Dingase Mkandawire, Sika Gbegbelegbe, Justus V Nsenga, Mastewal Yami, Edwin Kenamu
The study aims to analyse key determinants of urban and peri-urban youth employment in agribusiness in Malawi to support youth policies. A mixed-methods approach is used, which combines both quantitative and qualitative analyses. The quantitative method involved a Bivariate Logit Model and Multinomial Logit Model to analyse nationally representative survey data from the Fourth Integrated Household Survey in 2016-2017. The qualitative method employed thematic analysis to data generated through Focus Group Discussions and Key Informant Interviews for key stakeholders involved in agri-business in Lilongwe district...
2023: PloS One
Sherko Subhan Niranji, Sirwan M A Al-Jaf
Toll-like receptors (TLRs) are cellular innate immune receptors that explore microbial molecules. For instance, TLR4 can sense bacterial lipopolysaccharides, inducing cytokines and antimicrobial peptides against the bacteria. Single-nucleotide polymorphisms (SNPs) in TLR4 are associated with diseases such as septic shock. Therefore, investigations of common SNPs may help explain the pathogenesis of diseases and various innate immune responses to infections. This study investigated genotypic frequencies of the two common TLR4 SNPs, Asp299Gly and Thr399Ile, in a Kurdish population using restriction length fragment polymorphisms (RFLPs)...
September 2023: Human Biology
Lorrie K Hale Mitchell, Ronald B Koh, Javier G Nevarez
A 2-year-old female eclectus parrot ( Eclectus roratus ) was presented for suspected cervical myopathy due to trauma. Severe ventroflexion of the cervical spine and mental depression were identified during the physical examination. The bird was responsive to stimuli but otherwise quiet. Plasma biochemistry results were suggestive of a myopathy, based on marked elevations of both aspartate transaminase (25 652 U/L) and creatine kinase (253 240 U/L). Whole-body radiographic images were unremarkable. Treatment was initiated with supportive therapy for presumptive shock, dehydration, pain, myopathy, and possible spinal swelling...
September 2023: Journal of Avian Medicine and Surgery
Marco Loffi, Silvia Frattini, Marta Mazzotta, Chiara Bernelli, Gian B Danzi
No abstract text is available yet for this article.
September 21, 2023: Minerva cardiology and angiology
David G Valcarce, Marta F Riesco, Juan Manuel Martínez-Vázquez, José Luis Rodríguez Villanueva, Vanesa Robles
Aquaculture routine practices may cause stress induction on the fish and compromise their welfare affecting the production. This experiment aimed to evaluate the potential links between handling during culture with stress responses and growth on Senegalese sole (Solea senegalensis). We worked with two fish cohorts in terms of initial body weight and culture stage: Trial 1 included specimens in the fattening stage (226 ± 4.96 g) and Trial 2 animals in the pre-fattening stage (27.20 ± 0.44 g). The tested culture protocol, which lasted 6 and 4 months for Trial 1 and 2, respectively, mainly reduced handling-derived stressors in the experimental tanks via lowering routine samplings to a minimum...
September 21, 2023: Fish Physiology and Biochemistry
Haixin Huang, Jian Chen, Hongxing Dang, Chengjun Liu, Junming Huo, Yue-Qiang Fu
UNLABELLED: The therapeutic efficacy of intravenous immuneglobulin (IVIG) on children with septic shock remains uncertain. Therefore, we endeavored to investigate the impact of administering intravenous immunoglobulin (IVIG) in the pediatric intensive care unit (PICU) on patient with septic shock. We retrospectively analyzed the data of children admitted to the PICU due to septic shock from January 2017 to December 2021 in a tertiary pediatric hospital. The main outcome was in-hospital mortality...
September 21, 2023: European Journal of Pediatrics
Ruoxi Zhao, Yanlin Zhu, Lili Feng, Bin Liu, Yaoyu Hu, Haixia Zhu, Zhiyu Zhao, He Ding, Shili Gai, Piaoping Yang
Taking the significance of the special microenvironment for tumor cell survival into account, disrupting tumor redox homeostasis is highly prospective for improving therapeutic efficacy. Herein, a multifunctional two-dimensional vanadium-based MXene nanoplatform, V4 C3 /atovaquone@bovine albumin (V4 C3 /ATO@BSA, abbreviated as VAB) has been elaborately constructed for ATO-enhanced nanozyme catalytic/photothermal therapy. The redox homeostasis within the tumor cells has eventually been disrupted, showing a remarkable anti-tumor effect...
September 21, 2023: Advanced Materials
Hong Thi Bich Truong, Ha Manh Bui
This investigation is a review of the potential of aerobic granular sludge membrane bioreactor (AGMBR) in wastewater treatment due to the advantage of combination of membrane and aerobic granules for reducing membrane fouling and enhancing removal performance. The AGMBR is the same as the membrane bioreactor (MBR), but the activated sludge is replaced by aerobic granular sludge. This technology combines the advantages of aerobic granular sludge, such as good settleability, strong ability to withstand shock-loadings and high organic loading rate, and capacity of simultaneous chemical oxygen demand (COD) and nitrogen removal, and advantages of membrane bioreactor (MBR) such as excellent effluent quality, high biomass content, low excess sludge production, and small land requirement...
December 2023: Bioengineered
Laura Romeu Gordo, Julia Simonson, Alberto Lozano Alcántara
Despite major restrictions on economic activity due to the first lockdown starting in March 2020, public financial support helped to limit the financial consequences of the COVID-19 pandemic in Germany. However, certain groups were more affected than others. Most significantly, people in the lowest income quintile were more affected than those who had higher levels of income prior to the pandemic. Although this aspect has also been analyzed in other studies, less is known about how income shocks affected living standards...
September 21, 2023: Journal of Aging & Social Policy
Jerome W Breslin
Resolution of edema remains a significant clinical challenge. Conditions such as traumatic shock, sepsis, or diabetes often involve microvascular hyperpermeability, which leads to tissue and organ dysfunction. Lymphatic insufficiency due to genetic causes, surgical removal of lymph nodes, or infections, leads to varying degrees of tissue swelling that impair mobility and immune defenses. Treatment options are limited to management of edema as there are no specific therapeutics that have demonstrated significant success for ameliorating microvascular leakage or impaired lymphatic function...
September 27, 2023: Clinical Science (1979-)
Zhitao Chen, Peipei Li, Lingguang Shen, Xiuyu Jiang
In the present study, it was aimed to investigate the effects and potential mechanisms of heat shock protein B7 (HSPB7) on lung adenocarcinoma (LUAD). Bioinformatic analysis was performed to explore the association between HSPB7 expression and patients with LUAD. MTT, colony formation, wound healing and Transwell assays were performed to examine the proliferative, migratory and invasive abilities of H1975 and A549 cells. Western blot analysis was conducted to determine the corresponding protein expression. Co‑Immunoprecipitation and Chromatin immunoprecipitation assays were carried out to reveal the interaction between HSPB7 and myelodysplastic syndrome 1 and ecotropic viral integration site 1 complex locus (MECOM)...
November 2023: Oncology Reports
Nina Reinhardt, Christoph Schmitz, Stefan Milz, Matías de la Fuente
OBJECTIVES: Focused ultrasound is mainly known for focal ablation and localized hyperthermia of tissue. During the last decade new treatment options were developed for neurological indications based on blood-brain-barrier opening or neuromodulation. Recently, the transcranial application of shock waves has been a subject of research. However, the mechanisms of action are not yet understood. Hence, it is necessary to know the energy that reaches the brain during the treatment and the focusing characteristics within the tissue...
September 21, 2023: Biomedizinische Technik. Biomedical Engineering
Lifeng Zhou, Hu Xiaosan, Chen Jian, Shanping Wang
A 42-year-old male patient experienced hemorrhagic shock after endotracheal intubation. Emergency gastroscopy showed no upper gastrointestinal bleeding, but active tracheal bleeding. After sedation, the tracheal bleeding was successfully stopped with gastroscopy. Post-intubation airway bleeding is a rare but fatal adverse event, and finding the exact bleeding site and quickly stopping the bleeding is the key to successful treatment.
September 21, 2023: Revista Española de Enfermedades Digestivas
Khadijah Shanazz, Rebecca Nalloor, Almira Vazdarjanova
INTRODUCTION: Anxiety and anxiety-influenced disorders are sexually dimorphic with women being disproportionately affected compared to men. Given the increased prevalence in women and the documented differences in anxiety and trauma behavior between male and female rats this paper sought to examine the link between stress, anxiety, and fear learning and extinction in female rats. We tested the hypothesis that a mild stressor will induce short-and long-term increases in anxiety and produce long term effects on subsequent fear learning and extinction behavior...
2023: Frontiers in Behavioral Neuroscience
Daisuke Usuda, Masashi Kato, Yuto Sugawara, Runa Shimizu, Tomotari Inami, Shiho Tsuge, Riki Sakurai, Kenji Kawai, Shun Matsubara, Risa Tanaka, Makoto Suzuki, Shintaro Shimozawa, Yuta Hotchi, Ippei Osugi, Risa Katou, Sakurako Ito, Kentaro Mishima, Akihiko Kondo, Keiko Mizuno, Hiroki Takami, Takayuki Komatsu, Jiro Oba, Tomohisa Nomura, Manabu Sugita
BACKGROUND: Coronavirus disease 2019 (COVID-19)-associated invasive pulmonary aspergillosis presents a diagnostic challenge due to its non-specific clinical/ imaging features, as well as the fact that the proposed clinically diagnostic algorithms do not necessarily apply to COVID-19 patients. In addition, Fusarium spp . is a rare cause of opportunistic life-threatening fungal infections. Disseminated Fusarium infection in an immunocompromised host is intractable, with a high likelihood of resulting mortality...
September 16, 2023: World Journal of Clinical Cases
Juan Wang, Shu-Run Wei, Tong Ding, Li-Ping Zhang, Zhi-Hua Weng, Ming Cheng, Yang Zhou, Meng Zhang, Fang-Jun Liu, Bei-Bei Yan, Dan-Feng Wang, Ming-Wen Sun, Wei-Xin Cheng
BACKGROUND: The mortality rate from septic shock in patients with hematological malignancies (HMs) remains significantly higher than that in patients without HMs. A longer resuscitation time would definitely be harmful because of the irreversibly immunocompromised status of the patients. Shortening the resuscitation time through continuous renal replacement therapy (CRRT) with oXiris® would be an attractive strategy in managing such patients. AIM: To explore the effects of CRRT and oXiris® in shortening the resuscitation time and modifying the host response by reducing inflammation mediator levels...
September 16, 2023: World Journal of Clinical Cases
Sungwoo Park, Eun Jeong Jeong, Jung Hun Kang, Gyeong-Won Lee, Se-Il Go, Dong-Hyun Lee, Eun-Ha Koh
BACKGROUND: Mixed-phenotype acute leukemia (MPAL) is characterized by acute undifferentiated leukemia with blasts co-expressing myeloid and lymphoid antigens. However, consensus regarding the ideal management strategy for MPAL is yet to be established, owing to its rarity. CASE SUMMARY: A 55-year-old male was diagnosed with T/myeloid MPAL. Vincristine, prednisolone, daunorubicin, and L-asparaginase were administered as induction chemotherapy. Septic shock occurred 10 days after induction, and bone marrow examination following recovery from sepsis revealed refractory disease...
September 16, 2023: World Journal of Clinical Cases
Miloud Cherbi, Eric Bonnefoy, Nicolas Lamblin, Edouard Gerbaud, Laurent Bonello, François Roubille, Bruno Levy, Sebastien Champion, Pascal Lim, Francis Schneider, Meyer Elbaz, Hadi Khachab, Jeremy Bourenne, Marie-France Seronde, Guillaume Schurtz, Brahim Harbaoui, Gerald Vanzetto, Nicolas Combaret, Vincent Labbe, Benjamin Marchandot, Benoit Lattuca, Caroline Biendel-Picquet, Guillaume Leurent, Etienne Puymirat, Philippe Maury, Clément Delmas
BACKGROUND: Cardiogenic shock (CS) is the most severe form of heart failure (HF), resulting in high early and long-term mortality. Characteristics of CS secondary to supraventricular tachycardia (SVT) are poorly reported. Based on a large registry of unselected CS, we aimed to compare 1-year outcomes between SVT-triggered and non-SVT-triggered CS. METHODS: FRENSHOCK is a French prospective registry including 772 CS patients from 49 centers. For each patient, the investigator could report 1-3 CS triggers from a pre-established list (ischemic, mechanical complications, ventricular/supraventricular arrhythmia, bradycardia, iatrogenesis, infection, non-compliance, and others)...
2023: Frontiers in Cardiovascular Medicine
Stefan Weiss, Silva Holtfreter, Tanja C Meyer, Frieder Schmiedeke, Clemens Cammann, Marcus Dörr, Stephan B Felix, Hans J Grabe, Georg Homuth, Christian Kohler, Cedric Mahncke, Stephan Michalik, Matthias Nauck, Nele Friedrich, Stefanie Samietz, Henry Völzke, Uwe Völker, Barbara M Bröker
Life-threatening toxic shock syndrome is often caused by the superantigen toxic shock syndrome toxin-1 (TSST-1) produced by Staphylococcus aureus . A well-known risk factor is the lack of neutralizing antibodies. To identify determinants of the anti-TSST-1 antibody response, we examined 976 participants of the German population-based epidemiological Study of Health in Pomerania (SHIP-TREND-0). We measured anti-TSST-1 antibody levels, analyzed the colonization with TSST-1-encoding S. aureus strains, and performed a genome-wide association analysis of genetic risk factors...
2023: Frontiers in Immunology
Judit M Veres, Zsuzsanna Fekete, Kinga Müller, Tibor Andrasi, Laura Rovira-Esteban, Bence Barabas, Orsolya I Papp, Norbert Hajos
Inhibitory circuits in the basal amygdala (BA) have been shown to play a crucial role in associative fear learning. How the excitatory synaptic inputs received by BA GABAergic interneurons are influenced by memory formation, a network parameter that may contribute to learning processes, is still largely unknown. Here, we investigated the features of excitatory synaptic transmission received by the three types of perisomatic inhibitory interneurons upon cue-dependent fear conditioning and aversive stimulus and tone presentations without association...
2023: Frontiers in Cellular Neuroscience
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