Rory A Hills, Tiong Kit Tan, Alexander A Cohen, Jennifer R Keeffe, Anthony H Keeble, Priyanthi N P Gnanapragasam, Kaya N Storm, Annie V Rorick, Anthony P West, Michelle L Hill, Sai Liu, Javier Gilbert-Jaramillo, Madeeha Afzal, Amy Napier, Gabrielle Admans, William S James, Pamela J Bjorkman, Alain R Townsend, Mark R Howarth
Defending against future pandemics requires vaccine platforms that protect across a range of related pathogens. Nanoscale patterning can be used to address this issue. Here, we produce quartets of linked receptor-binding domains (RBDs) from a panel of SARS-like betacoronaviruses, coupled to a computationally designed nanocage through SpyTag/SpyCatcher links. These Quartet Nanocages, possessing a branched morphology, induce a high level of neutralizing antibodies against several different coronaviruses, including against viruses not represented in the vaccine...
May 6, 2024: Nature Nanotechnology