Yang Liu, Caoyuan Yao, Yuan Wang, Xiaolin Liu, Shanggang Xu, Longbin Liang
BACKGROUND: This study investigated the underlying mechanism of crocin in protecting rats with traumatic hemorrhagic shock (THS) from liver injury. MATERIALS AND METHODS: Eighty Sprague Dawley rats were randomly divided into four groups (n = 20), namely, Sham group, THS group, crocin group, and Sodium Acetate Ringer group. A rat model of THS was induced by hemorrhage from the left femur fracture. The effects of crocin on hemodynamics, cardiac output, blood gas, animal survival rate, and liver function in the rats with THS were determined, and its relationship with oxidative stress was also explored...
January 19, 2021: Journal of Surgical Research
Keerat Rai Ahuja, Salik Nazir, Vardhmaan Jain, Toshiaki Isogai, Anas M Saad, Beni R Verma, Shashank Shekhar, Ravi Kumar, Ehab A Eltahawy, John E Madias
BACKGROUND: Previous small-scale studies have reported conflicting findings regarding the prevalence of diabetes mellitus (DM) and its association with outcomes in patients with takotsubo syndrome (TTS) OBJECTIVE: We sought to assess the prevalence of DM and its association with outcomes in TTS patients. METHODS: Nationwide inpatient sample (NIS) was queried to extract patient information from January 1, 2009 to September 30, 2015. Propensity score matching (PSM) was done to compare mortality and other in-hospital outcomes...
January 19, 2021: Heart & Lung: the Journal of Critical Care
Emad Barsoum, Sherif Elhosseiny, Brijesh Patel, Sankalp Pathak, Ankitkumar Patel, Pranaychandra Vaidya
Reverse Takotsubo Cardiomyopathy (rTTC) is a rare variant of Takotsubo Cardiomyopathy (TTC) that is characterized by hypokinesis of the base and sparing of the mid to apical wall of the left ventricle best seen on echocardiogram. Intracranial hemorrhage (ICH) has been identified as a risk factor rTTC. Nearly around 10% of the patients with TTC develop cardiogenic shock. We hereby report the successful use of the Impella Ventricular Assist Device (Impella CP®) for management of rTTC in the setting of acute ICH...
January 19, 2021: Heart & Lung: the Journal of Critical Care
Mark E Stanton, Nathen J Murawski, Sarah A Jablonski, Patrese A Robinson-Drummer, Nicholas A Heroux
The article reviews our studies of contextual fear conditioning (CFC) in rats during a period of development---Postnatal Day (PND) 17-33---that represents the late-infant, juvenile, and early-adolescent stages. These studies seek to acquire 'systems level' knowledge of brain and memory development and apply it to a rodent model of Fetal Alcohol Spectrum Disorder (FASD). This rodent model focuses on alcohol exposure from PND4-9, a period of brain development equivalent to the human third trimester, when neocortex, hippocampus, and cerebellum are especially vulnerable to adverse effects of alcohol...
January 19, 2021: Neurobiology of Learning and Memory
Xiaozhou Li, Ye Yang, Fan Yang, Feihe Wang, Hong Li, Huayu Tian, Guiyun Wang
We reported previously a recombinant protein (rP-HSP90C) containing epitope C from heat shock protein 90 of Candida albicans mediates protective immune responses against systemic candidiasis. However, it exhibits weak immunogenicity. Therefore, we evaluated the potential and mechanisms of thermosensitive chitosan hydrogel (CH-HG) as an adjuvant in rP-HSP90C vaccine. CH-HG synthesized by ionic cross-linking showed buffering capacity and control-released rP-HSP90C in vitro. In comparison to naked rP-HSP90C, CH-HG-loaded rP-HSP90C (CH-HG/rP-HSP90C) not only evoked a long-lasting rP-HSP90C-specific IgG, but also enhanced Th1, Th2, Th17 responses and the ratio of Th1/Th2 in vivo; Meanwhile, CH-HG/rP-HSP90C provoked a stronger CTL response than rP-HSP90C...
January 19, 2021: International Journal of Biological Macromolecules
Avinash Gupta, Dolly Sharma, Harshita Gupta, Ajeet Singh, Daipayan Chowdhury, Ramesh Chand Meena, Lilly Ganju, Bhuvnesh Kumar
AIM: Environmental heat stress alters physiological and biochemical functions which leads to multiorgan dysfunction including severe hepatic injury in animals. We hypothesize that heat preconditioning can be potential intervention in combating heat illnesses. MAIN METHODS: Sprague-Dawley rats were exposed to moderate heat stress, severe heat stress and heat preconditioning in heat simulation chamber. Mean arterial pressure, heart rate, skin and core temperature were monitored in pre and post heat exposed animals...
January 19, 2021: Life Sciences
Joshua A Cohen, Robert A Montgomery, Mohammad A Zmaili, Penelope Rampersad, Venu Menon, Michael Z Tong, Edward G Soltesz, Aaron J Weiss
Optimal timing of surgical repair for patients diagnosed with a post-myocardial infarction ventricular septal rupture (post-MI VSR) is controversial. Urgent surgical intervention to prevent hemodynamic decompensation must be balanced against delayed repair to allow for tissue stabilization and increased likelihood of a successful outcome. We report the use of an axillary Impella 5.5 temporary left ventricular assist device to aid in hemodynamic stabilization, shunt fraction reduction, and tissue maturation with eventual definitive surgical repair in a patient that presented with a post-MI VSR and cardiogenic shock...
January 19, 2021: Annals of Thoracic Surgery
Joshua T Cohen, Michael Danise, Jason T Machan, Runping Zhao, Craig T Lefort
Hemorrhagic shock induces an aberrant immune response characterized by simultaneous induction of a proinflammatory state and impaired host defenses. The objective of this study was to evaluate the impact of conditionally immortalized neutrophil progenitors (NPs) on this aberrant immune response. We employed a mouse model of hemorrhagic shock, followed by the adoptive transfer of NPs and subsequent inoculation of Staphylococcus aureus to induce pneumonia. We observed that transplant of NPs decreases the proportion of host neutrophils that express programmed death ligand 1 and intercellular adhesion molecule 1 in the context of prior hemorrhage...
January 9, 2021: Stem Cell Reports
Ana Cristina Coelho, Rosa Pires, Gabriela Schütz, Cátia Santa, Bruno Manadas, Patrícia Pinto
The pathological interaction between oak trees and Phytophthora cinnamomi has implications in the cork oak decline observed over the last decades in the Iberian Peninsula. During host colonization, the phytopathogen secretes effector molecules like elicitins to increase disease effectiveness. The objective of this study was to unravel the proteome changes associated with the cork oak immune response triggered by P. cinnamomi inoculation in a long-term assay, through SWATH-MS quantitative proteomics performed in the oak leaves...
2021: PloS One
Tatsuma Fukuda, Naoko Ohashi-Fukuda, Ryota Inokuchi, Yutaka Kondo, Takayuki Taira, Ichiro Kukita
BACKGROUND: Current guidelines for cardiopulmonary resuscitation (CPR) recommend that standard dose of epinephrine be administered every 3 to 5 minutes during cardiac arrest. However, there is controversy about the association between timing of epinephrine administration and outcomes after out-of-hospital cardiac arrest (OHCA). This study aimed to determine whether the timing of intravenous epinephrine administration is associated with outcomes after OHCA. METHODS: We analyzed Japanese government-led nationwide population-based registry data for OHCA...
January 21, 2021: Shock
Kristian-Christos Ngamsri, Jan Böhne, Mariana-Sophie Simelitidis, Jutta Gamper-Tsigaras, Yi Zhang, Sabrina Ehnert, Franziska M Konrad
BACKGROUND: Peritonitis is a life-threatening condition on intensive care units. Inflammatory cytokines and their receptors drive inflammation, cause the formation of platelet-neutrophil complexes (PNCs) and therefore the migration of polymorphonuclear neutrophils (PMNs) into the inflamed tissue. CX3CL1 and its receptor CX3CR1 are expressed in various cells, and promote inflammation. The shedding of CX3CL1 is mediated by the a disintegrin and metalloprotease (ADAM) 17. The role of the CX3CL1-CX3CR1 axis in acute peritonitis remains elusive...
January 21, 2021: Shock
Marisa E Luck, Caroline J Herrnreiter, Mashkoor A Choudhry
Burn injuries are a common form of traumatic injury that leads to significant morbidity and mortality worldwide. Burn injuries are characterized by inflammatory processes and alterations in numerous organ systems and functions. Recently, it has become apparent that the gastrointestinal bacterial microbiome is a key component of regulating the immune response and recovery from burn and can also contribute to significant detrimental sequelae after injury, such as sepsis and multiple organ failure. Microbial dysbiosis has been linked to multiple disease states, however, its role in exacerbating acute traumatic injuries, such as burn, are poorly understood...
January 21, 2021: Shock
Anne White, Mary Beth R Maguire, Jane Brannan, Austin Brown
BACKGROUND AND PURPOSE: Prelicensure nursing students lack the situational awareness to promote timely intervention with a patient in septic shock. This study evaluated a multifaceted educational project that determined the impact on nursing students' knowledge retention and time to task (TTT). METHODS: A quasi-experimental, repeated-measures design was used to evaluate students' knowledge retention and TTT. Eighty-four prelicensure nursing students participated in groups of 4 students to participate in a high-fidelity simulation...
January 16, 2021: Nurse Educator
Juan Pablo Alister Herdener, Francisca Uribe, Mauricio Barreda, Sergio Olate, Rodrigo Fariña
Rates of severe complications in orthognathic surgery are low, but when they occur they can be fatal. This article reports a case of laceration of the junction of the posterior lateral nasal artery and the sphenopalatine artery, resulting in severe delayed bleeding. Patient undergoes a multiple segment Le Fort I osteotomy with no intraoperative or immediate postoperative complications. On the fourth postoperative day, he presents with epistaxis and intractable postnasal discharge, is admitted to emergency with signs of shock, and bleeding is detected endoscopically originating from the right sphenopalatine artery, which is treated with diathermocoagulation...
January 20, 2021: Journal of Craniofacial Surgery
Jérémie Joffre, Elliot Lloyd, Erika Wong, Che Chung-Yeh, Nina Nguyen, Fenguyn Xu, Matthieu Legrand, Judith Hellman
OBJECTIVES: Catecholaminergic vasopressors are the cornerstone of circulatory shock management. Nevertheless, catecholamines have problematic side effects, arousing a growing interest in noncatecholaminergic agents such as vasopressin or angiotensin-II. However, their respective effects on sepsis-associated microvascular endothelial dysfunction such as permeability or inflammation remain elusive. We investigated the role of catecholamines and other vasopressors on Toll-like receptor agonists-induced microvascular endothelial permeability and inflammation...
January 22, 2021: Critical Care Medicine
Eric E Chinaeke, Bryan L Love, Joe Magagnoli, Ismaeel Yunusa, Gene Reeder
OBJECTIVE: To evaluate the impact of pre-intensive care unit admission (pre-ICU) statin use on all-cause in-hospital mortality and ICU length of stay (LOS). DESIGN: Retrospective cohort study. SETTING: Adult ICUs at tertiary hospitals. PATIENTS: Adult critically ill patients diagnosed with sepsis admitted to the ICUs. INTERVENTION: The exposure was pre-ICU statin prescription (statin users); unexposed represented absence of pre-ICU prescription (non-users)...
January 22, 2021: Pharmacotherapy
Gurhan Sisman, Erol Barbur, Didem Saka, Sibel Erdamar Cetin
Advancements in medicine have enabled the use of monoclonal antibodies in the field of oncology. However, the new adverse effects of immunotherapeutic agents are still being reported. We present the first case of pembrolizumab-induced fatal colitis with concurrent Giardia infection in a patient with metastatic ovarian cancer. A 47-year-old woman with metastatic ovarian cancer who was being treated with pembrolizumab admitted to our clinic complaining of persisting bloody diarrhoea. Her stool antigen test was positive for Giardia...
January 22, 2021: Cancer Immunology, Immunotherapy: CII
Jing He, Lili Liu, Xiaoli Chen, Baiwen Qi, Yanqun Liu, Yingying Zhang, Jinbing Bai
AIM: To understand about the experiences and feelings of the nurses infected with COVID-19 when caring for patients with COVID-19. BACKGROUND: With the sudden outbreak of coronavirus disease 2019 (COVID-19), nurses take care of patients with COVID-19 and have a very high risk of being infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) themselves. METHODS: This study adopted a qualitative design of hermeneutic phenomenology...
January 22, 2021: Journal of Nursing Management
C Loureiro, M A R Buzalaf, F R N Moraes, T M O Ventura, V T Pelá, J P Pessan, R C Jacinto
AIM: To quantitatively and qualitatively compare the host proteomic profile in samples of symptomatic and asymptomatic apical periodontitis (AP) using nano Liquid Chromatography Electron Spray Tandem Mass Spectrometry. METHODOLOGY: Samples were obtained from 18 patients with radiographically evident AP, divided into symptomatic and asymptomatic groups (nine per group) according to clinical characteristics. After sample collection, protein extraction, purification and quantification of the samples were performed, which were analysed by reverse phase liquid chromatography coupled to mass spectrometry...
January 22, 2021: International Endodontic Journal
Ines Charrada, Sondoss Ben Arfa, Olfa Berriche, Mohamed Habib Sfar
Biermer's anemia is an auto immune disease that can lead to neurological manifestations. Medullary combined sclerosis accounts for only 10% of neurological complications. There are few reports of documented bone marrow involvement by magnetic resonance imaging (MRI). Observation: We report a case of combined sclerosis of the cervical spinal cord assessed by cerebro-medullary MRI in a context of vitamin B12 deficiency in a 36-year-old patient who was hospitalized in the intensive care unit for septic shock with respiratory starting point, requiring the use of mechanical ventilation for 13 days and the discovery in post-extubation of pancytopenia with macrocytic anemia and flasquo-spasmodic tetraparesis prompting an emergency MRI showing combined sclerosis of the spinal cord , with vitamin B12 deficiency and megaloblastic anemia at the myelogram...
December 2020: La Tunisie Médicale
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