Andrew S Perry, Kai Zhang, Venkatesh L Murthy, Bina Choi, Shilin Zhao, Priya Gajjar, Laura A Colangelo, Lifang Hou, Mary Rice, John Jeffrey Carr, April P Carson, Anne E Nigra, Ramachandran S Vasan, Robert E Gerszten, Sadiya S Khan, Ravi Kalhan, Matthew Nayor, Ravi V Shah
Rationale: The biological mechanisms linking environmental exposures with cardiovascular disease (CVD) pathobiology are incompletely understood. We sought to identify circulating proteomic signatures of environmental exposures, and examine their associations with cardiometabolic and respiratory disease (CMD) in observational cohort studies. Methods: We tested the relations of >6500 circulating proteins with 29 environmental exposures across the built environment, green space, air pollution, temperature, and social vulnerability indicators in nearly 3000 participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study across 4 centers using penalized and ordinary linear regression...
April 25, 2024: Circulation Research