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Polysaccharide Base Nanogel

Zihao Wei, Qingrong Huang
Protein-polysaccharide complexes can be created in various ways (physical mixing, enzymatic crosslinking, chemical crosslinking and Maillard reaction), and diverse protein-polysaccharide complexes are generally grouped into non-covalent and covalent ones. Delivery systems constructed through assembly of protein-polysaccharide complexes (DSAPC) consist of emulsion-based delivery systems, capsule-based delivery systems, molecular complexes, nanogels, core-shell particles, composite nanoparticles as well as micelles...
January 14, 2019: Journal of Agricultural and Food Chemistry
Tugba Bal, Dilem Ceren Oran, Yoshihiro Sasaki, Kazunari Akiyoshi, Seda Kizilel
Pancreatic islet transplantation has emerged as a promising treatment for type-1 diabetes (T1D); however, its clinical application is still limited by the life-long use of immunosuppressive drugs, insufficient number of islets to achieve normoglycemia, and large transplantation volume. This paper reports a unique approach for nanothin coating of insulin secreting beta cell aggregates. The coating is based on hydrophobic and covalent interactions between natural acrylate modified cholesterol bearing pullulan (CHPOA) nanogels and MIN6 beta cell aggregates...
May 2018: Macromolecular Bioscience
Tao Zhang, Ruyi Yang, Shengnan Yang, Jibin Guan, Dong Zhang, Yan Ma, Hongzhuo Liu
Polymer nano-sized hydrogels (nanogels) as drug delivery carriers have been investigated over the last few decades. Pullulan, a nontoxic and nonimmunogenic hydrophilic polysaccharide derived from fermentation of black yeast like Aureobasidium pullulans with great biocompatibility and biodegradability, is one of the most attractive carriers for drug delivery systems. In this review, we describe the preparation, characterization, and 'switch-on/off' mechanism of typical pullulan self-assembled nanogels (self-nanogels), and then introduce the development of hybrid hydrogels that are numerous resources applied for regenerative medicine...
November 2018: Drug Delivery
Lin Zhang, Jifei Pan, Shibo Dong, Zhaoming Li
Finding adequate carriers for proteins/peptides and anticancer drugs delivery has become an urgent need, owing to the growing number of therapeutic macromolecules and the increasing amount of cancer incidence. Polysaccharide-based nanogels have attracted interest as carriers for proteins/peptides and anticancer drugs because of their characteristic properties like biodegradability, biocompatibility, stimuli-responsive behaviour, softness and swelling to help achieve a controlled, triggered response at the target site...
September 2017: Journal of Drug Targeting
Tilahun Ayane Debele, Shewaye Lakew Mekuria, Hsieh-Chih Tsai
Polysaccharide-based nanoparticles have fascinated attention as a vesicle of different pharmaceutical agents due to their unique multi-functional groups in addition to their physicochemical properties, including biocompatibility and biodegradability. The existence of multi-functional groups on the polysaccharide backbone permits facile chemical or biochemical modification to synthesize polysaccharide based nanoparticles with miscellaneous structures. Polysaccharide-based nanogels have high water content, large surface area for multivalent bioconjugation, tunable size, and interior network for the incorporation of different pharmaceutical agents...
November 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Lin Zhang, Yuan Sang, Jing Feng, Zhaoming Li, Aili Zhao
Oral colon-targeted drug delivery has attracted many researchers because of its distinct advantages of increasing the bioavailability of the drug at the target site and reducing the side effects. Polysaccharides that are precisely activated by the physiological environment of the colon hold greater promise for colon targeting. Considerable research efforts have been directed towards developing polysaccharide-based micro/nanocarriers. Types of polysaccharides for colon targeting and in vitro/in vivo assessments of polysaccharide-based carriers for oral colon-targeted drug delivery are summarised...
August 2016: Journal of Drug Targeting
Minnie Chan, Jacques Lux, Tomoki Nishimura, Kazunari Akiyoshi, Adah Almutairi
Clinically approved small-molecule magnetic resonance imaging (MRI) contrast agents are all rapidly cleared from the body and offer weak signal enhancement. To avoid repeated administration of contrast agent and improve signal-to-noise ratios, agents with stronger signal enhancement and better retention in tumors are needed. Therefore, we focused on hydrogels because of their excellent water accessibility and biodegradability. Gadolinium (Gd)-chelating cross-linkers were incorporated into self-assembled pullulan nanogels to both impart magnetic properties and to stabilize this material that has been extensively studied for medical applications...
September 14, 2015: Biomacromolecules
Amos Olusegun Abioye, Sureya Issah, Adeola Tawakalitu Kola-Mustapha
The chemical potentials of drug-polymer electrostatic interaction have been utilized to develop a novel ternary chitosan-ibuprofen-gellan nanogel as controlled transdermal delivery tool for ibuprofen. The ternary nanogels were prepared by a combination of electrostatic nanoassembly and ionic gelation techniques. The electrostatic and hydrophobic interactions as well as hydrogen bonding between ibuprofen and chitosan were confirmed with FTIR, while DSC, TGA and SEM confirmed the physical state, thermal and morphological characteristics, respectively...
July 25, 2015: International Journal of Pharmaceutics
Jianwei Zhang, Xueyong Li, Jing Tian, Yuan Lu, Xiaowen Shi, Yingfei Zhan, Yumin Du, Huan Liu, Hongbing Deng
Rectorite (REC)-encapsulated lysozyme (LY)-alginate (ALG) nanogels (NGs) were prepared by adding ALG-REC composites suspensions into LY solutions at the mass ratio of 1:2. The morphology of the NGs and the NGs-assembled nanofibrous mats were studied by transmission electron microscope and field emission scanning electron microscopy, respectively. The composition of NGs-immobilized nanofibrous mats was detected by X-ray photoelectron spectroscopy. The NGs-assembled nanofibrous mats with the addition of REC could enhance the inhibition against Escherichia coli and Staphylococcus aureus...
September 1, 2015: Colloids and Surfaces. B, Biointerfaces
Xia Wang, Dechao Niu, Qing Wu, Song Bao, Teng Su, Xiaohang Liu, Shengjian Zhang, Qigang Wang
This work described a proof of concept study of hybrid nanogel-based magnetic resonance contrast agents, SPIO@GCS/acryl/biotin@Mn-gel, abb. as SGM, for highly efficient, pH-responsive T1 and T2 dual-mode magnetic resonance imaging (MRI). SGM have been synthesized by assembling superparamagnetic iron oxide particles into polysaccharide nanoclusters, followed by in-situ reduction of the manganese species on the clusters and a final mild polymerization. The dual-mode SGM showed an interesting pH-responsiveness in in vitro MRI, with both T1 and T2 relaxivities turned "ON" in the acidic environment, along with an increase in the r1 and r2 relaxivity values by 1...
2015: Biomaterials
Yifen Wen, Jung Kwon Oh
Polysaccharides are abundant in nature, renewable, nontoxic, and intrinsically biodegradable. They possess a high level of functional groups including hydroxyl, amino, and carboxylic acid groups. These functional groups can be utilized for further modification of polysaccharides with small molecules, polymers, and crosslinkers; the modified polysaccharides have been used as effective building blocks in fabricating novel biomaterials for various biomedical applications such as drug delivery carriers, cell-encapsulating biomaterials, and tissue engineering scaffolds...
November 2014: Macromolecular Rapid Communications
Sílvia Santos Pedrosa, Catarina Gonçalves, Laurent David, Miguel Gama
An amphiphilic hyaluronic acid conjugate is successfully developed based on grafting a thiolated hydrophobic molecule to the polysaccharide backbone. The engineered conjugate is capable of assembling into nanostructures once dispersed in water, with average diameter of 80.2 ± 0.4 nm (n = 5), stable up to 6 months. The thiolated HyA conjugate is reticulated by dissulfide bond with a homofunctional crosslinker-1,4-Bis(3-[2-pyridyldithio]propionamido)butane (DPDPB). The drug loading efficiency of the reticulated and non-reticulated nanogel is accessed with two hydrophobic drugs, curcumin and simvastatin...
November 2014: Macromolecular Bioscience
Paula Pereira, Daniela Morgado, Agnès Crepet, Laurent David, Francisco M Gama
A self-assembled glycol chitosan nanogel (GC) is synthesized by chemically grafting hydrophobic chains onto a polysaccharide, which is comprehensively characterized. The obtained macromolecular micelle is decorated with folate-conjugated poly(ethylene glycol) (PEG) (GCFA). An average size distribution of 250 and 200 nm is observed, respectively for the GC and GCFA nanogels. Differential cell localization is observed on incubating the materials with HeLa cells. Whereas the GC nanogel is detected on the cell surface, GCFA is localized in the cytoplasm...
October 2013: Macromolecular Bioscience
Nednaldo Dantas-Santos, Jailma Almeida-Lima, Arthur Anthunes Jacome Vidal, Dayanne Lopes Gomes, Ruth Medeiros Oliveira, Silvia Santos Pedrosa, Paula Pereira, Francisco Miguel Gama, Hugo Alexandre Oliveira Rocha
Sulfated fucans comprise families of polydisperse natural polysaccharides based on sulfated L-fucose. Our aim was to investigate whether fucan nanogel induces cell-specific responses. To that end, a non toxic fucan extracted from Spatoglossum schröederi was chemically modified by grafting hexadecylamine to the polymer hydrophilic backbone. The resulting modified material (SNFuc) formed nanosized particles. The degree of substitution with hydrophobic chains was close to 100%, as estimated by elemental analysis...
September 2012: Marine Drugs
Xian Xu, Amit K Jha, Daniel A Harrington, Mary C Farach-Carson, Xinqiao Jia
Hyaluronic acid (HA) is one of nature's most versatile and fascinating macromolecules. Being an essential component of the natural extracellular matrix (ECM), HA plays an important role in a variety of biological processes. Inherently biocompatible, biodegradable and non-immunogenic, HA is an attractive starting material for the construction of hydrogels with desired morphology, stiffness and bioactivity. While the interconnected network extends to the macroscopic level in HA bulk gels, HA hydrogel particles (HGPs, microgels or nanogels) confine the network to microscopic dimensions...
2012: Soft Matter
Yoshihiro Sasaki, Wakiko Asayama, Tatsuya Niwa, Shin-ichi Sawada, Takuya Ueda, Hideki Taguchi, Kazunari Akiyoshi
Cell-free protein synthesis is a promising technique for the rapid production of proteins. However, the application of the cell-free systems requires the development of an artificial chaperone that prevents aggregation of the protein and supports its correct folding. Here, nanogel-based artificial chaperones are introduced that improve the folding efficiency of rhodanese produced in cell-free systems. Although rhodanese suffers from rapid aggregation, rhodanese was successfully expressed in the presence of the nanogel and folded to the enzymatically active form after addition of cyclodextrin...
June 14, 2011: Macromolecular Bioscience
Sayaka Toita, Shin-ichi Sawada, Kazunari Akiyoshi
We developed a novel gene delivery system capable of endosome disruption using a polysaccharide-based cationic nanogel composed of a hexadecyl group-bearing cationic cycloamylose nanogel (C16-catCA nanogel) and phospholipaseA(2) (PLA(2)) to hydrolyze membrane phospholipids. C16-catCA nanogel formed nanoparticles with PLA(2) and pDNA by hydrophobic and electrostatic interactions. Both pDNA and PLA(2) were effectively internalized into cells by the C16-catCA nanogel. In addition, the pDNA expression level was enhanced when complexed with specific concentrations of PLA(2)...
October 10, 2011: Journal of Controlled Release: Official Journal of the Controlled Release Society
Byoung-chan Bae, Kun Na
Self-quenching polysaccharide-based nanogels synthesized from pullulan/folate-pheophorbide-a (Pheo-A) conjugates were investigated for their potential to reduce photosensitizer (PS) phototoxicity in normal tissue and to enhance the efficacy of tumor treatment. While the nanogels showed photoactive properties including fluorescence and singlet oxygen generation in organic solvent (DMF), these properties were suppressed in PBS due to the self-quenching of photosensitizer moieties similar to the fluorescence resonance energy transfer (FRET) effect...
August 2010: Biomaterials
Weitai Wu, Michael Aiello, Ting Zhou, Alexandra Berliner, Probal Banerjee, Shuiqin Zhou
We report a class of polysaccharide-based hybrid nanogels that can integrate the functional building blocks for optical pH-sensing, cancer cell imaging, and controlled drug release into a single nanoparticle system, which can offer broad opportunities for combined diagnosis and therapy. The hybrid nanogels were prepared by in-situ immobilization of CdSe quantum dots (QDs) in the interior of the pH and temperature dual responsive hydroxypropylcellulose-poly(acrylic acid) (HPC-PAA) semi-interpenetrating polymer networks...
April 2010: Biomaterials
Samia Daoud-Mahammed, Patrick Couvreur, Kawthar Bouchemal, Monique Chéron, Geneviève Lebas, Catherine Amiel, Ruxandra Gref
The entrapment of two hydrophobic molecules, benzophenone and tamoxifen, into self-assembling cyclodextrin (CD)-based nanogels has been studied. These nanogels formed spontaneously upon the association of a hydrophobically modified dextran (MD) and a cyclodextrin polymer (pbetaCD). The interactions of benzophenone and tamoxifen with MD and pbetaCD were investigated using phase solubility studies, circular dichroism, and isothermal titration calorimetry. Both hydrophobic molecules were included into the CD cavities of the pbetaCD and were also solubilized by MD into its hydrophobic microdomains...
March 9, 2009: Biomacromolecules
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