Tülay Kılınç, Aslı Sis Çelik
PURPOSE: The aim of this study was to determine the relationship between the social support and psychological resilience levels perceived by nurses in Turkey during the coronavirus disease-2019 (COVID-19) pandemic. DESIGN AND METHODS: The study was descriptive and cross-sectional. FINDINGS: The level of social support perceived by the nurses during the COVID-19 pandemic was very good, and the perceived psychological resilience level was moderately good...
October 19, 2020: Perspectives in Psychiatric Care
Umair Majid, Aghna Wasim, Simran Bakshi, Judy Truong
The severe acute respiratory syndrome-coronavirus-2 pandemic has spread rapidly and has a growing impact on individuals, communities, and healthcare systems worldwide. At the core of any pandemic response is the ability of authorities and other stakeholders to react appropriately by promoting hygiene and social distancing behaviors. Successfully reaching this goal requires both individual and collective efforts to drastically modify daily routines and activities. There is a need to clarify how knowledge and awareness of disease influence risk perception, and subsequent behavior in the context of pandemics and global outbreaks...
October 19, 2020: Public Understanding of Science
Konda Mani Saravanan, Haiping Zhang, Renganathan Senthil, Kevin Kumar Vijayakumar, Vignesh Sounderrajan, Yanjie Wei, Harshavardhan Shakila
A novel coronavirus (SARS-CoV2) has caused a major outbreak in humans around the globe, and it became a severe threat to human healthcare than all other infectious diseases. Researchers were urged to discover and test various approaches to control and prevent such a deadly disease. Considering the emergency and necessity, we screened reported antiviral compounds present in the traditional Indian medicinal plants for the inhibition of SARS-CoV2 main protease. In this study, we used molecular docking to screen 41 reported antiviral compounds that exist in Indian medicinal plants and shown amentoflavone from the plant Torreyanucifera with a higher docking score...
October 19, 2020: Journal of Biomolecular Structure & Dynamics
Raveen Rathnasinghe, Shirin Strohmeier, Fatima Amanat, Virginia L Gillespie, Florian Krammer, Adolfo García-Sastre, Lynda Coughlan, Michael Schotsaert, Melissa Uccellini
Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is currently causing a worldwide pandemic with high morbidity and mortality. Development of animal models that recapitulate important aspects of coronavirus disease 2019 (COVID-19) is critical for the evaluation of vaccines and antivirals, and understanding disease pathogenesis. SARS-CoV-2 has been shown to use the same entry receptor as SARS-CoV-1, human angiotensin-converting enzyme 2 (hACE2)(1-3). Due to amino acid differences between murine and hACE2, inbred mouse strains fail to support high titer viral replication of SARS-CoV-2 virus...
October 17, 2020: Emerging Microbes & Infections
Tianwen Lai, Fangfei Xiang, Jianfeng Zeng, Yingzi Huang, Liping Jia, Hui Chen, Jiayuan Wu, Jianfeng Xie, Shuna Liu, Wei Deng, Weiqiang Zheng, Yang Huang, Qinfu Zhang, Qingfeng Luo, Fan Mo, Lieming Long, Wuying Zhang, Wenna Chen, Huanqin Han
We previously reported that sputum induction was more sensitive than throat swabs for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in two convalescent coronavirus disease 2019 (COVID-19) patients; however, the value and safety of induced sputum testing require further study. We conducted a prospective multi-center cross-sectional study to compare induced sputum to throat swabs for SARS-CoV-2 detection. Confirmed COVID-19 patients from six hospitals in six cities across China who received one or more negative RT-PCR result for SARS-CoV-2 were enrolled, and paired specimens (induced sputum and throat swabs; 56 cases) were assayed...
December 2020: Virulence
Elishai Assayag, Maria Tsessler, Lauren M Wasser, Elena Drabkin, Ehud Reich, Yishay Weill, David Zadok, Akshay Gopintathan Nair, Aleza Andron
PURPOSE: The Coronavirus disease 2019 (COVID-19) pandemic is an ongoing healthcare crisis that continues its worldwide spread. Ophthalmologists are at high risk of acquiring and transmitting the virus. Telemedicine platforms have evolved and may play an important role in attenuating this risk. For patients, these platforms provide the possibility of clinic consultation without the concerns of a clinic visit. We aimed to assess the utilization of telemedicine by oculoplastics specialists worldwide during the COVID-19 pandemic...
October 17, 2020: European Journal of Ophthalmology
Cristian Vergallo
Among haematological parameters of patients seriously ill with the coronavirus infectious disease 2019 (COVID-19), leucocytosis, lymphocytopenia, and the abnormal release of circulating cytokines, termed cytokine storm syndrome (CSS, also known as cytokine release syndrome or CRS), were found associated with disease severity. In particular, according to the serum cytokine profiling, pro-inflammatory interleukin 6 (IL-6) and anti-inflammatory interleukin 10 (IL-10) were observed to be considerably higher in patients experiencing respiratory distress, septic shock and/or multi-organ failure, namely "critical cases" requiring intensive care unit (ICU) admission, very often resulting in death...
October 17, 2020: Electromagnetic Biology and Medicine
Ting Du, Jinyu Zhang, Chunqiao Li, Tao Song, Ping Li, Jifeng Liu, Xinjun Du, Shuo Wang
As a large enveloped RNA virus, coronavirus is of considerable medical and veterinary significance, and anticoronavirus treatment is challenging due to its biodiversity and rapid variability. In this study, Au@Ag nanorods (Au@AgNRs) were successfully synthesized by coating AuNRs with silver and were shown for the first time to have activity against the replication of porcine epidemic diarrhea virus (PEDV). Viral titer analysis demonstrated that Au@AgNRs could inhibit PEDV infection by 4 orders of magnitude at 12 h post-infection, which was verified by viral protein expression analysis...
October 18, 2020: Bioconjugate Chemistry
Francesca Sanguedolce, Magda Zanelli, Stefano Ascani, Maurizio Zizzo, Simona Tortorella, Alessandra Soriano, Alberto Cavazza, Francesco Sollitto, Domenico Loizzi
The ongoing global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been posing challenges to proper patients' management. Lungs are the first, and often the most affected organ by SARS-CoV-2; viral infection involves and damages both epithelial and vascular compartments, sometimes leading to severe and even fatal acute respiratory distress syndrome. Histopathological findings, mainly from postmortem examination of COVID-19 deceased patients, have been increasingly published in the last few months, helping to elucidate the sequence of events resulting in organ injury, and the complex multifactorial pathogenesis of this novel disease...
October 19, 2020: Panminerva Medica
Anna E Oja, Anno Saris, Cherien A Ghandour, Natasja A M Kragten, Boris M Hogema, Esther J Nossent, Leo M A Heunks, Susan Cuvalay, Ed Slot, Federica Linty, Francis H Swaneveld, Hans Vrielink, Gestur Vidarsson, Theo Rispens, Ellen van der Schoot, René A W van Lier, Anja Ten Brinke, Pleun Hombrink
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current coronavirus disease 2019 (COVID-19) pandemic. Understanding the immune response that provides specific immunity but may also lead to immunopathology is crucial for the design of potential preventive and therapeutic strategies. Here, we characterized and quantified SARS-CoV-2 specific immune responses in patients with different clinical courses. Compared to individuals with a mild clinical presentation, CD4+ T cell responses were qualitatively impaired in critically ill patients...
October 18, 2020: European Journal of Immunology
Charles W Stratton, Yi-Wei Tang, Hongzhou Lu
The 2019 novel coronavirus disease (COVID-19) now is considered a global public health emergency. One of the unprecedented challenges is defining optimal therapy for those patients with severe pneumonia and systemic manifestations of COVID-19. Optimal therapy should be largely based on the pathogenesis of infections caused by this novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the onset of COVID-19, there have been many prepublications and publications reviewing the therapy of COVID-19 as well as many prepublications and publications reviewing the pathogenesis of SARS-CoV-2...
October 19, 2020: Journal of Medical Virology
Olgar Birsel, İlker Eren, Mehmet Demirhan
Background: The Covid19 pandemic drastically affected the healthcare delivery worldwide. Elective surgical interventions were cancelled or postponed avoiding disease transmission and excessive consumption of critical hospital resources. The main objective for composing this survey was to document the preventive attitude and its variations against Covid19 pandemic in a specific group: Shoulder and elbow surgeons; to evaluate their perception of emergency and to envisage the 'new normal' with the altered order of priority in the upcoming post-coronavirus era...
October 13, 2020: JSES international
Madhu Sharma, Samuel Gorstein, Margaret L Aldrich, Daphne T Hsu, Nadine F Choueiter
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has been associated with myocardial dysfunction and heart failure in adult patients. We report a case of reversible myocardial injury and heart failure in an infant with SARS-CoV-2 infection.
October 12, 2020: JACC. Case reports
Gaetano Zizzo, Philip L Cohen
The unique cytokine signature of COVID-19 might provide clues to disease mechanisms and possible future therapies. Here, we propose a pathogenic model in which the alarmin cytokine, interleukin (IL)-33, is a key player in driving all stages of COVID-19 disease (ie, asymptomatic, mild-moderate, severe-critical, and chronic-fibrotic). In susceptible individuals, IL-33 release by damaged lower respiratory cells might induce dysregulated GATA-binding factor 3-expressing regulatory T cells, thereby breaking immune tolerance and eliciting severe acute respiratory syndrome coronavirus 2-induced autoinflammatory lung disease...
October 9, 2020: The Lancet Rheumatology
Ashish Verma, Ankit B Patel, Maria Clarissa Tio, Sushrut S Waikar
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a pandemic and a public health emergency. The overwhelming rise in the number of cases has brought significant challenges to healthcare systems worldwide. Patients with end-stage kidney disease (ESKD) are highly vulnerable with the multiple comorbidities that make them susceptible to adverse outcomes with COVID-19. Over 2 million people worldwide receive maintenance hemodialysis (HD) at outpatient centers...
October 14, 2020: Kidney medicine
Mirja Mittermaier, Philipp Pickerodt, Florian Kurth, Laure Bosquillon de Jarcy, Alexander Uhrig, Carmen Garcia, Felix Machleidt, Panagiotis Pergantis, Susanne Weber, Yaosi Li, Astrid Breitbart, Felix Bremer, Philipp Knape, Marc Dewey, Felix Doellinger, Steffen Weber-Carstens, Arthur S Slutsky, Wolfgang M Kuebler, Norbert Suttorp, Holger Müller-Redetzky
Background: In face of the Coronavirus Disease (COVID)-19 pandemic, best practice for mechanical ventilation in COVID-19 associated Acute Respiratory Distress Syndrome (ARDS) is intensely debated. Specifically, the rationale for high positive end-expiratory pressure (PEEP) and prone positioning in early COVID-19 ARDS has been questioned. Methods: The first 23 consecutive patients with COVID-19 associated respiratory failure transferred to a single ICU were assessed...
October 11, 2020: EClinicalMedicine
Sylvain Lamure, Rémy Duléry, Roberta Di Blasi, Adrien Chauchet, Cécile Laureana, Bénédicte Deau-Fischer, Bernard Drenou, Carole Soussain, Cédric Rossi, Nicolas Noël, Sylvain Choquet, Serge Bologna, Bertrand Joly, Milena Kohn, Sandra Malak, Guillemette Fouquet, Etienne Daguindau, Sophie Bernard, Catherine Thiéblemont, Guillaume Cartron, Karine Lacombe, Caroline Besson
Background: Patients with lymphoma are immunocompromised because of the disease per se and its treatments. We aimed to describe the characteristics of patients with lymphoma hospitalized for Coronavirus Disease 2019 (Covid-19) and to analyze pre-Covid-19 determinants of mortality. Methods: This retrospective multicentric cohort study used the Programme de Médicalisation des Systèmes d'Information database to identify all adult patients with lymphoma, hospitalized for Covid-19 in March and April 2020, in 12 hospitals of three French regions with pandemic outbreaks...
October 13, 2020: EClinicalMedicine
Sonali Sachdeva, Rupak Desai, Udita Gupta, Anupam Prakash, Abhinav Jain, Ankita Aggarwal
In the latter part of 2019, a cluster of unexplained pneumonia cases were reported in Wuhan, China. In less than a year, SARS-CoV-2 has infected over 27 million people and claimed more than 800,000 deaths worldwide. Diabetes is a highly prevalent chronic metabolic disease, and recent reports have suggested a possible existence of COVID-19 related new-onset diabetes. Hyperglycemia induces an inflammatory state in the body, which coupled with coronavirus associated immune response is a possible explanation for clinical worsening of patients...
October 12, 2020: SN comprehensive clinical medicine
Yohei Ishikawa, Toru Hifumi, Norio Otani, Ryosuke Miyamichi, Mitsuyoshi Urashima, Satoshi Takeda, Shinichi Ishimatsu
The first coronavirus 2019 (COVID-19) patients were reported in China on December 12, 2019, and the first COVID-19 patients were reported in Japan on January 16, 2020. Here, we investigated the number of patients in Emergency Departments (EDs) in three major hospitals in Tokyo, and also briefly discussed about the relationship between the number of patients in EDs and health system's capacity. We compared the number of patients in 2020 to the average number of patients from 2016 to 2019. Numbers were compared in three periods: before the first COVID-19 patient was reported in Japan (January 1 to January 16), after the government encouraged social distancing (February 26 to March 10), and the interval between them (January 17 to February 25)...
October 12, 2020: SN comprehensive clinical medicine
Melanie D Hingle, Carmen Byker Shanks, Courtney Parks, Joseph Prickitt, Kyung E Rhee, Jimmy Wright, Sarah Hiller-Venegas, Amy L Yaroch
The USDA Supplemental Nutrition Assistance Program (SNAP) provides food and financial assistance to food-insecure individuals and families. In the midst of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, SNAP benefits evolved. Policy changes and federal legislation expanded SNAP eligibility, raised benefit levels, and introduced program waivers that enabled online ordering to reduce participants' exposure to community-acquired SARS-CoV-2. Although rapid expansion of SNAP benefits in the online space represents significant progress for federal food assistance, changes also introduced unforeseen partiality in how benefits and services were accessed and utilized, as illustrated by 2 populations and regions in the early months of the SARS-CoV-2 pandemic: low-income older adults in rural Alabama and low-income Hispanic adults in urban California...
October 2020: Current Developments in Nutrition
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"