Cai
BACKGROUND: Proteomic signatures of Ming's infiltrative gastric cancer (IGC) remain unknown. AIM: To elucidate the molecular characteristics of IGC at the proteomics level. METHODS: Twelve pairs of IGC and adjacent normal tissues were collected and their proteomes were analyzed by high performance liquid chromatography tandem mass spectrometry. The identified peptides were sequenced de novo and matched against the SwissProt database using Maxquant software...
November 15, 2022: World Journal of Gastrointestinal Oncology
Rui-Ze Qu, Yan-Peng Ma, Xiao-Yuan Bao, Li-Yuan Tao, Xin Zhou, Si-Yi Lu, Yi Zhang, Bing-Yan Wang, Fei Li, Lin Tuo, Zhi-Peng Zhang, Wei Fu
BACKGROUND: The features of gastric cancer based on the anatomic site remain unknown in northern China patients. AIM: To analyze gastric cancer features and associated trends based on the anatomical site in northern China patients. METHODS: This cross-sectional study used incident gastric cancer case data from 10 Peking University-affiliated hospitals (2014 to 2018). The clinical and prevailing local features were analyzed. RESULTS: A total of 10709 patients were enrolled, including antral (42...
November 15, 2022: World Journal of Gastrointestinal Oncology
Xiao-Jing Gu, Ya-Jun Li, Fang Wang, Ting Ye
BACKGROUND: Gastric cancer (GC) is a common type of digestive cancer with high morbidity and mortality rates worldwide. Considerable effort has been expended in understanding the mechanism of GC development and metastasis. The current study therefore explores the involvement of microRNAs in the regulation of GC progression. AIM: To explore the expression and function of miR-30e-3p in GC development. METHODS: MiR-30e-3p was found to be downregulated in GC, with low levels thereof predicting poor outcomes among patients with GC...
November 15, 2022: World Journal of Gastrointestinal Oncology
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