Jiasheng Yin, Rui Wang, Han Chen, Hao Lu, Zhuoran Yang, Fei Xu, Tongtong Zang, Chengpeng Liu, Li Shen, Junbo Ge
OBJECTIVES: In this study, we aimed to investigate the vascular response to an intravascular lithotripsy (IVL) shockwave balloon in a healthy porcine coronary artery model. BACKGROUND: IVL is a novel clinical technique for modifying heavily calcified atherosclerotic plaques. METHODS: A total of 24 porcine coronary arteries were treated with IVL or plain old balloon angioplasty (POBA). Histology, histomorphometry, quantitative coronary angiography analysis (QCA), and optical coherence tomography (OCT) were performed postprocedure and at 1-month follow-up (1M-FU)...
March 19, 2023: Catheterization and Cardiovascular Interventions
Jiake Li, Yishuo Jiang, Mengmeng Zhai, Jiayu Gao, Yutong Yao, Yafang Li
Urban vulnerability is evident when highly complex flood risks overlap with diverse cities, and it is important to enhance the resilience of cities to flood shocks. In this study, a sponge city resilience assessment system is established considering engineering, environmental and social indicators, and the grey relational analysis method (GRA) is used to quantify sponge city resilience. At the same time, a multi-objective optimization model is established based on the three dimensions of water ecological environment, drainage safety, and waterlogging safety...
March 18, 2023: Environmental Science and Pollution Research International
Zulfiqar Ali, Yang Jianzhou, Amjad Ali, Jamal Hussain
In this study, the effects of financial inclusion (FI), agricultural innovation (AI), trade (TR), and forest rent (FR) on carbon dioxide emissions (CO2 ), economic growth (Y), and ecological footprint (EFP) for Pakistan from 1970 to 2017 are examined using symmetric and asymmetric cointegration approaches. These links are investigated using linear and non-linear autoregressive distributive lag (NARDL) techniques. In contrast to the asymmetry results, the symmetric results revealed no cointegration among the variables over the long run...
March 18, 2023: Environmental Science and Pollution Research International
N Patel, M A Johnson, N Vapniarsky, M W Van Brocklin, T K Williams, S T Youngquist, R Ford, N Ewer, L P Neff, G L Hoareau
ischemia-reperfusion injury (IRI) after hemorrhage is potentiated by aortic occlusion or resuscitative endovascular balloon occlusion of the aorta (REBOA). Given the central role of mitochondrial injury in shock, we hypothesized that Elamipretide, a peptide that protects mitochondria, would mitigate IRI after hemorrhagic shock and REBOA. Twelve pigs were subjected to hemorrhagic shock and 45 min of REBOA. After 25 min of REBOA, animals received either saline or Elamipretide. Animals were transfused with autologous blood during balloon deflation, and pigs were resuscitated with isotonic crystalloids and norepinephrine for 4...
March 18, 2023: Scientific Reports
Andre Mu, William P Klare, Sarah L Baines, C N Ignatius Pang, Romain Guérillot, Nichaela Harbison-Price, Nadia Keller, Jonathan Wilksch, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Bernhard Keller, Brunda Nijagal, Dedreia Tull, Saravanan Dayalan, Hwa Huat Charlie Chua, Dominik Skoneczny, Jason Koval, Abderrahman Hachani, Anup D Shah, Nitika Neha, Snehal Jadhav, Sally R Partridge, Amanda J Cork, Kate Peters, Olivia Bertolla, Stephan Brouwer, Steven J Hancock, Laura Álvarez-Fraga, David M P De Oliveira, Brian Forde, Ashleigh Dale, Warasinee Mujchariyakul, Calum J Walsh, Ian Monk, Anna Fitzgerald, Mabel Lum, Carolina Correa-Ospina, Piklu Roy Chowdhury, Robert G Parton, James De Voss, James Beckett, Francois Monty, Jessica McKinnon, Xiaomin Song, John R Stephen, Marie Everest, Matt I Bellgard, Matthew Tinning, Michael Leeming, Dianna Hocking, Leila Jebeli, Nancy Wang, Nouri Ben Zakour, Serhat A Yasar, Stefano Vecchiarelli, Tonia Russell, Thiri Zaw, Tyrone Chen, Don Teng, Zena Kassir, Trevor Lithgow, Adam Jenney, Jason N Cole, Victor Nizet, Tania C Sorrell, Anton Y Peleg, David L Paterson, Scott A Beatson, Jemma Wu, Mark P Molloy, Anna E Syme, Robert J A Goode, Adam A Hunter, Grahame Bowland, Nicholas P West, Marc R Wilkins, Steven P Djordjevic, Mark R Davies, Torsten Seemann, Benjamin P Howden, Dana Pascovici, Sonika Tyagi, Ralf B Schittenhelm, David P De Souza, Malcolm J McConville, Jonathan R Iredell, Stuart J Cordwell, Richard A Strugnell, Timothy P Stinear, Mark A Schembri, Mark J Walker
Even in the setting of optimal resuscitation in high-income countries severe sepsis and septic shock have a mortality of 20-40%, with antibiotic resistance dramatically increasing this mortality risk. To develop a reference dataset enabling the identification of common bacterial targets for therapeutic intervention, we applied a standardized genomic, transcriptomic, proteomic and metabolomic technological framework to multiple clinical isolates of four sepsis-causing pathogens: Escherichia coli, Klebsiella pneumoniae species complex, Staphylococcus aureus and Streptococcus pyogenes...
March 18, 2023: Nature Communications
Jefferson A Proaño-Zamudio, Dias Argandykov, Anthony Gebran, Angela Renne, Charudutt N Paranjape, Stephanie J Maroney, Louisa Onyewadume, Haytham M A Kaafarani, David R King, George C Velmahos, John O Hwabejire
INTRODUCTION: Elderly patients are frequently presenting with emergency surgical conditions. The open abdomen technique is widely used in abdominal emergencies needing rapid control of intrabdominal contamination. However, specific predictors of mortality identifying candidates for comfort care are understudied. METHODS: The 2013-2017 the American College of Surgeons-National Surgical Quality Improvement Program database was queried for emergent laparotomies performed in geriatric patients with sepsis or septic shock in whom fascial closure was delayed...
March 16, 2023: Journal of Surgical Research
Xin-Yu Shen, Jing-Mei Lu, Yu-Nan Lu, Guang-Nan Jin, Jing-Wen Ma, Jing-He Wang, Yu Wang, Xiang Xu, Lian-Xun Piao
Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite that causes pulmonary toxoplasmosis, although its pathogenesis is incompletely understood. There is no cure for toxoplasmosis. Coixol, a plant polyphenol extracted from coix seeds, has a variety of biological activities. However, the effects of coixol on T. gondii infection have not been clarified. In this study, we infected a mouse macrophage cell line (RAW 264.7) and BALB/c mice with the T. gondii RH strain to establish infection models in vitro and in vivo, respectively, to explore protective effects and potential mechanisms of coixol on lung injury caused by T...
March 16, 2023: International Immunopharmacology
Yong Cao, Li Shao, Lianyun Wang, Kai Su, Dong Zhang, Yilin Xie, Qing Zheng, Yanhua Xu, Hui Lu, Mei Xin, Zhongdong Qiao, Yinshi Guo
AIMS: In recent decades, Cinnamomum camphora have gradually become the main street trees in Shanghai. This study aims to investigate the allergenicity of camphor pollen. MAIN METHODS: A total of 194 serum samples from patients with respiratory allergy were collected and analyzed. Through protein profile identification and bioinformatics analysis, we hypothesized that heat shock cognate protein 2-like protein (HSC70L2) is the major potential allergenic protein in camphor pollen...
March 16, 2023: Molecular Immunology
Holly C Armstrong, Debbie J F Russell, Simon E W Moss, Paddy Pomeroy, Kimberley A Bennett
Life-history-oxidative stress theory predicts that elevated energy costs during reproduction reduce allocation to defences and increase cellular stress, with fitness consequences, particularly when resources are limited. As capital breeders, grey seals are a natural system in which to test this theory. We investigated oxidative damage (malondialdehyde (MDA) concentration) and cellular defences (relative mRNA abundance of heat shock proteins (Hsps) and redox enzymes (REs)) in blubber of wild female grey seals during the lactation fast (n = 17) and summer foraging (n = 13)...
March 18, 2023: Cell Stress & Chaperones
Claudio Iovino, Clemente Maria Iodice, Danila Pisani, Andrea Rosolia, Francesco Testa, Giuseppe Giannaccare, Jay Chhablani, Francesca Simonelli
Yellow subthreshold micropulse laser (YSML) is a retinal laser capable of inducing a biologic response without causing thermal damage to the targeted tissue. The 577-nm YSML is delivered to the retina abiding by different protocols in which wavelength, power, duration, spot size and number of spots can be properly set to achieve the most effective and safe treatment response in various chorioretinal disorders. The ultrashort trains of power modulate the activation of the retinal pigment epithelium cells and intraretinal cells, such as Müller cells, causing no visible retinal scars...
March 18, 2023: Ophthalmology and Therapy
Felipe A Carvalho, Ulrich Mühlenhoff, Joseph J Braymer, Vasilij Root, Martin Stümpfig, Carla C Oliveira, Roland Lill
Systematic studies have revealed interactions between components of the Hsp90 chaperone system and Fe/S protein biogenesis or iron regulation. In addition, two chloroplast-localized DnaJ-like proteins, DJA5 and DJA6, function as specific iron donors in plastidial Fe/S protein biogenesis. Here, we used Saccharomyces cerevisiae to study the impact of both the Hsp90 chaperone and the yeast DJA5-DJA6 homologs, the essential cytosolic Ydj1 and the mitochondrial Mdj1, on cellular iron-related processes. Despite severe phenotypes induced upon depletion of these crucial proteins, there was no critical in vivo impact on Fe/S protein biogenesis or iron regulation...
March 18, 2023: FEBS Letters
Silver Heinsar, Nicole Bartnikowski, Gunter Hartel, Samia M Farah, E-Peng Seah, Eric Wu, Sebastiano Maria Colombo, Clayton Semenzin, Andrew Haymet, Indrek Rätsep, Jo Pauls, John F Fraser, Jacky Y Suen
OBJECTIVE: Pulsatile-flow veno-arterial extracorporeal membrane oxygenation (V-A ECMO) has shown encouraging results for microcirculation resuscitation and left ventricle unloading in patients with refractory cardiogenic shock. We aimed to comprehensively assess different V-A ECMO parameters and their contribution to hemodynamic energy production and transfer through the device circuit. METHODS: We used the i-cor® ECMO circuit, which comprised of Deltastream DP3 diagonal pump and i-cor® console (Xenios AG), the Hilite 7000 membrane oxygenator (Xenios AG), venous and arterial tubing and a 1L soft venous pseudo-patient reservoir...
March 18, 2023: Artificial Organs
Mohammad Javad Soleimani, Hossein Shahrokh, Vahid Vahedi Soraki, Vahid Fakhar, Mohammad Ali Ghaed, Behzad Narouie
OBJECTIVE: Extracorporeal shock wave lithotripsy (ESWL) is one of the most important methods of treatment for stone in children. Therefore, this study was conducted to determine the success rate of ESWL in the treatment of kidney and ureteral stones in children referred to Hasheminejad kidney center during the second half of 2018. PATIENTS AND METHODS: This observational prospective study was conducted on 144 children referred to Hasheminejad kidney center during the 2018...
March 18, 2023: Urologia
James Yang, Aakash Trivedi, Jamshed Zuberi
Tension pneumothorax is a condition that can present with a myriad of symptoms, including chest pain, shortness of breath, rapid breathing, and tachycardia. If left untreated, these signs and symptoms can progress to shock causing haemodynamic collapse and even death. At times, it may be difficult to identify tension pneumothorax. We present the case of a 59-year-old male with a prolonged initial hospital course that eventually led to a diagnosis of tension pneumothorax with the use of CT scans rather than traditional X-rays...
March 2023: JPMA. the Journal of the Pakistan Medical Association
Roberto Rordorf, Stefano Viani, Mauro Biffi, Paolo Pieragnoli, Federico Migliore, Antonio D'Onofrio, Gerardo Nigro, Pietro Francia, Paola Ferrari, Antonio Dello Russo, Antonio Bisignani, Luca Ottaviano, Pietro Palmisano, Fabrizio Caravati, Ennio Pisanò, Antonio Pani, Giovanni Luca Botto, Mariolina Lovecchio, Sergio Valsecchi, Alessandro Vicentini
AIMS: In subcutaneous implantable cardioverter defibrillator (S-ICD) recipients, the UNTOUCHED study demonstrated a very low inappropriate shock rate on programming a conditional zone between 200 and 250 bpm and a shock zone for arrhythmias >250 bpm. The extent to which this programming approach is adopted in clinical practice is still unknown, as is its impact on the rates of inappropriate and appropriate therapies. METHODS AND RESULTS: We assessed ICD programming on implantation and during follow-up in a cohort of 1468 consecutive S-ICD recipients in 56 Italian centres...
March 18, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
R W Paddock, M W von der Leyen, R Aboushelbaya, P A Norreys, D J Chapman, D E Eakins, M Oliver, R J Clarke, M Notley, C D Baird, N Booth, C Spindloe, D Haddock, S Irving, R H H Scott, J Pasley, M Cipriani, F Consoli, B Albertazzi, M Koenig, A S Martynenko, L Wegert, P Neumayer, P Tchórz, P Rączka, P Mabey, W Garbett, R M N Goshadze, V V Karasiev, S X Hu
Wetted-foam layers are of significant interest for inertial-confinement-fusion capsules, due to the control they provide over the convergence ratio of the implosion and the opportunity this affords to minimize hydrodynamic instability growth. However, the equation of state for fusion-relevant foams are not well characterized, and many simulations rely on modeling such foams as a homogeneous medium with the foam average density. To address this issue, an experiment was performed using the VULCAN Nd:glass laser at the Central Laser Facility...
February 2023: Physical Review. E
Zhaoli Guo, Jiequan Li, Kun Xu
The kinetic theory provides a physical basis for developing multiscale methods for gas flows covering a wide range of flow regimes. A particular challenge for kinetic schemes is whether they can capture the correct hydrodynamic behaviors of the system in the continuum regime (i.e., as the Knudsen number ε≪1) without enforcing kinetic scale resolution. At the current stage, the main approach to analyze such a property is the asymptotic preserving (AP) concept, which aims to show whether a kinetic scheme reduces to a solver for the hydrodynamic equations as ε→0, such as the shock capturing scheme for the Euler equations...
February 2023: Physical Review. E
Mikhail Malkov, Martin Lemoine
A shock wave propagating perpendicularly to an ambient magnetic field accelerates particles considerably faster than in the parallel propagation regime. However, the perpendicular acceleration stops after the shock overruns a circular particle orbit. At the same time, it may continue in flows resulting from supersonically colliding plasmas bound by a pair of perpendicular shocks. Although the double-shock acceleration mechanism, which we consider in detail, is not advantageous for thermal particles, preenergized particles may avoid the premature end of acceleration...
February 2023: Physical Review. E
Daniel Pickard, Dmitro Martynowych, Jet Lem, Anwar Koshakji, Shaoting Lin, Xuanhe Zhao, Keith Nelson, Bianca Giovanardi, Raul Radovitzky
Intense surface eruptions are observed along the curved surface of a confined cylindrical film of hydrogel subject to laser-induced converging-diverging shock loading. Detailed numerical simulations are used to identify the dominant mechanisms causing mechanical instability. The mechanisms that produce surface instability are found to be fundamentally different from both acoustic parametric instability and shock-driven Richtmyer-Meshkov instability. The time scale of observed and simulated eruption formation is much larger than that of a single shock reflection, in stark contrast to previously studied shock-driven instabilities...
February 2023: Physical Review. E
Vikram Dharodi, Atul Kumar, Abhijit Sen
A charged body moving in a plasma can excite a variety of linear and nonlinear waves in the form of trailing wakes, fore-wake shocks, and precursor solitons. These structures can further interact with the background plasma to create secondary effects that can serve as signatures of the passage of the charged body. Using particle-in-cell simulations, we carry out a basic investigation of the dynamics of a plasma system that is being traversed by an energetic charged body. Using two different shapes of this charged source, namely, an idealized infinite length planar source and a two-dimensional thin rectangular source, we examine the differences in the nature of the excited wave structures and their consequent impact on the background plasma...
February 2023: Physical Review. E
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