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JOURNAL ARTICLE
Eric Gabriel, Zishen Wang, Vibhu Vardhan Singh, Kincaid Graff, Jue Liu, Cyrus Koroni, Dewen Hou, Darin Schwartz, Cheng Li, Juejing Liu, Xiaofeng Guo, Naresh C Osti, Shyue Ping Ong, Hui Xiong
P2-type Na2/3 Ni1/3 Mn2/3 O2 (PNNMO) has been extensively studied because of its desirable electrochemical properties as a positive electrode for sodium-ion batteries. PNNMO exhibits intralayer transition-metal ordering of Ni and Mn and intralayer Na+ /vacancy ordering. The Na+ /vacancy ordering is often considered a major impediment to fast Na+ transport and can be affected by transition-metal ordering. We show by neutron/X-ray diffraction and density functional theory (DFT) calculations that Li doping (Na2/3 Li0...
May 2, 2024: Journal of the American Chemical Society
#2
REVIEW
Wendy J Shaw, Michelle K Kidder, Simon R Bare, Massimiliano Delferro, James R Morris, Francesca M Toma, Sanjaya D Senanayake, Tom Autrey, Elizabeth J Biddinger, Shannon Boettcher, Mark E Bowden, Phillip F Britt, Robert C Brown, R Morris Bullock, Jingguang G Chen, Claus Daniel, Peter K Dorhout, Rebecca A Efroymson, Kelly J Gaffney, Laura Gagliardi, Aaron S Harper, David J Heldebrant, Oana R Luca, Maxim Lyubovsky, Jonathan L Male, Daniel J Miller, Tanya Prozorov, Robert Rallo, Rachita Rana, Robert M Rioux, Aaron D Sadow, Joshua A Schaidle, Lisa A Schulte, William A Tarpeh, Dionisios G Vlachos, Bryan D Vogt, Robert S Weber, Jenny Y Yang, Elke Arenholz, Brett A Helms, Wenyu Huang, James L Jordahl, Canan Karakaya, Kourosh Cyrus Kian, Jotheeswari Kothandaraman, Johannes Lercher, Ping Liu, Deepika Malhotra, Karl T Mueller, Casey P O'Brien, Robert M Palomino, Long Qi, José A Rodriguez, Roger Rousseau, Jake C Russell, Michele L Sarazen, David S Sholl, Emily A Smith, Michaela Burke Stevens, Yogesh Surendranath, Christopher J Tassone, Ba Tran, William Tumas, Krista S Walton
Electrification to reduce or eliminate greenhouse gas emissions is essential to mitigate climate change. However, a substantial portion of our manufacturing and transportation infrastructure will be difficult to electrify and/or will continue to use carbon as a key component, including areas in aviation, heavy-duty and marine transportation, and the chemical industry. In this Roadmap, we explore how multidisciplinary approaches will enable us to close the carbon cycle and create a circular economy by defossilizing these difficult-to-electrify areas and those that will continue to need carbon...
May 1, 2024: Nature Reviews. Chemistry
#3
JOURNAL ARTICLE
Leo D Westbury, Faidra Laskou, Harnish P Patel, Cyrus Cooper, Elaine M Dennison
OBJECTIVES: Therapeutic advances in the management of osteoporosis and sarcopenia have occurred at different rates over the last 2 decades. Here we examine associations between grip strength and BMD with subsequent all-cause and cause-specific mortality in a UK community-dwelling cohort. METHODS: Data from 495 men and 414 women from the Hertfordshire Cohort Study were analysed. Grip strength was assessed by grip dynamometry, femoral neck BMD was ascertained using DXA and deaths were recorded from baseline (1998-2004) until 31 December 2018...
2024: Rheumatology Advances in Practice
#4
JOURNAL ARTICLE
Hadi Esmaeili Gouvarchinghaleh, Cyrus Jalili, Maryam Zamir Nasta, Fatemeh Mokhles, Elmira Afrasiab, Farhad Babaei
BACKGROUND AND OBJECTIVES: Colorectal cancer (CRC) is a common type of cancer that has a high death rate and is becoming more common in developed countries. Currently, there are several treatment options available for CRC patients, and clinical trials are being conducted to improve conventional therapies. This study investigates the combined impact of Bacillus coagulans (B.C) and Newcastle disease virus (NDV) on the growth of human colorectal adenocarcinoma cells (HT29 cell line). MATERIALS AND METHODS: The HT29 cell line was cultured under controlled laboratory conditions...
February 2024: Iranian Journal of Microbiology
#5
REVIEW
Eriko Nakamura, Tomoaki Aoki, Yusuke Endo, Jacob Kazmi, Jun Hagiwara, Cyrus E Kuschner, Tai Yin, Junhwan Kim, Lance B Becker, Kei Hayashida
BACKGROUND: Mitochondrial dysfunction, which is triggered by systemic ischemia-reperfusion (IR) injury and affects various organs, is a key factor in the development of post-cardiac arrest syndrome (PCAS). Current research on PCAS primarily addresses generalized mitochondrial responses, resulting in a knowledge gap regarding organ-specific mitochondrial dynamics. This review focuses on the organ-specific mitochondrial responses to IR injury, particularly examining the brain, heart, and kidneys, to highlight potential therapeutic strategies targeting mitochondrial dysfunction to enhance outcomes post-IR injury...
April 5, 2024: Life
#6
JOURNAL ARTICLE
Viswanathan Saraswathi, Weilun Ai, Vikas Kumar, Kanika Sharma, Thiyagarajan Gopal, Narendra Kumar, Harmeet Malhi, Tejasav Sehrawat, Cyrus V Desouza
OBJECTIVE: Circulating exosome-enriched extracellular vesicles (EVs) have drawn considerable importance in obesity-related insulin-resistance (IR). We sought to compare the proteomics profile of serum exosomes from normal individuals and those with obesity and IR. METHODS: We isolated serum exosomes from male subjects with obesity and insulin resistance (Ob-IR, HOMA-IR > 2.0) and lean/overweight insulin-sensitive (Normal (N), HOMA-IR < 2.0) individuals. The differential protein expression between the two groups was detected by a label-free quantitative mass spectrometry analysis followed by GO annotation and ingenuity pathway analysis (IPA)...
April 3, 2024: Biomedicines
#7
JOURNAL ARTICLE
Cassandra L Hua, Sweta Patel, Kali S Thomas, Dylan J Jester, Cyrus M Kosar, Lindsay J Peterson, Debra Dobbs, Ross Andel, David M Dosa
IMPORTANCE: Evacuation has been found to be associated with adverse outcomes among nursing home residents during hurricanes, but the outcomes for assisted living (AL) residents remain unknown. OBJECTIVE: To examine the association between evacuation and health care outcomes (ie, emergency department visits, hospitalizations, mortality, and nursing home visits) among Florida AL residents exposed to Hurricane Irma. DESIGN, SETTING, AND PARTICIPANTS: Retrospective cohort study using 2017 Medicare claims data...
April 1, 2024: JAMA Network Open
#8
JOURNAL ARTICLE
Sandeep R Sehdev, Nigel S B Rawson, Olexiy I Aseyev, Catriona J Buick, Marcus O Butler, Scott Edwards, Sharlene Gill, Joanna M Gotfrit, Cyrus C Hsia, Rosalyn A Juergens, Mita Manna, Joy S McCarthy, Som D Mukherjee, Stephanie L Snow, Silvana Spadafora, David J Stewart, Jason R Wentzell, Ralph P W Wong, Pawel G Zalewski
Patient access to new oncology drugs in Canada is only possible after navigating multiple sequential systemic checkpoints for national regulatory approval, health technology assessment (HTA) and collective government price negotiation. These steps delay access and prevent health care providers from being able to prescribe optimal therapy. Eighteen Canadian oncology clinicians from the medicine, nursing and pharmacy professions met to develop consensus recommendations for defining reasonable government performance standards around process and timeliness to improve Canadian cancer patients' access to best care...
March 29, 2024: Current Oncology
#9
JOURNAL ARTICLE
Shamim Mortuza, Benjamin Chin-Yee, Tyler E James, Ian H Chin-Yee, Benjamin D Hedley, Jenny M Ho, Lalit Saini, Alejandro Lazo-Langner, Laila Schenkel, Pratibha Bhai, Bekim Sadikovic, Jonathan Keow, Nikhil Sangle, Cyrus C Hsia
Myelodysplastic neoplasms (MDS) with ring sideroblasts (RS) are diagnosed via bone marrow aspiration in the presence of either (i) ≥15% RS or (ii) 5-14% RS and an SF3B1 mutation. In the MEDALIST trial and in an interim analysis of the COMMANDS trial, lower-risk MDS-RS patients had decreased transfusion dependency with luspatercept treatment. A total of 6817 patients with suspected hematologic malignancies underwent molecular testing using a next-generation-sequencing-based genetic assay and 395 MDS patients, seen at our centre from 1 January 2018 to 31 May 2023, were reviewed...
March 29, 2024: Current Oncology
#10
REVIEW
Shelbi Olson, Lindsay Welton, Cyrus Jahansouz
Crohn's disease, a chronic inflammatory process of the gastrointestinal tract defined by flares and periods of remission, is increasing in incidence. Despite advances in multimodal medical therapy, disease progression often necessitates multiple operations with high morbidity. The inability to treat Crohn's disease successfully is likely in part because the etiopathogenesis is not completely understood; however, recent research suggests the gut microbiome plays a critical role. How traditional perioperative management, including bowel preparation and preoperative antibiotics, further changes the microbiome and affects outcomes is not well described, especially in Crohn's patients, who are unique given their immunosuppression and baseline dysbiosis...
March 30, 2024: Antibiotics
#11
JOURNAL ARTICLE
Roshan Rambukwella, Leo D Westbury, Cyrus Cooper, Nicholas C Harvey, Elaine M Dennison
BACKGROUND: Poor self-rated health (SRH) has been shown to predict adverse health outcomes among older people, however these associations have traditionally only been considered at one point in the lifecourse, usually midlife or later. Here we examined lifecourse correlates of SRH in early, mid and later life, relating these to subsequent risk of mortality in a community-dwelling cohort. METHODS: 2989 men and women from the Hertfordshire Cohort Study (HCS) were included in this study...
April 2024: J Med Surg Public Health
#12
JOURNAL ARTICLE
Pawandeep Sarai, Charlotte Luff, Cyrus Rohani-Shukla, Paul H Strutton
With an aging population, it is common to encounter people diagnosed with peripheral vascular disease (PVD). Some will undergo surgeries during which the spinal cord may be compromised and intraoperative neuromonitoring with motor evoked potentials (MEPs) is employed to help mitigate paralysis. No data exist on characteristics of MEPs in older, PVD patients, which would be valuable for patients undergoing spinal cord at-risk surgery or participating in neurophysiological research. Transcranial magnetic stimulation, which can be delivered to the awake patient, was used to stimulate the motor cortex of 20 patients (mean (±SD)) age 63...
2024: PloS One
#13
Sana Niazi, Jorge Alió Del Barrio, Farideh Doroodgar, Azad Sanginabadi, Cyrus Alinia, Seyed Javad Hashemian, Hassan Hashemi, Jorge L Alio
PURPOSE: To verify corneal biomechanical changes, poststromal augmentation using myopic small-incision lenticule extraction's (SMILEs) lenticules in advanced keratoconus (KCN) through Corvis ST (Oculus, Wetzlar, Germany). MATERIALS AND METHODS: A clinical trial enrolled 22 advanced KCN patients. We implanted lenticules exceeding 100 μ according to a nomogram and evaluated biomechanical factors through Corvis ST at 3-, 6-, and 24-month postimplantation. We examined parameters during the first applanation (A1), second applanation (A2), highest concavity (HC)/max concavity events, and Vinciguerra screening parameters, as recently established criteria derived from the ideal blend of diverse biomechanical and ocular factors and formulated through the application of logistic regression...
2024: Taiwan Journal of Ophthalmology
#14
Katherine Hickmann, Ryan Sweeney, Chelsea Peterson, Kathleen Faringer, Madeline Riley, Mark Bunker, Azam Hadi, Cyrus Khan, Yazan Samhouri
Post-transplant lymphoproliferative disorders (PTLDs) are opportunistic malignancies that complicate the success of hematopoietic stem cell or solid organ transplantation. These disorders often arise post-transplant due to the immunosuppression required for minimizing the risk of rejection of donor tissue. First-line treatment of these disorders includes limiting immunosuppression when permissible. Subsequent treatment includes the use of monoclonal anti-CD20 antibody (rituximab), and/or combination chemotherapy...
April 2024: Journal of Hematology (Brossard, Quebec)
#15
JOURNAL ARTICLE
Leslie M Peard, Belinda Li, Stacy Dorris, Shilin Zhao, Cyrus Adams, Douglass B Clayton, John C Thomas, John C Pope Ⅳ, Mark C Adams, John W Brock Ⅲ, Abby S Taylor
INTRODUCTION: There are multiple historic reports linking lower urinary tract symptoms (LUTS) in children with food allergies (FA), but contemporary studies are sparse. The objective of this study was to evaluate a potential link between FA and LUTS in the pediatric population. We hypothesized that children with FAs are more likely to have LUTS. MATERIALS AND METHODS: After local IRB approval, pediatric patients (6-17 years [y]) with FAs proven by positive skin prick and/or serum IgE testing were invited to participate...
April 2024: Canadian Journal of Urology
#16
REVIEW
Leonard Ho, Yolenda Man Kei Cheung, Cyrus Chung Ching Choi, Irene Xinyin Wu, Chen Mao, Vincent Chi Ho Chung
BACKGROUND: Systematic reviews (SRs) could offer the best evidence supporting interventions, but methodological flaws limit their trustworthiness in decision-making. This cross-sectional study appraised the methodological quality of SRs on atopic dermatitis (AD) treatments. METHODS: We searched MEDLINE, EMBASE, PsycINFO, and Cochrane Database for SRs on AD treatments published in 2019-2022. We extracted SRs' bibliographical data and appraised SRs' methodological quality with AMSTAR (A MeaSurement Tool to Assess systematic Reviews) 2...
December 2024: Journal of Dermatological Treatment
#17
JOURNAL ARTICLE
Cyrus Aseibichin, Wisdom Chukwuemeke Ulakpa, Ikoko Omenogor, Emmanuel Doyah, Ayodeji Arnold Olaseinde, Oghenekome Cyril Anakpoha, Mabel Keke, Shankar Karuppannan
The study effectively optimized the transesterification process of Jatropha oil to fatty acid methyl ester using response surface methodology (CCD) and Taguchi orthogonal method, leading to enhanced efficiency and product quality. The optimization of five process parameters was conducted to predict the biodiesel yield (%) from the transesterification of Jatropha oil. The procedure was made easier with the use of a nanocatalyst made from calcium oxide obtained from snail shells using the hydrothermal technique...
April 10, 2024: RSC Advances
#18
Alireza Khabbazi, Sepideh Tahsini Tekantapeh, Cyrus Asadzadeh, Amir Vahedi
KEY CLINICAL MESSAGE: Although the concurrent occurrence of vasculitis with AS is uncommon, when patients diagnosed with AS exhibit symptoms including skin petechiae, purpura, abdominal discomfort, malaise, elevated ESR, and reduced complement levels, vigilant monitoring for vasculitis is advisable following the exclusion of secondary vasculitis triggers such as malignancies, infections, and pharmaceutical agents. ABSTRACT: The primary characteristic of ankylosing spondylitis (AS) involves inflammation occurring within the sacroiliac joint and the spine, leading to destruction and eventual ankylosis...
April 2024: Clinical Case Reports
#19
JOURNAL ARTICLE
Cyrus Jalili, Ardeshir Abbasi, Nasim Rahmani-Kukia, Salar Andarzi, Seyran Kakebaraie, Touraj Zamir Nasta
Aflatoxins B1 (AFB1) a dangerous type of aflatoxin, poses a serious threat to human health. Meanwhile, Taraxasterol, a bioactive compound in dandelion, exhibits strong anti-inflammatory and antioxidant activity. Therefore, the aim of this study was to investigate the impact of AFB1 on the intrinsic and extrinsic pathways of apoptosis, as well as evaluate the protective role of taraxasterol in the TM3 Leydig cell line. Cell viability was evaluated using an MTT assay, measuring the effects of 3.6 µM AFB1 and varying concentrations of taraxasterol...
April 13, 2024: Ecotoxicology and Environmental Safety
#20
RANDOMIZED CONTROLLED TRIAL
Keren Middelkoop, Lisa Micklesfield, Justine Stewart, Neil Walker, David A Jolliffe, Amy E Mendham, Anna K Coussens, James Nuttall, Jonathan Tang, William D Fraser, Waheedullah Momand, Cyrus Cooper, Nicholas C Harvey, Robert J Wilkinson, Linda-Gail Bekker, Adrian R Martineau
OBJECTIVE: To determine whether weekly oral vitamin D supplementation influences growth, body composition, pubertal development or spirometric outcomes in South African schoolchildren. DESIGN: Phase 3 double-blind randomised placebo-controlled trial. SETTING: Socioeconomically disadvantaged peri-urban district of Cape Town, South Africa. PARTICIPANTS: 1682 children of black African ancestry attending government primary schools and aged 6-11 years at baseline...
April 10, 2024: BMJ Paediatrics Open
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