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JOURNAL ARTICLE
Annette Fenner
No abstract text is available yet for this article.
January 22, 2024: Nature Reviews. Urology
#22
JOURNAL ARTICLE
Nicolas Banholzer, Remo Schmutz, Keren Middelkoop, Jerry Hella, Matthias Egger, Robin Wood, Lukas Fenner
The COVID-19 pandemic renewed interest in airborne transmission of respiratory infections, particularly in congregate indoor settings, such as schools. We modeled transmission risks of tuberculosis (caused by Mycobacterium tuberculosis, Mtb) and COVID-19 (caused by SARS-CoV-2) in South African, Swiss and Tanzanian secondary schools. We estimated the risks of infection with the Wells-Riley equation, expressed as the median with 2.5% and 97.5% quantiles (credible interval [CrI]), based on the ventilation rate and the duration of exposure to infectious doses (so-called quanta)...
2024: PLOS Glob Public Health
#23
Nicolas Banholzer, Philipp Jent, Pascal Bittel, Kathrin Zürcher, Lavinia Furrer, Simon Bertschinger, Ernest Weingartner, Alban Ramette, Matthias Egger, Tina Hascher, Lukas Fenner
BACKGROUND: Using a multiple-measurement approach, we examined the real-world effectiveness of portable HEPA-air filtration devices (air cleaners) in a school setting. METHODS: We collected environmental (CO 2 , particle concentrations), epidemiological (absences related to respiratory infections), audio (coughing), and molecular data (bioaerosol and saliva samples) over seven weeks during winter 2022/2023 in two Swiss secondary school classes. Using a cross-over study design, we compared particle concentrations, coughing, and the risk of infection with vs without air cleaners...
December 30, 2023: medRxiv
#24
JOURNAL ARTICLE
Anna-Ricarda Schittich, Kathrin Fenner, Colin A Stedmon, Jianxin Xu, Ursula S McKnight, Barth F Smets
Some bacteria can degrade organic micropollutants (OMPs) as primary carbon sources. Due to typically low OMP concentrations, these bacteria may benefit from supplemental assimilation of natural substrates present in the pool of dissolved organic matter (DOM). The biodegradability of such auxiliary substrates and the impacts on OMP removal are tightly linked to biotransformation pathways. Here, we aimed to elucidate the biodegradability and effect of different DOM constituents for the carbofuran degrader Novosphingobium sp...
January 17, 2024: Environmental Microbiology
#25
JOURNAL ARTICLE
Wendy M Wong, Yih Chung Tham, Matthew P Simunovic, Fred Kuanfu Chen, Chi D Luu, Haoyu Chen, Zi-Bing Jin, Ren-Juan Shen, Shiying Li, Ruifang Sui, Chen Zhao, Liping Yang, Muna Bhende, Rajiv Raman, Parveen Sen, Arkasubhra Ghosh, B Poornachandra, Muhammad Bayu Sasongko, Alia Arianti, Valen Chia, Cosmos O Mangunsong, Florence Manurung, Kaoru Fujinami, Hanako Ikeda, Se Joon Woo, Sang Jin Kim, Safinaz Mohd Khialdin, Othmaliza Othman, Mae-Lynn Catherine Bastion, Ain Tengku Kamalden, Pooi Wah Penny Lott, Kenneth Fong, Manoharan Shunmugam, Amelia Lim, Raba Thapa, Eli Pradhan, Sthapit Purnima Rajkarnikar, Srijana Adhikari, B Manuel Benjamin Iv Ibañez, Adrian Koh, Choi Mun M Chan, Beau J Fenner, Tien-En Tan, Augustinus Laude, Wei Kiong Ngo, Graham E Holder, Xinyi Su, Ta-Ching Chen, Nan-Kai Wang, Eugene Yu-Chuan Kang, Chu-Hsuan Huang, Nuntachai Surawatsatien, Phattrawan Pisuchpen, Tharikarn Sujirakul, Govindasamy Kumaramanickavel, Mandeep Singh, Bart Leroy, Michel Michaelides, Ching-Yu Cheng, Li Jia Chen, Hwei Wuen Chan
PURPOSE: There are major gaps in our knowledge of hereditary ocular conditions in the Asia-Pacific population, which comprises approximately 60% of the world's population. Therefore, a concerted regional effort is urgently needed to close this critical knowledge gap and apply precision medicine technology to improve the quality of lives of these patients in the Asia-Pacific region. DESIGN: Multi-national, multi-center collaborative network. METHODS: The Research Standing Committee of the Asia-Pacific Academy of Ophthalmology and the Asia-Pacific Society of Eye Genetics fostered this research collaboration, which brings together renowned institutions and experts for inherited eye diseases in the Asia-Pacific region...
December 1, 2023: Asia-Pacific Journal of Ophthalmology
#26
JOURNAL ARTICLE
Leslie A Enane, Stephany N Duda, Thida Chanyachukul, Carolyn Bolton-Moore, Neelima Navuluri, Eugène Messou, Nana Mbonze, LaQuita R McDade, Marina Cruvinel Figueiredo, Jeremy Ross, Denise Evans, Lameck Diero, Robert Akpata, Natalia Zotova, Aimee Freeman, Marie Flore Pierre, Dhanushi Rupasinghe, Marie Ballif, Helen Byakwaga, Nathalie de Castro, Martine Tabala, Timothy R Sterling, Annette H Sohn, Lukas Fenner, Kara Wools-Kaloustian, Armel Poda, Marcel Yotebieng, Robin Huebner, Olivier Marcy
INTRODUCTION: Tuberculosis (TB) is a leading infectious cause of death globally. It is the most common opportunistic infection in people living with HIV, and the most common cause of their morbidity and mortality. Following TB treatment, surviving individuals may be at risk for post-TB lung disease. The TB Sentinel Research Network (TB-SRN) provides a platform for coordinated observational TB research within the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium...
January 9, 2024: BMJ Open
#27
JOURNAL ARTICLE
Sujan Gautam, Jennifer L Fenner, Boyuan Wang, Ryan C Range
Studies across a diverse group of metazoan embryos indicate that Wnt signaling often activates the transcription factor Sp5, forming a signaling 'cassette' that plays critical roles in many developmental processes. This study explores the role of Wnt/Sp5 signaling during the specification and patterning of the primary germ layers during early anterior-posterior axis formation in the deuterostome sea urchin embryo. Our functional analyses show that Sp5 is critical for endomesoderm specification downstream of Wnt/β-catenin in posterior cells as well as anterior neuroectoderm patterning downstream of non-canonical Wnt/JNK signaling in anterior cells...
January 19, 2024: IScience
#28
JOURNAL ARTICLE
Kelvin Yc Teo, Jinzhi Zhao, Farah Ilyana Ibrahim, Beau Fenner, Usha Chakravarthy, Chui Ming Gemmy Cheung
PURPOSE: To report the characteristics and correlation of visual acuity in eyes treated for neovascular AMD (nAMD) and developed fibrosis. DESIGN: Case-control study METHODS: 356 treatment naive nAMD eyes that were treated for 12 months were included. Fibrosis was defined as present if well-defined hyperreflective material (HRM) between the neurosensory retina and the Bruchs' membrane (BM) on optical coherence tomography (OCT) which correlated with well-defined regions of yellowish pallor on fundus photography and/or staining on fluorescence angiography were present...
December 20, 2023: American Journal of Ophthalmology
#29
Kiana Banafshay, Blayne Fenner, Kristina Blegen, Jackson Driskill, Michelle Tarbox
Relapsing polychondritis (RP) is a rare autoimmune condition that involves the recurrent inflammation of cartilage throughout the body, with a predilection for auricular and nasal cartilage. Given its rarity and diverse clinical presentations, RP is frequently misdiagnosed or left untreated, which can lead to significant morbidity and mortality. When it is correctly diagnosed, there are no standardized guidelines on the treatment of RP to date. Management of this disease requires a multidisciplinary approach, and about 30% of patients with RP have other autoimmune disorders, further complicating the approach to targeted treatment...
November 2023: Curēus
#30
JOURNAL ARTICLE
Veronika W Skrivankova, Stefanie Hossmann, Morna Cornell, Marie Ballif, Carole Dupont, Jacqueline Huwa, Konstantinos Seintaridis, Thokozani Kalua, Gilles Wandeler, Reshma Kassanjee, Andreas D Haas, Karl-Gunter Technau, Lukas Fenner, Nicola Low, Mary-Ann Davies, Matthias Egger
BACKGROUND: The International epidemiology Databases to Evaluate AIDS conducts research in several regions, including in Southern Africa. We assessed authorship inequalities for the Southern African region, which is led by South African and Swiss investigators. METHODS: We analysed authorships of publications from 2007 to 2020 by gender, country income group, time and citation impact. We used 2020 World Bank categories to define income groups and the relative citation ratio (RCR) to assess citation impact...
December 16, 2023: BMJ Global Health
#31
JOURNAL ARTICLE
John Fenner
No abstract text is available yet for this article.
December 11, 2023: Journal of Medical Engineering & Technology
#32
JOURNAL ARTICLE
Tien-En Tan, Rachael Wei Chao Tang, Choi Mun Chan, Ranjana S Mathur, Beau J Fenner
(1) Purpose: ABCA4 -associated retinal degeneration ( ABCA4 -RD) is a phenotypically diverse disease that often evades diagnosis, even by experienced retinal specialists. This may lead to inappropriate management, delayed genetic testing, or inaccurate interpretation of genetic testing results. Here, we illustrate the phenotypic diversity of ABCA4 -RD using a series of representative cases and compare these to other conditions that closely mimic ABCA4 -RD. (2) Methods: Genetically confirmed ABCA4 -RD cases with representative phenotypes were selected from an inherited retinal disease cohort in Singapore and compared to phenocopies involving other retinal diseases...
November 25, 2023: Diagnostics
#33
JOURNAL ARTICLE
Hiroko Satoh, Jasmin Hafner, Jürg Hutter, Kathrin Fenner
Micropollutants have become a serious environmental problem by threatening ecosystems and the quality of drinking water. This account investigates if advanced AI can be used to find solutions for this problem. We review background, the challenges involved, and the current state-of-the-art of quantitative structure-biodegradation relationships (QSBR). We report on recent progress combining experiment, quantum chemistry (QC) and chemoinformatics, and provide a perspective on potential future uses of AI technology to help improve water quality...
February 22, 2023: Chimia
#34
JOURNAL ARTICLE
Claudia Coll, Kathrin Fenner, Claudio Screpanti
The use of agrochemical and pharmaceutical active ingredients is essential in our modern society. Given the increased concern and awareness of the potential risks of some chemicals, there is a growing need to align with 'green chemistry' and 'safe and sustainable by design' principles and thus to evaluate the hazards of agrochemical and pharmaceutical active ingredients in early stages of R&D. We give an overview of the current challenges and opportunities to assess the principle of biodegradability in the environment...
November 29, 2023: Chimia
#35
Blayne Fenner, Kevin Burningham, Mahmud Alkul, Stephen Tyring
No abstract text is available yet for this article.
December 2023: JAAD Case Reports
#36
JOURNAL ARTICLE
Adam P DeLuca, S Scott Whitmore, Nicole J Tatro, Jeaneen L Andorf, Ben P Faga, Laurel A Faga, Malia M Colins, Meagan A Luse, Beau J Fenner, Edwin M Stone, Todd E Scheetz
PURPOSE: Choroideremia is an X-linked choroidopathy caused by pathogenic variants in the CHM gene. It is characterized by the early appearance of multiple scotomas in the peripheral visual field that spread and coalesce, usually sparing central vision until late in the disease. These features make quantitative monitoring of visual decline particularly challenging. Here, we describe a novel computational approach to convert Goldmann visual field (GVF) data into quantitative volumetric measurements...
December 2023: Ophthalmol Sci
#37
REVIEW
Julia Somers, Madeleine Fenner, Garth Kong, Dharani Thirumalaisamy, William M Yashar, Kisan Thapa, Meric Kinali, Olga Nikolova, Özgün Babur, Emek Demir
For decades, molecular biologists have been uncovering the mechanics of biological systems. Efforts to bring their findings together have led to the development of multiple databases and information systems that capture and present pathway information in a computable network format. Concurrently, the advent of modern omics technologies has empowered researchers to systematically profile cellular processes across different modalities. Numerous algorithms, methodologies, and tools have been developed to use prior knowledge networks (PKNs) in the analysis of omics datasets...
November 2023: Proteomics
#38
JOURNAL ARTICLE
Natalie Adams, Oliver Stirrup, James Blackstone, Maria Krutikov, Jackie A Cassell, Dorina Cadar, Catherine Henderson, Martin Knapp, Lara Goscé, Ruth Leiser, Martyn Regan, Iona Cullen-Stephenson, Robert Fenner, Arpana Verma, Adam Gordon, Susan Hopkins, Andrew Copas, Nick Freemantle, Paul Flowers, Laura Shallcross
INTRODUCTION: Care home residents have experienced significant morbidity, mortality and disruption following outbreaks of SARS-CoV-2. Regular SARS-CoV-2 testing of care home staff was introduced to reduce transmission of infection, but it is unclear whether this remains beneficial. This trial aims to investigate whether use of regular asymptomatic staff testing, alongside funding to reimburse sick pay for those who test positive and meet costs of employing agency staff, is a feasible and effective strategy to reduce COVID-19 impact in care homes...
November 14, 2023: BMJ Open
#39
JOURNAL ARTICLE
Leonie Heron, Catrina Mugglin, Kathrin Zürcher, Erich Brumann, Bettina Keune-Dübi, Nicola Low, Lukas Fenner
BACKGROUND: Contact tracing (CT) has played an important role in strategies to control COVID-19. However, there is limited evidence on the performance of digital tools for CT and no consensus on which indicators to use to monitor their performance. We aimed to describe the system and analyse outcomes of CT with a partially automated workflow in the Swiss canton of Solothurn, using key performance indicators (KPIs). METHODS: We describe the process of CT used in the canton of Solothurn between November 2020 and February 2022, including forward and backward CT...
October 22, 2023: Swiss Medical Weekly
#40
JOURNAL ARTICLE
Erin R Burnight, Beau J Fenner, Ian C Han, Adam P DeLuca, S Scott Whitmore, Laura R Bohrer, Jeaneen L Andorf, Elliott H Sohn, Robert F Mullins, Budd A Tucker, Edwin M Stone
Mutations in ABCA4 are the most common cause of Mendelian retinal disease. Clinical evaluation of this gene is challenging because of its extreme allelic diversity, the large fraction of non-exomic mutations, and the wide range of associated disease. We used patient-derived retinal organoids as well as DNA samples and clinical data from a large cohort of patients with ABCA4-associated retinal disease to investigate the pathogenicity of a variant in ABCA4 (IVS30 + 1321 A > G) that occurs heterozygously in 2% of Europeans...
October 31, 2023: Human Molecular Genetics
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