Jun Wang, Derek B Apel, Huawei Xu, Chong Wei
The assessment of yielding rockbolt performance during rockbursts with actual seismic loading is essential for rockburst supporting designs. In this paper, two types of yielding rockbolts (D-bolt and Roofex) and the fully resin-grouted rebar bolt are modeled via the "rockbolt" element in universal distinct element code (UDEC) after an exact calibration procedure. A two-dimensional (2D) model of a deep tunnel is built to fully evaluate the performance (e.g., capacity of energy-absorption and control of rock damage) of yielding and traditional rockbolts based on the simulated rockbursts...
2022: International Journal of Coal Science & Technology
Jayashree Kuppuswami, Gandhipuram Periyasamy Senthilkumar
Excess nutrient flux into the cellular energy system results in a scenario of cellular metabolic stress in diseases involving insulin resistance, such as type 2 diabetes, referred to as nutri-stress and results in cellular bioenergetic imbalance, which leads to insulin resistance and disease. Under nutri-stress, the heat shock response system is compromised due to metabolic abnormalities that disturb energy homeostasis. Heat shock proteins (HSPs) are the chief protectors of intracellular homeostasis during stress...
November 28, 2022: Cell Stress & Chaperones
Janet M Storey, Kenneth B Storey
Chaperone proteins have crucial roles to play in all animal species and are involved in mediating both the folding of newly synthesized peptides into their mature conformation, the refolding of misfolded proteins, and the trafficking of proteins between subcellular compartments. These highly conserved proteins have particularly important roles to play in dealing with disruptions of the proteome as a result of environmental stress since abiotic factors, including temperature, pressure, oxygen, water availability, and pollutants can readily disrupt the conformation and/or function of all types of proteins, e...
November 28, 2022: Cell Stress & Chaperones
Naihan Yuan, Quanjiang Song, Yan Jin, Zhenhao Zhang, Zheng Wu, Xihui Sheng, Xiaolong Qi, Kai Xing, Longfei Xiao, Xiangguo Wang
Bovine viral diarrhea (BVD) is a worldwide infectious disease caused by bovine viral diarrhea virus (BVDV) infection, which invades the placenta, causes abortion, produces immune tolerance and continuously infects calves, and causes huge economic losses to the cattle industry. The endoplasmic reticulum (ER) is an important organelle in cells, which is prone to ER stress after being stimulated by pathogens, thus activating the ER stress-related apoptosis. Studies have confirmed that BVDV can utilize the ER of its host to complete its own proliferation and stimulate ER stress to a certain extent...
November 28, 2022: Cell Stress & Chaperones
Abid Rashid Gill, Rabbia Riaz, Minhaj Ali
The current research aims to investigate the impact of financial development on the ecological footprint in Pakistan from 1980 to 2018 by controlling economic growth, the square of economic growth, and energy consumption. The structural break unit root test results show that all variables are stationary at first difference. The bound F-test for cointegration affirmed the indications of a long run connection between the parameters in the discussion. Moreover, we use the non-linear autoregressive distributed lag model to check the non-linear links in establishing the associations between financial development and ecological footprint...
November 28, 2022: Environmental Science and Pollution Research International
Miwa Nonaka, Hiroaki Kanouchi, Saki Torii, Hikaru Nagano, Shigetada Kondo, Akira Fujii, Masanobu Nagano, Shigeo Takenaka
Heat shock protein (HSP) A1A protects cells from various stressors. The concentrated liquid of the traditional Japanese rice black vinegar Kurozu increased HSPA1A expression in normal rat liver RLN-10 cells. Lactic acid, the primary component of concentrated Kurozu, induced HSPA1A expression in a concentration-dependent manner. Induction with 4 mM lactic acid increased HSPA1A expression by three times compared with that in the absence of lactic acid. The induction was inhibited by staurosporine or a selective MEK1/2 inhibitor (SL327)...
November 28, 2022: Bioscience, Biotechnology, and Biochemistry
Andrew King, Megan Fee, Erin McGlynn, Brandon Marshall, Katherine G Akers, Benjamin Hatten
INTRODUCTION: Hydrogen peroxide ingestions cause significant morbidity and mortality due to oxygen gas emboli and are treatable with hyperbaric oxygen therapy. Recommendations for observation are based on small case series. OBJECTIVES: The aim of this systematic review is to define the time of onset of embolic phenomena after hydrogen peroxide exposure and to describe the proportion of patients who received hyperbaric oxygen therapy. METHODS: Cases from a systematic literature search were combined with those from a prior study that used data derived from the American Association of Poison Control Centers National Poison Data System...
November 28, 2022: Clinical Toxicology
A Suárez-de-la-Rica, B Croes, L Ciudad, I Vallejo, J Mújica, M Díaz-Almirón, E Maseda
OBJECTIVE: This study aimed to evaluate whether early vitamin C and thiamine administration was associated with a lower 28-day and in-hospital mortality in surgical critically ill patients with refractory septic shock. METHODS: We performed a retrospective before-and-after study on patients with refractory septic shock. According to local protocol, hydrocortisone is initiated in case of refractory septic shock. In January 2017, the protocol was changed and vitamin C and thiamine were included...
November 28, 2022: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
Pawel Dubiela, Piotr Humeniuk, Merima Bublin, Carine Metz-Favre, Sébastien Viel, Francoise Bienvenu, Christine Hafner, Gabrielle Pauli, Karin Hoffmann-Sommergruber
Vegetables provide important nutrients but can also induce allergic symptoms. Celery tuber allergy frequently occurs in Central European countries and can cause allergic reactions including fatal anaphylactic shocks. There is little information about allergen content in seeds. Therefore, we analyzed 2 patients with allergic reaction after remoulade sauce consumption who entered the clinic for a diagnostic work-up. The routine diagnostic included serum derived specific IgE testing by ImmunoCAP, ImmunoCAP ISAC, and skin prick tests (SPTs)...
November 2022: World Allergy Organization Journal
Angeles Sánchez, Eduardo Jiménez-Fernández
The European Union Cohesion Policy for the period 2021-2027 focuses on five goals to make the European Union smarter, greener, more connected, more social and closer to citizens. However, a macroeconomic index is proposed as the predominant criterion for allocating the Structural Funds among regions. In this paper, we hypothesise that it is possible to take into account new, complementary criteria that better reflect citizens' quality of life. To that end, we build a composite index of socio-economic vulnerability for the 233 regions...
November 18, 2022: Applied Research in Quality of Life
Ozlem Colak, Marcus Enoch, Craig Morton
The COVID-19 pandemic had been a major crisis for the air transport industry due to its global reach, duration, and continuing uncertainty. Demand for air travel fell globally by around 90% in the period immediately following the introduction of lockdown restrictions which induced significant revenue loss for the industry and led to widespread bankruptcies and job losses. Within this extremely challenging business environment, commercially operated airports have struggled. This paper investigates how airport management has been impacted by this sudden and prolonged fall in the demand for air travel...
November 23, 2022: Journal of air transport management
Pradeep Kanta Ray, Anton Klarin, Sangeeta Ray
This study examines the impact of institutional shifts on the strategic choices of Russian firms. It proposes and tests hypotheses of how a shift from a weak to a strong institutional context is likely to affect firms' knowledge accumulation, absorptive capacities and internalisation of operations. Using discriminant analysis, the econometric investigation demonstrates that firms tend to allocate greater resources towards improving their knowledge and absorptive capacity and make more efforts to vertically integrate-in line with improvements in the institutional environment...
November 18, 2022: Studies in Comparative International Development
Amy K Pribadi, Sreekanth H Chalasani
Learning to identify and predict threats is a basic skill that allows animals to avoid harm. Studies in invertebrates like Aplysia californica, Drosophila melanogaster , and Caenorhabditis elegans have revealed that the basic mechanisms of learning and memory are conserved. We will summarize these studies and highlight the common pathways and mechanisms in invertebrate fear-associated behavioral changes. Fear conditioning studies utilizing electric shock in Aplysia and Drosophila have demonstrated that serotonin or dopamine are typically involved in relaying aversive stimuli, leading to changes in intracellular calcium levels and increased presynaptic neurotransmitter release and short-term changes in behavior...
2022: Frontiers in Behavioral Neuroscience
Meihui Zhang, Aolin Wang, Cheng Zhang, Fei Xu, Wei Liu, Jieru Fan, Zhanhong Ma, Yilin Zhou
With the increase of temperature in the winter wheat-growing regions in China, the high-temperature-resistant Blumeria graminis f. sp. tritici ( Bgt ) isolates developed in the fields. To clarify the key infection stages and the roles of heat shock protein (HSP) genes of high-temperature-resistant Bgt isolates defending high temperature, 3 high-temperature-resistant and 3 sensitive Bgt isolates were selected from 55 isolates after determination of temperature sensitivity. And then they were used to investigate the infection stages and the expression levels of HSP genes, including Bgthsp60 , Bgthsp70 , Bgthsp90, and Bgthsp104 , at 18°C and 25°C...
2022: Frontiers in Microbiology
Hongjun Zeng, Abdullahi D Ahmed, Ran Lu, Ningjing Dai
We first employ the method of multivariate GARCH models and Vine-Copula-CoVaR to analyse relationships between dependence, systematic risk spillover, and volatility spillover between the USD/CNY exchange rate and the returns on WTI crude oil futures and the Chinese stock market since China's 2005 foreign exchange reform. We utilise daily data from 2005 to 2020. We find a more complex dependence of the USD/CNY exchange rate on stock markets and WTI crude oil prices. All have negative risk spillovers among paired markets, with WTI having the most substantial risk spillover...
November 2022: Heliyon
Chenlu Song, Yiqiu Zhang, Qing Pei, Li Zheng, Meiyu Wang, Youzhen Shi, Shan Wu, Wei Ni, Xiujun Fu, Yinbo Peng, Wen Zhang, Min Yao
BACKGROUND: Sepsis-induced cardiomyopathy (SIC) is an identified serious complication of sepsis that is associated with adverse outcomes and high mortality. Heat shock proteins (HSPs) have been implicated in suppressing septic inflammation. The aim of this study was to investigate whether HSP70 can attenuate cellular mitochondrial dysfunction, exuberated inflammation and inflammasome-mediated pyroptosis for SIC intervention. METHODS: Mice with cecal ligation plus perforation (CLP) and lipopolysaccharide (LPS)-treated H9C2 cardiomyocytes were used as models of SIC...
2022: Burns and Trauma
Alessandra Cornaro
We provide a novel approach for analysing the financial resilience of the insurance sector during coronavirus pandemic. To this end, we build temporal directed and weighted networks where the weights on the arcs take into account the tail dependence between couple of firms. To assess the resilience of the network, we provide a new global indicator, aimed at capturing the impact on the clustering coefficient of a shock affecting in turn each firm and diffusing in the network via shortest paths. A local measure of resilience is also provided by quantifying the contribution of each firm to the global indicator...
November 18, 2022: Quality & Quantity
Ran An, Jing-Yi Ma, Xi-Hao Ni, Chang-Liang Wang
BACKGROUND: Breast angiosarcoma is a rare malignant tumor, accounting for approximately 0.04% of all breast malignancies. Angiosarcoma of the breast with hypofibrinogenemia is even rarer and has not been described in man. Breast angiosarcoma is associated with high metastatic potential and poor prognosis, and there is no specific manifestation in imaging. At present, surgery is considered to be the only effective treatment. There is no unified standard for postoperative adjuvant radiotherapy and chemotherapy...
2022: Frontiers in Oncology
Mathieu V Paulin, Elisabeth C Snead
A 6-year-old castrated male Labradoodle was referred in uncompensated hypovolemic shock, with a 72 - h history of lethargy, vomiting and diarrhea that had acutely worsened with subsequent development of profuse hemorrhagic diarrhea in the last 24 h after a visit to the groomer. In most respects this case was classic for a patient with a primary hypoadrenocortical crisis. After initial attempts to address hypovolemia and refractory hypotension, no clinical improvement was seen, and the respiratory rate had increased acutely to 80 bpm with crackles detected on thoracic auscultation and serosanguineous fluid began draining from the nose and mouth...
2022: Frontiers in Veterinary Science
Sabri Boubaker, John W Goodell, Satish Kumar, Riya Sureka
COVID-19 has posed unprecedented challenges to global finances because of its unparalleled global scope, with both concomitant shocks as well as the likely altering of risk assessments and forecasts for the foreseeable future. As the effects of COVID-19 on financial markets and institutions have been widely addressed by various literature, we systematically synthesize this literature. Through a comprehensive search process, we extract and review 818 articles. Appling bibliometric methods, we explore the trends among various research constituents involved in the field...
November 19, 2022: Int Rev Financ Anal
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