keyword
https://read.qxmd.com/read/33837031/maternal-finger-prick-allogenic-blood-for-persistent-corneal-epithelial-defects
#1
Rathin Pujari, Rashmi Deshmukh, Chirag Sheth, Madhavan S Rajan
This is a case of a 17-year-old patient with aniridia-related keratopathy and persistent epithelial defect (PED) treated successfully using maternal finger-prick blood (FPB). Maternal allogenic FPB treatment was initiated to the patient who was non-compliant with the use of autologous FPB. The PED was successfully managed with maternal FPB treatment with rapid and complete closure of the epithelial defect. Additionally, there was immediate and sustained symptomatic improvement to pain and recovery of vision in the only seeing eye...
April 9, 2021: BMJ Case Reports
https://read.qxmd.com/read/33824239/abo-incompatible-transfusion-events-reported-in-written-judgments-and-in-the-korean-hemovigilance-system
#2
Sooin Choi, Jungwon Hyun, HongBi Yu, Duck Cho
Fatal ABO-incompatible (ABOi) transfusion is one of the most common causes of transfusion-related death, but its reporting has been limited in Korea. We comprehensively reviewed ABOi transfusion events in Korea by analyzing cases reported in literature, Korean hemovigilance system (KOHEVIS) annual reports, and written judgments. Written judgments were assessed using a written judgment management system or a comprehensive legal information system. We found nine cases of ABOi transfusion events in written judgments (from 1953 to 2019), 16 in the KOHEVIS (from 2008 to 2018), and nine in published reports (from 1978 to 2019)...
September 1, 2021: Annals of Laboratory Medicine
https://read.qxmd.com/read/33822854/transfusion-associated-circulatory-overload-and-transfusion-related-acute-lung-injury
#3
Tayler A van den Akker, Zachary M Grimes, Mark T Friedman
OBJECTIVES: To review the new current diagnostic criteria of transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI) from the literature while highlighting distinguishing features. We provide comprehensive understanding of the importance of hemovigilance and its role in appropriately identifying and reporting these potentially fatal transfusion reactions. METHODS: A review of the English language literature was performed to analyze TACO and TRALI while providing further understanding of the rationale behind the historical underrecognition and underreporting...
April 5, 2021: American Journal of Clinical Pathology
https://read.qxmd.com/read/33819144/algorithm-development-and-diagnostic-accuracy-testing-for-non-invasive-foetal-rhd-genotyping-an-indian-experience
#4
Disha Parchure, Manisha Madkaikar, Swati Kulkarni
BACKGROUND: The discovery of the cell-free foetal DNA (cffDNA) circulating in the maternal plasma enabled prediction of foetal RHD thus eliminating the risks associated with invasive procedures. Non-invasive foetal RHD genotyping has now become the standard approach in developed countries for management of alloimmunised women and is also used for targeted antenatal prophylaxis in non-alloimmunised women. MATERIALS AND METHODS: cffDNA was extracted from the plasma of 217 RhD negative pregnant women at a gestational age of 10-34 weeks...
March 31, 2021: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/33819139/would-a-national-antibody-register-contribute-to-improving-patient-outcomes
#5
REVIEW
Zachary Powell, Nan Jiang, Rajeshwori Shrestha, Denise E Jackson
Despite stringent testing protocols, there always remains a chance of a delayed haemolytic transfusion reaction (DHTR) occurring as a result of an undetected or unknown antibody. In this systemic review and meta-analysis, we aimed to investigate improvements to patient outcomes that could be achieved through the implementation of a national antibody registry. A series of searches through PubMed and SCOPUS identified a collection of articles with relevant information, restricted to full text, English language articles available through the RMIT Library service...
March 12, 2021: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/33814606/effects-of-modified-ultrafiltration-on-thromboelastographic-profile-after-pediatric-cardiac-surgery
#6
Umair Abbas, Rohit S Loomba, Cynthia Urbas, Yi Li, Chawki El-Zein
Modified ultrafiltration (MUF) is still used after pediatric cardiopulmonary bypass (CPB) in some pediatric cardiac surgery centers to decrease transfusion requirements. Other potential benefits of MUF include clearance of inflammatory markers and improvement in myocardial function. Our hypothesis is that MUF will hemoconcentrate coagulation factors and improve thromboelastography (TEG) parameters after pediatric CPB. Patients younger than 6 months were prospectively enrolled over a year. TEG was carried out before MUF, after MUF, and after protamine administration...
March 2021: Journal of Extra-corporeal Technology
https://read.qxmd.com/read/33813877/complications-and-management-of-eptifibatide-induced-thrombocytopenia
#7
Faisal Masood, Saad Hashmi, Adib Chaus, Anna Hertsberg, Eli D Ehrenpreis
BACKGROUND: Eptifibatide is used in acute coronary syndromes to reversibly block platelet aggregation by inhibiting the platelet glycoprotein IIb/IIIa receptor. A serious adverse effect of eptifibatide is a profound drop in platelet count, termed eptifibatide-induced thrombocytopenia (EIT). OBJECTIVE: To provide insight into the types of complications and management of EIT. METHODS: Cases of EIT submitted to the Food and Drug Administration adverse event reporting system were evaluated...
April 3, 2021: Annals of Pharmacotherapy
https://read.qxmd.com/read/33797069/examining-knowledge-translation-in-blood-donor-research-a-review-of-vasovagal-reaction-literature
#8
REVIEW
Amanda Thijsen, Barbara Masser, Tanya E Davison, Sarah P Kruse, Anna Williamson
BACKGROUND: Knowledge translation focuses on the transfer of research findings into policy and practice. To provide insight into the state of knowledge translation in blood donor research, we undertook a rapid review of a key research area in the field with high potential for translation, vasovagal reactions (VVRs). We examined the number and nature of VVR-related studies to determine the availability of research evidence, and mapped the included articles along the research-to-practice trajectory using the Knowledge to Action framework...
April 2, 2021: Transfusion
https://read.qxmd.com/read/33792218/red-cell-transfusion-and-alloimmunization-in-sickle-cell-disease
#9
Grace E Linder, Stella T Chou
Red cell transfusion remains a critical component of care for acute and chronic complications of sickle cell disease. Randomized clinical trials demonstrated the benefits of transfusion therapy for prevention of primary and secondary strokes and postoperative acute chest syndrome. Transfusion for splenic sequestration, acute chest syndrome, and acute stroke are guided by expert consensus recommendations. Despite overall improvements in blood inventory safety, adverse effects of transfusion are prevalent among patients with sickle cell disease and include alloimmunization, acute and delayed hemolytic transfusion reactions, and iron overload...
April 1, 2021: Haematologica
https://read.qxmd.com/read/33792171/association-of-veterinary-hematology-and-transfusion-medicine-avhtm-transfusion-reaction-small-animal-consensus-statement-tracs-part-1-definitions-and-clinical-signs
#10
Elizabeth B Davidow, Shauna L Blois, Isabelle Goy-Thollot, Lauren Harris, Karen Humm, Sarah Musulin, Katherine J Nash, Adesola Odunayo, Claire R Sharp, Eva Spada, John Thomason, Jenny Walton, K Jane Wardrop
OBJECTIVE: To use a systematic, evidence-based consensus process to develop definitions for transfusion reactions in dogs and cats. DESIGN: Evidence evaluation of the literature was carried out for identified transfusion reaction types in dogs and cats. Reaction definitions were generated based on synthesis of human and veterinary literature. Consensus on the definitions was achieved through Delphi-style surveys. Draft recommendations were made available through industry specialty listservs and comments were incorporated...
March 2021: Journal of Veterinary Emergency and Critical Care
https://read.qxmd.com/read/33790897/the-future-of-blood-testing-is-the-immunome
#11
Ramy A Arnaout, Eline T Luning Prak, Nicholas Schwab, Florian Rubelt
It is increasingly clear that an extraordinarily diverse range of clinically important conditions-including infections, vaccinations, autoimmune diseases, transplants, transfusion reactions, aging, and cancers-leave telltale signatures in the millions of V(D)J-rearranged antibody and T cell receptor [TR per the Human Genome Organization (HUGO) nomenclature but more commonly known as TCR] genes collectively expressed by a person's B cells (antibodies) and T cells. We refer to these as the immunome . Because of its diversity and complexity, the immunome provides singular opportunities for advancing personalized medicine by serving as the substrate for a highly multiplexed, near-universal blood test...
2021: Frontiers in Immunology
https://read.qxmd.com/read/33790681/complement-in-sickle-cell-disease-are-we-ready-for-prime-time
#12
REVIEW
Christos Varelas, Athina Tampaki, Ioanna Sakellari, Αchilles Anagnostopoulos, Eleni Gavriilaki, Efthymia Vlachaki
Sickle cell disease (SCD) is a widely spread inherited hemoglobinopathy that includes a group of congenital hemolytic anemias, all characterized by the predominance of sickle hemoglobin (HbS). Its features are anemia, predisposal to bacterial infections and complications such as vaso-occlusive crisis (VOC) or delayed hemolytic transfusion reaction (DHTR), which lead to increased rate of morbidity and mortality even in the era of hydroxyurea. The interaction between sickle cells, neutrophils, platelets or endothelial cells in small vessels results in hemolysis and has been considered the disease's main pathophysiological mechanism...
2021: Journal of Blood Medicine
https://read.qxmd.com/read/33783986/nlrp3-inflammasome-of-renal-tubular-epithelial-cells-induces-kidney-injury-in-acute-hemolytic-transfusion-reactions
#13
Zhixin Liu, Yaozhen Chen, Bing Niu, Dandan Yin, Fan Feng, Shunli Gu, Qunxing An, Jinmei Xu, Ning An, Jing Zhang, Jing Yi, Wen Yin, Xiangyang Qin, Xingbin Hu
BACKGROUND: Blood transfusion, a common basic supporting therapy, can lead to acute hemolytic transfusion reaction (AHTR). AHTR poses a great risk to patients through kidney function damage in a short time. Previous reports found that heme from destroyed red blood cells impaired kidney function, and NLR family pyrin domain containing 3 (NLRP3) inflammasome was augmented in case of kidney injury. However, the detailed mechanism regarding whether NLRP3 inflammasome is involved in kidney function injury in AHTR is not fully understood yet...
March 2021: Clinical and Translational Medicine
https://read.qxmd.com/read/33775585/prevalence-of-thrombophilia-associated-genetic-risk-factors-in-blood-donors-of-a-regional-hospital-in-southern-brazil
#14
Jéssica Dick-Guareschi, Juliana Cristine Fontana, Maria Teresa Vieira Sanseverino, Francyne Kubaski, Leo Sekine, Nanci Félix Mesquita, Tor Gunnar Hugo Onsten, Sandra Leistner-Segal
INTRODUCTION: Thromboembolic events occur due to an imbalance in the hemostasis and some factors associated with this condition can be inherited. In order to evaluate the frequency of genotypes considered to be common hereditary risk factors for thrombophilia associated with venous thrombosis (g.1691G > A and g.20210G > A) and hyperhomocysteinemia (g.677C > T and g.1298A > C), samples from voluntary healthy blood donors at the Hospital de Clínicas de Porto Alegre were tested...
March 16, 2021: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/33773956/frequency-of-antigen-di-a-on-the-blood-donor-population-of-the-hemocenter-coordinator-of-the-hemopa-foundation
#15
Adna Dos Santos Caldas, Bruno Costa Dos Santos, Maurício Koury Palmeira, Fabiana Regina Ribeiro Carvalho, Carlos Eduardo de Melo Amaral
INTRODUCTION: Erythrocyte phenotyping is a very important test in the adoption of prophylactic measures to reduce transfusion reactions/alloimmunizations in polytransfused patients. The blood group Diego, in its current, form has 22 antigens, of which 4 are immunogenic, being Diª/Dib and Wra /Wrb , while the others are less expressive. The antigen Diª is of low incidence among whites and blacks, however, it is common in the South American indigenous and Asian Mongolian populations. It is also considered a system of clinical importance for its immunogenicity...
February 11, 2021: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/33772873/allogeneic-bone-marrow-derived-mesenchymal-stem-cell-safety-in-idiopathic-parkinson-s-disease
#16
Mya Schiess, Jessika Suescun, Marie-Francoise Doursout, Christopher Adams, Charles Green, Jerome G Saltarrelli, Sean Savitz, Timothy M Ellmore
BACKGROUND: Neuroinflammation plays a key role in PD pathogenesis, and allogeneic bone marrow-derived mesenchymal stem cells can be used as an immunomodulatory therapy. OBJECTIVE: The objective of this study was to prove the safety and tolerability of intravenous allogeneic bone marrow-derived mesenchymal stem cells in PD patients. METHODS: This was a 12-month single-center open-label dose-escalation phase 1 study of 20 subjects with mild/moderate PD assigned to a single intravenous infusion of 1 of 4 doses: 1, 3, 6, or 10 × 106 allogeneic bone marrow-derived mesenchymal stem cells/kg, evaluated 3, 12, 24, and 52 weeks postinfusion...
March 27, 2021: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/33772846/albumin-in-advanced-liver-diseases-the-good-and-bad-of-a-drug
#17
REVIEW
Rakesh Kumar Jagdish, Jaswinder Singh Maras, Shiv Kumar Sarin
Human serum albumin (HSA) is the most abundant plasma protein and it regulates diverse body functions. In advanced and decompensated cirrhosis patients, serum albumin levels are low due to reduction in hepatocyte mass and loss due to disease per se and multiple therapeutic interventions. Due to its oncotic and non-oncotic properties, administration of human albumin solutions (HAS) has been found to be beneficial in patients undergoing large volume paracentesis, hepatorenal syndrome and spontaneous bacterial peritonitis...
March 27, 2021: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/33769424/the-role-of-teg-and-rotem-in-damage-control-resuscitation
#18
Jason B Brill, Bryan A Cotton, Megan Brenner, Juan Duchesne, Paula Ferrada, Tal Horer, David Kauvar, Mansoor Khan, Derek Roberts, Carlos Ordonez, Bruno Perreira, Artai Priouzram, Andrew Kirkpatrick
Trauma induced coagulopathy is associated with very high mortality, and hemorrhage remains the leading preventable cause of death after injury. Directed methods to combat coagulopathy and attain hemostasis are needed. The available literature regarding viscoelastic testing, including thrombelastography (TEG) and rotational thromboelastometry (ROTEM), was reviewed to provide clinically relevant guidance for emergency resuscitation. These tests predict massive transfusion and developing coagulopathy earlier than conventional coagulation testing, within 15 minutes using rapid testing...
March 25, 2021: Shock
https://read.qxmd.com/read/33767551/adding-further-evidence-for-clinically-significant-anti-le-b-antibody-in-a-voluntary-blood-donor
#19
Gita Negi, Sheetal Malhotra, Sushant Kumar Meinia, Daljit Kaur, Divya Rai
Herein, we report a case of naturally occurring anti-Leb alloantibody identified in the plasma of a first time voluntary blood donor. The immunohematology workup was done on the pilot sample tubes collected during blood donation by the conventional tube technique and using ID-Micro Column System Glass Beads card (anti-IgG, C3 d; Ortho-Clinical Diagnostics, Raritan, New Jersey, USA). Blood group of the donor was confirmed to be B RhD positive, and the alloantibody in his plasma was identified as anti-Leb , having clinically significant characteristics...
July 2020: Asian Journal of Transfusion Science
https://read.qxmd.com/read/33767548/severe-drug-induced-immune-hemolysis-due-to-ceftriaxone
#20
Ravi C Dara, Rakesh Sharma, Himanshu Bhardwaj
Drug-induced immune hemolytic anemia (DIIHA) is a rare condition that results primarily due to drug-induced antibodies, either drug dependent or drug independent. For its diagnosis, specialized immunohematology laboratory is often required for performing complex serological tests. The exact incidence of DIIHA is not known, but as per data published by Garratty, the incidence of DIIHA is estimated to be one in million population.[1] There are many drugs which are implicated in causing DIIHA ranging from antimicrobials, antineoplastics to anti-inflammatory drugs...
July 2020: Asian Journal of Transfusion Science
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