keyword
https://read.qxmd.com/read/33592169/prevalence-and-distribution-of-major-%C3%AE-thalassemia-mutations-and-hbe-%C3%AE-thalassemia-variant-in-nepalese-ethnic-groups
#21
Raju Lama, Wardah Binti Yusof, Tilak R Shrestha, Sarifah Hanafi, Matrika Bhattarai, Rosline Hassan, Bin Alwi Zilfalil
BACKGROUND: Beta-thalassemia is a genetic disorder that is inherited in an autosomal recessive pattern. This genetic disease leads to a defective beta-globin hemoglobin chain causing partial or complete beta-globin chain synthesis loss. Beta-thalassemia major patients need a continuous blood transfusion and iron chelation to maintain the normal homeostasis of red blood cells (RBCs) and other systems in the body. Patients also require treatment procedures that are costly and tedious, resulting in a serious health burden for developing nations such as Nepal...
February 11, 2021: Hematology/oncology and Stem Cell Therapy
https://read.qxmd.com/read/33590501/covid-19-antibody-screening-with-sars-cov-2-red-cell-kodecytes-using-routine-serologic-diagnostic-platforms
#22
Radhika Nagappan, Willy A Flegel, Kshitij Srivastava, Eleanor C Williams, Ivan Ryzhov, Alexander Tuzikov, Oxana Galanina, Nadezhda Shilova, Gennady Sukhikh, Holly Perry, Nicolai V Bovin, Stephen M Henry
BACKGROUND: The COVID-19 pandemic is having a major global impact, and the resultant response in the development of new diagnostics is unprecedented. The detection of antibodies against SARS-CoV-2 has a role in managing the pandemic. We evaluated the feasibility of using SARS-CoV-2 peptide Kode Technology modified red cells (C19-kodecytes) to develop an assay compatible with existing routine serologic platforms. STUDY DESIGN AND METHODS: A panel of eight unique red cells modified using Kode Technology function-spacer-lipid constructs and bearing short SARS-CoV-2 peptides was developed (C19-kodecyte assay)...
February 15, 2021: Transfusion
https://read.qxmd.com/read/33589878/transfusion-reaction-to-hyperimmune-plasma-in-patients-with-severe-covid-19-infection
#23
Paloma Eugenia Edroso Jarne, Herminia Lozano Gómez, Paula Abansés Moreno
No abstract text is available yet for this article.
February 11, 2021: Medicina clínica
https://read.qxmd.com/read/33587767/donor-tolerability-of-convalescent-plasma-donation
#24
Rui He, Hui Lin, Songli Xie, Qilu Lv, Yujie Kong, Ling Li, Haixia Xu, Jue Wang, Wenjuan Li, Peng Fang, Yanyun Wu, Zhong Liu
BACKGROUND: Since early 2020, convalescent plasma has been widely used for treating coronavirus disease 2019 (COVID-19). There is limited information regarding donor tolerability of convalescent plasma donation. In this study, we evaluated the short-term donor tolerability of convalescent plasma donation. METHODS: A prospective study of 309 convalescent plasma donation related adverse events were conducted at Wuhan Blood Center of China, from February 12 to April 1, 2020...
February 15, 2021: Journal of Clinical Apheresis
https://read.qxmd.com/read/33585799/safety-and-efficacy-of-convalescent-plasma-in-elderly-covid-19-patients-the-rescue-trial
#25
Massimo Franchini, Claudia Glingani, Mario Morandi, Giovanni Corghi, Sara Cerzosimo, Gloria Beduzzi, Andrea Storti, Vincenza Di Stasi, Giulia Rastrelli, Linda Vignozzi, Carlo Mengoli, Martina Garuti, Massimiliano Beccaria, Francesco Inglese, Beatrice Caruso, Roberto Antonio Petilino, Massimo Amato, Michele Nicchio, Mauro Pagani, Angela Bellani, Gianpaolo Castelli, Salvatore Casari, Giuseppe De Donno
Objective: To assess the safety and efficacy of convalescent plasma (CP) transfusion in elderly people with moderate to severe COVID-19 living in a long-term care facility (LTCF). Patients and Methods: Twenty-two consecutive elderly COVID-19 patients living in a LTCF in Lombardy (Italy) who were given CP during the period May 15-July 31, 2020 were enrolled in a prospective cohort study. Their clinical, instrumental and laboratory parameters were assessed following the CP treatment...
February 8, 2021: Mayo Clinic Proceedings. Innovations, Quality & Outcomes
https://read.qxmd.com/read/33581999/recurrent-hyperhemolytic-transfusion-reaction-in-myelodysplastic-syndrome-a-case-based-approach
#26
Merline Augustine, Mohandoss Murugesan, Chandran K Nair, Vineetha Raghavan, Sangeetha K Nayanar
We present here a case report of a 27 year old female, with myelodysplatic syndrome suspected to have recurrent hyperhemolytic transfusion reactions (HHTR). Patient was transfusion dependent for ten years and was transfused with leukodepleted and irradiated Packed Red Blood Cells (PRBC). She presented with signs and symptoms of acute intravascular hemolysis, deranged coagulation profile with post transfusion Hb lower than baseline. Post transfusion workup was uneventful. She was managed conservatively with fluid support and methylprednisolone initially...
February 4, 2021: Transfusion and Apheresis Science
https://read.qxmd.com/read/33581714/evaluation-of-sars-cov-2-antigen-based-rapid-diagnostic-kits-in-pakistan-formulation-of-covid-19-national-testing-strategy
#27
Umar Saeed, Sara Rizwan Uppal, Zahra Zahid Piracha, Azhar Rasheed, Zubair Aftab, Hafsah Zaheer, Rizwan Uppal
Rapid diagnosis of SARS-CoV-2 during pandemic enables timely treatment and prevention of COVID-19. Evaluating the accuracy and reliability of rapid diagnostic testing kits is crucial for surveillance and diagnosis of SARS-CoV-2 infections in general population, injection drug users, multi-transfused populations, healthcare workers, prisoners, barbers and other high risk populations. The aim of this study was to evaluate performance and effectiveness of nasopharyngeal swab (NSP) and saliva based rapid antigen detection testing kits in comparison with USFDA approved triple target gold standard real-time polymerase chain reaction...
February 13, 2021: Virology Journal
https://read.qxmd.com/read/33581309/transfusion-associated-anxiety-recognised-and-overcome-in-an-adolescent-child
#28
John GnanaRaj, Esha Toora, Jyotis Pothen, Smrithi Sathish, Vikas Menon, Abhishekh Basavarajegowda
A 12-year-old boy presented to our palliative care cancer clinic with Ewing Sarcoma and anaemia in failure. Transfusion reactions were noted during several blood transfusions, which manifested as acute onset of breathlessness, mild chest pain, sweating, general discomfort, increased heart rate, respiratory rate, and blood pressure. All the possible causes of transfusion reaction were ruled out, other than transfusion-associated anxiety resembling a transfusion reaction. In this case, adequate reassurance, counselling about the blood transfusion, distraction techniques, and the visual technique of masking the blood bag with black polythene foil helped overcome the patient's anxiety during the blood transfusion, henceforth uneventful...
February 10, 2021: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://read.qxmd.com/read/33580978/immune-thrombocytopenia-induced-by-beta-lactam-antibiotics-cross-reactions-of-responsible-antibodies-with-other-beta-lactam-drugs
#29
Matthew Slaught, Mark Rasmussen, Daniel Bougie, Richard Aster
BACKGROUND: Beta-lactam antibiotics are a relatively common cause of immune thrombocytopenia. Because the many beta-lactam drugs now in clinical use have structural similarities, when a patient experiences this complication the question of whether an alternative member of this drug family can safely be used often arises but there are little data available to guide this decision. STUDY DESIGN AND METHODS: Drug-dependent, platelet-reactive antibodies from 32 patients who experienced thrombocytopenia while being treated with a beta-lactam drug of the penam (piperacillin, etc...
February 13, 2021: Transfusion
https://read.qxmd.com/read/33572864/canine-blood-group-prevalence-and-geographical-distribution-around-the-world-an-updated-systematic-review
#30
REVIEW
Sara Mangiaterra, Giacomo Rossi, Maria Teresa Antognoni, Matteo Cerquetella, Andrea Marchegiani, Arianna Miglio, Alessandra Gavazza
In recent years, blood transfusions have been more commonly given to pets. The importance of determining blood groups in dogs and cats is, therefore, well-known for reducing the risk of adverse reactions in the recipient blood caused by a "non-compatible" donor. This systematic review summarizes data from previously published reports and follows the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for systematic reviews. After applying the inclusion and exclusion criteria, we identified 41 eligible studies using different states and blood-typing methods to determine blood groups in dogs...
January 29, 2021: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/33560046/educational-and-electronic-based-tools-to-mitigate-the-risk-of-transfusion-adverse-events
#31
Jennifer Ding, Rebecca Krey, Laura Malone, VeRonika Merrill, Mona Krouss, Jennifer O'Brien, Magali J Fontaine
The transfusion of blood products is a widely used practice but comes with the risk of transfusion-associated adverse events and fatalities. The primary aim of this study was to evaluate if strict adherence to transfusion guidelines would lead to a decrease in the rate of transfusion reactions that occurred when blood products were given outside of established indications. Hospital-wide educational programs and dedicated electronic transfusion order sets were used to encourage adherence to guidelines. A secondary aim of this study was to evaluate if a decrease in the incidence of transfusion reactions also lead to a decrease in associated healthcare costs...
February 3, 2021: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://read.qxmd.com/read/33559248/impact-of-serological-and-pcr-testing-requirements-on-the-selection-of-covid-19-convalescent-plasma-donors
#32
Jason A Carter, Alex T Freedenberg, Jamie L Romeiser, Lillian R Talbot, Nicholas J Browne, Megan E Cosgrove, Margaret E Shevik, Laura M Generale, Molly G Rago, Giuseppina A Caravella, Tahmeena Ahmed, Linda J Mamone, Elliott Bennett-Guerrero
BACKGROUND: Convalescent plasma is undergoing randomized trials as a potential therapeutic option for COVID-19 infection. Little empirical evidence exists regarding the determination of donor eligibility and experiences with donor selection. STUDY DESIGN AND METHODS: This prospective study was conducted at a tertiary care hospital in New York to select plasma donors for a randomized, double-blind, controlled convalescent plasma trial. Clearance for donation required successful completion of an online questionnaire and an in-person screening visit, which included (a) completion of a Donor Health Questionnaire (DHQ), (b) Immunoglobulin G (IgG) antibody testing using an immunochromatographic anti- severe acute respiratory coronavirus 2 (SARS-CoV-2) test, (c) Polymerase chain reaction (PCR) testing if <28 days from symptom resolution, and (d) routine blood bank testing...
February 8, 2021: Transfusion
https://read.qxmd.com/read/33544619/clinical-impacts-of-dna-based-typing-and-provision-of-antigen-matched-red-blood-cell-units-for-chronically-transfused-patients-with-thalassemia
#33
Phandee Watanaboonyongcharoen, Sunisa Onspun, Ponlapat Rojnuckarin
Blood transfusion, the main therapy for patients with severe thalassemia, is challenged by alloantibodies that can lead to hemolytic transfusion reactions. The use of prophylactic antigen-matched units is recommended, but serologic typing, before the first transfusion, is rarely performed and is not reliable after chronic transfusion. Patient DNA-based typing is a promising strategy, but clinical outcome data are lacking. The aim of this study was to determine the benefits of antigenmatched transfusion guided by DNA-based typing in terms of new alloantibody formation and increases in mean pretransfusion hemoglobin (Hb) levels...
December 2020: Immunohematology
https://read.qxmd.com/read/33544617/a-resource-conserving-serologic-and-highthroughput-molecular-approach-to-screen-for-blood-donors-with-an-in-5-phenotype
#34
Sanmukh R Joshi, Snehal B Senjaliya, Kshitij Srivastava, Willy A Flegel
The Indian blood group system (ISBT 023) comprises one lowprevalence antigen, Ina (IN:1), and five high-prevalence antigens: Inb (IN:2), INFI (IN:3), INJA (IN:4), INRA (IN:5), and INSL (IN:6). The antigens are located on the single-pass trans-membrane glycoprotein encoded by the CD44 gene. The present study was designed to identify the prevalence of the INRA- (IN:-5) phenotype and the frequency of its associated allele (IN*02.- 05) to inform us of the probability of finding antigen-negative donors and to assess the risk of antibody formation in transfusion recipients...
December 2020: Immunohematology
https://read.qxmd.com/read/33540100/adverse-effects-of-perioperative-blood-transfusion-in-spine-surgery
#35
REVIEW
James J Zhou, Courtney Hemphill, Corey T Walker, S Harrison Farber, Juan S Uribe
BACKGROUND: Perioperative blood transfusion is often necessary during spine surgery because of blood loss from the surgical field during and after surgery. However, blood transfusions are associated with a small but significant risk of causing several adverse events, including hemolytic transfusion reactions and transfusion-associated circulatory overload. Moreover, many prior publications have noted increased rates of perioperative morbidity and worsened outcomes in spine surgery patients who received blood transfusions...
February 1, 2021: World Neurosurgery
https://read.qxmd.com/read/33539286/relationship-between-allergic-sensitisation-associated-single-nucleotide-polymorphisms-and-allergic-transfusion-reactions-and-febrile-non-haemolytic-transfusion-reactions-in-paediatric-cases
#36
Yuichiro Ide, Ryu Yanagisawa, Jun Kobayashi, Kazutoshi Komori, Kazuyuki Matsuda, Yuji Amano, Yozo Nakazawa, Toshikazu Takeshita, Kazuo Sakashita, Minoru Tozuka
BACKGROUND: Allergic transfusion reactions (ATR) and febrile non-haemolytic transfusion reactions (FNHTR) are common transfusion-related adverse reactions; however, their pathogenesis remains unclear and it is difficult to predict their occurrence. Single-nucleotide polymorphisms (SNP) are related to the onset of various diseases and therapy-related adverse events; therefore, identification of SNP related to transfusion-related adverse reactions may help to elucidate the underlying mechanism and predict the onset of these reactions...
February 3, 2021: Blood Transfusion
https://read.qxmd.com/read/33539285/periodontitis-increases-risk-of-viable-bacteria-in-freshly-drawn-blood-donations
#37
Christian Damgaard, Susanne G Sækmose, Martin Nilsson, Mogens Kilian, Claus H Nielsen, Palle Holmstrup
BACKGROUND: The aim of the study was to determine if periodontitis, which often causes transient bacteraemia, associates with viable bacteria in standard blood donations. MATERIALS AND METHODS: This was a cross-sectional study of 60 self-reported medically healthy blood donors aged over 50 years. According to standard procedures, whole blood was separated by fractionation into plasma, buffy-coat, and red blood cell (RBC)-fractions. The buffy-coat was screened for bacterial contamination using BacT/ALERT...
February 2, 2021: Blood Transfusion
https://read.qxmd.com/read/33534188/trends-in-erythropoiesis-stimulating-agent-use-and-blood-transfusions-for-chemotherapy-induced-anemia-throughout-fda-s-risk-evaluation-and-mitigation-strategy-lifecycle
#38
Amarilys Vega, Rongmei Zhang, Hui-Lee Wong, Michael Wernecke, Michael Alexander, Yuhui Feng, An-Chi Lo, Bradley Lufkin, Qin Ryan, Rima Izem, Thomas E MaCurdy, Jeffrey A Kelman, David J Graham
PURPOSE: Erythropoiesis-stimulating agent (ESA), indicated for treating some patients with chemotherapy-induced anemia (CIA), may increase risk of tumor progression and mortality.1-3 FDA required a Risk Evaluation and Mitigation Strategy (REMS) to mitigate these risks. We assessed REMS impact on ESA administration and red blood cell (RBC) transfusion as surrogate metrics for REMS effectiveness. METHODS: Retrospective cohort study including data from January 1, 2006 to December 31, 2018 for beneficiaries ≥65 years enrolled in Centers for Medicare & Medicaid Services (CMS) Medicare Parts A/B with a cancer diagnosis; patients with other indications for ESA use were excluded...
February 3, 2021: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/33530875/celsior-%C3%A2-crystalloid-cardioplegia-versus-standard-hyperkalemic-normothermic-blood-cardioplegia-analysis-of-myocardial-protection-in-elective-mitral-valve-repair
#39
Margaux Pontailler, Charles-Henri David, Philippe Lacoste, Guillaume Guimbretière, Basile Marie, Christian Perigaud, Antoine Mugniot, Imen Fellah, Jean-Christian Roussel, Thomas Senage
INTRODUCTION: With the increase and refinement of video assisted mitral valve surgery, cristalloïd cardioplegia started regaining popularity. The aim of our study was to evaluate the effectiveness of Celsior® , a crystalloid cardioplegic solution, on myocardial protection in elective surgical mitral valve repair in comparison to blood based hyperkalemic cardioplegia. METHODS: In this observational retrospective study, all consecutive elective isolated surgical mitral valve repair where Celsior® or normothermic hyperkalemic blood cardioplegia were used were included...
February 2, 2021: Perfusion
https://read.qxmd.com/read/33529383/transfusion-associated-circulatory-overload-and-high-blood-pressure-a-multicentre-retrospective-study-in-japan
#40
Asashi Tanaka, Akihiko Yokohama, Shin-Ichiro Fujiwara, Yasuhiko Fujii, Makoto Kaneko, Yasunori Ueda, Takashi Abe, Yoko Kato, Yuichi Hasegawa, Kazuhiko Ikeda, Keizo Fujino, Mayumi Matsumoto, Shigeyoshi Makino, Shuichi Kino, Akihiro Takeshita, Kazuo Muroi
BACKGROUND: Transfusion-associated circulatory overload (TACO) is an adverse reaction associated with a high risk of mortality. The actual incidence of TACO and hypertension associated with transfusion in Japan is unknown. METHODS: A multicentre retrospective observational study was conducted across 23 institutions during the 1-year period of 2016. Patients were included if they developed TACO or their blood pressure (either systolic or diastolic) increased by at least 30 mmHg during the transfusion...
February 2, 2021: Vox Sanguinis
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