keyword
https://read.qxmd.com/read/32659616/inguinal-lymphadenopathy-as-a-predicting-factor-for-ipsilateral-primary-limb-amputation-after-a-successful-endovascular-treatment
#1
Daniel Raskin, Boris Khaitovich, Shmuel Balan, Daniel Silverberg, Ahmad Abu Rmeileh, Moshe Halak, Uri Rimon
PURPOSE: To assess the correlation between inguinal lymph node characteristics and ipsilateral limb amputation rates in patients with ischemic foot ulcers after a successful endovascular treatment. METHOD: A retrospective review of patients who were endovascularly treated for ischemic foot ulcers between January 2015 and May 2017. Technical success was defined as arterial recanalization with stenosis less than 30 % and ankle brachial index improvement by > 0...
July 1, 2020: European Journal of Radiology
https://read.qxmd.com/read/32659457/crosstalk-between-brain-lung-and-heart-in-critical-care
#2
REVIEW
Ségolène Mrozek, Julie Gobin, Jean-Michel Constantin, Olivier Fourcade, Thomas Geeraerts
Extracerebral complications, especially pulmonary and cardiovascular, are frequent in brain-injured patients and are major determinants of the outcome. Two major pathways have been described: brain-lung and brain-heart interactions. Lung injuries after acute brain damages include ventilator-associated pneumonia (VAP), acute respiratory distress syndrome (ARDS) and neurogenic pulmonary œdema (NPE), whereas heart injuries can range from cardiac enzymes release, ECG abnormalities to left ventricle dysfunction or cardiogenic shock...
July 10, 2020: Anaesthesia, Critical Care & Pain Medicine
https://read.qxmd.com/read/32659307/identification-of-a-novel-host-protein-interacting-with-the-structural-protein-vp2-of-deformed-wing-virus-by-yeast-two-hybrid-screening
#3
Sichao Huang, Dongliang Fei, Yueyv Ma, Chen Wang, Donghui Shi, Kunyang Liu, Ming Li, Mingxiao Ma
Deformed wing virus (DWV) interacting with Varroa destructor is a possible cause of honeybee colony mortality. VP2 is the structural protein of DWV but its function remains unknown. To clarify the function of VP2 and screen for novel binding proteins that interact with VP2, we carried out a membrane protein yeast two-hybrid screening using VP2 as bait. Subsequently, the interaction between VP2 and the host interacting protein [heat shock protein 10 (Hsp10)] was further verified using glutathione S-transferase pull-down assay in vitro and co-immunoprecipitation assay in cells...
July 10, 2020: Virus Research
https://read.qxmd.com/read/32659301/geranylgeranyl-acetone-prevents-glutamate-induced-cell-death-in-ht-22-cells-by-increasing-mitochondrial-membrane-potential
#4
Eriko Sugano, Yuka Endo, Akihisa Sugai, Yuki Kikuchi, Kitako Tabata, Taku Ozaki, Takahiro Kurose, Yoshihiro Takai, Yoko Mistsuguchi, Yoichi Honma, Hiroshi Tomita
Geranylgeranyl acetone (GGA) protects against various types of cell damages by upregulating heat shock proteins. We investigated whether GGA protects neuronal cells from cell death induced by oxidative stress. Glutamate exposure was lethal to HT-22 cells which comprise a neuronal line derived from mouse hippocampus. This configuration is often used as a model for hippocampus neurodegeneration in vitro. In the present study, GGA protected HT-22 cells from glutamate-induced oxidative stress. GGA pretreatment did not induce heat shock proteins (Hsps)...
July 10, 2020: European Journal of Pharmacology
https://read.qxmd.com/read/32659296/comparison-of-simple-and-rapid-cell-wall-disruption-methods-for-improving-lipid-extraction-from-yeast-cells
#5
Anna M Kot, Iwona Gientka, Anna Bzducha-Wróbel, Stanisław Błażejak, Agnieszka Kurcz
The present study examined the effect of six disruption methods of the cell wall (acid hydrolysis, ultrasonication, osmotic shock, pasteurization, homogenization with zirconia balls, and freezing/defrosting) on the efficiency of lipid extraction from yeast cells and the composition of fatty acids. Acid hydrolysis and sonication led to a significant increase in lipid extraction from Cyberlindnera jadinii ATCC 9950 and Rhodotorula glutinis LOCKR13 yeast cells. The amount of lipids extracted in these conditions increased for C...
July 10, 2020: Journal of Microbiological Methods
https://read.qxmd.com/read/32659109/circulating-vitronectin-predicts-liver-injury-and-mortality-in-children-with-sepsis-a-prospective-observational-study
#6
Chunxia Wang, Yun Cui, Huijie Miao, Ting Sun, Ye Lu, Yucai Zhang
Vitronectin (VTN) is a key regulator of coagulation, but clinical relevance of serum VTN in pediatric sepsis remains poorly defined. The aim of this study was to access the value of serum VTN level on pediatric intensive care unit (PICU) admission in children with sepsis. Pediatric patients with sepsis were enrolled from January 2018 to December 2018. The serum VTN levels were determined on PICU admission, and the association of serum VTN level with PICU mortality and organ dysfunction was assessed. Serum VTN levels were significantly lower in nonsurvivors compared with survivors, in patients with septic shock compared with patients with sepsis, or in patients with sepsis-associated acute liver injury (ALI) compared with patients without ALI...
January 2020: Clinical and Applied Thrombosis/hemostasis
https://read.qxmd.com/read/32659088/deciphering-the-inhibition-mechanism-of-under-trial-hsp90-inhibitors-and-their-analogues-a-comparative-molecular-dynamics-simulation
#7
Asma Nazar, Ghulam Abbas, Syed Sikander Azam
Heat shock protein 90 (Hsp90) performs function in cellular activities together with other signaling pathways. Hsp90 is evolutionary conserved and universally articulated as a human cancer-causing agent involves in lung cancer, breast cancer followed by colon and rectum cancer. It emerged as an effective drug candidate and inhibition may affect several signaling pathways associated with cancer spreading. Therefore, in-silico approaches molecular docking, molecular dynamics simulation and binding free energy calculations were applied to have insights into the inhibition mechanism against Hsp90 to identify new cancer therapeutic drugs...
July 13, 2020: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/32658440/early-treatment-with-exosomes-following-traumatic-brain-injury-and-hemorrhagic-shock-in-a-swine-model-promotes-transcriptional-changes-associated-with-neuroprotection
#8
Aaron M Williams, Gerald A Higgins, Umar F Bhatti, Ben E Biesterveld, Simone E Dekker, Ranganath G Kathawate, Yuzi Tian, Zhenyu Wu, Michael T Kemp, Glenn K Wakam, Baoling Liu, Yongqing Li, Benjamin Buller, Hasan B Alam
BACKGROUND: We have shown that administration of mesenchymal stem cell (MSC)-derived exosomes (single dose given within 1 hour) in models of traumatic brain injury (TBI) and hemorrhagic shock (HS) is neuroprotective. The precise mechanisms responsible for the neuroprotection are not fully understood. This study was designed to investigate the transcriptomic changes in the brain that are associated with this treatment strategy. METHODS: Yorkshire swine (40-45 kg) were subjected to a severe TBI (12-mm cortical impact) and HS (40% estimated total blood volume)...
June 3, 2020: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/32657974/clinical-presentation-and-outcome-of-patients-with-spontaneous-coronary-artery-dissection-versus-atherosclerotic-coronary-plaque-dissection
#9
Amin Daoulah, Salem M Al-Faifi, Mina Madan, Amr A Arafat, Ahmad S Hersi, Abdulaziz Alasmari, Francis A Clarkson, Vincent Ball, Abdullah Alkhushail, Abdul Salim Khan, Farhan M Asrar, Ejazul Haq, Mohamed Nabil Alama, Mazen S Faden, Amir Lotfi
BACKGROUND: Atherosclerotic coronary plaque dissection (ACPD) is one cause of acute coronary syndrome caused by underlying atherosclerosis. Spontaneous coronary artery dissection (SCAD) occurs outside the setting of atherosclerosis among young women and individuals with few or no conventional atherosclerotic risk factors, and has emerged as an important cause of acute coronary syndrome, and sudden death. A comparison between ACPD and SCAD has not been previously addressed in the literature...
July 9, 2020: Critical Pathways in Cardiology
https://read.qxmd.com/read/32657912/increasing-confidence-through-the-development-of-a-transition-to-practice-orientation-program-for-the-experienced-nurse
#10
Tiffany Montgomery, Jenny Harshman, Sarah Kennedy, Kendel Richards, Martha Shaw
A formalized orientation program for experienced nurses was modeled after a program for new graduate nurses. Within a year, experienced nurses rotated through teaching stations, including simulations of shock and respiratory failure. Participants completed pre- and postsurveys and scored self-confidence on a Likert scale. Surveys showed a significant increase in participants' confidence related to elements in their new role. Future plans include a retention rate comparison of participants in this program versus nonparticipants...
July 10, 2020: Journal for Nurses in Professional Development
https://read.qxmd.com/read/32657828/extracorporeal-life-support-in-hemorrhagic-conditions-a-systematic-review
#11
Anne Willers, Justyna Swol, Mariusz Kowalewski, Giuseppe Maria Raffa, Paolo Meani, Federica Jiritano, Matteo Matteucci, Dario Fina, Samuel Heuts, Elham Bidar, Ehsan Natour, Jan Willem Sels, Thijs Delnoij, Roberto Lorusso
Extracorporeal life support (ECLS) is indicated in refractory acute respiratory or cardiac failure. According to the need for anticoagulation, bleeding conditions (e.g., in trauma, pulmonary bleeding) have been considered a contraindication for the use of ECLS. However, there is increasing evidence for improved outcomes after ECLS support in hemorrhagic patients based on the benefits of hemodynamic support outweighing the increased risk of bleeding. We conducted a systematic literature search according to the PRISMA guidelines and reviewed publications describing ECLS support in hemorrhagic conditions...
July 7, 2020: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/32657772/statement-of-the-independent-forensic-expert-group-on-conversion-therapy
#12
Djordje Alempijevic, Rusudan Beriashvili, Jonathan Beynon, Djordje Alempijevic Petersen, Bettina Birmanns, Marie Brasholt, Juliet Cohen, Djordje Alempijevic Petersen, Maximo Duque, Pierre Duterte, Adriaan Van Es, Ravindra Fernando, Sebnem Korur Fincanci, Steen Holger Hansen, Sana Hamzeh, Lilla Hardi, Michele Heisler, Vincent Iacopino, Peter Mygind Leth, James Lin, Said Louahlia, Hege Luytkis, Said Louahlia, Maria-Dolores Morcillo-Mendez, Alejandro Moreno, Valeria Moscoso, Resmiye Oral, Onder Ozkalipci, Jason Payne-James, Jose Quiroga, Onder Ozkalipci, Hernan Reyes, Sidsel Rogde, Antti Sajantilla, Onder Ozkalipci, Matthis Schick, Agis Terzidis, Jorgen Lange Thomsen, Morris Tidball-Binz, Felicitas Treue, Peter Vanezis, Duarte Nuno Viera
Conversion therapy is a set of practices that aim to change or alter an individual's sexual orientation or gender identity. It is premised on a belief that an individual's sexual orientation or gender identity can be changed and that doing so is a desirable outcome for the individual, family, or community. Other terms used to describe this practice include sexual orientation change effort (SOCE), reparative therapy, reintegrative therapy, reorientation therapy, ex-gay therapy, and gay cure. Conversion therapy is practiced in every region of the world...
2020: Torture: Quarterly Journal on Rehabilitation of Torture Victims and Prevention of Torture
https://read.qxmd.com/read/32657766/parrilla-urethra-a-sequalae-of-electric-shock-torture-to-genitals-in-men-a-40-case-series-in-kashmir-india
#13
Abdul Rouf Khawaja, Manzoor Dar, Yasir Dar, Javeed Magray, Tariq Sheikh, Suhail Zahur
INTRODUCTION: Since the 20th century, electric shock torture has become one of the most prevalent methods of torture partly because it produces sequelae that are more challenging to visibly detect, particularly when administered using high voltage and low current. In sexual torture, a wire is wrapped around the head of the penis and a wire electrode is inserted into the urethra.This produces unbearable pain and can lead to urethral strictures with devastating physical and psychological consequences...
2020: Torture: Quarterly Journal on Rehabilitation of Torture Victims and Prevention of Torture
https://read.qxmd.com/read/32657509/disruption-of-relapse-to-alcohol-seeking-by-aversive-counterconditioning-following-memory-retrieval
#14
Koral Goltseker, Hen Handrus, Segev Barak
Relapse to alcohol abuse is often caused by exposure to potent alcohol-associated cues. Therefore, disruption of the cue-alcohol memory can prevent relapse. It is believed that memories destabilize and become prone for updating upon their reactivation through retrieval and then restabilize within 6 h during a "reconsolidation" process. We recently showed that relapse to cocaine seeking in a place-conditioning paradigm could be prevented by counterconditioning the cocaine cues with aversive outcomes following cocaine-memory retrieval...
July 13, 2020: Addiction Biology
https://read.qxmd.com/read/32657445/expecting-the-unexpected-echo-laboratory-preparedness-in-the-time-of-covid-19
#15
REVIEW
Alan B Goldberg, Stella Kyung, Sean Swearingen, Anupama Rao
COVID-19 poses a unique set of challenges to the healthcare system due to its rapid spread, intensive resource utilization, and relatively high morbidity and mortality. Healthcare workers are at especially high risk of exposure given the viruses spread through close contact. Reported cardiac complications of COVID-19 include myocarditis, acute coronary syndrome, cardiomyopathy, pericardial effusion, arrhythmia, and shock. Thus, echocardiography is integral in the timely diagnosis and clinical management of COVID-19 patients...
July 13, 2020: Echocardiography
https://read.qxmd.com/read/32657282/successful-treatment-of-pseudomembranous-colitis-with-fecal-microbiota-transplantation-a-case-study-on-a-patient-rescued-by-extracorporeal-cardiopulmonary-resuscitation-after-cardiac-arrest
#16
Guang-Qing Huang, Yong Bai, Ze-Qun Sun, Jie Liu
BACKGROUND Pseudomembranous colitis (PMC) is an opportunistic, nosocomial infection caused by Clostridium difficile. CASE REPORT Here we described a patient who developed PMC during her recovery from cardiac arrest. A 16-year-old female high school student experienced sudden cardiac arrest. Spontaneous circulation was not returned by standard cardiopulmonary resuscitation. After her admission to the emergency unit, her cardiac function and neurologic function were finally resumed by extracorporeal cardiopulmonary resuscitation (ECPR); however, after 14 days, her recovery was complicated with excessive diarrhea and shock...
July 1, 2020: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/32657091/a-case-of-covid-19-with-acute-myocardial-infarction-and-cardiogenic-shock
#17
Hong Nyun Kim, Jang Hoon Lee, Hun Sik Park, Dong Heon Yang, Se Yong Jang, Myung Hwan Bae, Yongkeun Cho, Shung Chull Chae, Yong Hoon Lee
A 60-year-old male patient with coronavirus disease-2019 showed new onset ST-segment elevation in V1-V2 leads on electrocardiogram and cardiac enzyme elevation in intensive care unit. He had a history of type 2 diabetes mellitus, hypertension, and dyslipidemia. He was receiving mechanical ventilation and veno-venous extracorporeal membrane oxygenation treatment for severe hypoxia. Two-D echocardiogram showed regional wall motion abnormalities. We performed primary percutaneous coronary intervention for acute myocardial infarction complicating cardiogenic shock under hemodynamic support...
July 13, 2020: Journal of Korean Medical Science
https://read.qxmd.com/read/32656999/hsp90-interacts-with-cdc37-is-phosphorylated-by-pka-pkc-and-regulates-src-phosphorylation-in-human-sperm-capacitation
#18
Kun Li, Peibei Sun, Yayan Wang, Tian Gao, Dongwang Zheng, Ajuan Liu, Ya Ni
BACKGROUND: Heat shock protein 90 (Hsp90) signaling pathways participate in protein phosphorylation during sperm capacitation. However, the underlying mechanism is largely unknown. OBJECTIVE: The aim of this study was to explore the interaction between Hsp90 and its co-chaperone protein, cell division cycle protein Cdc37 (Cdc37), in human sperm. MATERIALS AND METHODS: We examined the effects of H-89 (a protein kinase A [PKA] inhibitor) and Go6983 (a protein kinase C [PKC] inhibitor) on the phosphorylation of serine, threonine, and tyrosine residues in Hsp90; the effect of 17-allylamino-17-demethoxygeldanamycin (17-AAG, Hsp90 inhibitor) on Y416-Src phosphorylation; and the effects of 17-AAG and geldanamycin on threonine phosphorylation during human sperm capacitation...
July 13, 2020: Andrology
https://read.qxmd.com/read/32656625/first-line-vasopressor-and-mortality-rates-in-ed-patients-with-acute-drug-overdose
#19
Christopher Clifford, Monica Sethi, Dalton Cox, Alex F Manini
INTRODUCTION: While emergency department (ED) visits for acute drug overdose are at an all-time high, the importance of vasopressors to treat circulatory shock in this patient population remains unclear. This study investigated the association between first-line vasopressor and mortality, for both push-dose and infusion, in this patient population. METHODS: From a prospective cohort of consecutive ED patients with drug overdose at two urban teaching centers over 5 years, we performed a secondary data analysis of patients with circulatory shock, defined as hypotension requiring either vasopressors, high-dose insulin euglycemia therapy, or both...
July 11, 2020: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://read.qxmd.com/read/32656624/persistent-hyperinsulinemia-following-high-dose-insulin-therapy-a-case-report
#20
Justin N Corcoran, Katherine J Jacoby, Travis D Olives, Stacey A Bangh, Jon B Cole
INTRODUCTION: Overdoses of beta-adrenergic antagonists and calcium channel antagonists represent an uncommonly encountered but highly morbid clinical presentation. Potential therapies include fluids, calcium salts, vasopressors, intravenous lipid emulsion, methylene blue, and high-dose insulin. Although high-dose insulin is commonly used, the kinetics of insulin under these conditions are unknown. CASE REPORT: We present a case of a 51-year-old male who sustained a life-threatening overdose after ingesting approximately 40 tablets of a mixture of amlodipine 5 mg and metoprolol tartrate 25 mg...
July 11, 2020: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
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