Monika Ogrodowczyk-Bobik, Klaudyna Borucka, Dariusz Kajdaniuk, Agata Urbanek, Szymon Janyga, Franciszek Mazur, Tomasz Miś, Bogdan Marek
Not required for Clinical Vignette.
July 22, 2021: Endokrynologia Polska
Jakob Josiassen, Martin Frydland, Christian Hassager, Jacob Eifer Møller, Anders Perner, Johannes Grand
BACKGROUND: Cardiogenic shock (CS) is a critical complication to acute myocardial infarction (AMI), with short-term mortality rates exceeding 40%. However, no international consensus of a CS definition exists. This may compromise interstudy comparability. AIMS: The aim of the current study was to review differences and similarities of CS enrolment criteria in AMI-related CS randomised clinical trials (RCT). METHODS: From the electronic databases MEDLINE and EMBASE we identified all AMI-related CS trials...
July 22, 2021: Kardiologia Polska
Y I Chernyak, I V Kudaeva
In 167 men with vibration syndrome (VS), allele and genotype frequencies of HSPA1B (+1267A>G) genetic polymorphism (rs1061581) were studied depending on the type of vibration exposure and on the presence or absence of metabolic syndrome (MetS). The examined subjects were divided into two groups: VS patients (n=80) and VS+MetS patients (n=87). The differences in the lipid profiles between groups were revealed against the background of the lack of distinctions in the age of patients for A/G and G/G genotypes carriers...
July 22, 2021: Bulletin of Experimental Biology and Medicine
Diego Araiza-Garaygordobil, Carlos Eduardo García-Martínez, Lucrecia María Burgos, Clara Saldarriaga, Kiera Liblik, Ivan Mendoza, Manuel Martinez-Selles, Cristhian Emmanuel Scatularo, Juan Maria Farina, Adrian Baranchuk
Dengue is a neglected viral arthropod-borne tropical disease transmitted by the bite of infected Aedes spp. mosquitoes. It is responsible for a significant global burden of disease and corresponding socio-economic implications. There are four different virus serotypes, all of which are found predominantly in countries with tropical climates. Patients with dengue may present with cardiovascular (CV) manifestations, contributing to associated death and disability. A systematic review was conducted to identify CV manifestations of dengue, wherein 30 relevant studies were identified in the MEDLINE and PubMed databases...
July 20, 2021: Cardiovascular Journal of Africa
Kehong Chen, Joaquin Cagliani, Monowar Aziz, Chuyi Tan, Max Brenner, Ping Wang
Stimulator of IFN genes (STING) activates TANK-binding kinase 1 (TBK1) and IFN regulatory factor 3 (IRF3) to produce type I IFNs. Extracellular cold-inducible RNA-binding protein (eCIRP) is released from cells during hemorrhagic shock (HS). We hypothesized that eCIRP activates STING to induce inflammation and acute lung injury (ALI) after HS. WT and STING-/- mice underwent controlled hemorrhage by bleeding, followed by fluid resuscitation. Blood and lungs were collected at 4 hours after resuscitation. Serum ALT, AST, LDH, IL-6, and IFN-β were significantly decreased in STING-/- mice compared with WT mice after HS...
July 22, 2021: JCI Insight
Precious Adedayo Adesina, Kana Isayama, Gertrude Cynthia Sitolo, Yoshinari Yamamoto, Takuya Suzuki
Short-chain fatty acids (SCFAs), including propionate, are major metabolites of intestinal microorganisms and play an essential role in regulating intestinal epithelial integrity. Heat shock proteins (HSPs) promote cellular homeostasis under physiological and stressed conditions. This study aimed to investigate the regulation of intestinal HSP70 by propionate in human intestinal Caco-2 cells and the colon of fermentable dietary fiber (DF)-fed mice and germ-free mice. The results showed that propionate increased Hspa1a (HSP70 mRNA) level in Caco-2 cells, upregulated HSP70 protein, and phosphorylation of heat shock factor 1; however, the latter two were reduced by mitogen-activated protein kinases and the mechanistic target of rapamycin inhibitors...
July 22, 2021: Journal of Agricultural and Food Chemistry
Jinghong Li, Xiaojun Ren, Ruijie Deng, Kaixiang Zhang, Yupeng Sun, Yue Li
N 6 -methyladenosine (m 6 A) modification - the most prevalent mammalian RNA internal modification - plays key regulatory roles in mRNA metabolism. Current approaches for m 6 A modified RNA analysis limit at bulk-population level, resulting in a loss of spatiotemporal and cell-to-cell variability information. Here we proposed a m 6 A-specific in situ hybridization mediated proximity ligation assay (m 6 AISH-PLA) for cellular imaging of m 6 A RNA, allowing to identify m 6 A modification at specific location in RNAs and image m 6 A RNA with single-cell and single-molecule resolution...
July 21, 2021: Angewandte Chemie
Aysel Cetinkaya-Fisgin, Jing Zhu, Xinghua Luan, Jun-Soon Kim, Byoungchol Oh, Cory Brayton, Jesse Alt, Rana Rais, Barbara Slusher, Ahmet Höke
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and often dose-limiting side effect of many cancer drugs. Because the onset of neuronal injury is known, it is an ideal clinical target to develop neuroprotective strategies. Several years ago, we had identified ethoxyquin as a potent neuroprotective drug against CIPN through a phenotypic drug screening and demonstrated a novel mechanism of action, inhibition of chaperone domain of heat shock protein 90. To improve its drug-like properties we synthesized a novel analogue of ethoxyquin and named it EQ-6 (6-(5-amino)-ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline hydrochloride)...
July 21, 2021: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
Yanpeng Shang, Yi Tian, Yan Wang, Ran Guo
Salinity fluctuations have severe impacts on sea cucumbers and therefore important consequences in sea cucumber farming. The responses of sea cucumbers to salinity changes are reflected in the expression profiles of multiple genes and non-coding RNAs (ncRNAs). The microRNA (let-7) which is a developmental regulator, the ion transporter gene sodium potassium ATPase gene (NKAα), and the long ncRNA lncRNA001074 were previously shown to be involved in responses to salinity changes in various marine species. To better understand the relationship between ncRNAs and target genes, the let-7/NKAα/lncRNA001074 predicted interaction was investigated in this study using luciferase reporter assays and gene knockdowns in the sea cucumber Apostichopus japonicus...
July 21, 2021: Cell Stress & Chaperones
Saqib Mehdi, Munawar Shah, Najam Abbas Naqvi
Global Navigation Satellite System (GNSS)-based Earthquake (EQ) anomalies in the ionosphere and troposphere provide explicit evidences to study the coupling between seismic events, atmosphere, and ionosphere in epicentral breeding regions consequent to the EQ day in the preparation period. EQs are still not predicted, but the space-based EQ anomalies aid in the development of monitoring pre- and post-seismic precursors around the seismogenic zone and associated fault lineament regions. In this paper, tropospheric and ionospheric anomalies are investigated for the July 06, 2019, Mw 7...
July 22, 2021: Environmental Monitoring and Assessment
Athanasia Mitropoulou, Hendrik Lehmann, Evelyn M Heier, Matthias Schneider, Esther Hassdenteufel
A 4-year-old female Boxer was referred for renal replacement therapy 2 days after observed grape ingestion. An 11-French dual-lumen dialysis catheter was placed into the right jugular vein and continuous renal replacement therapy was initiated for 66 h. Afterwards the patient received enoxaparin subcutaneously as a thromboprophylaxis. Four hours after removal of the dialysis catheter the patient developed severe dyspnea with hypercapnia and signs of hemorrhagic shock. Bedside ultrasound and X-rays of the thorax revealed a soft tissue opacity dorsally of the trachea, located in the mediastinum...
2021: Frontiers in Veterinary Science
Juan Niu, Zhimin Sun, Yaliang Shi, Kunyong Huang, Yicheng Zhong, Jing Chen, Jianhua Chen, Mingbao Luan
Owing to its medicinal and high nutritional values, Akebia trifoliata can be considered as a new type of medicinal and edible homologous resources, and it has begun to be widely cultivated in many areas of China. Over-softening of fruit would affect the sensorial quality, utilization rate, and consumer acceptance of the fruit postharvest. However, fruit softening has not been characterized and the molecular mechanism underlying A. trifoliata fruit softening during ripening remains unclear. A comparative proteomic analysis was performed on the fruit at three developmental stages using tandem mass tag technology...
2021: Frontiers in Nutrition
Longxiang Su, Zheng Xu, Fengxiang Chang, Yingying Ma, Shengjun Liu, Huizhen Jiang, Hao Wang, Dongkai Li, Huan Chen, Xiang Zhou, Na Hong, Weiguo Zhu, Yun Long
Background: Early prediction of the clinical outcome of patients with sepsis is of great significance and can guide treatment and reduce the mortality of patients. However, it is clinically difficult for clinicians. Methods: A total of 2,224 patients with sepsis were involved over a 3-year period (2016-2018) in the intensive care unit (ICU) of Peking Union Medical College Hospital. With all the key medical data from the first 6 h in the ICU, three machine learning models, logistic regression, random forest, and XGBoost, were used to predict mortality, severity (sepsis/septic shock), and length of ICU stay (LOS) (>6 days, ≤ 6 days)...
2021: Frontiers in Medicine
Zieratsho Kadyrov, Vladimir Stepanov, Emilbek Aldyrakov, Shota Ramishvili
Background: We present here the first case of Cowper's gland abscess complicated by septic shock and breakthrough of the abscess into the paraurethral region, cavernous body, scrotum, and pararectal tissue. Case Presentation: A 63-year-old patient was admitted with complaints of temperature increase up to 39°C, pain and enlargement of the perineum and the right half of the scrotum, frequent and difficulty urination, weakness, dizziness, dry mouth, and a sharp deterioration of the general condition...
2021: Research and Reports in Urology
Fred N Qafiti, David Rubay, Rebecca Shin, Lawrence Lottenberg, Robert Borrego
Trauma by electricity imposes mechanical, electrical, and thermal forces on the human body. Often, the delicate cardiac electrophysiology is disrupted causing dysrhythmia and subsequent cardiac arrest. Anoxic brain injury (ABI) is the most severe consequence and the main cause of mortality following cardiac arrest. Establishing a working protocol to treat patients who are at risk for ABI after suffering a cardiac arrest is of paramount importance. There has yet to be sufficient exploration of combination therapy of therapeutic hypothermia (TH) and progesterone as a neuroprotective strategy in patients who have suffered cardiac arrest after electric shock...
June 2021: Curēus
Amr Mohamed
Stress cardiomyopathy is typically a diagnosis of exclusion after appropriate rule out of other etiologies of ventricular dysfunction. It most commonly affects the left ventricle (LV). It rarely affects the right ventricle (RV) alone. Here we present a rare clinical dilemma in the setting of cardiac arrest, which occurred in the setting of a stressful event where the final diagnosis ended up being right ventricular takotsubu cardiomyopathy.
June 2021: Curēus
Osama Haddad, Samuel Jacob, Ryan L Ung, Rohan M Goswami, Parag C Patel, Si M Pham, Basar Sareyyupoglu
Axillary Impella devices are increasingly employed for long-term support of patients with systolic heart failure and shock. Axillary access allows for awake support and ambulation, which carries an inherent risk of disconnection or malposition. We report a series of two cases where device replacement due to dysfunction and malposition can be completed safely through the original axillary graft using axillary graft thrombectomy, given that the clot burden could be a major source of morbidity to the patient.
2021: SAGE Open Medical Case Reports
Daisuke Hara, Tomoka Hamahiro, Ryo Maeda, Takanori Ayabe, Masaki Tomita
We report a rare case of pulmonary torsion after nonpulmonary thoracotomy. A 38-year-old woman with schizophrenia committed suicide by a self-infliction of sharp force into the chest and abdomen. During emergent abdominal damage control surgery, a left-sided resuscitative thoracostomy was also performed due to hemorrhagic shock. Although abnormal shadow was detected on postoperative chest roentgenogram and computed tomography, the diagnosis of pulmonary torsion was delayed. Seven days after initial surgery, pulmonary torsion was diagnosed and managed by left upper lobectomy...
July 2021: Journal of Surgical Case Reports
Marium Sohail, Rahila Yasmeen
Objectives: To explore experiences of medical residents about stages and nature of transitional journey from induction into residency program to achievement of consultant title. Methods: Qualitative phenomenological study was conducted at Sir Gangaram hospital and Fatima Memorial Hospital, Lahore for six months from Feb 2019-July 2019 after IRB/ERC approval from Islamic International Medical College (Ref# Riphah/IIMC/ERC/19/0320). Using purposive criterion sampling, 16 semi-structured interviews in four departments, four strata of junior residents, senior residents, newly-qualified consultants, and supervising consultants with four participants each were conducted till theoretical saturation of data was achieved...
July 2021: Pakistan Journal of Medical Sciences Quarterly
Jean-François Llitjos, Yacine Bounab, Christophe Rousseau, Sophie Dixneuf, Blandine Rimbault, Jean-Daniel Chiche, Julien Textoris, Frédéric Pène, Christophe Védrine
Objective: The development of advanced single-cell technologies to decipher inter-cellular heterogeneity has enabled the dynamic assessment of individual cells behavior over time, overcoming the limitation of traditional assays. Here, we evaluated the feasibility of an advanced microfluidic assay combined to fluorescence microscopy to address the behavior of circulating monocytes from septic shock patients. Methods: Seven septic shock patients and ten healthy volunteers were enrolled in the study...
2021: Frontiers in Immunology
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