Eden D Alamaw, Kerriann M Casey, Krystal Tien, Benjamin D Franco, Gregory Gorman, Renee M Cotton, Claude Nagamine, Katechan Jampachaisri, Patrick Sharp, Cholawat Pacharinsak, Monika K Huss
Immunodeficient NSG mice are reported to be less responsive to buprenorphine analgesia. Here, we used NSG mice to compare the efficacy of the commonly used dose of carprofen (5 mg/kg) with 5 and 10 times that dose (25 and 50 mg/kg) for attenuating postoperative mechanical and thermal hypersensitivity following an incisional pain model. Male and female NSG mice ( n = 45) were randomly assigned to one of 4 groups and received daily subcutaneous injections for 3 d: saline (5 mL/kg), 5 mg/kg carprofen (Carp5), 25 mg/kg carprofen (Carp25), and 50 mg/kg carprofen (Carp50)...
March 29, 2024: Comparative Medicine