Paolo Agostinis, Giulia Bontempo, Paola Della Siega, Valentina Gerussi, Alberto Pagotto, Emanuela Barbano, Lucia Mazzoran, Mario Calci, Massimo Sponza, Francesco Sbrana, Stefano Fapranzi, Aldo Baritussio, Carlo Tascini
Coronavirus disease 2019 poses a serious threat to public health. The protocol developed at the Azienda Sanitaria Universitaria Friuli Centrale (Italy) is based on clinical data, laboratory tests, chest echography and HRCT. Several therapeutic options are considered, since patients vary in disease severity, evolution and co-morbidities and because so far there are no clear indications about therapeutic strategy based on randomized clinical trial. In this protocol chest echography has a central role in categorizing patient status, follow-up and decision-making...
December 16, 2020: New Microbiologica
E Dickson, N E Palmateer, J Murray, C Robertson, C Waugh, L A Wallace, L Mathie, K Heatlie, S Mavin, P Gousias, B Von Wissman, D J Goldberg, A McAuley
OBJECTIVES: The impact of the COVID-19 pandemic in Scotland has been amongst the most severe in Europe. Serological surveillance is critical to determine the overall extent of infection across populations and to inform the public health response. This study aimed to estimate the proportion of people who have antibodies to SARS-CoV-2 ('seroprevalence') in the general population of Scotland and to see if this changes over time. STUDY DESIGN/METHODS: Between International Organization for Standardization (ISO) week 17 (i...
November 24, 2020: Public Health
Wanggi Jaung
Pandemic outbreaks can cause diverse impacts on society by altering human-nature relations. This study analyzed these relational changes during the severe acute respiratory syndrome (SARS), Swine flu, Middle East respiratory syndrome (MERS), and Ebola outbreaks by applying machine learning and big data analyses of global news articles. The results showed that social-ecological systems play vital roles in analyzing indirect pandemic impacts. Herein, major pandemic impacts, including reduced use of cultural ecosystem services, can be analyzed by big data analyses at the global scale...
January 7, 2021: Science of the Total Environment
Adnan Azim, Laura Pini, Zeeshan Khakwani, Santosh Kumar, Peter Howarth
No abstract text is available yet for this article.
January 13, 2021: Annals of Allergy, Asthma & Immunology
Julian W Tang, William P Bahnfleth, Philomena M Bluyssen, Giorgio Buonanno, Jose L Jimenez, Jarek Kurnitski, Yuguo Li, Shelly Miller, Chandra Sekhar, Lidia Morawska, Linsey C Marr, Arsen Krikor Melikov, William W Nazaroff, Peter V Nielsen, Raymond Tellier, Pawel Wargocki, Stephanie J Dancer
The Covid-19 pandemic has caused untold disruption and enhanced mortality rates around the world. Understanding the mechanisms for transmission of SARS-CoV-2 is key to preventing further spread but there is confusion over the meaning of "airborne" whenever transmission is discussed. Scientific ambivalence originates from evidence published many years ago, which has generated mythological beliefs that obscure current thinking. This article gathers together and explores some of the most commonly held dogmas on airborne transmission in order to stimulate revision of the science in the light of current evidence...
January 13, 2021: Journal of Hospital Infection
Tania Regina Tozetto-Mendoza, Kelly Aparecida Kanunfre, Lucy Santos Vilas-Boas, Evelyn Patricia Sanchez Espinoza, Heuder Gustavo Oliveira Paião, Mussya Cisotto Rocha, Anderson Vicente de Paula, Maura Salaroli de Oliveira, Daniella Bosco Zampelli, José Mauro Vieira, Lewis Buss, Silvia Figueiredo Costa, Ester Cerdeira Sabino, Steven S Witkin, Thelma Suely Okay, Maria Cassia Mendes-Correa
OBJECTIVES: We evaluated the performance of a nucleoprotein-based enzyme-linked immunosorbent assay (ELISA) for detection of IgG antibodies to SARS-CoV-2. METHODS: The ELISA was based on serum IgG reactivity to a 46-kDa protein derived from the recombinant SARS-CoV2 nucleoprotein. Assay sensitivity was assessed using serum samples from 134 COVID-19 confirmed cases obtained > 15 days after symptom onset. Specificity was determined by testing sera from 94 healthy controls...
January 13, 2021: Journal of Virological Methods
Alfred B Addison, Billy Wong, Tanzime Ahmed, Alberto Macchi, Iordanis Konstantinidis, Caroline Huart, Johannes Frasnelli, Alexander W Fjaeldstad, Vijay R Ramakrishnan, Philippe Rombaux, Katherine L Whitcroft, Eric H Holbrook, Sophia C Poletti, Julien W Hsieh, Basile N Landis, James Boardman, Antje Welge-Lüssen, Devina Maru, Thomas Hummel, Carl M Philpott
BACKGROUND: Respiratory tract viruses are the second most common cause for olfactory dysfunction. As we learn more about the effects of the severe acute respiratory syndrome coronavirus (SARS-CoV-2), with the recognition that olfactory dysfunction is a key symptom of this disease process, there is now a greater need for evidence-based management for post infectious olfactory dysfunction (PIOD). OBJECTIVE: To provide an evidence based practical guide to the management of PIOD (including post-covid cases) for both primary care practitioners and hospital specialists...
January 13, 2021: Journal of Allergy and Clinical Immunology
Chueh-Lung Hwang, Szu-Hua Chen, Chih-Hsuan Chou, Georgios Grigoriadis, Tzu-Chieh Liao, Ibra S Fancher, Ross Arena, Shane A Phillips
Sedentary behavior (SB) and physical activity (PA) are important risk factors of cardiovascular disease morbidity and mortality. In addition to increasing the amount of moderate-to-vigorous PA; MVPA, the current PA guidelines recommend that adults should reduce SB, or any waking activity performed while sitting, reclining, or lying, with low energy expenditure. While mounting evidence has emphasized the benefits of increasing MVPA, little is focused on the effect of SB on health. Therefore, this review discusses the pathophysiological effects of SB and the potential physiological benefits of reducing/breaking up SB at the levels below the current guidelines for PA...
January 13, 2021: Progress in Cardiovascular Diseases
Zili Zhang, Tao Wang, Fei Liu, Airu Zhu, Guoping Gu, Jieping Luo, Jingyi Xu, Jincun Zhao, Yiming Li, Yuanyuan Li, Xiaoqing Liu, Nanshan Zhong, Wenju Lu
BACKGROUND: The pandemic of the coronavirus disease 2019 (COVID-19) has brought a global public health crisis. However, the pathogenesis underlying COVID-19 are barely understood. METHODS: In this study, we performed proteomic analyses of airway mucus obtained by bronchoscopy from severe COVID-19 patients. In total, 2351 and 2073 proteins were identified and quantified in COVID-19 patients and healthy controls, respectively. RESULTS: Among them, 92 differentiated expressed proteins (DEPs) (46 up-regulated and 46 down-regulated) were found with a fold change >1...
January 13, 2021: Life Sciences
Alan T Makhoul, Brian C Drolet
No abstract text is available yet for this article.
September 5, 2020: Chest
Arunkumar Krishnan, James P Hamilton, Saleh A Alqahtani, Tinsay A Woreta
Coronavirus disease 2019 (COVID-19) is an emerging infectious disease which has had a rapid surge in cases and deaths since it is first documented in Wuhan, China, in December 2019. COVID-19 is caused by the Betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 uses angiotensin-converting enzyme 2, which is highly expressed in the human lower respiratory tract but also in other tissues, as the cellular entry receptor. Thus, COVID-19 mainly affects the respiratory system but can cause damage to other body systems, including the cardiovascular, gastrointestinal, hepatobiliary, renal, and central nervous systems...
January 16, 2021: Internal and Emergency Medicine
Peter R Swiatek, Joseph A Weiner, Daniel J Johnson, Philip K Louie, Michael H McCarthy, Garrett K Harada, Niccole Germscheid, Jason P Y Cheung, Marko H Neva, Mohammad El-Sharkawi, Marcelo Valacco, Daniel M Sciubba, Norman B Chutkan, Howard S An, Dino Samartzis
PURPOSE: The COVID-19 pandemic forced many surgeons to adopt "virtual medicine" practices, defined as telehealth services for patient care and online platforms for continuing medical education. The purpose of this study was to assess spine surgeon reliance on virtual medicine during the pandemic and to discuss the future of virtual medicine in spine surgery. METHODS: A comprehensive survey addressing demographic data and virtual medicine practices was distributed to spine surgeons worldwide between March 27, 2020, and April 4, 2020...
January 16, 2021: European Spine Journal
Jerome R Lechien, Carlos M Chiesa-Estomba, Liugi A Varia, Giacomo De Riu, Giovanni Cammaroto, Younes Chekkoury-Idrissi, Marta Circiu, Lea Distinguin, Fabrice Journe, Christophe de Terwangne, Shahram Machayekhi, Maria R Barillari, Christian Calvo-Henriquez, Stéphane Hans, Sven Saussez
OBJECTIVE: To investigate prevalence and epidemiological and clinical factors associated with olfactory dysfunction (OD) and gustatory dysfunction (GD) in COVID-19 patients according to the disease severity. STUDY DESIGN: Cross-sectional study. METHODS: A total of 2579 patients with a positive diagnosis of COVID-19 were identified between March 22 and June 3, 2020 from 18 European hospitals. Epidemiological and clinical data were extracted...
January 16, 2021: European Archives of Oto-rhino-laryngology
Eric McGinnis, Robert J Guo, Krista M Marcon, Brian Berry, Robert Coupland, Victor Meneghetti, Douglas Morrison, Rodrigo Onell, Lisa Steele, Jacqueline Trudeau, Michelle Wong, Andrew W Shih
BACKGROUND: In March 2020, a state of emergency was declared to facilitate organized responses to the coronavirus disease 2019 (COVID-19) pandemic in British Columbia, Canada. Emergency blood management committees (EBMCs) were formed regionally and provincially to coordinate transfusion service activities and responses to possible national blood shortages. STUDY DESIGN AND METHODS: We describe the responses of transfusion services to COVID-19 in regional health authorities in British Columbia through a collaborative survey, contingency planning meeting minutes, and policy documents, including early trends observed in blood product usage...
January 16, 2021: Transfusion
Ilhwan Yeo, Seunghyup Baek, JoonHyuk Kim, Hadya Elshakh, Angelina Voronina, Man Si Lou, Joshua Vapnik, Ravinder Kaler, Xuming Dai, Seth Goldbarg
BACKGROUND: There is limited data on the characteristics of 30-day readmission after hospitalization with coronavirus disease 2019 (COVID-19). OBJECTIVES: To examine the rate, timing, causes, predictors, and outcomes of 30-day readmission after COVID-19 hospitalization. METHODS: From March 13 to April 9, 2020, all patients hospitalized with COVID-19 and discharged alive were included in this retrospective observational study. Multivariable logistic regression was used to identify the predictors of 30-day readmission, and a restricted cubic spline function was utilized to assess the linearity of the association between continuous predictors and 30-day readmission...
January 16, 2021: Journal of Internal Medicine
Haixiong Lin, Xiaotong Wang, Minyi Liu, Minling Huang, Zhen Shen, Junjie Feng, Huijun Yang, Zige Li, Junyan Gao, Xiaopeng Ye
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In China, Yinqiao powder is widely used to prevent and treat COVID-19 patients with Weifen syndrome. In this study, the screening and verification of active ingredients, target selection and DisGeNET scoring, drug-ingredient-gene network construction, protein-protein interaction network construction, molecular docking and surface plasmon resonance (SPR) analysis, gene ontology (GO) functional analysis, gene tissue analysis, and kyoto encyclopedia of genes and genomes (KEGG) pathway analysis were used to explore the active ingredients, targets, and potential mechanisms of Yinqiao powder in the treatment of COVID-19...
January 15, 2021: Phytotherapy Research: PTR
M Gosch, H J Heppner, S Lim, K Singler
Long-term care facilities (LTCF) and their vulnerable residents are particularly affected by the coronavirus disease 2019 (COVID-19) pandemic. Estimates from various countries suggest that 3-66% of all COVID-19 deaths were residents of LTCF, of which 80% died in their facilities. Despite these significant numbers, recommendations for LTCF for the prevention and medical care of residents during the COVID-19 pandemic are still lacking. These recommendations are based on the existing literature and the expertise of the authors who are specialists in geriatric medicine...
January 15, 2021: Zeitschrift Für Gerontologie und Geriatrie
John Tregoning
No abstract text is available yet for this article.
January 15, 2021: Nature
Takanao Tanaka, Shohei Okamoto
There is increasing concern that the coronavirus disease 2019 (COVID-19) pandemic could harm psychological health and exacerbate suicide risk. Here, based on month-level records of suicides covering the entire Japanese population in 1,848 administrative units, we assessed whether suicide mortality changed during the pandemic. Using difference-in-difference estimation, we found that monthly suicide rates declined by 14% during the first 5 months of the pandemic (February to June 2020). This could be due to a number of complex reasons, including the government's generous subsidies, reduced working hours and school closure...
January 15, 2021: Nature Human Behaviour
Yu Zuo, Mark Warnock, Alyssa Harbaugh, Srilakshmi Yalavarthi, Kelsey Gockman, Melanie Zuo, Jacqueline A Madison, Jason S Knight, Yogendra Kanthi, Daniel A Lawrence
Patients with coronavirus disease-19 (COVID-19) are at high risk for thrombotic arterial and venous occlusions. However, bleeding complications have also been observed in some patients. Understanding the balance between coagulation and fibrinolysis will help inform optimal approaches to thrombosis prophylaxis and potential utility of fibrinolytic-targeted therapies. 118 hospitalized COVID-19 patients and 30 healthy controls were included in the study. We measured plasma antigen levels of tissue-type plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) and performed spontaneous clot-lysis assays...
January 15, 2021: Scientific Reports
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