Youngsuk Lee, Van Giap Do, Seonae Kim, Hunjoong Kweon, Tony K McGhie
Fruit abscission is a complex physiological process that is regulated by internal and environmental factors. During early development, apple fruit are exposed to extreme temperature fluctuations that are associated with premature fruit drop; however, their effect on fruit abscission is largely unknown. We hypothesized that fruit abscission is triggered by cold stress and investigated the molecular basis of premature fruit drop using RNA-Seq and metabolomics data from apple fruit undergoing abscission following cold stress in the field...
2021: PloS One
(no author information available yet)
No abstract text is available yet for this article.
March 1, 2021: Pancreas
Xijin Ge
RNA sequencing (RNA-seq) has become a routine method for transcriptomic profiling. We developed a user-friendly web app called iDEP (integrated differential expression and pathway analysis) to help biologists interpret read counts or other types of expression matrices derived from read mapping. With iDEP, users can easily conduct exploratory data analysis, identify differentially expressed genes, and perform pathway analysis. Due to its intuitive user interface and massive annotation database, iDEP is being widely adopted for interactive analysis of RNA-seq data...
2021: Methods in Molecular Biology
Ane Catarine Tosi Costa, Jacob Hornick, Tathiana Ferreira Sá Antunes, Alexandre Martins Costa Santos, A Alberto R Fernandes, James R Broach, Patricia M B Fernandes
Distillation of fermented sugarcane juice produces both rum and cachaça, significant sources of revenue in Brazil and elsewhere. In this study, we provide a genomic analysis of a Saccharomyces cerevisiae strain isolated from a cachaça distillery in Brazil. We determined the complete genome sequence of a strain with high flocculation capacity, high tolerance to ethanol, osmotic and heat shock stress and high fermentation rates and compared the sequence with that of the reference S288c genome as well as those of two other cachaça strains...
April 9, 2021: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
Ze-Liang Qiu, Bi-Qing Yan, Dong-Wei Xu, Rui Zhao, Kan Shen, Shi-Qi Lu
PURPOSE: Acute kidney injury (AKI) is a common complication of sepsis and has high mortality. The 2017 Acute Disease Quality Initiative (AQDI) workgroup proposed new definitions for AKI - transient AKI and persistent AKI; however, very little is known about the effect of transient and persistent septic AKI on short-term mortality among critically ill patients with sepsis. The purpose of this study was to assess the impact of persistent AKI on mortality and to evaluate whether serum hepcidin can predict the occurrence of persistent AKI in critically ill patients with sepsis...
April 9, 2021: Clinical Nephrology
Yudan Wu, Meilan Liang, Meijing Wu, Qionge Fu, Cimei Zeng
OBJECTIVE: To observe the application effect of respiratory stepwise management in patients with septic shock combined with acute lung injury (ALI). METHODS: 100 patients with septic shock combined with ALI were selected as the research objects in Haikou Hospital Affiliated to Xiangya Medical College of Central South University from January 2018 to June 2020. Fifty patients were given endotracheal intubation or invasive ventilation on the basis of conventional treatment (conventional treatment group)...
March 2021: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Siyi Li, Xunshi Ding, Tao Ye, Lianchao Cheng, Caiyan Cui, Yumei Zhang, Feng Zhu, Xinglin Jiang, Lin Cai
OBJECTIVE: To assess the age-related differences in the management strategies and outcomes of patients with acute coronary syndrome (ACS) under the chest pain center model. METHODS: Clinical data of 2 833 patients with ACS were enrolled in the retrospective observational registry between January 2017 and June 2019 at 11 hospitals with chest pain centers in Chengdu. The patients were divided into four groups according to their ages: < 55 years old group (n = 569), 55-64 years old group (n = 556), 65-74 years old group (n = 804), ≥ 75 years old group (n = 904)...
March 2021: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Yanming Qin, Peng Wang, Xuanxuan Xu, Zheng Li
OBJECTIVE: To explore the risk factors of acute respiratory distress syndrome (ARDS) secondary to severe multiple trauma and the role of clinical guidance. METHODS: The clinical data of 115 patients with severe multiple trauma admitted to the trauma center of Zhenjiang First People's Hospital from December 2017 to September 2020 were retrospectively analyzed. According to whether ARDS occurred within 1 week of the disease course, the patients were divided into ARDS group and non-ARDS group...
March 2021: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Cuiping Hao, Qinghe Hu, Lina Zhu, Hongying Xu, Yaqing Zhang
OBJECTIVE: To explore the value of lactic acid (Lac), procalcitonin (PCT), sequential organ failure assessment (SOFA) score and acute physiology and chronic health evaluation II (APACHE II) score in assessing the severity and predicting the prognosis in sepsis shock. METHODS: A retrospectively study was conducted. Patients with septic shock hospitalized in the department of critical care medicine of the Affiliated Hospital of Jining Medical University from April 2015 to June 2019 were enrrolled...
March 2021: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Fang Feng, Weiwei Yang, Zhengxin Zhang, Chenghua Mu, Min Li, Yu Chen
OBJECTIVE: To analysis the risk factors and safety of administration of norepinephrine (NE) via peripheral vein line (PVL) in patients with septic shock. METHODS: A single-center retrospective study was conducted. According to the Lanzhou University Second Hospital information system (HIS) and nursing adverse events report cards, patients with septic shock administrated with NE via PVL to correct the hypotension from January 1st 2015 to December 31st, 2019 were enrolled...
March 2021: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Ting Yang, Huibin Huang, Li Weng, Bin Du
OBJECTIVE: To explore the validity of the effective arterial elastance (Ea) before and after fluid challenge in evaluating the fluid challenge in septic shock patients. METHODS: A retrospective study was conducted in the medical intensive care unit (MICU) of Peking Union Medical College Hospital from October 2016 to October 2020. 116 septic shock patients were enrolled. All patients received fluid challenge by 500 mL Gelatin or normal saline under invasive hemodynamic monitoring...
March 2021: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Jin-Hui Xu, Hui-Liang Xue, Zhe Wang, Chao Fan, Ming Wu, Lai-Xiang Xu
The social behavior mechanisms have not been thoroughly reported in the solitary female striped dwarf hamster ( Cricetulus barabensis ). In this study, the handling bag test and neutral arena measurements were used to detect the changes of aggression in the face of rivals of different genders of wild striped dwarf hamsters. We found that female hamsters had the highest aggressive performance in proestrus, followed by estrus, and the lowest in metestrus and the dioestrus, and the increased aggression during the proestrus or estrus period was low-intensity aggression such as intimidation, shock, boxing and counterattack, or even ritualized non-harmful behaviors to drive away opponents...
March 30, 2021: Journal of Integrative Neuroscience
Daniela Gouveia, José Máximo, Nuno Costa, Soraia Moreira, Armando Abreu, Paulo Pinho, Jorge Casanova
OBJECTIVES: Our objective was to examine the results of ECMO post cardiotomy in Centro Hospitalar Universitário S. João (CHUSJ). METHODS: Between 2011 and 2019, 13 patients were cannulated for refractory cardiogenic shock post-cardiotomy; 8 (61,5%) male and 5 (38,5%) female. Patients under 18 years old were excluded. Data was collected from hospital archives concerning preoperative comorbidities, open-heart surgery procedure, dates of ECMO cannulation and decannulation, postoperative complications, hospital mortality and cause of death...
April 8, 2021: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
Manuela Silva, Carolina Rodrigues, Tiago Silva, Pedro Coelho, Nuno Banazol, Rui Rodrigues, Paulo Franco, José Fragata
OBJECTIVES: We aim to report our experience on venoarterial extracorporeal membrane oxygenation (VA-ECMO) for postcardiotomy shock (PCS). METHODS: Single center, retrospective study of all patients on VA-ECMO for PCS, from November 2006 to July 2019. Pediatric and adult patients were analysed separately. Primary outcomes were survival to discharge and one-year survival. RESULTS: Twenty-nine patients were included. Pediatric group (group PED) (62%, n=18): mean age 1,3±2,1 years and 39% male...
April 8, 2021: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
Luis R P Dallan, Luis A O Dallan, Luiz A F Lisboa, Omar A V Mejia, Elinthon T Veronese, Juliana P M Camilo, Polyanna C M Nascimento, Fabio B Jatene
INTRODUCTION: Ventricular septal rupture (VSR) is a serious mechanical complication after acute coronary syndrome and is related to high mortality. Even with advances in the management of acute myocardial infarction (AMI) such as reperfusion therapies, complication rates are still high. During quarantine, patients presenting mechanical complications after AMI have increased in our institution. METHODS: From a retrospective database analysis in our institution between the years 2004 and 2020, we identified 37 cases of VSR after AMI...
April 8, 2021: Journal of Cardiac Surgery
Chan-Gi Pack
Confocal laser scanning microscopy (CLSM) and related microscopic techniques allow a unique and versatile approach to image and analyze living cells due to their specificity and high sensitivity. Among confocal related techniques, fluorescence correlation methods, such as fluorescence correlation spectroscopy (FCS) and dual-color fluorescence cross-correlation spectroscopy (FCCS), are highly sensitive biophysical methods for analyzing the complex dynamic events of molecular diffusion and interaction change in live cells as well as in solution by exploiting the characteristics of fluorescence signals...
2021: Advances in Experimental Medicine and Biology
Mohammad Ehsan Taghavizadeh Yazdi, Mohammad Sadegh Amiri, Fahimeh Nourbakhsh, Mostafa Rahnama, Fatemeh Forouzanfar, Seyed Hadi Mousavi
Heat shock proteins (HSPs) are a family of proteins that are expressed by cells in reply to stressors. The changes in concentration of HSPs could be utilized as a bio-indicator of oxidative stress caused by heavy metal. Exposure to the different heavy metals may induce or reduce the expression of different HSPs. The exposure to cadmium ion (Cd2+ ) could increase HSP70 and HSP27 over 2- to 10-fold or even more. The in vitro and in vivo models indicate that the HSP70 family is more sensitive to Cd intoxication than other HSPs...
April 8, 2021: Environmental Science and Pollution Research International
Shanthakumar Shivalingappa, K N Manjunath, Veena Waiker, M Kumaraswamy, Udayashankar Odeyar
BACKGROUND: Necrotizing fasciitis is a potentially fatal infection of β hemolytic Group-A Streptococcus, often occurring in patients with other comorbidities, but can occur in healthy individuals as well. It commonly affects the extremities, perineum, and abdominal wall. The aim of this study was to highlight various presentations of necrotizing fasciitis in unusual anatomical sites with delayed diagnosis and treatment. METHODS: In a retrospective analysis, seven cases of unusual presentations of necrotizing fasciitis were enrolled during a period of five years treated in a tertiary centre...
January 2021: World Journal of Plastic Surgery
Abdul Baqi, Sheema Saadia
Background Saphenous vein graft (SVG) may occlude either early or several months to years after coronary artery bypass graft (CABG) surgery. Doing re-do CABG surgery is associated with higher complication and mortality rate as compared to percutaneous coronary intervention (PCI) in SVG. However, PCI of SVG is associated with more periprocedural and in-hospital complications as compared to PCI of native coronary arteries. Due to the scarcity of local data in this regard, this study was designed to estimate the periprocedural and in-hospital outcomes among PCI in SVG...
April 1, 2021: Curēus
Hendri Susilo, Rerdin Julario, Citrawati Dyah Kencono Wungu
Pulmonary embolism is a potentially life-threatening condition. Despite advances in diagnostics, lack of consensus and delays in determining the diagnosis of pulmonary embolism are still important problems. We report the diagnosis and management of a 37-year-old man suffering from massive pulmonary embolism, a large protruding thrombus, and dilated cardiomyopathy. Echocardiography showed dilatation of all cardiac chambers, a large protruding thrombus in the right atrium to the inferior vena cava, impaired left and right ventricular systolic function, and global hypokinetic of the left ventricle with eccentric left ventricular hypertrophy...
2021: F1000Research
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