Lin Zhao, Ye Wang, Zhenggang Guo
BACKGROUND: While survival rates among cardiac allograft recipients have improved, there has been a rise in post-transplant malignancies, with gastric cancer being less commonly reported. This study presented a successful treatment of gastric cancer in an individual 10 years after undergoing a heart transplant. CASE PRESENTATION: A 66-year-old Chinese man presented to the gastrointestinal clinic with a complaint of diagnosis of gastric cancer for 4 months and treated with neoadjuvant therapy for 1 month...
April 19, 2024: Medicine (Baltimore)
Mirte H M Ketel, Bastiaan R Klarenbeek, Inger Abma, Eric H J Belgers, Peter-Paul L O Coene, Jan Willem T Dekker, Peter van Duijvendijk, Marloes Emous, Suzanne S Gisbertz, Jan Willem Haveman, Joos Heisterkamp, Grard A P Nieuwenhuijzen, Jelle P Ruurda, Johanna W van Sandick, Pieter C van der Sluis, Marc J van Det, Stijn van Esser, Simon Law, Wobbe O de Steur, Meindert N Sosef, Bas Wijnhoven, Gerjon Hannink, Camiel Rosman, Frans van Workum
IMPORTANCE: Suboptimal surgical performance is hypothesized to be associated with less favorable patient outcomes in minimally invasive esophagectomy (MIE). Establishing this association may lead to programs that promote better surgical performance of MIE and improve patient outcomes. OBJECTIVE: To investigate associations between surgical performance and postoperative outcomes after MIE. DESIGN, SETTING, AND PARTICIPANTS: In this nationwide cohort study of 15 Dutch hospitals that perform more than 20 MIEs per year, 7 masked expert MIE surgeons assessed surgical performance using videos and a previously developed and validated competency assessment tool (CAT)...
April 1, 2024: JAMA Network Open
Lee C Brackman, Matthew S Jung, Eseoghene I Ogaga, Nikhita Joshi, Lydia E Wroblewski, M Blanca Piazuelo, Richard M Peek, Yash A Choksi, Holly M Scott Algood
Helicobacter pylori is a Gram-negative pathogen that colonizes the stomach, induces inflammation, and drives pathological changes in the stomach tissue, including gastric cancer. As the principal cytokine produced by Th17 cells, IL-17 mediates protective immunity against pathogens by inducing the activation and mobilization of neutrophils. Whereas IL-17A is largely produced by lymphocytes, the IL-17 receptor is expressed in epithelial cells, fibroblasts, and hematopoietic cells. Loss of the IL-17RA in mice results in impaired antimicrobial responses to extracellular bacteria...
April 1, 2024: ImmunoHorizons
Yanzheng Wang, Jiahui Zhang, Hui Shi, Maoye Wang, Dan Yu, Min Fu, Yu Qian, Xiaoxin Zhang, Runbi Ji, Shouyu Wang, Jianmei Gu, Xu Zhang
M2-polarized tumor-associated macrophages (M2 TAMs) promote cancer progression. Exosomes mediate cellular communication in the tumor microenvironment (TME). However, the roles of exosomes from M2 TAMs in gastric cancer progression are unclear. Herein, it is reported that M2 TAMs-derived exosomes induced aerobic glycolysis in gastric cancer cells and enhanced their proliferation, metastasis, and chemoresistance in a glycolysis-dependent manner. It is identified that MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) is enriched in M2 TAM exosomes and confirmed that MALAT1 transfer from M2 TAMs to gastric cancer cells via exosomes mediates this effect...
April 19, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Joon Young Hur, Kyueng-Whan Min, Yung-Kyun Noh, Young-Woong Won, Yoomi Yeo, Dong-Hoon Kim, Byoung Kwan Son, Mi Jung Kwon, Jung Soo Pyo
INTRODUCTION: The CLDN18 gene, encoding claudin 18.1 and claudin 18.2, is a key component of tight junction strands in epithelial cells that form a paracellular barrier that is critical in Stomach Adenocarcinoma (STAD). METHODS: Our study included 1,095 patients with proven STAD, 415 from The Cancer Genome Atlas (TCGA) cohort and 680 from the Gene Expression Omnibus database. We applied various analyses, including gene set enrichment analysis, pathway analysis, and in vitro drug screening to evaluate survival, immune cells, and genes and gene sets associated with cancer progression, based on CLDN18 expression levels...
April 18, 2024: Current Medicinal Chemistry
Rui Yu, Meiling Sun, Shuli Xia, Li Zhang
Colon cancer is a common gastrointestinal malignant tumor. In addition to conventional treatment, thoughtful and comprehensive aftercare should be given to patients. The present study aimed to explore the effects of explain-simulate-practice-communication-support (ESPCS) model nursing on the surgical tolerance, gastrointestinal recovery and self-management efficacy of patients with colon cancer. The clinical data of 136 patients with colon cancer diagnosed and treated at the Second Affiliated Hospital of Harbin Medical University (Harbin, China) from June 2020 to April 2022 were retrospectively analyzed and a total of 84 patients met the inclusion criteria...
June 2024: Oncology Letters
Takaki Kitamura, Tomonori Shigemura, Yohei Yamamoto, Yasuaki Murata
Metastatic pelvic tumors pose a significant challenge in oncologic orthopedics due to their complex management and the high potential for postoperative complications. This case study discusses a 75-year-old male with a sacral stress fracture following a type 3 internal hemipelvectomy for a metastatic lesion from gastric cancer in the left pubic bone. Initial conservative treatments failed to yield satisfactory improvement, leading to surgical intervention. Open reduction and internal fixation with an iliosacral screw, despite complications, significantly alleviated pain and improved mobility...
March 2024: Curēus
Tessa S Groen-van Schooten, Micaela Harrasser, Jens Seidel, Emma N Bos, Tania Fleitas, Monique van Mourik, Roos E Pouw, Ruben S A Goedegebuure, Benthe H Doeve, Jasper Sanders, Joris Bos, Mark I van Berge Henegouwen, Victor L J L Thijssen, Nicole C T van Grieken, Hanneke W M van Laarhoven, Tanja D de Gruijl, Sarah Derks
BACKGROUND: Tumors in the distal esophagus (EAC), gastro-esophageal junction including cardia (GEJAC), and stomach (GAC) develop in close proximity and show strong similarities on a molecular and cellular level. However, recent clinical data showed that the effectiveness of chemo-immunotherapy is limited to a subset of GEAC patients and that EACs and GEJACs generally benefit less from checkpoint inhibition compared to GACs. As the composition of the tumor immune microenvironment drives response to (immuno)therapy we here performed a detailed immune analysis of a large series of GEACs to facilitate the development of a more individualized immunomodulatory strategy...
2024: Frontiers in Immunology
Chongxin Zhang, Fan Zhang, Yukun Li, Pengfei Yang, Yang Liu, Wenxiao Yang
BACKGROUND/AIMS: : The occurrence and development of circular RNAs in gastric cancer (GC) has attracted increasing attention. This study focused on investigating the biological role and molecular mechanism of circ_0043947 in GC. METHODS: : The expression levels of circ_0043947, miR-384 and CAMP response element binding protein (CREB1) were determined by quantitative real-time polymerase chain reaction or Western blotting. Cell proliferation, migration, and invasion, the cell cycle and apoptosis were determined using a cell counting kit-8 assay, 5-ethynyl-2'-deoxyuridine assay, colony formation assay, wound healing assay, transwell assay, and flow cytometry assay...
April 19, 2024: Gut and Liver
Dong-Seok Han, Yoonjin Kwak, Seungho Lee, Soo Kyung Nam, Seong-Ho Kong, Do Joong Park, Hyuk-Joon Lee, Nak-Jung Kwon, Hye Seung Lee, Han-Kwang Yang
PURPOSE: Gastric cancer exhibits molecular heterogeneity, with the microsatellite instability high (MSI-H) subtype drawing attention for its distinct features. Despite a higher survival rate, MSI-H gastric cancer lack significant benefits from conventional chemotherapy. The immune checkpoint inhibitors (ICIs), presents a potential avenue, but a deeper understanding of the tumor immune microenvironment of MSI-H gastric cancer is essential. MATERIALS AND METHODS: We explored the molecular characteristics of CD8+ T cell subtypes in three MSI-H and three microsatellite stable (MSS) gastric cancer samples using single-cell RNA sequencing and spatial transcriptome analysis...
April 12, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Qi Wang, Kexin Shen, Bingyuan Fei, Mengqiang Wei, Xinbin Ge, Zhongshi Xie
This investigation aimed to explore the prognostic factors in elderly patients with unresected gastric cancer (GC) who have received chemotherapy and to develop a nomogram for predicting their cancer-specific survival (CSS). Elderly gastric cancer patients who have received chemotherapy but no surgery in the Surveillance, Epidemiology, and End Results Database between 2004 and 2015 were included in this study. Cox analyses were conducted to identify prognostic factors, leading to the formulation of a nomogram...
April 19, 2024: Scientific Reports
Jiajia Wu, Siyu Li, Li Fan, Yuqing Cheng, Jin Huang, Min Lin
BACKGROUND: Endoscopic submucosal dissection (ESD) is widely used as a standard treatment regimen for early gastric cancers (EGCs). However, such an approach is time-consuming and has a high risk of perforation and bleeding in some corner-site lesions because of the obscured view and difficulty in submucosal lifting. The newly developed pocket-creation method (PCM) provides a clearer view and better traction of the submucosal layer than conventional ESD (c-ESD). Nevertheless, no prospective randomized study has evaluated the efficacy of the PCM in EGCs and precancerous lesions...
April 16, 2024: Journal of Gastrointestinal Surgery
Jiafeng Liu, Tianxiao Wang, Wenxin Zhang, Yuxin Huang, Xinhai Wang, Qunyi Li
BACKGROUND: The cancers of the digestive tract, including colorectal cancer (CRC), gastric cancer (GC) and Esophageal cancer (ESCA), are part of the most common cancers as well as one of the most important leading causes of cancer death worldwide. SUMMARY: Despite the emergence of immune checkpoint inhibitors (e.g., anti-CTLA-4 and anti-PD-1/PD-L1) in the past decade, offering renewed optimism in cancer treatment, only a fraction of patients derive benefit from these therapies...
April 18, 2024: Oncology Research and Treatment
Jia-Li Hu, Zhao-Jiao Guo, Chun Wang, Jun Yan, Hao Yang
Ovarian cancer is a common tumor among women. It is often asymptomatic in the early stages, with most cases already at stage III to IVE at the time of diagnosis. Direct spread and lymphatic metastasis are the primary modes of metastasis, whereas hematogenous spread is rare. An initial diagnosis of ovarian cancer that has metastasized to the stomach is also uncommon. Therefore, clear treatment methods and prognostic data for such metastasis are lacking. In our hospital, we encountered a patient with an initial imaging diagnosis of a gastric tumor and a history of an ovarian tumor with endoscopic abdominal metastasis...
April 2024: Journal of International Medical Research
Tomonori Morimoto, Shigeo Hisamori, Hiromitsu Kinoshita, Yosuke Yamada, Yuki Teramoto, Takashi Sakamoto, Keiko Kasahara, Shintaro Okumura, Tatsuto Nishigori, Shigeru Tsunoda, Kazutaka Obama
BACKGROUND: Even in cancer of unknown primary (CUP), which is rare clinical condition, solitary anterosuperior lymph node (LN) along the common hepatic artery (No.8a LN) enlargement diagnosed as metastatic adenocarcinoma has never been reported. CASE PRESENTATION: A 68-year-old Japanese male, with a history of early gastric cancer that had been completely treated by endoscopic submucosal dissection 26 years ago, was detected a single enlarged nodule along the common hepatic artery, No...
April 18, 2024: Surgical Case Reports
Ayaka Ishida, Yasuhiro Inokuchi, Makoto Hirata, Hiroto Narimatsu, Emi Yoshioka, Kota Washimi, Nozomu Machida, Shin Maeda
A 35-year-old woman of Asian descent with epigastralgia was referred to our hospital. Esophagogastroduodenoscopy revealed gastric cancer in the upper body and carpeting fundic gland polyposis in the fornix and body. Computed tomography revealed no metastases. Total colonoscopy and capsule endoscopy revealed no polyposis, except in the stomach. The patient was diagnosed with advanced gastric cancer and underwent open total gastrectomy. We speculated that her gastric cancer was a hereditary tumor due to its early onset and accompanying fundic gland polyposis...
April 18, 2024: Clinical Journal of Gastroenterology
Yukinori Yamagata, Takaki Yoshikawa, Ryota Sakon, Kenichi Ishizu, Takeyuki Wada, Tsutomu Hayashi
BACKGROUND: Total gastrectomy with D2 dissection including splenectomy (TGS) is usually selected for locally resectable scirrhous gastric cancer (SGC), which was established in the era of surgery alone. However, it remains unclear whether TGS for SGC is justified in the era of effective adjuvant chemotherapy. METHODS: This study included 112 SGC patients, consisting of 60 cases treated between January 2000 and December 2006 (Former group), and 52 cases treated between January 2007 and December 2016 (Latter group)...
April 18, 2024: Journal of Gastrointestinal Cancer
Meagan D Read, Justin Drake, Ghazal Hashemipour, Benjamin D Powers, Rutika Mehta, Andrew Sinnamon, Jose M Pimiento, Sean P Dineen
No abstract text is available yet for this article.
April 18, 2024: Annals of Surgical Oncology
Muhammad Musaab Munir, Selamawit Woldesenbet, Yutaka Endo, Mary Dillhoff, Susan Tsai, Timothy M Pawlik
BACKGROUND: The association of hospital market competition, financial costs, and quality of oncologic care has not been well-defined. This study sought to evaluate variations in patient outcomes and financial expenditures after complex cancer surgery across high- and low-competition markets. METHODS: Medicare 100% Standard Analytic Files were used to identify patients with lung, esophageal, gastric, hepatopancreaticobiliary, or colorectal cancer who underwent surgical resection between 2018 and 2021...
April 18, 2024: Annals of Surgical Oncology
Xiangyu Wang, Jingyu Deng
No abstract text is available yet for this article.
April 18, 2024: Annals of Surgical Oncology
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