keyword
https://read.qxmd.com/read/34332125/inhibition-of-usp11-sensitizes-gastric-cancer-to-chemotherapy-via-suppressing-rhoa-and-ras-mediated-signaling-pathways
#1
Hongfang Liu, Mei Liu, Bin He, Qinghuan Li
BACKGROUND: The poor outcomes in advanced gastric cancer (GC) necessitate alternative therapeutic strategy. Ubiquitin-specific protease 11 (USP11) has recently garnered attention as a therapeutic target in cancer because of its important regulatory role in cancer cell functions. Here, we revealed the expression, function and underlying molecular interactions of USP11 in gastric cancer. METHODS: The expression of USP11 was analyzed using immunohistochemistry and ELISA...
July 28, 2021: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/34332115/local-ablation-of-gastric-cancer-by-reconstituted-apolipoprotein-b-lipoparticles-carrying-epigenetic-drugs
#2
Chia-Lung Yang, Ying-Jui Chao, Hao-Chen Wang, Ya-Chin Hou, Caleb Gonshen Chen, Chia-Ching Chang, Yan-Shen Shan
Epigenetic inhibitors have shown anticancer effects. Combination chemotherapy with epigenetic inhibitors has shown high effectiveness in gastric cancer clinical trials, but severe side effect and local progression are the causes of treatment failure. Therefore, we sought to develop an acidity-sensitive drug delivery system to release drugs locally to diminish unfavorable outcome of gastric cancer. In this study, we showed that, as compared with single agents, combination treatment with the demethylating agent 5'-aza-2'-deoxycytidine and HDAC inhibitors Trichostatin A or LBH589 decreased cell survival, blocked cell cycle by reducing number of S-phase cells and expression of cyclins, increased cell apoptosis by inducing expression of Bim and cleaved Caspase 3, and reexpressed tumor suppressor genes more effectively in MGCC3I cells...
July 28, 2021: Nanomedicine: Nanotechnology, Biology, and Medicine
https://read.qxmd.com/read/34331561/influence-of-fpgs-abcc4-slc29a1-and-mthfr-genes-on-the-pharmacogenomics-of-fluoropyrimidines-in-patients-with-gastrointestinal-cancer-from-the-brazilian-amazon
#3
Marianne Rodrigues Fernandes, Juliana Carla Gomes Rodrigues, Elizabeth Ayres Fragoso Dobbin, Lucas Favacho Pastana, Danielle Feio da Costa, Williams Fernandes Barra, Antônio André Conde Modesto, Paula Baraúna de Assumpção, Artur Luiz da Costa Silva, Sidney Emanuel Batista Dos Santos, Rommel Mario Rodriguez Burbano, Paulo Pimentel de Assumpção, Ney Pereira Carneiro Dos Santos
PURPOSE: Fluoropyrimidines are one of the most used drug class to treat cancer patients, although they show high levels of associated toxicity. This study analyzed 33 polymorphisms in 17 pharmacogenes involved with the pharmacogenomics of fluoropyrimidines, in gastrointestinal cancer patients undergoing fluoropyrimidine-based treatment in the Brazilian Amazon. METHODS: The study population was composed of 216 patients, 92 of whom have an anatomopathological diagnosis of gastric cancer and 124 of colorectal cancer...
July 31, 2021: Cancer Chemotherapy and Pharmacology
https://read.qxmd.com/read/34331360/activation-of-aquaporin-5-by-carcinogenic-helicobacter-pylori-infection-promotes-epithelial-mesenchymal-transition-via-the-mek-erk-pathway
#4
Nianshuang Li, Xinbo Xu, Hui Yang, Huan Wang, Yaobin Ouyang, Yanan Zhou, Chao Peng, Zhenxiang Yuan, Cong He, Chunyan Zeng, Junbo Hong
BACKGROUND: Helicobacter pylori (H. pylori) is a major risk factor for gastric cancer. The water channel protein Aquaporin 5 (AQP5) is involved in the tumorigenesis and progression of various cancers. In this study, we aimed to explore the role of AQP5 in H. pylori-induced gastric carcinogenesis. MATERIALS AND METHODS: We collected 160 samples which inculded CNAG, IM, Dys and gastric cancer from patients who underwent endoscopy and detected the expression of AQP5...
July 30, 2021: Helicobacter
https://read.qxmd.com/read/34331126/east-meets-west-the-initial-results-of-laparoscopic-gastric-cancer-resections-with-eastern-principles-in-a-single-western-centre-a-propensity-score-matched-study
#5
Tomaz Jagric
BACKGROUND: We compared the initial experience of totally laparoscopic gastric cancer surgery with Eastern principles with the results of propensity score-matched counterparts operated with open surgery. METHODS: From 1163 patients stored in our database, 62 PSM patients were selected for this study. The quality control was assured with video documentation and standardisation of the procedures. RESULTS: According to the distribution of age, comorbidities, and general health, patients in the LG and OG were well-balanced...
July 31, 2021: Langenbeck's Archives of Surgery
https://read.qxmd.com/read/34331011/blockade-of-chrnb2-signaling-with-a-therapeutic-monoclonal-antibody-attenuates-the-aggressiveness-of-gastric-cancer-cells
#6
Mitsuro Kanda, Dai Shimizu, Shunsuke Nakamura, Koichi Sawaki, Shinichi Umeda, Takashi Miwa, Haruyoshi Tanaka, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Chie Tanaka, Goro Nakayama, Yohei Iguchi, Masahisa Katsuno, Yasuhiro Kodera
Here, we evaluated the therapeutic potential of antibodies (Abs) targeting cholinergic receptor nicotinic beta 2 subunit (CHRNB2) in gastric cancer. To investigate the effects of these Abs on malignant phenotypes in vitro and in mouse xenograft models, we generated gene knockouts through genome editing, performed RNA interference-mediated knockdown of gene expression, and ectopically expressed CHRNB2 in gastric cancer cells. The effects of anti-CHRNB2 Abs on the proliferation of cancer cells were evaluated both in vitro and in vivo...
July 30, 2021: Oncogene
https://read.qxmd.com/read/34330715/results-and-molecular-correlates-from-a-pilot-study-of-neoadjuvant-induction-folfirinox-followed-by-chemoradiation-and-surgery-for-gastroesophageal-adenocarcinomas
#7
Jennifer Y Wo, Jeffrey W Clark, Christine E Eyler, Mari Mino-Kenudson, Samuel J Klempner, Jill N Allen, Florence K Keane, Aparna R Parikh, Eric Roeland, Lorraine C Drapek, David P Ryan, Ryan B Corcoran, Emily Van Seventer, Isobel J Fetter, Heather A Shahzade, Melin J Khandekar, Michael Lanuti, Christopher R Morse, Rebecca S Heist, Christine A Ulysse, Benjamin Christopher, Christian Baglini, Beow Y Yeap, John T Mullen, Theodore S Hong
PURPOSE: We performed a NCI-sponsored, prospective study of neoadjuvant FOLFIRINOX followed by chemoradiation (CRT) with carboplatin/paclitaxel followed by surgery in patients with locally advanced gastric or gastroesophageal (GEA) cancer. EXPERIMENTAL DESIGN: The primary objective was to determine completion rate of neoadjuvant FOLFIRINOX x 8 followed by CRT. Secondary endpoints were toxicity and pathologic complete response (pCR) rate. Exploratory analysis was performed of ctDNA to treatment response...
July 30, 2021: Clinical Cancer Research
https://read.qxmd.com/read/34330586/risk-of-extracolonic-malignancies-and-metachronous-rectal-cancer-after-colectomy-and-ileorectal-anastomosis-in-familial-adenomatous-polyposis
#8
Kazuhito Sasaki, Hiroaki Nozawa, Kazushige Kawai, Koji Murono, Shigenobu Emoto, Junko Kishikawa, Hiroaki Ishii, Yuichiro Yokoyama, Shinya Abe, Yuzo Nagai, Hiroyuki Anzai, Hirofumi Sonoda, Tetsuro Taira, Soichiro Ishihara
BACKGROUND: Analysis of long-term clinical outcomes of patients with familial adenomatous polyposis is critical in reducing or preventing the incidence of extracolonic malignancies after initial surgery. The aim of the present study was to clarify the long-term outcomes, and establish a surveillance strategy for surgically treated familial adenomatous polyposis patients. METHODS: Between January 1967 and March 2020, retrospective data were collected from 37 patients with familial adenomatous polyposis treated or monitored in our department...
July 27, 2021: Asian Journal of Surgery
https://read.qxmd.com/read/34330299/exosome-derived-noncoding-rnas-in-gastric-cancer-functions-and-clinical-applications
#9
REVIEW
Xiao-Huan Tang, Ting Guo, Xiang-Yu Gao, Xiao-Long Wu, Xiao-Fang Xing, Jia-Fu Ji, Zi-Yu Li
Exosomes are a subpopulation of the tumour microenvironment (TME) that transmit various biological molecules to promote intercellular communication. Exosomes are derived from nearly all types of cells and exist in all body fluids. Noncoding RNAs (ncRNAs) are among the most abundant contents in exosomes, and some ncRNAs with biological functions are specifically packaged into exosomes. Recent studies have revealed that exosome-derived ncRNAs play crucial roles in the tumorigenesis, progression and drug resistance of gastric cancer (GC)...
July 30, 2021: Molecular Cancer
https://read.qxmd.com/read/34330293/effect-and-mechanism-of-downregulating-the-long-chain-noncoding-rna-tm4sf1-as1-on-the-proliferation-apoptosis-and-invasion-of-gastric-cancer-cells
#10
Chengzhi He, Wenjing Qi, Zhihui Wang
BACKGROUND: To investigate long-chain noncoding TM4SF1-AS1 in gastric cancer (GC) tissues and cells. METHODS: TM4SF1-AS1 in 40 GC tissues and adjacent tissues was detected and compared using real-time fluorescence quantitative PCR (qRT-PCR). TM4SF1-AS1 in MKN28 and SGC7901 GC cells was downregulated using small interfering RNA (shRNA). The cells were grouped into an interference group (shTM4SF1-AS1 group) and a control group (shControl group). MTT and Transwell tests were applied to determine the proliferation and invasion of the cells in both groups, and flow cytometry was performed to assess the apoptosis rate in the two groups...
July 31, 2021: World Journal of Surgical Oncology
https://read.qxmd.com/read/34330284/association-between-wnt-1-inducible-signaling-pathway-protein-1-wisp1-genetic-polymorphisms-and-the-risk-of-gastric-cancer-in-guangxi-chinese
#11
Yanqiong Liu, Weijuan Qin, Fuyong Zhang, Jian Wang, Xi Li, Shan Li, Xue Qin, Yuefeng Lu
BACKGROUND: WNT1-inducible signaling pathway protein 1 (WISP1) is a member of the CCN protein family and a downstream target of β-catenin. Aberrant WISP1 expression may be involved in carcinogenesis. To date, no studies have investigated the association between single-nucleotide polymorphisms (SNPs) of WISP1 and gastric cancer. Therefore, we conducted this study to explore their relationship. METHODS: Polymerase chain reaction-restriction fragment length polymorphism assay was used to analyze three SNPs of WISP1 in 204 gastric cancer patients and 227 controls...
July 30, 2021: Cancer Cell International
https://read.qxmd.com/read/34329848/ftir-microspectroscopic-study-of-biomacromolecular-changes-in-as-2-o-3-induced-mgc803-cells-apoptosis
#12
Ling Zong, Chao Li, Jie Shi, Jianjun Yue, Xin Wang
It is well-known that As2 O3 has significant anticancer effects, however, little is known regarding its mechanism for treating gastric cancer. Thus, we investigated biomacromolecular (DNA, proteins and lipids) changes of human gastric cancer cell line MGC803 to further understand As2 O3 -induced apoptosis. Conventional methods showed the increase of the apoptosis rate, the decrease of mitochondrial membrane potential (MMP), the accumulation of reactive oxygen species (ROS) and the changes of apoptotic proteins, etc...
July 23, 2021: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/34328799/neoadjuvant-intraperitoneal-and-systemic-chemotherapy-versus-neoadjuvant-systemic-chemotherapy-with-docetaxel-oxaliplatin-and-s-1-for-gastric-cancer-with-peritoneal-metastasis-a-propensity-score-matched-analysis
#13
Xin Zhang, Hejing Huang, Dejun Yang, Peng Wang, Xin Huang, Zunqi Hu, Yu Zhang, Ronglin Yan, Zhenxin Zhu, Qingping Cai
BACKGROUND: The optimal treatment for gastric cancer with peritoneal metastasis (GCPM) remains debatable. This study aimed to compare the efficacy and safety of neoadjuvant intraperitoneal and systemic chemotherapy (NIPS) versus neoadjuvant systemic chemotherapy (NSC) for GCPM. METHODS: Patients of GCPM received neoadjuvant chemotherapy with docetaxel, oxaliplatin and S-1 between January 2011 and June 2019 were retrospectively evaluated. Propensity score matched (PSM) analysis was carried out to reduce the selection bias...
January 2021: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/34328628/primary-lymphoepithelioma-like-carcinoma-of-the-esophagus-with-metastatic-lymph-node-and-gastric-cancer
#14
Kosuke Narumiya, Yosuke Yagawa, Kenji Kudo, Shinsuke Maeda, Yukinori Toyoshima, Kyohei Ogawa, Sho Izumika, Kimito Harada, Masayuki Itabashi, Harushi Osugi
Upper gastrointestinal lymphoepithelioma-like carcinoma (LELC) is a rare disease-especially esophageal LELC (ELELC). Here, we report a surgically treated case of ELELC with gastric carcinoma. The patient was a 68-year-old asymptomatic Japanese man. Endoscopy revealed a submucosal-like protruding tumor located in the anterior wall of the esophagus 31-33 cm from the upper incisors and a slightly ulcerative lesion at the antrum of stomach. Histopathological diagnosis from biopsy of the esophageal lesion revealed a poorly differentiated squamous cell carcinoma; the stomach lesion was found to be well-differentiated tubular adenocarcinoma...
July 30, 2021: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/34328245/tifa-has-dual-functions-in-helicobacter-pylori-induced-classical-and-alternative-nf-%C3%AE%C2%BAb-pathways
#15
Gunter Maubach, Michelle C C Lim, Olga Sokolova, Steffen Backert, Thomas F Meyer, Michael Naumann
Helicobacter pylori infection constitutes one of the major risk factors for the development of gastric diseases including gastric cancer. The activation of nuclear factor-kappa-light-chain-enhancer of activated B cells (NF-κB) via classical and alternative pathways is a hallmark of H. pylori infection leading to inflammation in gastric epithelial cells. Tumor necrosis factor receptor-associated factor (TRAF)-interacting protein with forkhead-associated domain (TIFA) was previously suggested to trigger classical NF-κB activation, but its role in alternative NF-κB activation remains unexplored...
July 30, 2021: EMBO Reports
https://read.qxmd.com/read/34328237/scoring-model-for-discriminating-gastric-cancer-risk-in-patients-with-negative-serum-pepsinogen-and-anti-helicobacter-pylori-antibody-results
#16
Jun-Hyung Cho, So-Young Jin, Suyeon Park
BACKGROUND: The ABC test measures serum pepsinogen and anti-Helicobacter pylori IgG antibody levels to predict precancerous conditions in the stomach and gastric cancer. However, a limitation of this test is that the gastric cancer risk is not negligible in patients with a negative result. METHODS: Based on their ABC results, 1157 patients were classified into Groups A (n = 392), B (n = 479), C (n = 247), and D (n = 39). In Group A, 24.2% of patients had atrophic gastritis and/or intestinal metaplasia and had thus been incorrectly assigned to Group A...
July 19, 2021: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/34328085/cudraxanthone-l-inhibits-gastric-cancer-by-regulating-the-mapk-signalling-and-promoting-fas-mediated-pathway
#17
Jiamei Zhang, Huihui Sun, KunXiu Jiang, Xingzhuo Song, Xirui Wang, Yuqian Yang, Hanying Liu, Qingxuan Ji, Xue Yu, Yonggang Liu, Jing Han, Wei Wang
Gastric cancer (GC) is one of the most common malignancies and has the second highest lethal rate in the world; thus, finding new medicines with high potency and low toxicity is urgent. Cudrania tricuspidata (Carr.) Bur. ex Lavallee (Moraceae) is a traditional medicinal herb that is considered to have antitumour efficacy. We extracted and isolated cudraxanthone L (CXL) from Cudrania tricuspidata and evaluated its anti-cancer efficacy. CXL treatment inhibited angiogenesis of chorioallantoic membrane (CAM) and repressed the cell viability of various human cancer cells, indicating it presented the antitumour potential...
July 10, 2021: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/34327603/treatment-switch-in-poor-responders-with-locally-advanced-gastric-cancer-after-neoadjuvant-chemotherapy
#18
Zining Liu, Yinkui Wang, Fei Shan, Xiangji Ying, Yan Zhang, Shuangxi Li, Yongning Jia, Rulin Miao, Kan Xue, Zhemin Li, Ziyu Li, Jiafu Ji
BACKGROUND: Among locally advanced gastric cancer (LAGC) patients, poor response to initial neoadjuvant chemotherapy (NAC) is associated with unfavorable outcomes; however, changing the postoperative therapy regimen in this group of patients is unclear. We compared the poor responders who continued the original protocols with that of patients who switched treatment after NAC plus D2 gastrectomy. METHODS: Our study included LAGC patients who achieved tumor regression grade 3 according to the American Joint Committee on Cancer/College of American Pathologists system, after NAC, between December 2006 and December 2017 at our institution...
July 29, 2021: Annals of Surgical Oncology
https://read.qxmd.com/read/34327549/association-between-mucin-phenotype-and-lesion-border-detection-using-acetic-acid-indigo-carmine-chromoendoscopy-in-early-gastric-cancers
#19
Seung Min Hong, Gwang Ha Kim, Bong Eun Lee, Moon Won Lee, Da Mi Kim, Dong Hoon Baek, Geun Am Song
BACKGROUND: For successful treatment of early gastric cancers (EGCs), it is crucial to define the horizontal border of the lesion with high accuracy. Acetic acid-indigo carmine (AI) chromoendoscopy has been used to determine the horizontal border in EGCs, but this technique is less potent in certain situations. Mucin phenotype in gastric cancers refers to biological differences in precursor lesions and differences in histopathologic findings, and it might affect AI chromoendoscopy findings...
July 29, 2021: Surgical Endoscopy
https://read.qxmd.com/read/34327141/the-role-of-lncrna-pcat6-in-cancers
#20
REVIEW
Siying Wang, Zhenyao Chen, Jingyao Gu, Xin Chen, Zhaoxia Wang
Long non-coding RNA (lncRNA) PCAT6 is a member of the Prostate Cancer Associated Transcripts family of molecules. In this review, we focus on the latest studies involving PCAT6 in the diagnosis, treatment, and prognosis of malignant tumors of the digestive, respiratory, urinary, reproductive, motion, and nervous systems. PCAT6 was found to be highly expressed in gastric cancer, colon cancer, hepatocellular carcinoma, lung cancer, bladder cancer, ovarian cancer, breast cancer, cervical cancer, osteosarcoma, glioblastoma, and other tumors...
2021: Frontiers in Oncology
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