Philippe T Gilchrist, Amanda Thijsen, Barbara M Masser, Christopher R France, Tanya E Davison
BACKGROUND: Fear of blood donation is implicated in vasovagal reactions, donor recruitment, and retention. This study examined the extent to which fear among donors is associated with various donor outcomes in an Australian sample, and whether fear can be addressed on-site to reduce adverse reactions and improve the donation experience. STUDY DESIGN AND METHODS: Six hundred and sixty-four donors (age M = 33.4, SD = 12.7; 55% female) participated in a two-center, pragmatic, parallel group, individually randomized controlled trial...
April 26, 2021: Transfusion
Maura Lima Pereira Bueno, Marcely Braga Mitestainer, Jussara Aparecida Rodrigues Da Silva, Bruno Deltreggia Benites, Fernanda Marconi Roversi
OBJECTIVES: Blood transfusion is a key intervention for decreasing morbidity and mortality in many cases and, besides its importance, potentially fatal consequences of incompatible transfusion are a great risk to patients. This study evaluated the incidence and specificity of erythrocyte alloantibodies in multi-transfused patients enrolled at an important Regional Blood Center. MATERIALS/METHODS: This was a single-center retrospective cohort study that eveluated patients enrolled at a Regional Blood Center in a period of four years...
April 23, 2021: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
Samantha Taylor, Eva Spada, Mary Beth Callan, Rachel Korman, Ellie Leister, Paulo Steagall, Remo Lobetti, Mayank Seth, Séverine Tasker
PRACTICAL RELEVANCE: Blood and blood products are increasingly available for practitioners to use in the management of haematological conditions, and can be lifesaving and therapeutically useful for patients with anaemia and/or coagulopathies. It is important for feline healthcare that donors are selected appropriately, and transfusions of blood or blood products are given to recipients that will benefit from them. Complications can occur, but can be largely avoided with careful donor management and recipient selection, understanding of blood type compatibility, and transfusion monitoring...
May 2021: Journal of Feline Medicine and Surgery
Atsumu Kouketsu, Yoshinaka Shimizu, Shinnosuke Nogami, Minami Yamada-Fujiwara, Hirokazu Nagai, Kensuke Yamauchi, Hitoshi Miyashita, Haruka Saito, Kenji Odashima, Yuta Yanagisawa, Tetsu Takahashi
Fibrin glue from autologous plasma may prevent viral infection and allergic reaction. Moreover, this biomaterial contains growth factors such as TGF-β and VEGF that promote reconstruction of the mucous membrane by stimulating fibroblast proliferation and angiogenesis. Thus, autologous fibrin glue is predicted to improve healing better than commercial fibrin glue. Here, we evaluated the effects of autologous fibrin glue on the crucial early phase of wound healing. Epithelial defects were introduced in rats and covered with polyglycolic acid (PGA) sheets with or without commercial or autologous fibrin glue...
April 20, 2021: Transfusion and Apheresis Science
Mindy Goldman, Samra Uzicanin, Lynne Marquis-Boyle, Sheila F O'Brien
BACKGROUND: There are several strategies to reduce donor reactions. We report donor participation and reaction rates before and after implementing multiple measures at Canadian Blood Services. STUDY DESIGN AND METHODS: We introduced a structured program of 500 mL of water and a salty snack pre-donation and applied muscle tension (AMT) during donation. Donors were not deferred for out of range blood pressure (BP); however, BP was measured in first time donors. Time on the donation chair post-donation was decreased from 5 to 2 min for repeat donors...
April 20, 2021: Transfusion
Ian Kracalik, Sanjida Mowla, Sridhar V Basavaraju, Mathew R P Sapiano
BACKGROUND: Despite current blood safety measures, transfusion recipients can experience transfusion-related adverse reactions. Monitoring these reactions can aid in understanding the effectiveness of current transfusion safety measures. Data from the National Healthcare Safety Network Hemovigilance Module were used to quantify adverse reaction risk. METHODS: Facilities reporting at least one month of transfused blood components and transfusion-related adverse reactions during January 2013-December 2018 were included...
April 20, 2021: Transfusion
Majid Zamani, Yoda Yaghoubi, Adel Naimi, Ali Hassanzadeh, Ramin Pourakbari, Leili Aghebati-Maleki, Roza Motavalli, Afsoon Aghlmandi, Amir Mehdizadeh, Mehdi Nazari, Mehdi Yousefi, Ali Akbar Movassaghpour
Purpose: Transfusion of red blood cells (RBCs) is a supportive and common treatment in surgical care, trauma, and anemia. However, in vivo production of RBC seems to be a suitable alternative for blood transfusions due to the limitation of blood resources, the possibility of disease transmission, immune reactions, and the presence of rare blood groups. Cell cultures require serum-free or culture media supplemented with highly expensive animal serum, which can transmit xenoviruses. Platelet lysate (PL) can be considered as a suitable alternative containing a high level of growth factors and a low production cost...
February 2021: Advanced Pharmaceutical Bulletin
Neslihan Andıç, Nur Oğuz, Eren Gündüz, Tuba Kiraz Bulduk, Hava Üsküdar Teke
Glanzmann thrombasthenia is an inherited disease causing bleeding episodes due to platelet dysfunction. The standard treatment for moderate-severe bleeding is platelet transfusion. Recombinant factor VIIa (rFVIIa) is successfully used in bleeding episodes and invasive procedures. Here, we present a patient with Glanzmann thrombasthenia, whose bleeding episodes could only be controlled by rFVIIa. The patient is a 28 years old male, who has had frequent bleeding episodes unresponsive to local hemostatic agents and tranexamic acid and had an anaphylactoid reaction to platelet transfusion...
April 20, 2021: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Laura Grech, Janet Sultana, Karen Borg, Joseph Borg
IntroductionBeta-thalassemia is an autosomal recessive hereditary anemia characterized by reduced or absent β-globin chain synthesis, affecting about 60,000 people per year. The only curative treatment is hematopoietic stem cell transplantation but this is risky and expensive. Management for β-thalassemia major includes regular blood transfusions followed by iron chelating therapy and drug targeting ineffective erythropoiesis.Areas covered:The safety of currently licenced drugs for the management of β-thalassemia is reviewed in detail, using evidence from clinical trials and observational research...
April 20, 2021: Expert Opinion on Drug Safety
Parisa Bagheri, Mohammadreza Sharifi, Ava Ghadiri
Long noncoding ribonucleic acids (lncRNAs) are ribonucleic acid (RNA) molecules longer than 200 nucleotides without protein-coding capacity. Several studies have shown that lncRNAs play a pivotal role in the initiation, maintenance, and progression of acute myeloid leukemia (AML), which could make them a promising candidate in the diagnosis and treatment of leukemia. Acute Megakaryoblastic leukemia (AMKL) is a rare form of AML with a poor prognosis and low survival. It has been reported that lncRNA MIR100HG is involved several types of malignancies...
April 2021: Indian Journal of Hematology & Blood Transfusion
Thalia Mok, Deisy Contreras, Ramen H Chmait, Jeffrey Goldstein, Ilina D Pluym, Khalil Tabsh, Grace Aldrovandi, Yalda Afshar
OBJECTIVE:  A majority of studies evaluating the risk of vertical transmission and adverse outcomes in pregnancies with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are mostly based on third-trimester infections. There is limited data available on pregnancy sequelae of maternal infection in the first or second trimester. STUDY DESIGN:  We present a patient with monochorionic-diamniotic twins that develops coronavirus disease 2019 infection at 15 weeks of gestation...
April 14, 2021: American Journal of Perinatology
Shaimaa Sahmoud, Esraa M Ashry, Mohamed El Kalioby, Noha Kamel
Human factors account for most reported errors in the serious hazards of blood transfusion report, thus staff training on safe blood transfusion is strongly recommended. This study aimed to assess knowledge of blood transfusion safety among pediatricians and determine the impact of an educational initiative. A quasi-experimental study was conducted on 190 pediatricians. A questionnaire was designed and validated through a pilot study after which all participants were invited to fill it pre- and posteducational intervention...
March 19, 2021: Transfusion Medicine Reviews
Jakob Gubensek, Rafael Ponikvar, Tanja Premru Srsen, Vesna Fabjan Vodusek, Manfred Georg Moertl, Miha Lucovnik
AIM: To evaluate effectiveness and safety of therapeutic plasma exchange (TPE) and dextran-sulfate plasma adsorption (DSA) for extracorporeal removal of soluble Fms-like tyrosine kinase-1 (sFlt-1) as part of expectant management of preeclampsia at extremely preterm gestational age. METHODS: Retrospective case series of six patients with preeclampsia at <28 weeks of gestation, treated with DSA or TPE. Laboratory results, clinical characteristics and neonatal outcomes were collected from charts and National Perinatal Information System...
April 13, 2021: Journal of Clinical Apheresis
Zhimeng Wang, Yao Lu, Qiang Huang, Hanzhong Xue, Cheng Ran, Qian Wang, Teng Ma, Kun Zhang, Zhong Li, Liang Sun
Femoral shaft nonunion is a complication that seriously affects physiological functions. We aimed to assess the effectiveness and safety of short- and long-term intravenous tranexamic acid (TXA) administration in the perioperative period of revision surgery for femoral shaft nonunion. In this retrospective study, 53 patients undergoing double-locking plates with channel bone grafting technology for the treatment of femoral shaft nonunion were divided into 3 groups: the patients in group A without use TXA during hospitalization, the patients in group B received intravenous (IV) 1-g TXA at 30 min before the surgery and deep soaked 1-g TXA for 5 min before closing the incision, and then 1-g TXA IV again 6 h after surgery, and the patients in group C received 1-g TXA IV before the operation, 1-g TXA topically during the operation, and subsequent long-term 1-g TXA IV until discharged...
January 2021: Clinical and Applied Thrombosis/hemostasis
Kai Guo, Shuxuan Ma
As an initiator of respiratory distress, transfusion-related acute lung injury (TRALI) is regarded as one of the rare complications associated with transfusion medicine. However, to date, the pathogenesis of TRALI is still unclear, and specific therapies are unavailable. Understanding the mechanisms of TRALI may promote the design of preventive and therapeutic strategies. The immune system plays vital roles in reproduction, development and homeostasis. Sterile tissue damage, such as physical trauma, ischemia, or reperfusion injury, induces an inflammatory reaction that results in wound healing and regenerative mechanisms...
2021: Frontiers in Molecular Biosciences
Qing Ma, Jiancheng Liu, Chunbo Li, Dong Wang
OBJECTIVE: To explore the effects of off-pump coronary artery bypass grafting (OPC) on clinical efficacy, cardiac function and the occurrence of major adverse cardiovascular events (MACE) in patients with coronary heart disease. METHODS: According to different surgical methods, 93 patients with coronary heart disease who were hospitalized and treated in our hospital were collapsed into the off-pump coronary artery bypass grafting group (OPC group) and the extracorporeal circulation coronary artery bypass grafting group (PC group)...
2021: American Journal of Translational Research
A Koh, A Adiamah, D Gomez, S Sanyal
BACKGROUND: Perioperative bleeding is associated with increased morbidity and mortality in patients undergoing elective abdominal surgery. The antifibrinolytic agent tranexamic acid (TXA) has been shown to reduce perioperative bleeding and mortality risk in patients with traumatic injuries, but there is a lack of evidence for its use in elective abdominal and pelvic surgery. This meta-analysis of RCTs evaluated the effectiveness and safety of TXA in elective extrahepatic abdominopelvic surgery...
March 5, 2021: BJS Open
Yajun Liu, Junzhi Sun, Yun Xia, Michael R Lyaker, Jianshe Yu
BACKGROUND: Blood transfusion can cause immunosuppression and lead to worse outcomes in patients with digestive tract malignancies; however, the specific mechanism behind this is not completely understood. One theory is that increased numbers of regulatory CD3+ CD4+ CD25+ FOXP3+ T cells (Tregs) and forkhead box protein-3 mRNA (FOXP3) expression in the blood after transfusion contribute to these outcomes. The effect of blood transfusion on immune function in patients with different ABO blood types is variable...
April 10, 2021: BMC Anesthesiology
Rathin Pujari, Rashmi Deshmukh, Chirag Sheth, Madhavan S Rajan
This is a case of a 17-year-old patient with aniridia-related keratopathy and persistent epithelial defect (PED) treated successfully using maternal finger-prick blood (FPB). Maternal allogenic FPB treatment was initiated to the patient who was non-compliant with the use of autologous FPB. The PED was successfully managed with maternal FPB treatment with rapid and complete closure of the epithelial defect. Additionally, there was immediate and sustained symptomatic improvement to pain and recovery of vision in the only seeing eye...
April 9, 2021: BMJ Case Reports
Sooin Choi, Jungwon Hyun, HongBi Yu, Duck Cho
Fatal ABO-incompatible (ABOi) transfusion is one of the most common causes of transfusion-related death, but its reporting has been limited in Korea. We comprehensively reviewed ABOi transfusion events in Korea by analyzing cases reported in literature, Korean hemovigilance system (KOHEVIS) annual reports, and written judgments. Written judgments were assessed using a written judgment management system or a comprehensive legal information system. We found nine cases of ABOi transfusion events in written judgments (from 1953 to 2019), 16 in the KOHEVIS (from 2008 to 2018), and nine in published reports (from 1978 to 2019)...
September 1, 2021: Annals of Laboratory Medicine
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