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MS OR Multiple Sclerosis

Martin Diebold, Simon Müller, Tobias Derfuss, Bernhard F Décard
BACKGROUND: Multiple sclerosis (MS) and psoriasis vulgaris (PV) are two disorders with autoimmune pathophysiology and a supposed altered T helper (TH ) cell response. OBJECTIVE: To report a case of concomitant relapsing remitting MS and PV treated with different immunomodulatory medications, particularly secukinumab and rituximab. METHODS: Case report. RESULTS: In a 68-year-old woman diagnosed with MS and PV, secukinumab alleviated the dermatological condition, but could not control neuroinflammation...
March 9, 2019: Multiple Sclerosis and related Disorders
D Doesburg, A Vennegoor, B M J Uitdehaag, B W van Oosten
BACKGROUND: Multiple sclerosis (MS) is associated with high rates of disability pension and work absence. Little is known about work absence in early MS. The objectives of this study were (1) to assess the prevalence of work absence shortly after MS diagnosis, (2) to explore health-related quality of life (HRQoL) and disease impact in relation to work absence and (3) to investigate demographic and clinical factors that may be associated with high work absence. METHODS: Patients with relapsing remitting (RRMS) or primary progressive MS (PPMS) were included shortly after MS diagnosis...
March 16, 2019: Multiple Sclerosis and related Disorders
Ban-Yu Saitoh, Ryo Yamasaki, Akio Hiwatashi, Takuya Matsushita, Shintaro Hayashi, Yoshihiro Mitsunaga, Yasuhiro Maeda, Noriko Isobe, Kunihiro Yoshida, Shu-Ichi Ikeda, Jun-Ichi Kira
BACKGROUND: Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) is a rare autosomal-dominant white matter disease, typically characterized by juvenile cognitive decline and frontoparietal white matter lesions. A portion of HDLS patients exhibit preferential motor dysfunctions as their initial symptoms, mimicking multiple sclerosis (MS). However, there is no study comparing this phenotype of HDLS and primary progressive multiple sclerosis (PPMS), which greatly resemble each other...
March 12, 2019: Multiple Sclerosis and related Disorders
Kim V Korrell, Jolande Disser, Kristina Parley, Auguste Vadisiute, Maï-Carmen Requena-Komuro, Harriet Fodder, Charlotte Pollart, Graham Knott, Zoltán Molnár, Anna Hoerder-Suabedissen
Myelination of axons by oligodendrocytes in the central nervous system is crucial for fast, saltatory conduction of action potentials. As myelination is central for brain development and plasticity, and deficits are implicated in several neural disorders such as multiple sclerosis, major depressive disorder, bipolar disorder and schizophrenia, it is important to elucidate the underlying mechanisms regulating myelination. Numerous mechanisms have been proposed by which the communication between oligodendrocytes and active axons may regulate the onset and maintenance of activity-dependent myelination...
March 22, 2019: Journal of Anatomy
Vanesa Pytel, Jordi A Matías-Guiu, Laura Torre-Fuentes, Paloma Montero-Escribano, Paolo Maietta, Javier Botet, Sara Álvarez, Ulises Gómez-Pinedo, Jorge Matías-Guiu
INTRODUCTION: Vitamin D (VD) deficiency has been associated with multiple sclerosis (MS) and other autoimmune diseases (AIDs). However, the effect of the genetics of VD on the risk of MS is subject to debate. This study focuses on genes linked to the VD signaling pathway in families with MS. The evaluation of gene variants in all the members of families could contribute to an additional knowledge on the information obtained from case-control studies that use nonrelated healthy people...
March 21, 2019: Brain and Behavior
Maria Pia Amato, Vincenzo Brescia Morra, Monica Falautano, Angelo Ghezzi, Benedetta Goretti, Francesco Patti, Alice Riccardi, Flavia Mattioli
In the original article, Maria Pia Amato's second affiliation was not included. The second affiliation is IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy. The correct affiliation is presented here.
March 21, 2019: Neurological Sciences
Baokun He, Thomas K Hoang, Xiangjun Tian, Christopher M Taylor, Eugene Blanchard, Meng Luo, Meenakshi B Bhattacharjee, Jasmin Freeborn, Sinyoung Park, Jacob Couturier, John William Lindsey, Dat Q Tran, Jon Marc Rhoads, Yuying Liu
The gut microbiome plays an important role in immune function and has been implicated in multiple sclerosis (MS). However, how and if the modulation of microbiota can prevent or treat MS remain largely unknown. In this study, we showed that probiotic Lactobacillus reuteri DSM 17938 ( L. reuteri ) ameliorated the development of murine experimental autoimmune encephalomyelitis (EAE), a widely used animal model of MS, a model which is primarily mediated by TH 17 and TH 1 cells. We discovered that L. reuteri treatment reduced TH 1/TH 17 cells and their associated cytokines IFN-γ/IL-17 in EAE mice...
2019: Frontiers in Immunology
Maria Grazia Maggio, Margherita Russo, Marilena Foti Cuzzola, Massimo Destro, Gianluca La Rosa, Francesco Molonia, Placido Bramanti, Giuseppe Lombardo, Rosaria De Luca, Rocco Salvatore Calabrò
Multiple sclerosis (MS) is a demyelinating neurodegenerative disease with lesions involving the central nervous system. Clinical symptoms consist of disturbances in motor activity (e.g., weakness, spasticity, and tremor), sensory functioning (e.g., pain), visual functions (e.g., diplopia and optic neuritis), besides different cognitive (attention deficit and executive dysfunction) and behavioral abnormalities. This review aims to evaluate the role of VR tools in cognitive and motor rehabilitation of MS patients...
March 18, 2019: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Chiara Dianzani, Domizia Vecchio, Nausicaa Clemente, Annalisa Chiocchetti, Filippo Martinelli Boneschi, Daniela Galimberti, Umberto Dianzani, Cristoforo Comi, Michele Mishto, Juliane Liepe
The function of proteasomes in extracellular space is still largely unknown. The extracellular proteasome-osteopontin circuit has recently been hypothesized to be part of the inflammatory machinery regulating relapse/remission phase alternation in multiple sclerosis. However, it is still unclear what dynamics there are between the different elements of the circuit, what the role of proteasome isoforms is, and whether these inflammatory circuit dynamics are associated with the clinical severity of multiple sclerosis...
March 20, 2019: Cells
Iara Barreto Neves Oliveira, Rodrigo Saar Gomes, Larissa Fonseca Gomides, Jéssica Cristina Dos Santos, Marcos Alexandre Diniz Carneiro, Fátima Ribeiro-Dias, Denise Sisterolli Diniz
OBJECTIVE: Multiple sclerosis (MS) is a multifactorial chronic disease that affects the central nervous system (CNS). Toll-like receptors (TLRs) play a central role in cytokine production after pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and contribute to CNS damage in MS patients. Here, we evaluated the effects of interferon (IFN)-β treatment in TLR2 and TLR4-dependent cytokine production and mRNA expression in whole-blood cell cultures from MS patients. METHODS: We evaluated cytokine production by ELISA from whole-blood cell culture supernatants and mRNA expression by real-time polymerase chain reaction in peripheral blood mononuclear cells (PBMCs)...
March 21, 2019: Neuroimmunomodulation
Casey Cook, Leonard Petrucelli
Amyotrophic lateral sclerosis (ALS) is an aggressive neurodegenerative disorder that orchestrates an attack on the motor nervous system that is unrelenting. Recent discoveries into the pathogenic consequences of repeat expansions in C9ORF72, which are the most common genetic cause of ALS, combined with the identification of new genetic mutations are providing novel insight into the underlying mechanism(s) that cause ALS. In particular, the myriad of functions linked to ALS-associated genes have collectively implicated four main pathways in disease pathogenesis, including RNA metabolism and translational biology; protein quality control; cytoskeletal integrity and trafficking; and mitochondrial function and transport...
March 20, 2019: Neuron
Emily Donaldson, Viral P Patel, Prathiba Shammi, Anthony Feinstein
BACKGROUND: Cognitive dysfunction affects 40% to 70% of people with multiple sclerosis (MS). Sex may influence a person's cognition. Although a few studies have reported greater cognitive deficits in men than women, it is unclear whether specific cognitive domains are more vulnerable than others to the effects of sex or whether cognition is influenced by neurologic or psychiatric variables. METHODS: A chart review was undertaken of 408 people with MS referred to neuropsychological services...
March 2019: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
Rachel E Bollaert, Brian M Sandroff, Elizabeth A L Stine-Morrow, Bradley P Sutton, Robert W Motl
OBJECTIVE: To examine the associations between physical function (walking speed and endurance and functional mobility) and cognitive function (information processing speed and verbal memory) in older adults with multiple sclerosis (MS) and healthy controls. BACKGROUND: Older adults with MS have worse physical and cognitive function than older adults without MS and young and middle-aged adults with MS. To date, little is known about the associations between, or coupling of, physical and cognitive function outcomes in older adults with MS...
March 2019: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
Fernando C Ortiz, Chloé Habermacher, Mariana Graciarena, Pierre-Yves Houry, Akiko Nishiyama, Brahim Nait-Oumesmar, Maria Cecilia Angulo
In demyelinating diseases such as Multiple Sclerosis (MS), demyelination of neuronal fibers impairs impulse conduction and causes axon degeneration. While neuronal activity stimulates oligodendrocyte production and myelination in normal conditions, it remains unclear whether the activity of demyelinated axons restores their loss-of-function in a harmful environment. To investigate this question, we established a model to induce a moderate optogenetic stimulation of demyelinated axons in the corpus callosum at the level of the motor cortex in which cortical circuit activation and locomotor effects were reduced in adult freely moving mice...
March 21, 2019: JCI Insight
Amir Reza Moravejolahkami, Zamzam Paknahad, Ahmad Chitsaz
BACKGROUND: Multiple sclerosis (MS) is associated with changes in quality of life, disability, fatigue and anthropometric measurements. The important relationship of dietary patterns with such clinical manifestations was not completely investigated. AIMS: The goal of this study was to define the dietary patterns and their association with systemic inflammation, Health-Related Quality Of Life, disease severity, Relapse Rate, severity of fatigue and anthropometric measurements in MS subjects...
March 21, 2019: Nutritional Neuroscience
Elizabeth S Gromisch, Robert D Kerns, John Beauvais
OBJECTIVES: Pain has been identified as a highly prevalent and common correlate of physical and emotional dysfunction among persons with multiple sclerosis (PwMS). Yet, it remains unknown how PwMS experience the intrusiveness of pain relative to other challenges associated with living with MS. This study aimed to determine the extent to which PwMS experience pain as a particularly intrusive problem among the totality of their experience of MS-related challenges and to examine how cognitive and affective factors, including resiliency, are associated with PwMS's pain-related illness intrusiveness...
March 21, 2019: Rehabilitation Psychology
Tessa Dhaeze, Catherine Lachance, Laurence Tremblay, Camille Grasmuck, Lyne Bourbonnière, Sandra Larouche, Olivia Saint-Laurent, Marc-André Lécuyer, Rose-Marie Rébillard, Stephanie Zandee, Alexandre Prat
TCR1640 mice, which have a T cell receptor (TCR) directed against MOG92-106, spontaneously develop experimental autoimmune encephalomyelitis. Female mice mostly develop a relapsing-remitting (RR) course and have a higher incidence of disease, while males most frequently suffer from progressive disease, reflecting the unresolved clinical sex discrepancies seen in multiple sclerosis. Herein, we performed adoptive transfers of male and female TCR1640 immune cells into WT animals to investigate if disease course is dependent on the sex of the donor immune cells or on the sex of the recipient animal...
March 21, 2019: JCI Insight
Gabriel Bsteh, Ruth Steiger, Noora Tuovinen, Harald Hegen, Klaus Berek, Sebastian Wurth, Michael Auer, Franziska Di Pauli, Elke R Gizewski, Florian Deisenhammer, Thomas Berger, Christoph Scherfler
BACKGROUND: Impairment of odor discrimination (D), identification (I), and threshold (T) are characteristic features of multiple sclerosis (MS). OBJECTIVE: To identify patterns of gray matter concentration (GMC) associated with different qualities of olfactory function. METHODS: Olfactory function (T and combined DI score) was measured by Sniffin' Sticks-Test over 2 years longitudinally, and T1-weighted 3-T magnetic resonance imaging (MRI) was performed in 37 MS patients and 18 matched healthy controls (HCs)...
March 21, 2019: Multiple Sclerosis: Clinical and Laboratory Research
Candice Torres de Melo Bezerra Cavalcante, Valdester Cavalcante Pinto Junior, Ronald Guedes Pompeu, Andrea Consuelo de Oliveira Teles, Jeanne Araújo Bandeira, Isabel Cristina Leite Maia, Fabio Rocha Fernandes Tavora, Marcelo Borges Cavalcante, Ana Cristina Perez Zamarian, Edward Araujo Júnior, Klebia Magalhães Castello Branco
OBJECTIVE: To report a case of prenatal diagnosis of cardiac rhabdomyoma (CR) and neonatal surgical treatment as well as undertaking a systematic review of the literature to determine most frequent localization of CR, common signs and symptoms, associated pathologies, incidence of surgery, and prognoses for CR. METHODS: We conducted systematic review of the literature on CR that were diagnosed and treated in the perinatal period, searching for English language articles in the PubMed/Medline database that were published within the past 20 years, using the following search terms: "cardiac rhabdomyoma"; "neonates"; "newborn"; "surgery"...
March 21, 2019: Journal of Maternal-fetal & Neonatal Medicine
Mohammad Mahdi Eftekharian, Alireza Komaki, Mehrdokht Mazdeh, Shahram Arsang-Jang, Mohammad Taheri, Soudeh Ghafouri-Fard
Multiple sclerosis (MS) as a chronic autoimmune disease of the central nervous system (CNS) has been associated with dysregulation of several genes including miRNAs. In the present study, we assessed transcript levels of seven miRNAs (miR-96-5p, miR-211-5p, miR-15a, miR-34a-5p, miR-204-5p, miR-501-5p, and miR-524-5p) in the peripheral blood of MS patients compared with healthy subjects in association with response to fingolimod treatment. Expression levels of miR-211-5p and miR-34a-5p were significantly decreased in MS patients compared with healthy subjects (P values of 0...
March 21, 2019: Journal of Molecular Neuroscience: MN
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