Xuezhao Liu, Dazhuan Eric Xin, Xiaowen Zhong, Chuntao Zhao, Zhidan Li, Liguo Zhang, Adam J Dourson, Lindsay Lee, Shreya Mishra, Arman E Bayat, Eva Nicholson, William L Seibel, Bingfang Yan, Joel Mason, Bradley J Turner, David G Gonsalvez, William Ong, Sing Yian Chew, Balaram Ghosh, Sung Ok Yoon, Mei Xin, Zhigang He, Jason Tchieu, Michael Wegner, Klaus-Armin Nave, Robin J M Franklin, Ranjan Dutta, Bruce D Trapp, Ming Hu, Matthew A Smith, Michael P Jankowski, Samantha K Barton, Xuelian He, Q Richard Lu
Remyelination failure in diseases like multiple sclerosis (MS) was thought to involve suppressed maturation of oligodendrocyte precursors; however, oligodendrocytes are present in MS lesions yet lack myelin production. We found that oligodendrocytes in the lesions are epigenetically silenced. Developing a transgenic reporter labeling differentiated oligodendrocytes for phenotypic screening, we identified a small-molecule epigenetic-silencing-inhibitor (ESI1) that enhances myelin production and ensheathment...
April 25, 2024: Cell