Ehtesham Arif, Danira Medunjanin, Ashish Solanki, Xiaofeng Zuo, Yanhui Su, Yujing Dang, Brennan Winkler, Kasey Lerner, Ahmed I Kamal, Oleg Palygin, Marc-Andre Cornier, Bethany J Wolf, Kelly J Hunt, Joshua H Lipschutz
We have previously shown that the long-acting β2 -adrenergic receptor (β2 -AR) agonist formoterol induced recovery from acute kidney injury in mice. To determine whether formoterol protected against diabetic nephropathy, the most common cause of end-stage kidney disease (ESKD), we used a high-fat diet (HFD), a murine type 2 diabetes model, and streptozotocin, a murine type 1 diabetes model. Following formoterol treatment, there was a marked recovery from and reversal of diabetic nephropathy in HFD mice compared with those treated with vehicle alone at the ultrastructural, histological, and functional levels...
January 1, 2024: American Journal of Physiology. Renal Physiology