keyword
https://read.qxmd.com/read/33636175/targeting-rage-to-prevent-sars-cov-2-mediated-multiple-organ-failure-hypotheses-and-perspectives
#21
REVIEW
Sara Chiappalupi, Laura Salvadori, Aleksandra Vukasinovic, Rosario Donato, Guglielmo Sorci, Francesca Riuzzi
A novel infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was detected in December 2019 and declared as a global pandemic by the World Health. Approximately 15% of patients with COVID-19 progress to severe pneumonia and eventually develop acute respiratory distress syndrome (ARDS), septic shock and/or multiple organ failure with high morbidity and mortality. Evidence points towards a determinant pathogenic role of members of the renin-angiotensin system (RAS) in mediating the susceptibility, infection, inflammatory response and parenchymal injury in lungs and other organs of COVID-19 patients...
February 23, 2021: Life Sciences
https://read.qxmd.com/read/33636023/does-extracorporeal-shock-wave-lithotripsy-before-retrograde-intrarenal-surgery-complicate-the-surgery-for-upper-ureter-stone-the-results-of-rirsearch-group
#22
Cenk Murat Yazici, Duygu Siddikoglu, Onder Cinar, Oktay Ozman, Cem Basatac, Murat Akgul, Eyup Burak Sancak, Bulent Onal, Haluk Akpinar
AIMS: To evaluate the effect of pre-RIRS ESWL on the efficiency and safety of RIRS in the treatment of proximal ureter stones. METHODS: The patients in the study population were divided into 2 groups. Group-1 was composed of patients who had undergone ESWL for proximal ureter stones before RIRS, and Group-2 was composed of patients who directly underwent RIRS without any prior ESWL. The clinical and demographic properties of the patients were analysed in the RIRSearch database...
February 26, 2021: International Journal of Clinical Practice
https://read.qxmd.com/read/33635931/inhibition-of-anti-viral-stress-granule-formation-by-coronavirus-endoribonuclease-nsp15-ensures-efficient-virus-replication
#23
Bo Gao, Xiaoqian Gong, Shouguo Fang, Wenlian Weng, Huan Wang, Hongyan Chu, Yingjie Sun, Chunchun Meng, Lei Tan, Cuiping Song, Xusheng Qiu, Weiwei Liu, Maria Forlenza, Chan Ding, Ying Liao
Cytoplasmic stress granules (SGs) are generally triggered by stress-induced translation arrest for storing mRNAs. Recently, it has been shown that SGs exert anti-viral functions due to their involvement in protein synthesis shut off and recruitment of innate immune signaling intermediates. The largest RNA viruses, coronaviruses, impose great threat to public safety and animal health; however, the significance of SGs in coronavirus infection is largely unknown. Infectious Bronchitis Virus (IBV) is the first identified coronavirus in 1930s and has been prevalent in poultry farm for many years...
February 26, 2021: PLoS Pathogens
https://read.qxmd.com/read/33635889/impella-use-in-real-world-cardiogenic-shock-patients-sobering-outcomes
#24
Khaled Q A Abdullah, Jana V Roedler, Juergen Vom Dahl, Istvan Szendey, Hendrik Haake, Lars Eckardt, Albert Topf, Bernhard Ohnewein, Peter Jirak, Lukas J Motloch, Bernhard Wernly, Robert Larbig
BACKGROUND: Critically ill patients with cardiogenic shock could benefit from ventricular assist device support using the Impella microaxial blood pump. However, recent studies suggested Impella not to improve outcomes. We, therefore, evaluated outcomes and predictors in a real-world scenario. METHODS: In this retrospective single-center trial, 125 patients suffering from cardiac arrest/cardiogenic shock between 2008 and 2018 were analyzed. 93 Patients had a prior successful cardiopulmonary resuscitation...
2021: PloS One
https://read.qxmd.com/read/33635879/transcriptome-analysis-of-the-role-of-autophagy-in-plant-response-to-heat-stress
#25
Yan Zhang, Haoxuan Min, Chengchen Shi, Gengshou Xia, Zhibing Lai
Autophagy plays a critical role in plant heat tolerance in part by targeting heat-induced nonnative proteins for degradation. Autophagy also regulates metabolism, signaling and other processes and it is less understood how the broad function of autophagy affects plant heat stress responses. To address this issue, we performed transcriptome profiling of Arabidopsis wild-type and autophagy-deficient atg5 mutant in response to heat stress. A large number of differentially expressed genes (DEGs) were identified between wild-type and atg5 mutant even under normal conditions...
2021: PloS One
https://read.qxmd.com/read/33635463/asymmetric-effects-of-energy-consumption-and-economic-growth-on-ecological-footprint-new-evidence-from-pakistan
#26
Muhammad Tariq Majeed, Aisha Tauqir, Maria Mazhar, Isma Samreen
This study explores the asymmetric effects of both aggregate and disaggregate forms of energy consumption along with economic growth on environmental quality for Pakistan covering the period from 1971 to 2014. We have employed unit root test with breaks for stationary checks, BDS test for nonlinearity check and nonlinear autoregressive distributed lag (NARDL) approach for assessing the asymmetric co-integrating relationships among the variables by decomposing them into positive and negative shocks. The empirical findings for aggregate consumption reveal that only negative shocks have a significant impact on ecological footprint...
February 26, 2021: Environmental Science and Pollution Research International
https://read.qxmd.com/read/33635416/morphologies-and-prognostic-significance-of-left-ventricular-volume-time-curves-with-cardiac-magnetic-resonance-in-patients-with-non-ischaemic-heart-failure-and-left-bundle-branch-block
#27
Alberto Aimo, Alessandro Valleggi, Andrea Barison, Sara Salerni, Michele Emdin, Giovanni Donato Aquaro
Patients with non-ischaemic systolic heart failure (HF) and left bundle branch block (LBBB) can display a wide or narrow pattern (WP/NP) of the systolic phase of the left ventricular (LV) volume/time (V/t) curve in cardiac magnetic resonance (CMR). The clinical and prognostic significance of these patterns is unknown. Consecutive patients with non-ischaemic HF, LV ejection fraction < 50% and LBBB underwent 1.5 T CMR. Maximal dyssynchrony time (time between the earliest and latest end-systolic peaks), systolic dyssynchrony index (standard deviation of times to peak volume change), and contractility index (maximum rate of change of pressure-normalized stress) were calculated...
February 26, 2021: International Journal of Cardiovascular Imaging
https://read.qxmd.com/read/33635238/efficacy-of-histidine-tryptophan-ketoglutarate-solution-versus-blood-cardioplegia-in-cardiac-surgical-procedures-a-randomized-controlled-parallel-group-study
#28
Ihab Ali, Ahmed Hassan, Hoda Shokri, Ramy Khorshed
BACKGROUND: In cardiac surgery, myocardial protection is required during cross-clamping followed by reperfusion. The use of cardioplegic solutions helps preserve myocardial energy stores, hindering electrolyte disturbances and acidosis during periods of myocardial ischaemia. This study aimed to compare the efficacy and safety between the histidine-tryptophan-ketoglutarate (HTK) solution and blood cardioplegia in various cardiac surgeries. METHODS: Three-hundred-twenty patients aged 30-70 years old undergoing various cardiac surgeries were randomized into the HTK group and the blood cardioplegia group...
February 17, 2021: Heart Surgery Forum
https://read.qxmd.com/read/33634761/treatment-of-catatonia-with-asenapine-in-a-patient-with-schizotypal-personality-disorder-psychotic-depression-and-septic-shock-from-sars-cov-2-a-case-report
#29
F Fiaschè, B Adriani, I Mancinelli, A Taranto
INTRODUCTION: Catatonia is a psychomotor syndrome that presents with severe symptoms which can lead to dangerous and lethal conditions if not diagnosed and treated properly. SARS-CoV-2 is a positive-sense single-stranded RNA virus that can occur in severe cases with acute pneumonia, ARDS, sepsis and septic shock. In these cases, ICU admission is necessary. CASE SUMMARY: A 59-year-old Caucasian man with septic shock and bilateral interstitial pneumonia from SARS-CoV-2 and schizotypal personality disorder presented with catatonic behaviour manifested by soporous state, response to intense painful stimuli with opening of the eyes, execution of simple verbal commands, maintenance of the same position, catalepsy, immobility, rigidity and mutism...
February 25, 2021: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/33634606/acute-heart-transplantation-from-mechanical-circulatory-support-in-a-human-immunodeficiency-virus-positive-patient-with-fulminant-myocarditis
#30
Zsofia Szakal-Toth, Janos Szlavik, Adam Soltesz, Viktor Berzsenyi, Gergely Csikos, Tamas Varga, Kristof Racz, Akos Kiraly, Balazs Sax, Istvan Hartyanszky, Attila Fintha, Zoltan Prohaszka, Katalin Monostory, Bela Merkely, Endre Nemeth
Since the establishment of highly active antiretroviral therapy, survival rates have improved among patients with human immunodeficiency virus infection giving them the possibility to become transplant candidates. Recent publications revealed that human immunodeficiency virus-positive heart transplant recipients' survival is similar to non-infected patients. We present the case of a 40-year-old human immunodeficiency virus infected patient, who was hospitalized due to severely decreased left ventricular function with a possible aetiology of acute myocarditis, that has later been confirmed by histological investigation of myocardial biopsy...
February 25, 2021: ESC Heart Failure
https://read.qxmd.com/read/33634556/a-flash-induced-robust-cu-electrode-on-glass-substrates-and-its-application-for-thin-film-%C3%AE-leds
#31
Jung Ho Shin, Jung Hwan Park, Jeongmin Seo, Tae Hong Im, Jong Chan Kim, Han Eol Lee, Do Hyun Kim, Kie Young Woo, Hu Young Jeong, Yong-Hoon Cho, Taek-Soo Kim, Il-Suk Kang, Keon Jae Lee
A robust Cu conductor on a glass substrate for thin-film μLEDs using the flash-induced chemical/physical interlocking between Cu and glass is reported. During millisecond light irradiation, CuO nanoparticles (NPs) on the display substrate are transformed into a conductive Cu film by reduction and sintering. At the same time, intensive heating at the boundary of CuO NPs and glass chemically induces the formation of an ultrathin Cu2 O interlayer within the Cu/glass interface for strong adhesion. Cu nanointerlocking occurs by transient glass softening and interface fluctuation to increase the contact area...
February 26, 2021: Advanced Materials
https://read.qxmd.com/read/33634515/matrix-metalloproteinases-in-the-pathogenesis-of-dengue-virus-disease-involvement-of-immune-system-and-newer-therapeutic-strategies
#32
REVIEW
Rituraj Niranjan, Sumitha Kishor, Ashwani Kumar
Globally, the burden due to dengue infection is increasing with a recent estimate of 96 million progressing to disease every year. Dengue pathogenesis and the factors influencing it are not completely known. It is now widely speculated that, there is an important role of matrix metalloproteinases (MMPs) in the initiation and progression of dengue pathogenesis, however their exact roles are not fully understood. Over activation of matrix metalloproteinases may contribute to the severity of dengue pathogenesis...
February 25, 2021: Journal of Medical Virology
https://read.qxmd.com/read/33634478/rationale-and-design-of-the-optimal-reperfusion-trial-a-prospective-randomized-multi-center-clinical-trial-comparing-different-fibrinolysis-transfer-percutaneous-coronary-intervention-strategies-in-acute-st-segment-elevation-myocardial-infarction
#33
Zhongxiu Chen, Duolao Wang, Min Ma, Chen Li, Zhi Wan, Li Zhang, Ye Zhu, Mian Wang, Hua Wang, Sen He, Yong Peng, Jiafu Wei, Baotao Huang, Yong He
Primary percutaneous coronary intervention (PPCI), the preferred reperfusion strategy for all acute ST-segment elevation myocardial infarction (STEMI) patients, is not universally available in clinical practice. Pharmacoinvasive strategy has been proposed as a therapeutic option in patients with STEMI when timely PPCI is not feasible. However, pharmacoinvasive strategy has potential delay between clinical patency and complete myocardial perfusion. The optimal reperfusion strategy for STEMI patients with anticipated PPCI delay according to current practice is uncertain...
February 25, 2021: Clinical Cardiology
https://read.qxmd.com/read/33634228/fulminant-eosinophilic-myocarditis-treated-with-steroids-and-mechanical-unloading-a-case-report
#34
Tim Balthazar, Tom Adriaenssens, Walter Droogne, Christophe Vandenbriele
Background: Eosinophilic myocarditis is a rare form of myocardial inflammatory disease. Eosinophilic infiltration of the myocardium is often the consequence of a systemic disorder but can remain unexplained in up to a third of patients. The disease course can range from mild to fulminant myocarditis and mortality remains high for fulminant cases. Case summary: A 42-year-old male was admitted for cardiogenic shock. He presented in another hospital with fever, low blood pressure, diffuse electrocardiogram-abnormalities, and elevated troponin T (4...
December 2020: European Heart Journal. Case Reports
https://read.qxmd.com/read/33634226/systemic-thrombolysis-and-anticoagulation-improved-biomarker-measurements-in-massive-like-pulmonary-embolism-and-severe-covid-19-pneumonia-a-case-report
#35
Hector Betancourt-Del Campo, Carlos Jerjes-Sanchez, Mauricio Castillo-Perez, Hector López-de la Garza, José Gildardo Paredes-Vázquez, Yoezer Z Flores-Sayavedra, Francisco Moreno-Abril Hoyos, Marcos Ibarra-Flores
Background: From asymptomatic patients to severe acute respiratory distress syndrome, COVID-19 has a wide range of clinical presentations, and venous thromboembolism has emerged as a critical and frequent complication. Case summary: We present a case of a 69-year-old man with a clinical presentation of massive-like pulmonary embolism (PE) overlapping with severe COVID-19 pneumonia. The diagnosis was made based on hypotension, severe oxygen desaturation (33%), and right ventricular dysfunction (RVD)...
December 2020: European Heart Journal. Case Reports
https://read.qxmd.com/read/33634214/age-of-thawed-plasma-does-not-affect-clinical-outcomes-or-biomarker-expression-in-patients-receiving-prehospital-thawed-plasma-a-pamper-secondary-analysis
#36
Katherine M Reitz, Danielle S Gruen, Frances Guyette, Joshua B Brown, Mark H Yazer, Yoram Vodovotz, Pär I Johanssen, Jakob Stensballe, Brian Daley, Richard S Miller, Brian G Harbrecht, Jeffrey Claridge, Herb A Phelan, Matthew D Neal, Brian S Zuckerbraun, Jason L Sperry
Background: Prehospital plasma administration during air medical transport reduces the endotheliopathy of trauma, circulating pro-inflammatory cytokines, and 30-day mortality among traumatically injured patients at risk of hemorrhagic shock. No clinical data currently exists evaluating the age of thawed plasma and its association with clinical outcomes and biomarker expression post-injury. Methods: We performed a secondary analysis from the prehospital plasma administration randomized controlled trial, PAMPer...
2021: Trauma Surgery & Acute Care Open
https://read.qxmd.com/read/33633944/multisystem-inflammatory-syndrome-in-children-during-the-coronavirus-disease-2019-covid-19-pandemic-a-systematic-review-of-published-case-studies
#37
Yuyi Tang, Weiguo Li, Muna Baskota, Qi Zhou, Zhou Fu, Zhengxiu Luo, Yuan Shi, Yaolong Chen, Enmei Liu
Background: Many cases have been reported recently on multisystem inflammatory syndrome in children (MIS-C), a newly emerged disease that seemed to correlate with coronavirus disease 2019 (COVID-19). The aim of this review was to describe the clinical features, treatment and outcomes of MIS-C, as well as to assess the risk of bias of published case studies, analyzing their reporting quality. Methods: We searched all articles reporting on multisystem inflammatory condition in children and adolescents in the context of COVID-19 through MEDLINE (via PubMed), Web of Science, China Biology Medicine disc (CBM) and China National Knowledge Infrastructure (CNKI) from their inception to June 17, 2020...
January 2021: Translational Pediatrics
https://read.qxmd.com/read/33633705/genetics-structure-and-function-of-group-a-streptococcal-pili
#38
REVIEW
Masanobu Nakata, Bernd Kreikemeyer
Streptococcus pyogenes (Group A Streptococcus ; GAS) is an exclusively human pathogen. This bacterial species is responsible for a large variety of infections, ranging from purulent but mostly self-limiting oropharynx/skin diseases to streptococcal sequelae, including glomerulonephritis and rheumatic fever, as well as life-threatening streptococcal toxic-shock syndrome. GAS displays a wide array of surface proteins, with antigenicity of the M protein and pili utilized for M- and T-serotyping, respectively. Since the discovery of GAS pili in 2005, their genetic features, including regulation of expression, and structural features, including assembly mechanisms and protein conformation, as well as their functional role in GAS pathogenesis have been intensively examined...
2021: Frontiers in Microbiology
https://read.qxmd.com/read/33633341/comparison-of-e-coli-based-self-inducible-expression-systems-containing-different-human-heat-shock-proteins
#39
Fatemeh Sadat Shariati, Malihe Keramati, Vahideh Valizadeh, Reza Ahangari Cohan, Dariush Norouzian
IPTG-inducible promoter is popularly used for the expression of recombinant proteins. However, it is not suitable at the industrial scale due to the high cost and toxicity on the producing cells. Recently, a Self-Inducible Expression (SILEX) system has developed to bypass such problems using Hsp70 as an autoinducer. Herein, the effect of other heat shock proteins on the autoinduction of green fluorescent protein (EGFP), romiplostim, and interleukin-2 was investigated. For quantitative measurements, EGFP expression was monitored after double-transformation of pET28a-EGFP and pET21a-(Hsp27/Hsp40/Hsp70) plasmids into E...
February 25, 2021: Scientific Reports
https://read.qxmd.com/read/33632984/role-of-medial-prefrontal-cortical-neurons-and-oxytocin-modulation-in-the-establishment-of-social-buffering
#40
Taesub Jung, Minji Jang, Jihyun Noh
Fear-related behaviors are rigidly controlled by the medial prefrontal cortex (mPFC). The mPFC is activated by the prosocial hormone oxytocin, which plays an important role in social buffering. We used a slice patch current-clamp recording in single- and pair-exposed rats who were subjected to electric shocks, to determine the cellular mechanism of the action of oxytocin in the mPFC under social buffering conditions. Pair-exposed rats showed a significant reduction in both freezing and passive avoidance behaviors compared to single-exposed rats...
February 28, 2021: Experimental Neurobiology
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