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https://read.qxmd.com/read/30850824/plazomicin-once-daily-effective-for-complicated-uti
#1
Annette Fenner
No abstract text is available yet for this article.
March 8, 2019: Nature Reviews. Urology
https://read.qxmd.com/read/30821812/mediators-of-corneal-haze-following-implantation-of-presbyopic-corneal-inlays
#2
Beau J Fenner, Yu-Chi Liu, Siew Kwan Koh, Yan Gao, Lu Deng, Roger W Beuerman, Lei Zhou, Julian T S Theng, Jodhbir S Mehta
Purpose: To identify protein mediators of corneal haze following presbyopic corneal inlay surgery. Methods: Tears were collected from eyes with corneal haze following surgery with a shape-changing corneal inlay. Samples were subjected to quantitative proteomic analysis using iTRAQ and proteins significantly increased or decreased (1.3-fold or more) in haze eyes relative to fellow eyes were identified. Expression ratios were compared to postoperative eyes without corneal haze to identify proteins selectively increased or decreased in corneal haze eyes...
March 1, 2019: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/30792855/differential-effect-of-regadenoson-versus-dipyridamole-on-heart-rate-in-patients-with-left-bundle-branch-block-how-does-it-affect-the-results-of-pharmacological-nuclear-stress-testing
#3
Mahmoud Assaad, Abeer Berry, Jaishree Palanisamy, Joseph Fenner, Marcel Zughaib
Background: Myocardial perfusion imaging (MPI) stress test is performed either using exercise as a stress modality or through the use of pharmacological vasodilator agents in those who cannot exercise. Regadenoson and dipyridamole are some of the most common vasodilator agents used. We aim to study the effect of these agents on the heart rate and the imaging results. Methods: This was a retrospective study which included 187 patients with left bundle branch block...
January 2019: JRSM Cardiovascular Disease
https://read.qxmd.com/read/30787397/microbial-residence-time-is-a-controlling-parameter-of-the-taxonomic-composition-and-functional-profile-of-microbial-communities
#4
Cresten Mansfeldt, Stefan Achermann, Yujie Men, Jean-Claude Walser, Kris Villez, Adriano Joss, David R Johnson, Kathrin Fenner
A remaining challenge within microbial ecology is to understand the determinants of richness and diversity observed in environmental microbial communities. In a range of systems, including activated sludge bioreactors, the microbial residence time (MRT) has been previously shown to shape the microbial community composition. However, the physiological and ecological mechanisms driving this influence have remained unclear. Here, this relationship is explored by analyzing an activated sludge system fed with municipal wastewater...
February 20, 2019: ISME Journal
https://read.qxmd.com/read/30778198/prostate-cancer-a-tale-of-two-sides
#5
EDITORIAL
Annette Fenner
No abstract text is available yet for this article.
February 18, 2019: Nature Reviews. Urology
https://read.qxmd.com/read/30744962/drug-susceptibility-testing-and-mortality-in-patients-treated-for-tuberculosis-in-high-burden-countries-a-multicentre-cohort-study
#6
Kathrin Zürcher, Marie Ballif, Lukas Fenner, Sonia Borrell, Peter M Keller, Joachim Gnokoro, Olivier Marcy, Marcel Yotebieng, Lameck Diero, E Jane Carter, Neesha Rockwood, Robert J Wilkinson, Helen Cox, Nicholas Ezati, Alash'le G Abimiku, Jimena Collantes, Anchalee Avihingsanon, Kamon Kawkitinarong, Miriam Reinhard, Rico Hömke, Robin Huebner, Sebastien Gagneux, Erik C Böttger, Matthias Egger
BACKGROUND: Drug resistance is a challenge for the global control of tuberculosis. We examined mortality in patients with tuberculosis from high-burden countries, according to concordance or discordance of results from drug susceptibility testing done locally and in a reference laboratory. METHODS: This multicentre cohort study was done in Côte d'Ivoire, Democratic Republic of the Congo, Kenya, Nigeria, South Africa, Peru, and Thailand. We collected Mycobacterium tuberculosis isolates and clinical data from adult patients aged 16 years or older...
February 7, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30736350/nucleolar-expression-and-chromosomal-associations-in-robertsonian-spermatocytes-of-mus-musculus-domesticus
#7
Fernanda López-Moncada, Daniel Tapia, Nolberto Zuñiga, Eliana Ayarza, Julio López-Fenner, Carlo Alberto Redi, Soledad Berríos
We studied and compared the nucleolar expression or nucleoli from specific bivalents in spermatocytes of the standard Mus musculus domesticus 2n=40, of Robertsonian (Rb) homozygotes 2n = 24 and heterozygotes 2n = 32. We analyzed 200 nuclear microspreads of each specific nucleolar chromosome and spermatocyte karyotype, using FISH to identify specific nucleolar bivalents, immunofluorescence for both fibrillarin of the nucleolus and the synaptonemal complex of the bivalents, and DAPI for heterochromatin. There was nucleolar expression in all the chromosomal conditions studied...
February 6, 2019: Genes
https://read.qxmd.com/read/30734826/hba1c-is-associated-with-frailty-in-a-group-of-aboriginal-australians
#8
Z Hyde, K Smith, L Flicker, D Atkinson, S Fenner, L Skeaf, R Malay, D Lo Giudice
In this cross-sectional study of 141 Aboriginal Australians aged ≥45 years living in the remote Kimberley region of Western Australia, we explored whether glycated haemoglobin (HbA1c) levels were associated with frailty. Sixty-four participants (45.4%) had a HbA1c level ≥6.5% and 84 participants (59.6%) were frail. A significant trend was observed with regard to HbA1c levels and frailty, with those having HbA1c levels ≥6.5% having the greatest prevalence of frailty (70.3%). In binary logistic regression analyses, having a HbA1c level ≥6...
2019: Journal of Frailty & Aging
https://read.qxmd.com/read/30673116/trends-in-influenza-vaccination-uptake-in-switzerland-swiss-health-survey-2007-and-2012
#9
Kathrin Zürcher, Marcel Zwahlen, Claudia Berlin, Matthias Egger, Lukas Fenner
AIMS: We studied time trends in seasonal influenza vaccination and assessed associations with socioeconomic and health-related determinants in Switzerland (overall and people aged ≥65 years). METHODS: We used data from the Swiss Health Surveys of 2007 and 2012. We calculated the proportion of the population (overall and those ≥65 years old) reporting influenza vaccination in the last 12 months, and performed multivariate logistic regression analyses, presented as adjusted odds ratios (aORs)...
January 14, 2019: Swiss Medical Weekly
https://read.qxmd.com/read/30664742/a-new-class-of-ar-antagonists
#10
Annette Fenner
No abstract text is available yet for this article.
January 21, 2019: Nature Reviews. Urology
https://read.qxmd.com/read/30664676/a-new-class-of-ar-antagonists
#11
Annette Fenner
No abstract text is available yet for this article.
March 2019: Nature Reviews. Endocrinology
https://read.qxmd.com/read/30660801/chemical-carcinogenicity-revisited-2-current-knowledge-of-carcinogenesis-shows-that-categorization-as-a-carcinogen-or-non-carcinogen-is-not-scientifically-credible
#12
John E Doe, Alan R Boobis, Vicki Dellarco, Penelope A Fenner-Crisp, Angelo Moretto, Timothy P Pastoor, Rita S Schoeny, Jennifer G Seed, Douglas C Wolf
Developments in the understanding of the etiology of cancer have undermined the 1970s concept that chemicals are either "carcinogens" or "non-carcinogens". The capacity to induce cancer should not be classified in an inflexible binary manner as present (carcinogen) or absent (non-carcinogen). Chemicals may induce cancer by three categories of mode of action: direct interaction with DNA or DNA replication including DNA repair and epigenetics; receptor-mediated induction of cell division; and non-specific induction of cell division...
January 17, 2019: Regulatory Toxicology and Pharmacology: RTP
https://read.qxmd.com/read/30634023/chemical-carcinogenicity-revisited-1-a-unified-theory-of-carcinogenicity-based-on-contemporary-knowledge
#13
Douglas C Wolf, Samuel M Cohen, Alan R Boobis, Vicki L Dellarco, Penelope A Fenner-Crisp, Angelo Moretto, Timothy P Pastoor, Rita S Schoeny, Jennifer G Seed, John E Doe
Developments in the understanding of the etiology of cancer have profound implications for the way the carcinogenicity of chemicals is addressed. This paper proposes a unified theory of carcinogenesis that will illuminate better ways to evaluate and regulate chemicals. In the last four decades, we have come to understand that for a cell and a group of cells to begin the process of unrestrained growth that is defined as cancer, there must be changes in DNA that reprogram the cell from normal to abnormal. Cancer is the consequence of DNA coding errors that arise either directly from mutagenic events or indirectly from cell proliferation especially if sustained...
January 8, 2019: Regulatory Toxicology and Pharmacology: RTP
https://read.qxmd.com/read/30634021/chemical-carcinogenicity-revisited-3-risk-assessment-of-carcinogenic-potential-based-on-the-current-state-of-knowledge-of-carcinogenesis-in-humans
#14
Samuel M Cohen, Alan R Boobis, Vicki L Dellarco, John E Doe, Penelope A Fenner-Crisp, Angelo Moretto, Timothy P Pastoor, Rita S Schoeny, Jennifer G Seed, Douglas C Wolf
Over 50 years, we have learned a great deal about the biology that underpins cancer but our approach to testing chemicals for carcinogenic potential has not kept up. Only a small number of chemicals has been tested in animal-intensive, time consuming, and expensive long-term bioassays in rodents. We now recommend a transition from the bioassay to a decision-tree matrix that can be applied to a broader range of chemicals, with better predictivity, based on the premise that cancer is the consequence of DNA coding errors that arise either directly from mutagenic events or indirectly from sustained cell proliferation...
January 8, 2019: Regulatory Toxicology and Pharmacology: RTP
https://read.qxmd.com/read/30611926/full-field-analysis-of-epicardial-strain-in-an-in-vitro-porcine-heart-platform
#15
Paolo Ferraiuoli, Benjamin Kappler, Sjoerd van Tuijl, Marco Stijnen, Bas A J M de Mol, John W Fenner, Andrew J Narracott
The quantitative assessment of cardiac strain is increasingly performed to provide valuable insights on heart function. Currently, the most frequently used technique in the clinic is ultrasound-based speckle tracking echocardiography (STE). However, verification and validation of this modality are still under investigation and further reference measurements are required to support this activity. The aim of this work was to enable these reference measurements using a dynamic beating heart simulator to ensure reproducible, controlled, and realistic haemodynamic conditions and to validate the reliability of optical-based three-dimensional digital image correlation (3D-DIC) for a dynamic full-field analysis of epicardial strain...
November 30, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://read.qxmd.com/read/30608987/change-in-skeletal-muscle-associated-with-unplanned-hospital-admissions-in-adult-patients-a-systematic-review-and-meta-analysis
#16
Peter Hartley, Patricia Costello, Rachel Fenner, Nathalie Gibbins, Édáin Quinn, Isla Kuhn, Victoria L Keevil, Roman Romero-Ortuno
OBJECTIVES: The primary objective of the review was to describe change that occurs in skeletal muscle during periods of unplanned hospitalisation in adult patients. The secondary objective was to examine the relationship between both physical activity and inflammation with the change in skeletal muscle. A further objective was to investigate the effect of interventions on change in skeletal muscle during periods of unplanned hospitalisation. DESIGN: A systematic review and meta-analyses...
2019: PloS One
https://read.qxmd.com/read/30607030/hyperpolarized-mri-illustrates-metabolic-response-to-therapy
#17
Annette Fenner
No abstract text is available yet for this article.
January 3, 2019: Nature Reviews. Urology
https://read.qxmd.com/read/30527470/effects-of-ghrelin-on-the-oxidative-stress-and-healing-of-the-colonic-anastomosis-in-rats
#18
Humberto Fenner Lyra Junior, Leonardo de Lucca Schiavon, Igor Kunze Rodrigues, Daniella Serafin Couto Vieira, Roberta de Paula Martins, Bruna Lenfers Turnes, Alexandra Susana Latini, Armando José D'Acâmpora
BACKGROUND: Anastomotic leakage is the deadliest complication of colonic procedures. Ghrelin is an orexigenic hormone with potent actions on growth hormone release and functions in the processes of growth, tissue inflammation, repair, and oxidative stress. We evaluated the hypothesis that the exogenous administration of ghrelin causes beneficial effects on the healing of colonic anastomosis. MATERIALS AND METHODS: Sixty-four male Wistar rats were randomly assigned to eight subgroups receiving postoperative intraperitoneal administration of ghrelin (23 μg/kg/d) or saline after a colonic anastomosis...
February 2019: Journal of Surgical Research
https://read.qxmd.com/read/30514967/efficacy-of-a-novel-single-dose-oral-antibiotic-for-urogenital-gonorrhoea
#19
Annette Fenner
No abstract text is available yet for this article.
February 2019: Nature Reviews. Urology
https://read.qxmd.com/read/30425343/ecoin-device-stops-patients-from-spending-a-penny
#20
Annette Fenner
No abstract text is available yet for this article.
November 13, 2018: Nature Reviews. Urology
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