Vincent Brandenburg, Johann Bauersachs, Michael Böhm, Danilo Fliser, Stefan Frantz, Norbert Frey, Gerd Hasenfuß, Jan T Kielstein
For heart failure patients with reduced ejection fraction, optimised medication improves symptom control and reduces mortality. Substances influencing the renin-angiotensin-aldosteron-system, so-called RAAS-inhibitors, are the cornerstone of heart failure treatment. This article summarises a consensus between experts in cardiology and in nephrology on a pragmatic approach to manage a drop in glomerular filtration rate and incident hyperkalaemia - the two most common reasons for reducing or discontinuing heart failure medication...
January 22, 2021: Deutsche Medizinische Wochenschrift
Luke G Eckersley, Simon Urschel
No abstract text is available yet for this article.
January 19, 2021: Canadian Journal of Cardiology
Roxana Marino, Natalia Perez Garrido, Pablo Ramirez, Guillermo Notaristéfano, Angélica Moresco, Maria Sol Touzon, Elisa Vaiani, Gabriela Finkielstain, María Gabriela Obregón, Viviana Balbi, Ianina Soria, Alicia Belgorosky
CONTEXT: The syndrome CAH-X is due to a contiguous gene deletion of CYP21A2 and TNXB resulting in TNXA/TNXB chimeras. OBJECTIVE: To analyze TNXB gene status and to clinically evaluate the Ehlers-Danlos syndrome phenotype in a large cohort of Argentine congenital adrenal hyperplasia (CAH) patients to assess the prevalence of this condition in our population. DESIGN, SETTINGS, PARTICIPANTS, INTERVENTION: TNXB-gene analysis was performed in 66 non-related CAH patients that were carriers of the CYP21A2 gene deletion...
January 22, 2021: Journal of Clinical Endocrinology and Metabolism
Lua Jafari, Nausheen Akhter
PURPOSE: Cardiotoxicity from anti-human epidermal growth factor receptor 2 (HER2) therapy carries a short- and long-term risk of incident heart failure and increased cardiovascular mortality in patients with breast cancer. Interruptions in anti-HER2 therapy due to cardiotoxicity can lead to suboptimal cancer treatment. The purpose of this narrative review is to outline opportunities to optimize cardiovascular care in patients with HER2-positive breast cancer to prevent interruptions in therapy...
January 22, 2021: Breast Cancer Research and Treatment
Selina Hein, Jennifer Furkel, Maximilian Knoll, Fabian Aus dem Siepen, Stefan Schönland, Ute Hegenbart, Hugo A Katus, Arnt V Kristen, Mathias H Konstandin
OBJECTIVES: Direct toxic effects of transthyretin amyloid in patient plasma upon cardiomyocytes are discussed. However, no data regarding the relevance of this putative effect for clinical outcome are available. In this monocentric prospective study, we analyzed cellular hypertrophy after phenylephrine stimulation in vitro in the presence of patient plasma and correlated the cellular growth response with phenotype and prognosis. METHODS AND RESULTS: Progress in automated microscopy and image analysis allows high-throughput analysis of cell morphology...
January 22, 2021: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Leonardo A Sechi, Gianluca Colussi, Luca Bulfone, Gabriele Brosolo, Andrea Da Porto, Maddalena Peghin, Vincenzo Patruno, Carlo Tascini, Cristiana Catena
BACKGROUND: COVID-19 has caused considerable morbidity and mortality worldwide and cardiac involvement has been reported during infection. The short-term cardiac outcome in survivors of COVID-19 is not known. OBJECTIVE: To examine the heart of patients who survived COVID-19 and to compare the cardiac outcome between patients who recovered from mild-to-moderate or severe illness. METHODS: With use of ECG and echocardiography, we examined the heart of 105 patients who had been hospitalized with COVID-19 and were consecutively recruited after hospital discharge while attending follow-up visits...
January 22, 2021: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Richard U Garcia, Kathleen L Meert, Raya Safa, Sanjeev Aggarwal
The inferior vena cava collapsibility index (IVCCI) is an ultrasound method used to assess central venous pressure (CVP). Our objective was to evaluate the correlation between IVCCI and CVP in children during the early period following surgery for congenital heart disease (CHD). Prospective study performed in a single tertiary care center. Patients  ≤ 18 years old, who underwent cardiopulmonary bypass surgery for CHD, were enrolled. Ultrasound images of the inferior vena cava (IVC) were obtained at two time points; the first was within 2 h of arrival to the CICU and the second was 12-18 h from the first measurement...
January 22, 2021: Pediatric Cardiology
Zareen M Farukhi, Samia Mora
No abstract text is available yet for this article.
January 22, 2021: European Heart Journal
Dimitrios A Vrachatis, Georgios V Giannopoulos, Spyridon G Deftereos
No abstract text is available yet for this article.
January 22, 2021: European Heart Journal
Patricia Jepma, Marjolein Snaterse, Simone Du Puy, Ron J G Peters, Wilma J M Scholte Op Reimer
BACKGROUND: lifestyle-related secondary prevention reduces cardiac events and is recommended irrespective of age. However, motivation may be influenced by age and disease progression. OBJECTIVE: to explore older cardiac patients' perspectives toward lifestyle-related secondary prevention after a hospital admission. METHODS: a generic qualitative design was used. Semi-structured interviews were performed with cardiac patients ≥ 70 years within 3 months after a hospital admission...
January 22, 2021: Age and Ageing
Raquel López-Vilella, Elena Marqués-Sulé, Ignacio Sánchez-Lázaro, Rocío Laymito Quispe, Luis Martínez Dolz, Luis Almenar Bonet
BACKGROUND: Heart failure (HF) is a clinical syndrome that causes high morbidity and mortality with a high number of admissions and sometimes prolonged admissions. This study aimed at assessing whether parameters detected during the first 24 h of admission may predict a prolonged hospital stay in patients admitted to hospital for decompensated HF. METHODS: From January 2016 to December 2019, 2359 admissions of decompensated HF were recorded. In-hospital transfers, de novo HF, deaths and scheduled admissions were discarded to homogenise the sample...
January 22, 2021: Acta Cardiologica
Rishabh Khurana, Vineeta Ojha, Sreenivasa Raju, Sanjeev Kumar
No abstract text is available yet for this article.
January 22, 2021: Acta Cardiologica
Sumaya Yacoob, Stéphanie Marlière, Raphaëlle-Ashley Guerbaai, Pierre-Vladimir Ennezat
No abstract text is available yet for this article.
January 22, 2021: Acta Cardiologica
Jong Weon Lee, Hunsun Lim, Jong Hun Kim, Hyoung Seop Kim
BACKGROUND AND PURPOSE: The American College of Cardiology and the American Heart Association (ACC-AHA) have released new guidelines and expanded indications for statin treatment. We aimed to reveal the clinical efficacy of each indication in the guidelines using a large-scale national cohort. METHODS: We used National Health Screening Cohort data to determine the proportions of participants for whom statin therapy would be recommended using the different guidelines...
January 2021: Journal of Clinical Neurology
Ihsen Zairi, Khadija Mzoughi, Imtinen Ben Mrad, Emna Allouch, Sofien Kamoun, Fethia Ben Moussa, Sondos Kraiem
BACKGROUND: Simulation allows learning in action, reflection and feedback. All these factors suggest the positive contribution of the simulation to the development of clinical reasoning. The main assessment tool for standardized testing of this skill is the script matching test. AIM: To assess the impact of teaching through high-fidelity clinical simulation on the clinical reasoning of third-year medical students, while assessing their teaching practices, satisfaction and confidence in the learning they received during this session...
June 2020: La Tunisie Médicale
David R Okada, Hugh Calkins
No abstract text is available yet for this article.
January 20, 2021: European Heart Journal
Sumita Mishra, David A Kass
No abstract text is available yet for this article.
January 21, 2021: Nature Reviews. Cardiology
Heather M Siefkes, Satyan Lakshminrusimha
In persistent pulmonary hypertension of the newborn (PPHN), the ratio of pulmonary vascular resistance to systemic vascular resistance is increased. Extrapulmonary shunts (patent ductus arteriosus and patent foramen value) allow for right-to-left shunting and hypoxaemia. Systemic hypotension can occur in newborns with PPHN due to variety of reasons, such as enhanced peripheral vasodilation, impaired left ventricular function and decreased preload. Systemic hypotension can lead to end organ injury from poor perfusion and hypoxaemia in the newborn with PPHN...
January 21, 2021: Archives of Disease in Childhood. Fetal and Neonatal Edition
Mattia Lunardi, Charlie Gao, Hironori Hara, Masafumi Ono, Hideyuki Kawashima, Rutao Wang, William Wijns, Patrick W Serruys, Yoshinobu Onuma
No abstract text is available yet for this article.
January 22, 2021: EuroIntervention
Frédéric Sacher, Estelle Gandjbakhch, Philippe Maury, Catherine Jenny, Jonathan Khalifa, Serge Boveda, Pascal Defaye, Daniel Gras, Didier Klug, Gabriel Laurent, Nicolas Lellouche, Jacques Mansourati, Eloi Marijon, Olivier Piot, Jerome Taieb, Hubert Cochet, Philippe Maingon, Etienne Pruvot, Laurent Fauchier
Ventricular tachycardia has a significant recurrence rate after ablation for several reasons, including inaccessible substrate. A non-invasive technique to ablate any defined areas of myocardium involved in arrhythmogenesis would be a potentially important therapeutic improvement if shown to be safe and effective. Early feasibility studies of single-fraction stereotactic body radiotherapy have demonstrated encouraging results, but rigorous evaluation and follow-up are required. In this document, the basic concepts of stereotactic body radiotherapy are summarized, before focusing on stereotactic arrhythmia radioablation...
January 18, 2021: Archives of Cardiovascular Diseases
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