Valentin Femenia, Victor Pommier, Helena Huguet, Xavier Iriart, Marie-Christine Picot, Charlene Bredy, Laura Lorca, Gregoire De La Villeon, Sophie Guillaumont, Jean-Luc Pasquie, Stefan Matecki, François Roubertie, Bertrand Leobon, Jean-Benoît Thambo, Zakaria Jalal, Julie Thomas, Jean-Baptiste Mouton, Martina Avesani, Pascal Amedro
BACKGROUND: The prognosis of patients with a functional single ventricle has improved, with better cardiopulmonary fitness, health-related quality of life and survival. Conventional echocardiography remains the first-line technique in single ventricle follow-up. Three-dimensional (3D) echocardiography has shown recent value in congenital cardiology, but its ability to predict functional status in patients with a single ventricle remains unknown. AIM: To evaluate, in patients with a single ventricle, the association between 3D echocardiography variables and functional status determined by cardiopulmonary fitness...
March 9, 2023: Archives of Cardiovascular Diseases
Salim S Virani, Karen Aspry, Dave L Dixon, Keith C Ferdinand, Paul A Heidenreich, Elizabeth J Jackson, Terry A Jacobson, Janice L McAlister, David R Neff, Martha Gulati, Christie M Ballantyne
Despite the established role of low-density lipoprotein cholesterol (LDL-C) as a major risk factor for cardiovascular disease (CVD), and the persistence of CVD as the leading cause of morbidity and mortality in the United States, national quality assurance metrics no longer include LDL-C measurement as a required performance metric. This clinical perspective reviews the history of LDL-C as a quality and performance metric and the events that led to its replacement. It also presents patient, healthcare provider, and health system rationales for re-establishing LDL-C measurement as a performance measure to improve cholesterol control in high-risk groups and to stem the rising tide of CVD morbidity and mortality, cardiovascular care disparities, and related healthcare costs...
2023: Journal of Clinical Lipidology
Paige E Brlecic, Clark A Bonham, Todd K Rosengart, Megumi Mathison
Cardiovascular disease is one of the leading causes of morbidity and mortality worldwide, with myocardial infarctions being amongst the deadliest manifestations. Reduced blood flow to the heart can result in the death of cardiac tissue, leaving affected patients susceptible to further complications and recurrent disease. Further, contemporary management typically involves a pharmacopeia to manage the metabolic conditions contributing to atherosclerotic and hypertensive heart disease, rather than regeneration of the damaged myocardium...
March 23, 2023: Journal of Molecular and Cellular Cardiology
Motoki Nakao, Masaya Watanabe, Lucile Miquerol, Hiroyuki Natsui, Takuya Koizumi, Takahide Kadosaka, Taro Koya, Hikaru Hagiwara, Rui Kamada, Taro Temma, Antoine A F de Vries, Toshihisa Anzai
AIMS: The most efficient way to acutely restore sinus rhythm from atrial fibrillation (AF) is electrical cardioversion, which is painful without adequate sedation. Recent studies in various experimental models have indicated that optogenetic termination of AF using light-gated ion channels may provide a myocardium-specific and potentially painless alternative future therapy. However, its underlying mechanism(s) remain(s) incompletely understood. As brief pulsed light stimulation, even without global illumination, can achieve optogenetic AF termination, besides direct conduction block also modulation of action potential (AP) properties may be involved in the termination mechanism...
March 23, 2023: Journal of Molecular and Cellular Cardiology
Congwu Chi, Kunhua Song
Myocardial infarction causes the loss of cardiomyocytes and the formation of cardiac fibrosis due to the activation of cardiac fibroblasts, leading to cardiac dysfunction and heart failure. Unfortunately, current therapeutic interventions can only slow the disease progression. Furthermore, they cannot fully restore cardiac function, likely because the adult human heart lacks sufficient capacity to regenerate cardiomyocytes. Therefore, intensive efforts have focused on developing therapeutics to regenerate the damaged heart...
March 23, 2023: Journal of Molecular and Cellular Cardiology
Shoma Kitano, Toru Awaya, Masao Moroi, Hidehiko Hara, Hideki Itaya, Mari Matsushima, Kei Takahashi, Toshiki Fujioka, Masato Nakamura
Patient 1 with giant cell myocarditis was the first case at our hospital to present with ocular symptoms. Unfortunately, the patient died because cardiac arrest occurred before giant cell myocarditis could be diagnosed. In contrast, in Patient 2, our previous experience enabled us to suspect giant cell myocarditis earlier based on similar ocular symptoms. Thus, we were able to perform a myocardial biopsy and administer immunosuppressive drugs at an early stage. Thus, it is vital to understand that ocular symptoms may be indicative of giant cell myocarditis, and an urgent diagnosis is needed to prevent patient death...
March 23, 2023: Canadian Journal of Cardiology
Charlotte Midey, Silvana Kalakech, Ludovic Lacroix, Jean-Claude Dib, Stephane Aubert, Julien Rosencher, Arthur Cescau, Caroline Eymerit, Axel Le Cesne, Guillaume Geri, Olivier Hoffman, Carine Ngo
This case describes a 57-year old female patient with no past medical history who was referred for investigation of dyspnea. Cardiac exams revealed a voluminous septate mass with liquid tone, developed from the right atrium with minimal compression of the inferior vena cava. Patient underwent surgical removal of the mass with reconstruction of interatrial septum using pericardial patch. Histopathological examination of the mass revealed RREB1::MKL2 fusion characteristic of ectomesenchymal chondromyxoid tumors of the tongue...
March 23, 2023: Canadian Journal of Cardiology
Sharon Chih, Brian A Clark, Martin Albert, C Arianne Buchan, Tahir S Kafil, Daniel H Kim, Deepali Kumar, Stuart J Smith, Javier Tomas Solera Rallo, Michael J Stubbs, Michael A McDonald
In this review, we provide a comprehensive overview of the impact of the COVID-19 pandemic on adult heart transplantation. We highlight the decline in the number of adult transplant performed throughout the pandemic as a consequence of restrictions imposed on individual programs and hospitals. There were challenges to maintaining cardiac transplant activity at multiple levels, including organ donation in intensive care units, logistical difficulties with organ procurement, and rapidly changing resource considerations at a health system and jurisdictional level...
March 23, 2023: Canadian Journal of Cardiology
Marie-Claude Beaulieu, Joel Neves Briard, Michaël Chassé
It is challenging in COVID-19 patients to determine if the virus is the primary cause of their symptoms, or if it is exacerbating an underlying condition. When the virus is a significant contributing factor, drug therapies must be tailored to the severity of the clinical presentation. We aimed to summarize the indications of drug therapies for SARS-CoV-2 infected patients.
March 23, 2023: Canadian Journal of Cardiology
Kinga Grebur, Zsófia Gregor, Anna Réka Kiss, Márton Horváth, Balázs Mester, Csilla Czimbalmos, Attila Tóth, Liliána Szabó, Zsófia Dohy, Hajnalka Vágó, Béla Merkely, Andrea Szűcs
BACKGROUND: The quantitative differences of left and right ventricular (LV, RV) parameters of using different cardiac MRI (CMR) post-processing techniques and their clinical impact are less studied. We aimed to assess the differences and their clinical impact between the conventional contouring (CC) and the threshold-based (TB) methods using 70% and 50% thresholds in different hypertrabeculated conditions. METHODS: This retrospective study included 30 dilated cardiomyopathy, 30 left ventricular non-compaction (LVNC), 30 arrhythmogenic cardiomyopathy patients, 30 healthy athletes and 30 healthy volunteers...
March 23, 2023: International Journal of Cardiology
Michela Barisone, Luca Ghirotto, Gianluca Catana, Milko Zanini, Alberto Dal Molin, Loredana Sasso, Annamaria Bagnasco
INTRODUCTION: Heart failure has an enormous impact in terms of mortality, morbidity, and costs for healthcare organizations. Indications for implanted heart devices, such as pacemakers or implantable cardioverter defibrillators (ICDs) are constantly increasing. With the arrival of the telemedicine, nurses play an important role in the remote management of chronic heart diseases. The purpose of this study was to describe the experiences of nurses who remotely monitor patients with an implanted heart device in Italy...
July 1, 2022: Professioni Infermieristiche
M Wallbach, M Valentova, M R Schroeter, A Alkabariti, I Iraki, A Leha, D Tampe, G Hasenfuß, M Zeisberg, K Hellenkamp, M J Koziolek
OBJECTIVES: Renal venous congestion due to backward heart failure leads to disturbance of renal function in acute decompensated heart failure (ADHF). Whether decongestion strategies have an impact on renal venous congestion is unknown. Objective was to evaluate changes in intrarenal hemodynamics using intrarenal Doppler ultrasonography (IRD) in patients with heart failure with reduced ejection fraction (HFrEF) and ADHF undergoing recompensation. METHODS: Prospective observational study in patients with left ventricular ejection fraction (LV-EF) ≤ 35% hospitalized due to ADHF...
March 25, 2023: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Sophia Gu, Abhay Katyal, Qian Zhang, Winnie Chung, Sonia Franciosi, Shubhayan Sanatani
Congenital heart disease (CHD) is linked to an increased incidence of neurodevelopmental impairments in young patients. Given the number of published studies on this topic, a synthesis of the literature is timely and needed. We performed a systematic review and meta-analysis of the medical literature to assess the evidence linking CHD to incidence of autism spectrum disorder (ASD). A systematic review of studies on CHD and ASD in PubMed, Cochrane and Institute for Scientific Information (ISI) from 1965 to May 2021 was conducted...
March 25, 2023: Pediatric Cardiology
(no author information available yet)
No abstract text is available yet for this article.
March 25, 2023: European Heart Journal
Ying-Hwa Chen, Hsiao-Huang Chang, Hsin-Bang Leu
No abstract text is available yet for this article.
March 25, 2023: European Heart Journal
Aron K Krizsan, Kornel Kukuts, Walid Al-Muhanna, Zoltan Szoboszlai, Laszlo Balazs, Balazs Szabo, Janos Kiss, Stephan Nekolla, Sandor Barna, Ildiko Garai, Tamas Bukki, Attila Forgacs
BACKGROUND: In this study we evaluated the imaging capabilities of a novel Multi-pinhole collimator (MPH-Cardiac) specially designed for nuclear cardiology imaging on a Triple-NaI-detector based SPECT/CT system. METHODS: 99m Tc point source measurements covering the field of view (FOV) were used to determine tomographic sensitivity (TSpointsource ) and spatial resolution. Organ-size tomographic sensitivity (TSorgan ) was measured with a left ventricle (LV) phantom filled with typical myocardial activity of a patient scan...
March 25, 2023: EJNMMI Physics
Pradeep Bhambhvani, Fadi G Hage, Ami E Iskandrian
"A quick glance at selected topics in this issue" aims to highlight contents of the Journal and provide a quick review to the readers.
March 24, 2023: Journal of Nuclear Cardiology
Carlos Alberto Lodeiro Jordan, Faraz Alizadeh, Levi Sanchez Ramirez, Rachel Kimbro, Keila Natilde Lopez
The prevalence of obesity in children with congenital heart disease (CHD) is greater than 25%, putting these patients at-risk for increased surgical morbidity and mortality. Our goal was to determine the association between CHD complexity, sociodemographic factors, and obesity. Our hypothesis was that among CHD patients, the odds of obesity would be highest in older children with simple CHD, and in all children with a lower socioeconomic status. We conducted a retrospective cohort study, reviewing electronic medical records of children aged 2-17 years from over 50 outpatient pediatric clinics in Houston, TX...
March 24, 2023: Pediatric Cardiology
Anne Herefoss Davidsen, Stian Andersen, Peder Andreas Halvorsen, Henrik Schirmer, Eirik Reierth, Hasse Melbye
OBJECTIVE: The objective of this study was to determine the diagnostic accuracy in detecting valvular heart disease (VHD) by heart auscultation, performed by medical doctors. DESIGN/METHODS: A systematic literature search for diagnostic studies comparing heart auscultation to echocardiography or angiography, to evaluate VHD in adults, was performed in MEDLINE (1947-November 2021) and EMBASE (1947-November 2021). Two reviewers screened all references by title and abstract, to select studies to be included...
March 24, 2023: BMJ Open
Shohei Fujii, Shigeki Kobayashi, Yaowei Chang, Junya Nawata, Ryosuke Yoshitomi, Shinji Tanaka, Michiaki Kohno, Yoshihide Nakamura, Hironori Ishiguchi, Takeshi Suetomi, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Takayuki Okamura, Takeshi Yamamoto, Masafumi Yano
BACKGROUND: Dantrolene binds to the Leu601 -Cys620 region of the N-terminal domain of cardiac ryanodine receptor (RyR2), which corresponds to the Leu590 -Cys609 region of the skeletal ryanodine receptor, and suppresses diastolic Ca2+ leakage through RyR2. OBJECTIVE: We investigated whether the chronic administration of dantrolene prevented left ventricular (LV) remodeling and ventricular tachycardia (VT) after myocardial infarction (MI) by the same mechanism with the mutation V3599K of RyR2, which indicated that the inhibition of diastolic Ca2+ leakage occurred by enhancing the binding affinity of calmodulin (CaM) to RyR2...
March 22, 2023: Journal of Molecular and Cellular Cardiology
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