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BaiLi Song, XiangLiang Chen, Dan Tang, Mako Ibrahim, YuKai Liu, Linda Nyame, Teng Jiang, Wei Wang, Xiang Li, Chao Sun, Zheng Zhao, Jie Yang, JunShan Zhou, JianJun Zou
BACKGROUND: Recently, the NIHSS STroke Scale score, Age, pre-stroke mRS score, onset-to-treatment Time (START nomogram) predicts 3-month functional outcome after intravenous thrombolysis in ischemic stroke patients. However, this model has not yet been an external validation. We aim to validate the performance of START nomogram. METHODS: Data were derived from the stroke center of the Nanjing First Hospital (China). Patients who lacked the necessary data to calculate the nomogram and missed 3-month modified Ranking scale scores were excluded...
March 18, 2019: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
BaiLi Song, YuKai Liu, Linda Nyame, XiangLiang Chen, Teng Jiang, Wei Wang, Chao Sun, Dan Tang, Chen Chen, Mako Ibrahim, Jie Yang, JunShan Zhou, JianJun Zou
BACKGROUND: Accurate prognostication of unfavorable outcome made at the early onset of stroke is important to both the clinician and the patient management. This study was aimed to develop a nomogram based on the integration of parameters to predict the probability of 3-month unfavorable functional outcome in Chinese acute ischemic stroke patients. METHODS: We retrospectively collected patients who underwent acute ischemic stroke at Stroke Center of the Nanjing First Hospital (China) between May 2013 and May 2018...
March 21, 2019: Cerebrovascular Diseases
Mako Tamura, Minatsu Tanabe, Jari P T Valkonen, Motomu Akita
Mosses are ecologically important plants also used for greening, gardening, and decorative purposes. Knowledge of the microbial flora associated with mosses is expected to be important for control and preservation of global and local environments. However, the moss-associated microbial flora is often poorly known. Moss-associated fungi and bacteria may promote plant growth and pest control, but they may be alternative hosts for pathogens of vascular plants. In this study, the fungus Sclerotinia delphinii was identified for the first time as a pathogen that causes severe damage to Sunagoke moss ( Racomitrium japonicum )...
2019: Frontiers in Microbiology
Xiaotu Liu, Yan Wu, Xianming Zhang, Li Shen, Allison L Brazeau, Douglas H Adams, Hillary Marler, Bryan Watts, Da Chen
During the investigation of dechlorane-related chemicals in North American wildlife, two unknown polychlorinated compounds (referred to as U1 and U2) were discovered. After extensive sample cleanup, structural information of U1 and U2 was characterized by gas chromatography (GC) coupled with single quadrupole mass spectrometer (MS) or GC-quadrupole time-of-flight (QToF) MS. Mass spectral evidence suggests that both U1 and U2 are structurally related to Dechlorane 603 (Dec603; C17H8Cl12), an analogue of the chlorinated flame retardant Dechlorane Plus...
March 9, 2019: Environmental Science & Technology
Yuji Shimizu, Hirotomo Yamanashi, Yuko Noguchi, Jun Koyamatsu, Mako Nagayoshi, Kairi Kiyoura, Shoichi Fukui, Mami Tamai, Shin-Ya Kawashiri, Hideaki Kondo, Takahiro Maeda
BACKGROUND AND AIMS: Endothelial injury is well-known as a process that can lead to chronic kidney disease (CKD) and atherosclerosis. Hematopoietic activity is known to be associated inversely with CKD and positively with atherosclerosis. Since bone-derived progenitor cells (CD34-positive cells) contribute to endothelial repair (including the progression of atherosclerosis), understanding the association between CKD and carotid intima-media thickness (CIMT), in relation to circulating CD34-positive cell count, may be an efficient means of clarifying the mechanisms underlying endothelial activity...
February 11, 2019: Atherosclerosis
Yoshinori Inagaki, Takashi Kokudo, Mako Kamiya, Shin-Nosuke Uno, Masumitsu Sato, Junichi Kaneko, Norihiro Kokudo, Yasuteru Urano, Kiyoshi Hasegawa
Indocyanine green (ICG) accumulates only in hepatocytes and their malignant counterpart, hepatocellular carcinoma (HCC). We have developed ICG-conjugated anti-cancer drugs and noted their significant accumulation in HCC cells both in vitro and in vivo. ICG-conjugated gemcitabine was less toxic to normal cells and it had superior anti-tumor action compared to gemcitabine alone in a subcutaneous tumor xenograft. ICG conjugation can provide a novel fluorescent drug delivery system for treatment of liver cancer and this system can be used to both diagnose and treat HCC...
February 28, 2019: Scientific Reports
Satoshi Okuyama, Mako Katoh, Tomoko Kanzaki, Yoshimi Kotani, Yoshiaki Amakura, Morio Yoshimura, Naohiro Fukuda, Takahisa Tamai, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukawa
Cerebral ischemia/reperfusion leads to delayed neuronal cell death, resulting in brain damage. Auraptene (AUR) and naringin (NGIN), which exert neuroprotective effects in ischemic brain, are abundant in the peel of Citrus kawachiensis. Although parts of AUR/NGIN are transited from the peel to the juice during the squeezing of this fruit, these amounts in juice might be too low to exert effects. We thus prepared the AUR/NGIN-rich fruit juice of C. kawachiensis by addition of peel paste to the raw juice. The present study revealed that orally administration of the dried powder of this AUR/NGIN-rich fruit juice (2...
2019: Journal of Nutritional Science and Vitaminology
Daisuke Mashima, Yoshiaki Oka, Takafumi Gotoh, Shozo Tomonaga, Shoko Sawano, Mako Nakamura, Ryuichi Tatsumi, Wataru Mizunoya
Free amino acids are important components of tastants and flavor precursors in meat. To clarify the correlation between muscle fiber type and free amino acids, we determined the concentrations of various free amino acids and dipeptides in samples of different muscle tissues (n = 21), collected from 26-month-old Japanese Black steers (n = 3) at 2 days postmortem. The proportions of the myosin heavy chain (MyHC), slow (MyHC1) and fast (MyHC2) isoforms were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE)...
February 27, 2019: Animal Science Journal
Katalin Mako, Attila Puskas
Iliac vein compression syndrome (May-Thurner syndrome - MTS) is an anatomically variable clinical condition in which the left common iliac vein is compressed between the right common iliac artery and the underlying spine. This anatomic variant results in an increased incidence of left iliac or iliofemoral vein thrombosis. It predominantly affects young women in the second or third decades of life with preponderance during pregnancy or oral contraceptive use. Although MTS is rare, its true prevalence is underestimated but it can be a life-threatening condition due to development of pulmonary embolism (PE)...
February 20, 2019: VASA. Zeitschrift Für Gefässkrankheiten
Ergin Beyret, Hsin-Kai Liao, Mako Yamamoto, Reyna Hernandez-Benitez, Yunpeng Fu, Galina Erikson, Pradeep Reddy, Juan Carlos Izpisua Belmonte
Hutchinson-Gilford progeria syndrome (HGPS) is a rare lethal genetic disorder characterized by symptoms reminiscent of accelerated aging. The major underlying genetic cause is a substitution mutation in the gene coding for lamin A, causing the production of a toxic isoform called progerin. Here we show that reduction of lamin A/progerin by a single-dose systemic administration of adeno-associated virus-delivered CRISPR-Cas9 components suppresses HGPS in a mouse model.
February 18, 2019: Nature Medicine
Tomohiro Takehara, Tetsuo Tani, Ken Yajima, Mako Watanabe, Yoshihito Otsuka, Hidefumi Koh
BACKGROUND: Helicobacter cinaedi is a microaerobic Gram-negative spiral-shaped bacterium that causes enteritis, cellulitis, and bacteremia in both immunocompromised and immunocompetent patients. While there have been increasing numbers of reported H. cinaedi infections recently, there has been no thyroid abscess case caused by H. cinaedi presenting with thyroid storm. CASE PRESENTATION: A 50-year-old Japanese man presented with a 9-day history of high fever associated with palpitations, dry cough, and chronic diarrhea...
February 15, 2019: BMC Infectious Diseases
Jay R Rooker, Michael A Dance, R J David Wells, Matthew J Ajemian, Barbara A Block, Michael R Castleton, J Marcus Drymon, Brett J Falterman, James S Franks, Neil Hammerschlag, Jill M Hendon, Eric R Hoffmayer, Richard T Kraus, Jennifer A McKinney, David H Secor, Gregory W Stunz, John F Walter
The timing and extent of international crossings by billfishes, tunas, and sharks in the Cuba-Mexico-United States (U.S.) triangle was investigated using electronic tagging data from eight species that resulted in >22,000 tracking days. Transnational movements of these highly mobile marine predators were pronounced with varying levels of bi- or tri-national population connectivity displayed by each species. Billfishes and tunas moved throughout the Gulf of Mexico and all species investigated (blue marlin, white marlin, Atlantic bluefin tuna, yellowfin tuna) frequently crossed international boundaries and entered the territorial waters of Cuba and/or Mexico...
February 7, 2019: Scientific Reports
Yuji Shimizu, Hirotomo Yamanashi, Yuko Noguchi, Jun Koyamatsu, Mako Nagayoshi, Kairi Kiyoura, Shoichi Fukui, Mami Tamai, Shin-Ya Kawashiri, Kazuhiko Arima, Takahiro Maeda
Recent studies have revealed an inverse association between height and cardiovascular disease and that endothelial progenitor cells (CD34-positive cells) contribute to vascular maintenance, which is associated with cardiovascular disease. However, evidence of the association between height and CD34-positive positive cells among elderly participants is limited. To assess this association, we conducted a cross-sectional study of 231 elderly Japanese men aged 65-69. Since enhanced production of circulating CD34-positive cells in response to endothelial injury might act have a strong confounding effect on the association between height and circulating CD34-positive cells, the median value for the levels of these cells (0...
January 29, 2019: Aging
Haruhito Kinoshita, Hitoshi Teraoka, Yoshitaka Maekawa, Mako Kitano, Mayo Morikawa, Yoshimi Sugita, Akiko Sakamoto, Hiroko Uono, Takuya Mori, Tsuyoshi Hasegawa, Eiji Noda, Takaaki Chikugo, Shinichiro Kashiwagi, Kosei Hirakawa, Masaichi Ohira
A 61-year-old woman with a breast tumor detected by mammography examination was admitted to our hospital. Ultrasonography showed a 15.5×7.2mm sized irregular mass at the left BD area. Vacuum-assisted biopsy did not reveal any malignant cells. After 3 months, ultrasonography reexamination showed that the irregular mass had increased to 24.2×16.5mm in size, and it had spread to multiple axillary lymph nodes. The patient was diagnosed with breast cancer by core needle biopsy of the axillary lymph node. Total mastectomy with axillary lymph node dissection was performed...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Patrycja Makoś, Andrzej Przyjazny, Grzegorz Boczkaj
The paper is a review of the procedures for the determination of volatile and semivolatile oxygenated organic compounds (O-VOCs) in effluent samples by gas chromatography. Current trends and outlook for individual steps of the procedure for the determination of O-VOCs in effluents are discussed. The available sample preparation techniques and their limitations are described along with GC capillary columns used for O-VOCs separation and selective and universal detectors used for their determination. The results of determination of O-VOC content in various types of real effluents are presented...
January 18, 2019: Journal of Chromatography. A
Takafumi Nakano, Yoshihiko Nakamura, Kiyoshi Matsuyama, Keiichi Irie, Mako Yasumura, Yurie Hirata, Motoki Yamasaki, Kanae Misumi, Yuta Yamashita, Takayuki Myose, Koichi Matsuo, Kazunori Sano, Hidetoshi Kamimura, Hiroyasu Ishikura, Takashi Egawa, Kenichi Mishima
Our previous study indicated that recombinant human soluble thrombomodulin (rhsTM) could attenuate brain damage when administered as a bolus in the cerebral ischaemic early phase. Then, we considered that treatment with rhsTM may show therapeutic effects even when administered in the ischaemic delayed phase, because rhsTM has an action of inhibiting high-mobility group box 1 (HMGB1) as a late mediator of lethal systemic inflammation. This study was performed to investigate the effects of delayed treatment with rhsTM on ischaemic brain damage induced by high HMGB1 level in mice subjected to 4-hour middle cerebral artery occlusion (MCAO)...
January 21, 2019: Thrombosis and Haemostasis
Chiharu Kai, Mako Ishimaru, Yoshikazu Uchiyama, Junji Shiraishi, Norimitsu Shinohara, Hiroshi Fujita
Subtype classification of breast cancer by analyzing the gene expression profile of cancer cells is becoming a standard procedure. Breast cancer subtype classification is more useful than the conventional method because the characteristics of subtype classification is directly connected with the treatment method. However, genetic testing is invasive, and a part of cancer cells may not represent the overall nature of the cancer. In the computer-aided diagnosis (CAD) scheme for differentiation of triple-negative breast cancer (TNBC) by estimating the genetic properties of cancer based on Radiogenomics, principal component analysis (PCA) and least absolute shrinkage and selection operator (Lasso) were used for reducing the dimension of radiomic features, and we compared usefulness of both...
2019: Nihon Hoshasen Gijutsu Gakkai Zasshi
Shinji Kobuchi, Mako Akutagawa, Yukako Ito, Toshiyuki Sakaeda
Capecitabine is a 5-fluorouracil (5-FU) derivative that is used widely in the treatment of colorectal cancer. The plasma ratio of dihydrouracil (UH2 ) to uracil (Ura) is expected to gain relevance as an indirect-response biomarker to estimate the activity of dihydropyrimidine dehydrogenase (DPD). The latter is a rate-limiting enzyme in the catabolism of 5-FU in the capecitabine-based regimen. However, the relationship between the pharmacokinetics of capecitabine and the plasma UH2 /Ura ratio is still unknown...
December 28, 2018: Biopharmaceutics & Drug Disposition
Hidemasa Kubo, Kenjiro Hanaoka, Yugo Kuriki, Toru Komatsu, Tasuku Ueno, Ryosuke Kojima, Mako Kamiya, Yasutoshi Murayama, Eigo Otsuji, Yasuteru Urano
Rapid diagnosis of metastatic lymph nodes (mLNs) of colorectal cancer (CRC) is desirable either intraoperatively or in resected fresh specimens. We have developed a series of activatable fluorescence probes for peptidase activities that are specifically upregulated in various tumors. We aimed to discover a target enzyme for detecting mLNs of CRC. Among our probes, we found that gGlu-HMRG, a gamma-glutamyl transpeptidase (GGT)-activatable fluorescence probe, could detect mLNs. This was unexpected, because we have previously reported that gGlu-HMRG could not detect primary CRC...
December 12, 2018: Scientific Reports
Shohei Kojima, Ryo Sato, Mako Yanai, Yumiko Komatsu, Masayuki Horie, Manabu Igarashi, Keizo Tomonaga
Targeting of viral proteins to specific subcellular compartments is a fundamental step for viruses to achieve successful replication in infected cells. Borna disease virus-1 (BoDV), a non-segmented, negative-strand RNA virus, uniquely replicates and persists in the cell nucleus. Here, it is demonstrated that BoDV nucleoprotein (N) transcripts undergo mRNA splicing to generate truncated isoforms. In combination with alternative usage of translation initiation sites, the N gene potentially expresses at least six different isoforms, which exhibit diverse intracellular localizations, including the nucleoplasm, cytoplasm and endoplasmic reticulum (ER), as well as intranuclear viral replication sites...
December 12, 2018: Journal of Virology
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