Christine Schumacher
Background: Large cardiovascular outcomes trials in individuals with heart failure, with and without diabetes, have demonstrated a significant risk reduction in the composite outcome of cardiovascular death or hospitalizations for heart failure with SGLT2 inhibitor therapy. These positive outcomes have led to the recommendation that SGLT2 inhibitors serve as backbone therapy in patients with heart failure reduced ejection fraction (HFrEF). To date, there has not been enough participants in clinical trials on concomitant SGLT2 inhibitor and angiotensin receptor-neprilysin inhibitor therapy to evaluate the benefits and risks of combination therapy with these two agents outside of smaller subgroup analyses...
November 28, 2022: Journal of Pharmacy Practice
Pankaj Garg, Magdy M El-Sayed Ahmed, Ian A Makey, Samuel Jacob
No abstract text is available yet for this article.
November 1, 2022: Texas Heart Institute Journal
Rachel E Goodman, Morgan Lamberg, Kate Wilcox, Anum Minhas, Rachel Bond, Eric H Yang, Negeen Shahandeh, Sherry-Ann Brown
PURPOSE OF REVIEW: Cardiovascular disease (CVD) is the leading cause of mortality in adult women in the USA, yet CVD is underrecognized in women. Disparities in care are further pronounced in women of racial/ethnic minority backgrounds. In this review, we discuss the role of social media (SoMe) as a tool to (i) promote women's cardiovascular (CV) health and (ii) address and potentially reduce gaps in care, particularly in general cardiology (targeting atherosclerotic cardiovascular disease), cardio-oncology, and cardio-obstetrics...
November 28, 2022: Current Atherosclerosis Reports
Muhammad Furqan, Sanchit Chawla, Muhammad Majid, Samia Mazumdar, Gauranga Mahalwar, Evan Harmon, Allan Klein
PURPOSE OF REVIEW: To review myocarditis and pericarditis developing after COVID-19 vaccinations and identify the management strategies. RECENT FINDINGS: COVID-19 mRNA vaccines are safe and effective. Systemic side effects of the vaccines are usually mild and transient. The incidence of acute myocarditis/pericarditis following COVID-19 vaccination is extremely low and ranges 2-20 per 100,000. The absolute number of myocarditis events is 1-10 per million after COVID-19 vaccination as compared to 40 per million after a COVID-19 infection...
November 28, 2022: Current Cardiology Reports
Ian M Graham, Emanuele Di Angelantonio, Radu Huculeci
PURPOSE OF REVIEW: Prior European Society of Cardiology (ESC) guidelines endorsed the SCORE 10-year cardiovascular disease (CVD) risk calculator to inform the total risk approach to CVD prevention, including the use of preventive interventions like lipid lowering therapies. However, SCORE was released in 2003, did not allow for estimation of fatal and non-fatal CVD events, and was limited to adults aged 40 to 70 years. The ESC's Cardiovascular Risk Collaboration (CRC) was tasked with updating SCORE (SCORE2) and with extending the upper age range of adults eligible for risk estimation (SCORE2-OP)...
November 28, 2022: Current Cardiology Reports
V M M Vorselaars, M Minneboo, W C Meijers, A C van der Heijden, D Haroun, V J M Baggen, W R Berger, G P J van Hout
In the Netherlands, concerns have been raised regarding the high unemployment rates and the lack of permanent positions for young medical specialists. In the current study, we present data on contemporary early career perspectives in the field of cardiology. We conducted a survey among 304 young cardiologists who completed their training between 2015 and 2020; the response rate was 91%. Our analysis revealed a low unemployment rate (0.3%). One, 3 and 5 years after registration, 81%, 41% and 18% of the respondents, respectively, had not gained a permanent position...
November 28, 2022: Netherlands Heart Journal
Lars Michel, Matthias Totzeck, Tienush Rassaf
The continuous improvement in cancer treatment leads to a growing number of long-term survivors. Arguably, the treatment of cardiovascular side effects from cancer therapy is therefore of major importance for the morbidity and mortality affected patients. The 2022 ESC guidelines on cardio-oncology of the European Society of Cardiology (ESC) aim to improve the treatment of affected patients across the entire continuum of therapy and in the long term by establishing standardized procedures for prevention, diagnostics, and treatment of cardiovascular side effects...
November 28, 2022: Herz
Hilke Könemann, Gerrit Frommeyer, Katja Zeppenfeld, Lars Eckardt
The recently published guidelines of the European Society of Cardiology (ESC) on the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death is an update of the 2015 guideline. For the first time a new section is dedicated to public basic life support. In the acute treatment of ventricular arrhythmias electrical cardioversion is upgraded, and there is a new focus on the management of electrical storm. Recommendations for the comprehensive diagnostic evaluation of patients with first manifestations of ventricular arrhythmias structured according to common clinical scenarios are also new...
November 28, 2022: Herz
Hanna J Tadros, Tam T Doan, Amol S Pednekar, Prakash M Masand, Joseph A Spinner, Tobias R Schlingmann, Ricardo Pignatelli, Cory V Noel, James C Wilkinson
AIMS: We set out to design a reliable, semi-automated, and quantitative imaging tool using cardiac magnetic resonance (CMR) imaging that captures LV trabeculations in relation to the morphologic endocardial and epicardial surface, or perimeter-derived ratios, and assess its diagnostic and prognostic utility. METHODS AND RESULTS: We queried our institutional database between January 2008 and December 2018. Non-compacted (NC)-to-compacted (C) (NC/C) myocardium ratios were calculated and our tool was used to calculate fractal dimension (FD), total mass ratio (TMR), and composite surface ratios (SRcomp)...
November 28, 2022: European Heart Journal Cardiovascular Imaging
Alexandros Leonidas Liarakos, Patrick Tran, Michelle Keegan, Tim Robbins, Nadia Chaudhuri, Narasimha Murthy, Harpal Randeva, Nitin Narayan Gholap
INTRODUCTION: Admission hyperglycaemia in acute coronary syndromes (ACS) is a strong independent predictor of adverse clinical outcomes post-ACS. We examined the safety, efficacy, and feasibility of a modified, weight-adjusted variable rate intravenous insulin infusion (VRIII) and evaluated current practice of prescribing novel cardio-protective glucose-lowering therapies in patients presenting with acute hyperglycaemia across the ACS spectrum. METHODS: REGULATE-ACS was an observational single-centre study of consecutive patients admitted with acute hyperglycaemia post-ACS between 2020 and 2021...
October 29, 2022: International Journal of Cardiology
Harigopal Sandhyavenu, Waqas Ullah, Irisha Badu, Mohamed Zghouzi, Omar Baqal, Mobeen Ali, Tanveer Mir, Abdul Mannan Khan Minhas, Drew Johnson, Salim S Virani, David L Fischman, M Chadi Alraies, Michael P Savage
The impact of intravascular imaging guidance [intravascular ultrasound (IVUS)/optical coherence tomography (OCT)] on clinical outcomes in patients undergoing orbital atherectomy (OA) and percutaneous intervention (PCI) are not well characterized. The Nationwide Readmissions Database (NRD) from 2015 to 2019 was used to select all cases of OA. The adjusted odds ratios (aOR) of in-hospital, 30-day, and 180-day hospitalization outcomes between patients who underwent PCI with OA vs without intravascular imaging were calculated using a propensity-matched analysis...
October 29, 2022: Current Problems in Cardiology
Christopher P Cannon, Liuba Fusco
No abstract text is available yet for this article.
December 1, 2022: Critical Pathways in Cardiology
Luca Branca, Daniela Tomasoni, Giuliana Cimino, Angelica Cersosimo, Carlo Mario Lombardi, Giuliano Chizzola, Marco Metra, Marianna Adamo
Device-related thrombus (DRT) is a known complication occurring in up to 7% of patients undergoing percutaneous left atrial appendage closure (LAAC). Since the target population of LAAC is generally ineligible for oral anticoagulant therapies, DRT raises important concerns. The aim of this review will be to summarize available evidence on DRT after LAAC focusing on its possible impact on outcomes. Recent findings showed a tighter association between DRT and neurological ischemic events. Antithrombotic regimen adopted after LAAC may have a protective effect against DRT...
November 23, 2022: Journal of Cardiovascular Medicine
Won-Keun Kim, Corrado Tamburino, Helge Möllmann, Matteo Montorfano, Julia Ellert-Gregersen, Tanja K Rudolph, Nicolas M Van Mieghem, Michael Hilker, Ignacio J Amat-Santos, Christian Juhl Terkelsen, Anna Sonia Petronio, Pieter R Stella, Matthias Götberg, Andreas Rück, A Markus Kasel, Ramiro Trillo, Clare Appleby, Marco Barbanti, Philipp Blanke, Rodrigo Modolo, Dominic J Allocco, Lars Sondergaard
BACKGROUND: The next-generation ACURATE neo2 transcatheter aortic valve was designed for simplified implantation and to mitigate the risk of paravalvular leak (PVL) compared to the earlier device. AIMS: To collect clinical outcomes and device performance data, including echocardiography and 4-dimensional computed tomography (4D-CT) data, with the ACURATE neo2 transcatheter heart valve in patients with severe aortic stenosis (AS). METHODS: ACURATE neo2 PMCF is a single-arm, multicentre study of patients with severe AS treated in routine clinical practice...
November 27, 2022: EuroIntervention
Kara S Motonaga, Loren Sacks, Inger Olson, Sowmya Balasubramanian, Sharon Chen, Lynn Peng, Jeffrey A Feinstein, Norman H Silverman, Frank L Hanley, David M Axelrod, Catherine D Krawczeski, Alisa Arunamata, David M Kwiatkowski, Scott R Ceresnak
BACKGROUND: The transition from residency to paediatric cardiology fellowship is challenging due to the new knowledge and technical skills required. Online learning can be an effective didactic modality that can be widely accessed by trainees. We sought to evaluate the effectiveness of a paediatric cardiology Fellowship Online Preparatory Course prior to the start of fellowship. METHODS: The Online Preparatory Course contained 18 online learning modules covering basic concepts in anatomy, auscultation, echocardiography, catheterisation, cardiovascular intensive care, electrophysiology, pulmonary hypertension, heart failure, and cardiac surgery...
November 28, 2022: Cardiology in the Young
Adam L Ware, Lauren Reiter, Melissa Winder, Dallin Kelly, Jennifer Marietta, Sonja Ohsiek, Zhining Ou, Angela Presson, David K Bailly
OBJECTIVE: Children with heart disease may require inpatient care for many reasons, but ultimately have a final reason for hospitalisation prior to discharge. Factors influencing length of stay in paediatric cardiac acute care units have been described but the last reason for hospitalisation has not been studied. Our aim was to describe Final Hospital Need as a novel measure, determine Final Hospital Need in our patients, and describe factors associated with this Need. METHODS: Single-centre survey design...
November 28, 2022: Cardiology in the Young
Norman Mangner, Miriam Brinkert, Lukas S Keller, Noriaki Moriyama, Daniel Hagemeyer, Stephan Haussig, Lisa Crusius, Richard Kobza, Mohamed Abdel-Wahab, Mika Laine, Stefan Stortecky, Thomas Pilgrim, Fabian Nietlispach, Frank Ruschitzka, Holger Thiele, Stefan Toggweiler, Axel Linke
BACKGROUND: One-third of patients undergoing transcatheter aortic valve implantation (TAVI) have an indication for long-term oral anticoagulation (OAC). AIMS: We aimed to investigate whether continued non-vitamin K antagonist oral anticoagulant (NOAC) therapy compared with continued vitamin K antagonist (VKA) therapy during TAVI is equally safe and effective.  Methods: Consecutive patients on OAC with either NOAC or VKA undergoing transfemoral TAVI at five European centres were enrolled...
November 28, 2022: EuroIntervention
Nicolina Conti, Enrico Ammirati, Andrea Tedeschi, Dobromir Dobrev
No abstract text is available yet for this article.
December 2022: IJC Heart & Vasculature
Sulafa Ali, Mohamed Eamin A M E Medani
Pediatric cardiology (PC) is a rapidly advancing specialty addressing a large population of children as well as adults with congenital heart disease. It requires huge technical and financial resources; therefore, establishing, maintaining, and developing such services in limited resource settings are challenging. A PC program that includes clinical aspects, echocardiography, diagnostic and interventional cardiac catheterization and cardiac surgery, and rheumatic heart disease control was established in Sudan in 2004...
2022: Frontiers in Pediatrics
Thiago A Laranjeira, Antonio S Menezes
Post-coronavirus disease (COVID) syndrome involves the presentation of various new, returning, or ongoing symptoms, more than four weeks after COVID-19 infection. Post-infectious myocarditis is a potential sequela, associated with greater arrhythmogenic potential. Thus, it is an outcome that should be considered in athletes. An undiagnosed heart condition associated with adrenergic stimulus caused by high-intensity exercises can lead to sudden cardiac death. Electrocardiography (ECG) plays a role in cardiac screening for potential cardiac changes associated with myocarditis...
November 2022: Curēus
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