O Zahdi, Y Tijani, M Hormat-Allah, H El Bhali, S El Khloufi, Y Sefiani, A El Mesnaoui, B Lekehal
Arterial involvement in Behçet's disease is rare, the aortic localization is one of the most severe manifestations of the disease. We present an exceptional case of Behçet's disease revealed by two infrarenal abdominal aorta aneurysms, associated to a femoral artery pseudoaneurysm. The management of aneurysms in Behçet's disease is delicate, and requires the combination of surgical treatment with adjuvant medical drug therapy in order to reduce complications risk.
February 23, 2021: Annales de Cardiologie et D'angéiologie
A Belhassen, S Toujani, A El Ouni, Z Meddeb, C Abdelkefi, T Larbi, S Hamzaoui, K Bouslama
AIM OF THE STUDY: Our study aimed to identify the characteristics of cardiac involvement in eosinophilic granulomatosis with polyangiitis (EGPA). METHODS: We conducted a retrospective analytic study including EGPA cases diagnosed between 2000 and 2019 in an internal medicine department. Diagnosis was made according to the 1990 American College of Rheumatology criteria and the 2012 Chapel Hill Concensus. RESULTS: Eleven EGPA cases were included, 64% of patients were female...
February 23, 2021: Annales de Cardiologie et D'angéiologie
S Delma, G Coulibaly, H Y A Lengani, N Rouamba, Y J Bonzi
AIM: The aim of our study was to determine the prevalence and factors associated with intradialytic hypotension in our cohort of chronic hemodialysis patients. METHODS: This was a prospective monocentric study over a six-month period. Intradialytic hypotension was defined as a decrease in systolic blood pressure ≥ 20mmHg or a decrease in mean arterial pressure of 10mmHg associated with clinical events and the need for nursing interventions. The groups were compared using univariate analysis of variance...
February 23, 2021: Annales de Cardiologie et D'angéiologie
J Rhissassi, H Bouhdadi, H Wazaren, W El Aamadi, M Bouchikh, M Laaroussi
BACKGROUND: Cardiac hydatid cyst is a rare parasitic disease. Since it may be associated with fatal complications, early diagnosis and treatment of a cardiac hydatid cyst is very important, however, it may stay asymptomatic for a long time, until they reveal themselves being perforated into cardiac chambers and/or pulmonary artery or systemic circulation. CASE PRESENTATION: We report a case of a young asymptomatic boy, who underwent a routine chest x ray in a pre employment check up in whom we discovered a multiple pulmonary lesions and a right ventricle hydatid cyst...
February 23, 2021: Annales de Cardiologie et D'angéiologie
B K Rauniyar, A Kadel, K Thakur, R B Adhikari, D Limbu, S Rajbhandari, S Kansakar, R Malla, C M Adhikari, A Maskey, R Rajbhandar
BACKGROUND: Even in developing countries like Nepal, prevalence of ST-elevation myocardial infarction has been shown to be increased with rise in prevalence of conventional risk factors like diabetes, Hypertension, smoking, dyslipidemia and obesity. Our aim is to retrospectively analyze for various risk factors and angiographic patterns of coronary artery disease in patients with ST-elevation myocardial infarction undergoing Primary Percutaneous Intervention. RESULTS: During the period of 1 year (January 2019 to December 2019), 816 patients presented to our ER with acute STEMI, among them 437 (53...
February 23, 2021: Annales de Cardiologie et D'angéiologie
H Foudad, S Latreche, A Quessar, S Benkhedda, A Benabdelaziz, S Tliba
INTRODUCTION: Type 2 diabetes is associated with an increased risk of coronary disease and is the leading cause of morbidity and mortality in this population. The main objective of our work is to study the correlation of diastolic function of the left ventricle with coronary disease in type 2 diabetics. MATERIAL AND METHODS: Analytical cross-sectional, monocentric prospective-looking study of 703 type 2 diabetic patients performed at the Military Regional Hospital of Constantine over a period of 04 years (2016-2019)...
February 23, 2021: Annales de Cardiologie et D'angéiologie
Kathryn E Foti, Dan Wang, Alexander R Chang, Elizabeth Selvin, Mark J Sarnak, Tara I Chang, Paul Muntner, Josef Coresh
The 2021 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease (CKD) recommends a target systolic blood pressure under 120 mmHg based on standardized office blood pressure measurement. Here, we examined the potential implications of this new guideline for blood pressure lowering with antihypertensive medication among adults in the United States with CKD compared to the 2012 KDIGO guideline (target blood pressure 130/80 mmHg or under with albuminuria or 140/90 mmHg or under without albuminuria) and the 2017 American College of Cardiology/American Heart Association (target blood pressure under 130/80 mmHg) guideline...
March 2021: Kidney International
Rajat Das Gupta, Maxwell Akonde, Ibrahim Hossain Sajal, Gulam Muhammed Al Kibria
BACKGROUND: Previous studies that investigated association of height with prevalence and control of hypertension found mixed results. This cross-sectional study explored these associations among US adults (≥20 years). METHODS: The National Health and Nutrition Examination Survey (NHANES) 2007-18 data was analyzed. Height was measured in meters and was converted into centimeters (cm) and was further divided into quartiles: Q1 (135.3-159.2 cm), Q2 (159.3-166...
February 26, 2021: Clinical Hypertension
Craig I Coleman, Olivia S Costa, Christopher W Brescia, Burcu Vardar, Khaled Abdelgawwad, Nitesh Sood
BACKGROUND: Diabetes increases a patient's risk of developing atrial fibrillation by 49%. Patients with nonvalvular atrial fibrillation are at a fivefold increased risk of stroke and die more frequently from vascular causes. We sought to evaluate the effectiveness and safety of rivaroxaban versus warfarin in nonvalvular atrial fibrillation patients with type 2 diabetes. METHODS: This was an analysis of Optum® De-Identified electronic health record data from 11/2010 to 12/2019...
February 26, 2021: Cardiovascular Diabetology
Roberto F E Pedretti, Marie-Christine Iliou, Carsten W Israel, Ana Abreu, Hielko Miljoen, Ugo Corrà, Christoph Stellbrink, Andreas B Gevaert, Dominic A Theuns, Massimo F Piepoli, Rona Reibis, Jean Paul Schmid, Matthias Wilhelm, Hein Heidbuchel, Heinz Völler
Cardiac rehabilitation (CR) is a multidisciplinary intervention including patient assessment and medical actions to promote stabilization, management of cardiovascular risk factors, vocational support, psychosocial management, physical activity counselling, and prescription of exercise training. Millions of people with cardiac implantable electronic devices live in Europe and their numbers are progressively increasing, therefore, large subsets of patients admitted in CR facilities have a cardiac implantable electronic device...
February 26, 2021: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
M F Nagoor Meeran, Sheikh Azimullah, Ernest Adeghate, Shreesh Ojha
BACKGROUND: Myocardial infarction (MI) is a lethal manifestation of cardiovascular diseases. Oxidative stress, inflammation, and subsequent cell death are known to play crucial roles in the pathogenesis of MI. Despite tremendous developments in interventional cardiology, there is need for novel drugs for the prevention and treatment of MI. For the development of novel drugs, usage of natural products has gained attention as a therapeutic approach for ischemic myocardial injury. Among many popular plant-derived compounds, Nootkatone (NKT), a natural bioactive sesquiterpene, abundantly found in grapefruit, has attracted attention for its plausible health benefits and pharmacological properties...
November 7, 2020: Phytomedicine
Jiangang Wang, Qing Ye, Shuyun Bai, Pengfei Chen, Yichen Zhao, Xiaolong Ma, Chen Bai, Yang Liu, Meng Xin, Caiwu Zeng, Quan Liu, Cheng Zhao, Yan Yao, Yue Ma
BACKGROUND: Reduction in L-type Ca2+ current (ICa,L ) density is a hallmark of the electrical remodeling in atrial fibrillation (AF). The expression of miR-155, whose predicted target gene is the α1c subunit of the calcium channel (CACNA1C), was upregulated in atrial cardiomyocytes (aCMs) from patients with paroxysmal AF.The study is to determine miR-155 could target the gene expression of ICa,L and contribute to electrical remodeling in AF. METHODS: The expression of miR-155 and CACNA1C was assessed in aCMs from patients with paroxysmal AF and healthy control...
February 23, 2021: Journal of Molecular and Cellular Cardiology
Srboljub M Mijailovich, Momcilo Prodanovic, Corrado Poggesi, Joseph D Powers, Jennifer Davis, Michael A Geeves, Michael Regnier
One of the complexities of understanding the pathology of familial forms of cardiac diseases is the level of mutation incorporation in sarcomeres. Computational models of the sarcomere that are spatially explicit offer an approach to study aspects of mutational incorporation into myofilaments that are more challenging to get experimentally. We studied two well characterized mutations of cardiac TnC, L48Q and I61Q, that decrease or increase the release rate of Ca2+ from cTnC, k-Ca , resulting in HCM and DCM respectively [1]...
February 23, 2021: Journal of Molecular and Cellular Cardiology
Madeleine R Miles, John Seo, Min Jiang, Zachary T Wilson, Janay Little, Jon Hao, Joshua Andrade, Beatrix Ueberheide, Gea-Ny Tseng
High-throughput experiments suggest that almost 20% of human proteins may be S-palmitoylatable, a post-translational modification (PTM) whereby fatty acyl chains, most commonly palmitoyl chain, are linked to cysteine thiol groups that impact on protein trafficking, distribution and function. In human, protein S-palmitoylation is mediated by a group of 23 palmitoylating 'Asp-His-His-Cys' domain-containing (DHHC) enzymes. There is no information on the scope of protein S-palmitoylation, or the pattern of DHHC enzyme expression, in the heart...
February 23, 2021: Journal of Molecular and Cellular Cardiology
Wayne B Batchelor, Abdulla A Damluji, Celina Yong, Mona Fiuzat, Scott D Barnett, David E Kandzari, Matthew W Sherwood, Kelly C Epps, Behnam N Tehrani, Dominic J Allocco, Ian T Meredith, JoAnn Lindenfeld, Christopher M O'Connor, Roxana Mehran
BACKGROUND: Minorities and women are underrepresented in cardiovascular research. Whether their higher enrollment can be predicted or influences research site performance is unclear. METHODS: We evaluated 104 sites that enrolled 4,184 patients in the U.S. Platinum Diversity (PD) and Promus Element Plus (PE Plus) studies (2012 to 2016). Research sites were ranked from lowest to highest minority and female enrollment, respectively. United States Census bureau division and core-based statistical area (CBSA) populations were determined for each site and the following study performance metrics compared across quartiles of minority and female enrollment, respectively: (1) study subject enrollment rate (SER), (2) time to first patient enrolled, (3) rate of follow-up visits not done, (4) rate of follow-up visits out of window, and (5) protocol deviation rate (PDR)...
February 23, 2021: American Heart Journal
Tabassum Z Insaf, Kristin M Sommerhalter, Treeva A Jaff, Sherry L Farr, Karrie F Downing, Ali N Zaidi, George K Lui, Alissa R Van Zutphen
BACKGROUND: Individuals with congenital heart defects (CHDs) are recommended to receive all inpatient cardiac and non-cardiac care at facilities that can offer specialized care. We describe geographic accessibility to such centers in New York State and determine several factors associated with receiving care there. METHODS: We used inpatient hospitalization data from the Statewide Planning and Research Cooperative System (SPARCS) in New York State 2008-2013. In the absence of specific adult CHD care center designations during our study period, we identified pediatric/adult and adult-only cardiac surgery centers through the Cardiac Surgery Reporting System to estimate age-based specialized care...
February 23, 2021: American Heart Journal
Kamiar Kersten Rueckert, Adrian Willersinn
INTRODUCTION: The electrocardiogram (ECG) is the key player in the diagnosis of an acute coronary syndrome. In the light of normal ECG findings, the diagnosis can be missed. The high-sensitive troponin is a necessary laboratory value for patients with uncommon symptoms. CASE PRESENTATION: A 53-year-old man without a history of coronary heart disease initially presented to his general practitioner with persistent hiccups for 3 weeks. In the emergency department, the patient complained of nausea and burping...
December 2020: Permanente Journal
Márcio Galindo Kiuchi, Kavitha Ganesan, John Keating, Revathy Carnagarin, Vance B Matthews, Lakshini Y Herat, Gerard Goh, Leon Adams, Markus P Schlaich
BACKGROUND: Cardiovascular and metabolic regulation is governed by neurohumoral signalling in relevant organs such as kidney, liver, pancreas, duodenum, adipose tissue, and skeletal muscle. Combined targeting of relevant neural outflows may provide a unique therapeutic opportunity for cardiometabolic disease. OBJECTIVES: We aimed to investigate the feasibility, safety, and performance of a novel device-based approach for multi-organ denervation in a swine model over 30 and 90 days of follow-up...
February 26, 2021: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Evangelos Giannitsis, Stefan Blankenberg, Robert H Christenson, Norbert Frey, Stephan von Haehling, Christian W Hamm, Kenji Inoue, Hugo A Katus, Chien-Chang Lee, James McCord, Martin Möckel, Jack Tan Wei Chieh, Marco Tubaro, Kai C Wollert, Kurt Huber
Multiple new recommendations have been introduced in the 2020 ESC guidelines for the management of acute coronary syndromes with a focus on diagnosis, prognosis, and management of patients presenting without persistent ST-segment elevation. Most recommendations are supported by high-quality scientific evidence. The guidelines provide solutions to overcome obstacles presumed to complicate a convenient interpretation of troponin results such as age-, or sex-specific cutoffs, and to give practical advice to overcome delays of laboratory reporting...
February 26, 2021: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
John Gierula, Maria F Paton, Klaus K Witte
Cardiovascular implantable electronic devices have revolutionized the management of heart failure with reduced ejection fraction. New device generations tend to be launched every few years, with incremental improvements in performance and safety and with an expectation that these will improve patient management and outcomes while remaining cost-effective. As a result, today's cardiac resynchronization therapy (CRT) and implantable cardioverter defibrillator devices are quite different from the pioneering but often bulky devices of the late 20th century...
February 26, 2021: Future Cardiology
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