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JOURNAL ARTICLE
Yael Goverover, Saumya Sharan, Lauren Krupp, John DeLuca
IMPORTANCE: This pilot study evaluates a remote strategy-based intervention for individuals with multiple sclerosis who experience everyday memory impairments. The intervention can potentially inform cognitive rehabilitation for this population. OBJECTIVE: To investigate the feasibility and efficacy of an intervention (TELE-Self-GEN) to determine whether it can alleviate everyday memory impairments of individuals with multiple sclerosis. DESIGN: Pretest-posttest...
July 1, 2024: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
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JOURNAL ARTICLE
Arya Yazdan-Panah, Benedetta Bodini, Théodore Soulier, Mattia Veronese, Michel Bottlaender, Matteo Tonietto, Bruno Stankoff
BACKGROUND: Exploring the relationship between oxygen supply and myelin damage would benefit from a simultaneous quantification of myelin and cerebral blood flow (CBF) in the brain's white matter (WM). To validate an analytical method for quantifying both CBF and myelin content in the WM using dynamic [11 C]PiB positron emission tomography (PET). METHODS: A test-retest study was performed on eight healthy subjects who underwent two consecutive dynamic [11 C]PiB-PET scans...
May 27, 2024: EJNMMI Research
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JOURNAL ARTICLE
Nicolette A Pirjanian, Kriti Kalpana, Ilya Kruglikov, Pinar Mesci, Jana Stoudemire, Paula Grisanti, Scott A Noggle, Jeanne F Loring, Valentina Fossati
Recent findings from studies involving astronauts and animal models indicate that microgravity increases immune cell activity and potentially alters the white and gray matter of the central nervous system (CNS). To further investigate the impact of microgravity on CNS cells, we established cultures of three-dimensional neural organoids containing isogenic microglia, the brain's resident immune cells, and sent them onboard the International Space Station. When using induced pluripotent stem cell (iPSC) lines from individuals affected by neuroinflammatory and neurodegenerative diseases such as multiple sclerosis (MS) and Parkinson's disease (PD), these cultures can provide novel insights into pathogenic pathways that may be exacerbated by microgravity...
May 28, 2024: Methods in Molecular Biology
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JOURNAL ARTICLE
Sohyun Jeong, Ming-Ju Tsai, Changbing Shen, Yi-Hsiang Hsu
INTRODUCTION: Patients with multiple sclerosis (MS) commonly present musculoskeletal disorders characterized by lower bone mineral density (BMD) and muscle weakness. However, the underlying etiology remains unclear. Our objective is to identify shared pleiotropic genetic effects and estimate the causal relationship between MS and musculoskeletal disorders. MATERIALS AND METHODS: We conducted linkage disequilibrium score regression (LDSR), colocalization, and Mendelian randomization (MR) analyses using summary statistics from recent large-scale genome-wide association studies (GWAS), encompassing MS, falls, fractures, and frailty...
May 27, 2024: Journal of Bone and Mineral Metabolism
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JOURNAL ARTICLE
Tao Wu, Shangwei Ning, Huixue Zhang, Yuze Cao, Xia Li, Junwei Hao, Lihua Wang
Previous studies have found that ferroptosis plays an important role in a variety of neurological diseases. However, the precise role of ferroptosis in the multiple sclerosis patients remains uncertain. We defined and validated a computational metric of ferroptosis levels. The ferroptosis scores were computed using the AUCell method, which reflects the enrichment scores of ferroptosis-related genes through gene ranking. The reliability of the ferroptosis score was assessed using various methods, involving cells induced to undergo ferroptosis by six different ferroptosis inducers...
May 2024: Journal of Cellular and Molecular Medicine
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JOURNAL ARTICLE
Suhayl Dhib-Jalbut
No abstract text is available yet for this article.
May 27, 2024: Journal of Interferon & Cytokine Research
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JOURNAL ARTICLE
Jingqi Fan, Qing Liu, Xin Liu, Mengjiao Gong, Ian I Leong, YauKeung Tsang, Xiaoyan Xu, Suying Lei, Lining Duan, Yifan Zhang, Muxi Liao, Lixing Zhuang
BACKGROUND: Aging has always been considered as a risk factor for neurodegenerative diseases, but there are individual differences and its mechanism is not yet clear. Epigenetics may unveil the relationship between aging and neurodegenerative diseases. METHODS: Our study employed a bidirectional two-sample Mendelian randomization (MR) design to assess the potential causal association between epigenetic aging and neurodegenerative diseases. We utilized publicly available summary datasets from several genome-wide association studies (GWAS)...
2024: Frontiers in Endocrinology
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JOURNAL ARTICLE
Tim Spelman, Sara Eichau, Raed Alroughani, Serkan Ozakbas, Samia J Khoury, Francesco Patti, Eva Kubala Havrdova, Cavit Boz, Murat Terzi, Jens Kuhle, Pierre Grammond, Jeanette Lechner-Scott, Orla Gray, Maria Pia Amato, Guy Laureys, Vahid Shaygannejad, Robert Hyde, Haijue Wang, Ivan Bozin, Nicholas Belviso, Chao Quan, Feng Zeng, Anneke van der Walt, Helmut Butzkueven
BACKGROUND: The use of non-specific immunosuppressants (NSIS) to treat multiple sclerosis (MS) remains prevalent in certain geographies despite safety concerns, likely due to resource limitations. OBJECTIVE: To use MSBase registry data to compare real-world outcomes in adults with relapsing-remitting MS (RRMS) treated with dimethyl fumarate (DMF) or NSIS (azathioprine, cyclosporine, cyclophosphamide, methotrexate, mitoxantrone or mycophenolate mofetil) between January 1, 2014 and April 1, 2022...
2024: Multiple Sclerosis Journal—Experimental, Translational and Clinical
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Vincent E Provasek, Albino Bacolla, Suganya Rangaswamy, Joy Mitra, Manohar Kodavati, Issa O Yusuf, Vikas H Malojirao, Velmarini Vasquez, Gavin W Britz, Guo-Min Li, Zuoshang Xu, Sankar Mitra, Ralph M Garruto, John A Tainer, Muralidhar L Hegde
TDP43 is an RNA/DNA binding protein increasingly recognized for its role in neurodegenerative conditions including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). As characterized by its aberrant nuclear export and cytoplasmic aggregation, TDP43 proteinopathy is a hallmark feature in over 95% of ALS/FTD cases, leading to the formation of detrimental cytosolic aggregates and a reduction in nuclear functionality within neurons. Building on our prior work linking TDP43 proteinopathy to the accumulation of DNA double-strand breaks (DSBs) in neurons, the present investigation uncovers a novel regulatory relationship between TDP43 and DNA mismatch repair (MMR) gene expressions...
May 17, 2024: bioRxiv
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JOURNAL ARTICLE
Larissa Jank, Riley B Catenacci, Veronica Minney, Danny Galleguillos, Peter A Calabresi
Preclinical studies of pro-remyelinating therapies for multiple sclerosis tend to neglect the effect of the disease-relevant inflammatory milieu. Interferon-gamma (IFN-γ) is known to suppress oligodendrocyte progenitor cell (OPC) differentiation and induce a recently described immune OPC (iOPC) phenotype characterized by expression of major histocompatibility complex (MHC) molecules. We tested the effects of cladribine (CDB), dimethylfumarate (DMF), and interferon-beta (IFN-β), existing anti-inflammatory therapies for MS, on the IFN-γ-induced iOPC formation and OPC differentiation block...
May 25, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
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REVIEW
Juan F Zapata-Acevedo, Alejandra Mantilla-Galindo, Karina Vargas-Sánchez, Rodrigo E González-Reyes
The blood-brain barrier (BBB) is a dynamic interface that regulates the exchange of molecules and cells between the brain parenchyma and the peripheral blood. The BBB is mainly composed of endothelial cells, astrocytes and pericytes. The integrity of this structure is essential for maintaining brain and spinal cord homeostasis and protection from injury or disease. However, in various neurological disorders, such as traumatic brain injury, Alzheimer's disease, and multiple sclerosis, the BBB can become compromised thus allowing passage of molecules and cells in and out of the central nervous system parenchyma...
2024: Advances in Clinical Chemistry
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JOURNAL ARTICLE
Maria A Piedrabuena, Jorge Correale, Marcela Fiol, Mariano Marrodan, Juan I Rojas, Marina Alonso, Agustín Pappolla, Jimena Miguez, Liliana Patrucco, Edgardo Cristiano, Carlos Vrech, Leila Cohen, Ricardo Alonso, Berenice Silva, Geraldine Luetic, Norma Deri, Marcos Burgos, Susana Liwacki, Raul Piedrabuena, Verónica Tkachuk, Andres Barboza, Alejandra Martinez, Maria E Balbuena, Amelia Alves Pinheiro, Pedro Nofal, Pablo A Lopez, Dario Tavolini, Felisa Leguizamon, Javier P Hryb, Santiago Tizio, Luciano Recchia, Edgardo Reich, Edgar Carnero Contentti, Marcela Parada Marcilla, Fatima Pagani, Lorena M Cabrera, Maria C Curbelo, Carolina Mainella, Nora Fernández Liguori, Mariano Coppola, Juan P Pettinicchi, Adriana Carra, Gustavo Jose, Debora Nadur, Santiago Bestoso, Claudia Pestchanker, Guido D Vazquez, Carlos M Martinez, María C Ysrraelit
BACKGROUND: Knowledge of the safety and efficacy of disease-modifying therapies (DMTs) in older patients with Multiple Sclerosis (pwMS) is limited due to their exclusion from clinical trials. Our purpose is to evaluate the choice of DMTs in pwMS older than 50 years old in a real-world setting. METHODS: Cross-sectional study of pwMS from the Argentine MS and NMOSD Registry. We included patients under 35 and above 50 years old prescribed DMTs. Disease activity was categorized as highly active (HA) or not highly active (NHA), and DMTs were classified as low efficacy therapies (LET) or high efficacy therapies (HET)...
May 16, 2024: Journal of the Neurological Sciences
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JOURNAL ARTICLE
Angelo Fonseca, Ernestina Santos, Ricardo Taipa
BACKGROUND: Baló's concentric sclerosis (BCS) is a rare variant of multiple sclerosis characterized by unique pathological features of alternating demyelination and preserved myelin. OBJECTIVES: To describe two cases of BCS, radiological and pathological findings and its clinical course. RESULTS: We report two distinct cases of BCS that presented with unique MRI findings suggestive of BCS, but with different clinical courses and responses to treatment...
May 17, 2024: Journal of Neuroimmunology
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JOURNAL ARTICLE
Zhong Shi, Huanhuan Sun, Xinyi Tian, Xiujuan Song, Jingyi Fan, Shichao Sun, Jinli Wang, Jing Zhang, Jueqiong Wang
Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system. Recent research has revealed that mesenchymal stem cell-derived extracellular vesicles (MSC-EVs), containing specific miRNAs, possess immunomodulatory properties and have demonstrated therapeutic potential in the treatment of MS. This study aimed to investigate the role MSC-EVs, containing microRNA-181a-5p (miR-181a-5p) in both experimental autoimmune encephalomyelitis (EAE), an established animal model of MS, and lipopolysaccharide-stimulated BV2 microglia...
May 25, 2024: International Immunopharmacology
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JOURNAL ARTICLE
Luis Andreu-Caravaca, Domingo J Ramos-Campo, Ana Martos-Bonilla, Alberto Rando-Martín, Jacobo Á Rubio-Arias
BACKGROUND: Physical exercise programs are commonly designed without consideration for sex differences. Nevertheless, disease progression exhibits sex-specific patterns, resulting in different functionality and strength performances. OBJECTIVES: To analyze sex differences in strength, functional capacity, and mobility, and to evaluate sex-dependent differences in leg strength in multiple sclerosis (MS) patients. METHODS: A cross-sectional study was conducted with 35 participants (female: n = 19; Expanded Disability Status Scale (EDSS)= 3...
May 23, 2024: Multiple Sclerosis and related Disorders
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REVIEW
Maria G Campos, Maria China, Mariana Cláudio, Miguel Capinha, Rita Torres, Simão Oliveira, Ana Fortuna
Clinical practice entails a translation of research that assists in the use of scientific data and therapeutic evidence for the benefit of the patient. This review critically summarizes the potential impact of cannabinoids in conjunction with other drugs when associated with treatments for epilepsy, autism spectrum disorder, cancer, multiple sclerosis, and chronic pain. In these associations, potential drug interactions may occur and alter the predicted clinical results. Therefore, the potential for drug interactions must always be assessed to avoid therapeutic failures and/or increased side effects...
May 10, 2024: Pharmaceuticals
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JOURNAL ARTICLE
Miriam Gorostidi-Aicua, Iraia Reparaz, Ane Otaegui-Chivite, Koldo García, Leire Romarate, Amaya Álvarez de Arcaya, Idoia Mendiburu, Maialen Arruti, Tamara Castillo-Triviño, Laura Moles, David Otaegui
Multiple sclerosis (MS) arises from a complex interplay between host genetic factors and environmental components, with the gut microbiota emerging as a key area of investigation. In the current study, we used ion torrent sequencing to delve into the bacteriome (bacterial microbiota) and mycobiome (fungal microbiota) of people with MS (pwMS), and compared them to healthy controls (HC). Through principal coordinate, diversity, and abundance analyses, as well as clustering and cross-kingdom microbial correlation assessments, we uncovered significant differences in the microbial profiles between pwMS and HC...
April 26, 2024: Microorganisms
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REVIEW
Katarzyna Paczwa, Magdalena Rerych, Katarzyna Romanowska-Próchnicka, Radosław Różycki, Joanna Gołębiewska
Systemic sclerosis (SSc) is a chronic autoimmune connective tissue disease that affects more than 2 million people worldwide. It manifests through vasculopathy, an abnormal immunological response, and fibrosis leading to dysfunction of the multiple organs. The disease is categorized into two subtypes: limited cutaneous SSc and diffuse cutaneous SSc. Scleroderma can affect vital organs with respiratory, cardiac, renal, ocular, and dermatological complications. The ocular manifestations of the disease can occur in the anterior and posterior segments of the eye...
May 13, 2024: Life
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JOURNAL ARTICLE
Rosaria Sacco, Gianna Carla Riccitelli, Giulio Disanto, Julien Bogousslavsky, Ariane Cavelti, David Czell, Christian Philipp Kamm, Uta Kliesch, Simon Peter Ramseier, Claudio Gobbi, Chiara Zecca
Background: Cannabinoid oro-mucosal spray nabiximols is approved for patients with moderate to severe multiple sclerosis spasticity (MSS) resistant to other antispastic medications. Few real-world data are available on the effectiveness, safety and patients' satisfaction in MS patients treated with nabiximols as monotherapy. Methods: To investigate the effectiveness, tolerability and satisfaction of nabiximols in a real-life multicentric Swiss cohort as monotherapy or with stable doses of other antispastic medications, and explore clinical features which may predict treatment response...
May 14, 2024: Journal of Clinical Medicine
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JOURNAL ARTICLE
Thaïs De Bock, Carola Brussaard, Silke François, Karlien François, Laura Seynaeve, Anna Jansen, Karl Martin Wissing, Peter Janssens
Introduction: Tuberous sclerosis complex (TSC) is a genetic disease caused by pathogenetic variants in either the TSC1 or TSC2 genes. Consequently, the mechanistic target of the rapamycin complex 1 (mTORC1) pathway, a regulator of cell growth, metabolism, and survival, becomes inappropriately activated, leading to the development of benign tumors in multiple organs. The role of mTORC1 in lipid metabolism and liver steatosis in TSC patients has not been well-studied, and clinical data on liver involvement in this population are scarce...
May 14, 2024: Journal of Clinical Medicine
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