Maffeis Caterinaa, Rossi Andreaa, Faggiano Pompiliob
No abstract text is available yet for this article.
July 19, 2021: International Journal of Cardiology
Connor Lantz, Amanda Becker, Edward B Thorp
While largely appreciated for their antimicrobial and repair functions, macrophages have emerged as indispensable for the development, homeostasis, and regeneration of tissue, including regeneration of the neonatal heart. Upon activation, mammalian neonatal macrophages express and secrete factors that coordinate angiogenesis, resolution of inflammation, and ultimately cardiomyocyte proliferation. This is contrary to adult macrophages in the adult heart, which are incapable of inducing significant levels of cardiac regeneration...
July 20, 2021: Journal of Molecular and Cellular Cardiology
James B Wetmore, Heng Yan, Yi Peng, David T Gilbertson, Charles A Herzog
INTRODUCTION: While severe hyperkalemia is commonly encountered, its manifestation in hospitalized patients and related outcomes are unclear. We aimed to examine development of hyperkalemia in hospitalized patients and associated outcomes. METHODS: Data from a county hospital electronic health record were used to assess all inpatient admissions, 2012-2016, for non-dialysis-dependent patients with ≥1 K value for development of hyperkalemia. Unadjusted odds ratios (ORs) were calculated for associations of the maximum K value with in-hospital mortality and adjusted ORs were calculated for death associated with hyperkalemia...
July 19, 2021: American Heart Journal
Dirk De Bacquer, Felicity Astin, Kornelia Kotseva, Nana Pogosova, Delphine De Smedt, Guy De Backer, Lars Rydén, David Wood, Catriona Jennings
AIMS : Despite the high use of cardioprotective medications, the risk factor control in patients with coronary heart disease (CHD) is still inadequate. Guidelines identify healthy lifestyles as equally important in secondary prevention as pharmacotherapy. Here, we describe reasons for poor lifestyle adherence from the patient's perspective. METHODS AND RESULTS : In the EUROASPIRE IV and V surveys, 16 259 CHD patients were examined and interviewed during a study visit ≥6 months after hospital discharge...
July 19, 2021: European Journal of Preventive Cardiology
Suzanne R Avis, Stephen T Vernon, Emil Hagström, Gemma A Figtree
No abstract text is available yet for this article.
July 22, 2021: European Heart Journal
Giuseppe Limongelli, Emanuele Monda, Marcella Nunziato, Francesco Salvatore
No abstract text is available yet for this article.
July 22, 2021: European Journal of Preventive Cardiology
Hidekazu Kondo, Ioannis Akoumianakis, Ileana Badi, Nadia Akawi, Christos P Kotanidis, Murray Polkinghorne, Ilaria Stadiotti, Elena Sommariva, Alexios S Antonopoulos, Maria C Carena, Evangelos K Oikonomou, Elsa Mauricio Reus, Rana Sayeed, George Krasopoulos, Vivek Srivastava, Shakil Farid, Surawee Chuaiphichai, Cheerag Shirodaria, Keith M Channon, Barbara Casadei, Charalambos Antoniades
AIMS: Recent clinical trials indicate that sodium-glucose cotransporter 2 (SGLT2) inhibitors improve cardiovascular outcomes in heart failure patients, but the underlying mechanisms remain unknown. We explored the direct effects of canagliflozin, an SGLT2 inhibitor with mild SGLT1 inhibitory effects, on myocardial redox signalling in humans. METHODS AND RESULTS: Study 1 included 364 patients undergoing cardiac surgery. Right atrial appendage biopsies were harvested to quantify superoxide (O2...
July 19, 2021: European Heart Journal
Renato Quispe, Seth S Martin, Erin D Michos, Isha Lamba, Roger S Blumenthal, Anum Saeed, Joao A C Lima, Rishi Puri, Sarah O Nomura, Michael Y Tsai, John T Wilkins, Christie M Ballantyne, Stephen J Nicholls, Steven R Jones, Mohamed B Elshazly
AIMS: Emerging evidence suggests that remnant cholesterol (RC) promotes atherosclerotic cardiovascular disease (ASCVD). We aimed to estimate RC-related risk beyond low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apoB) in patients without known ASCVD. METHODS AND RESULTS: We pooled data from 17 532 ASCVD-free individuals from the Atherosclerosis Risk in Communities study (n = 9748), the Multi-Ethnic Study of Atherosclerosis (n = 3049), and the Coronary Artery Risk Development in Young Adults (n = 4735)...
July 19, 2021: European Heart Journal
Xiaoliang Wang, Xiuchun Li, Hannah Ong, Tao Tan, Ki Ho Park, Zehua Bian, Xunchang Zou, Erin Haggard, Paul M Janssen, Robert E Merritt, Timothy M Pawlik, Bryan A Whitson, Nahush A Mokadam, Lei Cao, Hua Zhu, Chuanxi Cai, Jianjie Ma
Aging is associated with chronic oxidative stress and inflammation that impact the tissue repair and regeneration capacity. MG53 is a TRIM family protein that facilitates repair of cell membrane injury in a redox-dependent manner. Here we demonstrate that the expression of MG53 is reduced in failing human heart and aging mouse heart, concomitant with elevated NFκB activation. We evaluate the safety and efficacy of longitudinal, systemic administration of recombinant human MG53 (rhMG53) protein in aged mice...
July 22, 2021: JCI Insight
Mathilde Csc Vermeer, Maria C Bolling, Jacqueline M Bliley, Karla F Arevalo Gomez, Mario G Pavez-Giani, Duco Kramer, Pedro H Romero-Herrera, B Daan Westenbrink, Gilles Fh Diercks, Maarten P van den Berg, Adam W Feinberg, Herman H W Silljé, Peter van der Meer
The start codon c.1A>G mutation in KLHL24, encoding ubiquitin-ligase KLHL24, results in the loss of 28 N-terminal amino acids (KLHL24-ΔN28) by skipping the initial start codon. In skin, KLHL24-ΔN28 leads to gain of function, excessively targeting intermediate filament keratin-14 for proteasomal degradation, ultimately causing epidermolysis bullosa simplex (EBS). The majority of these EBS-patients are also diagnosed with dilated cardiomyopathy (DCM), but the pathological mechanism in the heart is unknown...
July 22, 2021: Journal of Clinical Investigation
Michał Terlecki, Wiktoria Wojciechowska, Marek Klocek, Michał Kania, Maciej Małecki, Tomasz Grodzicki, Marek Rajzer
No abstract text is available yet for this article.
July 22, 2021: Kardiologia Polska
Dimitrios Patoulias, Christodoulos Papadopoulos, George Kassimis, Michael Doumas
No abstract text is available yet for this article.
July 22, 2021: Kardiologia Polska
Jacek Kądziela, Janusz Kochman, Marek Grygier, Ilona Michałowska, Mariusz Tomaniak, Wojciech Wojakowski, Aleksander Araszkiewicz, Maciej Dąbrowski, Michał Hawranek, Zenon Huczek, Paweł Kralisz, Jacek Kusa, Tomasz Roleder, Andrzej Januszewicz, Adam Witkowski, David Adlam, Stanisław Bartuś
No abstract text is available yet for this article.
July 22, 2021: Kardiologia Polska
Jakob Josiassen, Martin Frydland, Christian Hassager, Jacob Eifer Møller, Anders Perner, Johannes Grand
BACKGROUND: Cardiogenic shock (CS) is a critical complication to acute myocardial infarction (AMI), with short-term mortality rates exceeding 40%. However, no international consensus of a CS definition exists. This may compromise interstudy comparability. AIMS: The aim of the current study was to review differences and similarities of CS enrolment criteria in AMI-related CS randomised clinical trials (RCT). METHODS: From the electronic databases MEDLINE and EMBASE we identified all AMI-related CS trials...
July 22, 2021: Kardiologia Polska
Karol Zbroński, Kajetan Grodecki, Roksana Gozdowska, Ewa Ostrowska, Julia Wysińska, Bartosz Rymuza, Piotr Scisło, Radosław Wilimski, Janusz Kochman, Krzysztof J Filipiak, Grzegorz Opolski, Zenon Huczek
BACKGROUND: Bleeding complications after transcatheter aortic valve implantation (TAVI) negatively affect the post-procedural prognosis. Routine use of protamine sulfate (PS) to reverse unfractionated heparin after TAVI was never assessed in a randomized controlled trial. AIMS: The aim of this study was to assess the impact of PS on bleeding complications after TAVI. METHODS: Between December 2016 and July 2020 311 patients qualified to TAVI in one academic center were screened...
July 22, 2021: Kardiologia Polska
Aleksandra Wróblewska, Antoni Wileczek, Agnieszka Reichert, Sebastian Stec
No abstract text is available yet for this article.
July 22, 2021: Kardiologia Polska
Marcin Protasiewicz, Michał Kosowski, Grzegorz Onisk, Krzysztof Reczuch, Roman Przybylski, Piotr Kubler
No abstract text is available yet for this article.
July 22, 2021: Kardiologia Polska
Islam Mohammad Shehata, Tiffany D Odell, Amir Elhassan, Maxim Spektor, Ivan Urits, Omar Viswanath, George M Jeha, Elyse M Cornett, Alan D Kaye
No abstract text is available yet for this article.
July 22, 2021: Cardiology and Therapy
Nolwazi Mokitimi, Katherina van der Donck, Hlamatsi Moutlana, Palesa Motshabi Chakane
BACKGROUND: Peri-operative morbidity and mortality are increased in patients with rheumatic heart disease. Pre-operative risk stratification is imperative for optimisation and a better outcome. METHODS: This was a descriptive, retrospective, contextual study. A consecutive convenience sampling method was used. Eighty-nine patients who underwent mitral valve surgery at Charlotte Maxeke Johannesburg Academic Hospital between January 2014 and December 2015 were enrolled...
July 20, 2021: Cardiovascular Journal of Africa
Jayakumar Sreenivasan, Sagar Ranka, Shubham Lahan, Ahmed Abu-Haniyeh, Heyi Li, Risheek Kaul, Aaqib Malik, Wilbert S Aronow, William H Frishman, Steven Lansman
Coronavirus disease 2019 (COVID-19) is characterized by a clinical spectrum of diseases ranging from asymptomatic or mild cases to severe pneumonia with acute respiratory distress syndrome (ARDS) requiring mechanical ventilation. Extracorporeal membrane oxygenation (ECMO) has been used as rescue therapy in appropriate patients with COVID-19 complicated by ARDS refractory to mechanical ventilation. In this study, we review the indications, challenges, complications and clinical outcomes of ECMO utilization in critically ill patients with COVID-19 related ARDS...
July 20, 2021: Cardiology in Review
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