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JOURNAL ARTICLE
Mohd Zakwan Md Muslim, Aniza Mohammed Jelani, Noorazliyana Shafii, Najib Majdi Yaacob, Noor Azlin Azraini Che Soh, Hanim Afzan Ibrahim
BACKGROUND: Epidemiological studies regarding the correlation between anti-Müllerian hormone (AMH) and insulin resistance (IR) in polycystic ovarian syndrome (PCOS) remain inconsistent. The primary aim of this study was to determine the correlations between AMH and IR in patients with PCOS and to explore the selected factors that influence the correlations. METHODS: We conducted systemic searches of online databases (PubMed, Science Direct, Taylor and Francis, Scopus, and ProQuest) from inception to December 20, 2023 and manual searches of the associated bibliographies to identify relevant studies...
May 18, 2024: Journal of Ovarian Research
#2
JOURNAL ARTICLE
Semra Kaya, Serap Koral Taşcı, Murat Can Demir, Muhammet Ali Karadağ, Merve Sena Kumcu, Cihan Kaçar, Dilem Gülece Ermutlu, Mushap Kuru
In recent years, blood anti-Müllerian hormone (AMH) levels have been investigated in female animals to diagnose many conditions, such as the presence of ovarian tissue, follicle reserve, and granulosa cell tumors. Since blood collection is an invasive method, diagnosis with a non-invasive method is important in terms of practicality and animal welfare. This study aimed to investigate the presence of AMH in cat urine and determine whether a correlation exists between blood and urine AMH levels. In addition, it was aimed at revealing whether there was a change in blood and urine AMH levels according to ovarian follicle distribution...
May 14, 2024: Theriogenology
#3
REVIEW
C Decanter, E Elefant, C Poirot, B Courbiere
Fertility capacity has been shown to be one of the main concerns of young cancer survivors. Gonadotoxic treatments may lead to both premature ovarian failure and/or infertility. This review aimed to define which, and when, reproductive indicators should be followed-up to help doctors to counsel patients regarding their fertility and ovarian function, and to determine if a second stage of fertility preservation after the end of cancer treatment is clinically relevant. Longitudinal assessment of anti-Müllerian hormone (AMH) concentrations during cancer treatment indicates the degree of follicular depletion, and allows discrimination between low and high gonadotoxic treatments...
February 16, 2024: Reproductive Biomedicine Online
#4
JOURNAL ARTICLE
Máté Éliás, Márton Kónya, Zsófia Kekk, Caner Turan, Isabel Pinto Amorim das Virgens, Réka Tóth, Márton Keszthelyi, Péter Hegyi, Szabolcs Várbíró, Miklós Sipos
INTRODUCTION: The incidence of infertility caused by diminished ovarian reserve has become a significant problem worldwide. The beneficial effect of PRP treatment of the ovaries has already been described, but the high-level evidence of its effectiveness has not yet been proven. MATERIALS AND METHODS: A systematic search was performed in five databases, until March 12th, 2024. Both randomized and non-randomized studies that compared PRP treatment of the ovaries to self-control among women with diminished ovarian reserve were eligible for inclusion...
May 17, 2024: Journal of Ovarian Research
#5
JOURNAL ARTICLE
Ines Agusti, Maria Isabel Alvarez-Mora, Robin Wijngaard, Aina Borras, Tamara Barcos, Sara Peralta, Marta Guimera, Anna Goday, Dolors Manau, Laia Rodriguez-Revenga
BACKGROUND: Fragile X-associated primary ovarian insufficiency (FXPOI), characterized by amenorrhea before age 40 years, occurs in 20% of female FMR1 premutation carriers. Presently, there are no molecular or biomarkers that can help predicting which FMR1 premutation women will develop FXPOI. We previously demonstrated that high FMR4 levels can discriminate between FMR1 premutation carriers with and without FXPOI. In the present study the relationship between the expression levels of FMR4 and the ovarian reserve markers was assessed in female FMR1 premutation carriers under age of 35 years...
May 17, 2024: Journal of Ovarian Research
#6
JOURNAL ARTICLE
Ling-Ling Ruan, Xing-Yu Lv, Yu-Lin Hu, Ming-Xing Chen, Jing-Tang, Zhao-Hui Zhong, Mei-Hua Bao, Li-Juan Fu, Xin Luo, Shao-Min Yu, Qi Wan, Yu-Bin Ding
BACKGROUND: In the realm of assisted reproduction, a subset of infertile patients demonstrates high ovarian response following controlled ovarian stimulation (COS), with approximately 29.7% facing the risk of Ovarian Hyperstimulation Syndrome (OHSS). Management of OHSS risk often necessitates embryo transfer cancellation, leading to delayed prospects of successful pregnancy and significant psychological distress. Regrettably, these patients have received limited research attention, particularly regarding their metabolic profile...
May 17, 2024: Journal of Ovarian Research
#7
JOURNAL ARTICLE
Chaobao Chen, Xin Wang, Yajuan Li, Tianwei Zhao, Huan Wang, Yunqi Gao, Yuanzhou Feng, Jing Wang, Lixin Shang, Yongan Wang, Baoquan Zhao, Wu Dong
Hypobaric Hypoxia (HH) negatively affects the cardiovascular and respiratory systems as well as gonadal development and the therefore next generation. This study investigated the effects of HH on zebrafish and SD rats, by exposing them to a low-pressure environment at 6,000m elevation for 30 days to simulate high-altitude conditions. It was indicated that parental zebrafish reared amh under HH had increased embryo mortality, reduced hatchability, and abnormal cartilage development in the offspring. Furthermore, the HH-exposed SD rats had fewer reproductive cells and smaller litters...
May 15, 2024: Reproductive Toxicology
#8
JOURNAL ARTICLE
Luiz Fernando Rodrigues Feres, Luiz Gustavo Bruno Siqueira, Miller Pereira Palhao, Livia Loiola Dos Santos, Luiz Francisco Machado Pfeifer, Carlos Antônio de Carvalho Fernandes, Joao Henrique Moreira Viana
The aims of this study were to determine anti-müllerian hormone (AMH) cutoff values for selecting Gir (Bos taurus indicus) oocyte donors and estimate the impact of using AMH concentrations as a selection criterion. In Exp. 1, Gir heifers (n=120) were sampled for AMH analysis and submitted to ovum pick-up and in vitro embryo production (OPU-IVEP). AMH cutoff values were calculated using ROC analysis or, alternatively, by the successive exclusion of heifers with the lowest AMH values. The correlations between AMH and OPU-IVEP outcomes were significant (P<0...
May 7, 2024: Animal Reproduction Science
#9
JOURNAL ARTICLE
Kim van der Ham, Loes M E Moolhuijsen, Kelly Brewer, Ryan Sisk, Andrea Dunaif, Joop S E Laven, Yvonne V Louwers, Jenny A Visser
CONTEXT: Hierarchical clustering (HC) identifies subtypes of polycystic ovary syndrome (PCOS). OBJECTIVE: This work aimed to identify clinically significant subtypes in a PCOS cohort diagnosed with the Rotterdam criteria and to further characterize the distinct subtypes. METHODS: Clustering was performed using the variables body mass index (BMI), luteinizing hormone (LH), follicle-stimulating hormone, dehydroepiandrosterone sulfate, sex hormone-binding globulin (SHBG), testosterone, insulin, and glucose...
May 16, 2024: Journal of Clinical Endocrinology and Metabolism
#10
JOURNAL ARTICLE
Annelore Van Der Kelen, Kathelijn Keymolen, Wilfried Cools, Anick De Vos, Laura Pölsler, Michel De Vos, Christophe Blockeel, Elia Fernandez-Gallardo, Martine De Rycke, Veerle Berckmoes, Pieter Verdyck, Frederik Jan Hes, Willem Verpoest
PURPOSE: Our objective is to predict the cumulative live birth rate (CLBR) and identify the specific subset within the population undergoing preimplantation genetic testing for monogenic disorders (PGT-M) and chromosomal structural rearrangements (PGT-SR) which is likely to exhibit a diminished expected CLBR based on various patient demographics. METHODS: We performed a single-centre retrospective cohort study including 1522 women undergoing 3130 PGT cycles at a referral centre for PGT...
May 16, 2024: Journal of Assisted Reproduction and Genetics
#11
REVIEW
Scott M Nelson, Martin Shaw, Karema Alrashid, Richard A Anderson
IMPORTANCE: For women undertaking assisted conception, the dose of gonadotropin has historically been driven by clinical experience. A different and individualised strategy was developed for follitropin delta, a human cell line derived recombinant follicle stimulating hormone, with dose based on anti-Müllerian hormone (AMH) stratification; for women with a high ovarian reserve (AMH ≥15pmol/l; approx. 2.1ng/ml) the dose is based on the combination of AMH and body weight in a continuous manner...
May 13, 2024: Fertility and Sterility
#12
JOURNAL ARTICLE
Antonino Giordano, Béatrice Pignolet, Elisabetta Mascia, Ferdinando Clarelli, Melissa Sorosina, Kaalindi Misra, Florence Bucciarelli, Laura Ferrè, Lucia Moiola, Roland Liblau, Massimo Filippi, Federica Esposito
OBJECTIVE: Multiple sclerosis (MS) has a complex pathobiology, with genetic and environmental factors being crucial players. Understanding the mechanisms underlying heterogeneity in disease activity is crucial for tailored treatment. We explored the impact of DNA methylation, a key mechanism in the genetics-environment interplay, on disease activity in MS. METHODS: Peripheral immune methylome profiling using Illumina Infinium MethylationEPIC BeadChips was conducted on 249 untreated relapsing-remitting MS patients, sampled at the start of disease-modifying treatment (DMT)...
May 15, 2024: Annals of Neurology
#13
JOURNAL ARTICLE
Bo Sun, Lu Li, Yile Zhang, Fang Wang, Yingpu Sun
PURPOSE: This study aims to retrospectively estimate cumulative reproductive outcomes in women with primary ovarian insufficiency (POI) in assisted reproductive technology (ART) therapy. METHODS: A total of 139 patients diagnosed with POI were reviewed in this study. Firstly, they were divided into two groups according to oocyte origin: using their own oocytes (OG group) or accepting oocyte donations (OD I group). Secondly, the patients were split depending on the pregnancy outcome...
2024: Frontiers in Endocrinology
#14
JOURNAL ARTICLE
Yuan Li, Jinquan Lai, Wenbo Wu, Shuyi Ling, Yuqing Dai, Zhisheng Zhong, Xiaodong Chen, Yuehui Zheng
Previous observational studies have suggested that anti-Müllerian hormone (AMH) and reproductive factors are linked to reduced bone mineral density (BMD) and an increased risk of osteoporosis (OP) in women. However, related studies are limited, and these traditional observational studies may be subject to residual confounders and reverse causation, while also lacking a more comprehensive observation of various reproductive factors. Univariate and multivariate two-sample Mendelian randomization analyses were conducted to determine the causal associations of AMH levels and six reproductive factors with BMD and OP, using the random-effects inverse-variance weighted method...
May 14, 2024: Calcified Tissue International
#15
JOURNAL ARTICLE
Olusola Olowoselu, Kehinde S Okunade, Olufemi A Oyedeji, Nosimot O Davies, Obiefuna I Ajie, Ademola Adewoyin, Gaurav Kharya
BACKGROUND: Haematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for sickle cell anaemia (SCA). While HSCT offers the possibility of disease remission, it can also lead to long-term complications, including gonadal dysfunction and premature menopause. METHODS: We conducted a retrospective cohort study of female survivors who had hydroxyurea therapy and those who underwent post-HSCT follow-up for SCA at a teaching hospital in Lagos, Nigeria, between January 2019 and December 2022...
April 2024: Curēus
#16
JOURNAL ARTICLE
Menghui Zhang, Shujun Liu, Fuli Zhang, Hao Shi, Fang Wang, Caihong Chen, Qingling Yang, Shanjun Dai, Yuling Liang, Yihong Guo
BACKGROUND: Patients with polycystic ovary syndrome (PCOS) have a higher risk of obstetric complications. The association between anti-Müllerian hormone (AMH) and gestational hypertension in these patients is poorly understood. OBJECTIVE: To determine the association between serum AMH levels and gestational hypertension in patients with PCOS undergoing fresh embryo transfer. METHODS: This retrospective study included 649 patients with PCOS who had singleton live births after undergoing fresh embryo transfers...
May 13, 2024: Journal of Clinical Endocrinology and Metabolism
#17
JOURNAL ARTICLE
Viktor Vedelek, Petra Bicskei, Mariann Tábi, Noémi Lajkó, Csaba Ékes, Kristóf Bereczki, Zsófia Meixner-Csáti, Rita Sinka, Anna Vágvölgyi, János Zádori
INTRODUCTION: The impact of the obesity pandemic on female reproductive capability is a factor that needs to be investigated. In addition, the link between endometrial thickness and in vitro fertilization (IVF) outcomes is contentious. GOAL: Our goal was to analyze the association among endometrium development, hormone levels, embryo quality, clinical pregnancy, anamnestic parameters, and body mass index (BMI) in women receiving IVF treatment. PATIENTS AND METHODS: 537 participants undergoing IVF/ICSI cycles with successful oocyte retrieval were enrolled...
2024: Frontiers in Endocrinology
#18
JOURNAL ARTICLE
Yuanyi Liu, Ming Du, Xinyu Li, Lei Zhang, Bilig Zhao, Na Wang, Manglai Dugarjaviin
This study aimed to investigate differences in testicular tissue morphology, gene expression, and marker genes between sexually immature (1-year-old) and sexually mature (10-year-old) Mongolian horses. The purposes of our research were to provide insights into the reproductive physiology of male Mongolian horses and to identify potential markers for sexual maturity. The methods we applied included the transcriptomic profiling of testicular cells using single-cell sequencing techniques. Our results revealed significant differences in tissue morphology and gene expression patterns between the two age groups...
April 23, 2024: Animals: An Open Access Journal From MDPI
#19
JOURNAL ARTICLE
Qinglei Xu, Maolin Ye, Yun Su, Li Feng, Linyan Zhou, Jian Xu, Deshou Wang
Relaxin 3 is a neuropeptide that plays a crucial role in reproductive functions of mammals. Previous studies have confirmed that rln3a plays an important role in the male reproduction of tilapia. To further understand the significance of its paralogous gene rln3b in male fertility, we generated a homozygous mutant line of rln3b in Nile tilapia. Our findings indicated that rln3b mutation delayed spermatogenesis and led to abnormal testes structure. Knocking out rln3b gene resulted in a decrease in sperm count and motility and a significant decrease in male fish fertility...
May 8, 2024: International Journal of Biological Macromolecules
#20
JOURNAL ARTICLE
M E Madeleine van der Perk, Linda Broer, Yutaka Yasui, Joop S E Laven, Leslie L Robison, Wim J E Tissing, Birgitta Versluys, Dorine Bresters, Gertjan J L Kaspers, Cornelis B Lambalk, Annelies Overbeek, Jacqueline J Loonen, Catharina C M Beerendonk, Julianne Byrne, Claire Berger, Eva Clemens, Eline van Dulmen-den Broeder, Uta Dirksen, Helena J van der Pal, Andrica C H de Vries, Jeanette Falck Winther, Andreas Ranft, Sophie D Fosså, Desiree Grabow, Monica Muraca, Melanie Kaiser, Tomáš Kepák, Jarmila Kruseova, Dalit Modan-Moses, Claudia Spix, Oliver Zolk, Peter Kaatsch, Leontien C M Kremer, Russell J Brooke, Fan Wang, Jessica L Baedke, André G Uitterlinden, Annelies M E Bos, Flora E van Leeuwen, Kirsten K Ness, Melissa M Hudson, Anne-Lotte L F van der Kooi, Marry M van den Heuvel-Eibrink
OBJECTIVE: We aimed to discover new variants associated with low ovarian reserve after gonadotoxic treatment among adult female childhood cancer survivors using a genome-wide association study approach. DESIGN: Genome-wide association study. SUBJECTS: A discovery cohort of adult female childhood cancer survivors, from the pan-European PanCareLIFE cohort (n=743; median age: 25.8 years), excluding those who received bilateral ovarian irradiation, bilateral oophorectomy, central nerve system or total body irradiation, or stem cell transplantation...
May 8, 2024: Fertility and Sterility
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