keyword
https://read.qxmd.com/read/37702463/waitlist-and-post-transplant-outcomes-among-candidates-listed-for-liver-transplant-liver-alone-versus-simultaneous-liver-kidney-listings
#21
JOURNAL ARTICLE
Ashwani K Singal, Yong-Fang Kuo
BACKGROUND: Data comparing waitlist and post-transplant outcomes of liver transplantation (LT) alone (LTA) versus simultaneous liver kidney (SLK) listings are limited. AIM: To examine 90-days waitlist and 1-year post-transplant outcomes of LT listings since Organ Procurement Transplant Network (OPTN) policy for SLK, who had cirrhosis with eGFR <30 mL/min or on dialysis at listing. METHODS: Adults (08/2017-03/2021) with first LT listing (2628 SLK) were stratified on renal function from listing: acute kidney injury (AKI): rise of serum creatinine by ≥0...
November 2023: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/37699636/intravenous-versus-oral-hydration-to-reduce-the-risk-of-postcontrast-acute-kidney-injury-after-intravenous-contrast-enhanced-ct-in-patients-with-severe-chronic-kidney-disease-enrich-a-study-protocol-for-a-single-centre-parallel-group-open-labelled-non-inferiority
#22
JOURNAL ARTICLE
Emil Johannes Ravn, Selma Hasific, Mads Thomassen, Rikke Hjortebjerg, Kristian Bach Laursen, Axel Diederichsen, Claus Bistrup, Kristian A Øvrehus
INTRODUCTION: Contrast-enhanced CT (CECT) is widely used for diagnostic purposes. The use of contrast medium carries a risk for postcontrast acute kidney injury (PC-AKI), especially in patients with AKI or chronic kidney disease (CKD). Current guidelines recommend prophylactic intravenous hydration to prevent PC-AKI in high-risk patients. Oral hydration is non-inferior to intravenous hydration in patients with moderate CKD, but it has not been evaluated in high-risk patients. METHODS AND ANALYSIS: The ENRICH trial will enrol 254 patients with estimated glomerular filtration rate ≤30 mL/min/1...
September 12, 2023: BMJ Open
https://read.qxmd.com/read/37658873/kidney-disease-progression-in-pediatric-and-adult-posterior-urethral-valves-puv-patients
#23
JOURNAL ARTICLE
Victoria W Huang, Mohga Behairy, Benjamin Abelson, Alice Crane, Wei Liu, Lu Wang, Katherine M Dell, Audrey Rhee
BACKGROUND: Posterior urethral valves (PUV) is the most common cause of obstructive uropathy in boys; approximately 15% develop kidney failure by early adulthood. However, rates of kidney function decline are poorly defined in PUV children and adults, as is the impact of potentially modifiable chronic kidney disease (CKD) progression risk factors. METHODS: We conducted a retrospective review of all PUV patients followed at our institution from 1995 to 2018. Inclusion criteria were estimated glomerular filtration rate (eGFR) > 20 ml/min/1...
September 2, 2023: Pediatric Nephrology
https://read.qxmd.com/read/37624325/incidence-of-and-risk-factors-and-outcomes-associated-with-acute-kidney-injury-in-covid-19-at-the-national-kidney-and-transplant-institute-philippines
#24
JOURNAL ARTICLE
Melchor Altillero, Romina Danguilan, Mel Hatra Arakama
(1) Background: Acute kidney injury (AKI) in COVID-19 leads to an increase in patient mortality, especially among chronic kidney disease (CKD) patients. (2) Methods: A retrospective cohort of 519 adults admitted from 1 March 2020 to 1 March 2022 were reviewed for baseline characteristics and their association with renal outcomes. Patients were divided into diagnosed CKD, undiagnosed CKD, and normal eGFR. Chronic dialysis and kidney-transplant patients were excluded. Kaplan-Meier survival analysis at 7, 14, and 30 days from admission was performed...
July 28, 2023: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/37573145/recovery-of-kidney-function-after-acute-kidney-disease-a-multi-cohort-analysis
#25
JOURNAL ARTICLE
Simon Sawhney, William Ball, Samira Bell, Corri Black, Christian Fynbo Christiansen, Uffe Heide-Jørgensen, Simon Kok Jensen, Emilie Lambourg, Paul E Ronksley, Zhi Tan, Marcello Tonelli, Matthew T James
BACKGROUND: There are no consensus definitions for evaluating kidney function recovery after acute kidney injury (AKI) and acute kidney disease (AKD), nor is it clear how recovery varies across populations and clinical subsets. We present a federated analysis of four population-based cohorts from Canada, Denmark, and Scotland, 2011-2018. METHODS: We identified incident AKD defined by serum creatinine changes within 48 hours, 7 days, and 90 days based on KDIGO AKI and AKD criteria...
August 12, 2023: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/37309038/the-association-between-dual-raas-inhibition-and-risk-of-acute-kidney-injury-and-hyperkalemia-in-patients-with-diabetic-kidney-disease-a-systematic-review-and-meta-analysis
#26
JOURNAL ARTICLE
Reid Whitlock, Silvia J Leon, Hazel Manacsa, Nicole Askin, Claudio Rigatto, Samuel T Fatoba, Youssef M K Farag, Navdeep Tangri
BACKGROUND AND OBJECTIVES: Dual renin-angiotensin-aldosterone system (RAAS) blockade involves dual therapy with a combination of angiotensin-converting enzyme inhibitors (ACEis), angiotensin-receptor blockers (ARBs), direct renin inhibitors (DRIs), or mineralocorticoid receptor antagonists (MRAs). It is hypothesized that dual RAAS blockade would result in a more complete inhibition of the RAAS cascade. However, large clinical trials on dual RAAS inhibition have shown increased risk of acute kidney injury (AKI) and hyperkalemia without additional benefit on mortality, cardiovascular events, or chronic kidney disease (CKD) progression compared to RAAS inhibitor monotherapy in patients with diabetic kidney disease (DKD)...
October 31, 2023: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/37287918/review-of-acute-kidney-injury-and-progression-to-chronic-kidney-disease-in-pediatric-patients-undergoing-hematopoietic-cell-transplant
#27
REVIEW
Kim T Vuong, Catherine Joseph, Joseph R Angelo
While acute kidney injury (AKI) after hematopoietic cell transplant (HCT) has been well-described in pediatric patients, literature regarding the long term renal consequences of HCT-related AKI, the development of chronic kidney disease (CKD), and CKD care in pediatric patients post-HCT is limited. CKD affects almost 50% of patients after HCT with multifactorial etiology including infection, nephrotoxic medications, transplant-associated thrombotic microangiopathy, graft-versus-host disease, and sinusoidal obstruction syndrome...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37243325/a-single-administration-of-fgf2-after-renal-ischemia-reperfusion-injury-alleviates-post-injury-interstitial-fibrosis
#28
JOURNAL ARTICLE
Xiaohua Tan, Qianyu Tao, Shulan Yin, Guangming Fu, Chengqin Wang, Fenggang Xiang, Haiqi Hu, Sudan Zhang, Zheng Wang, Dequan Li
BACKGROUND: Despite lack of clinical therapy in acute kidney injury (AKI) or its progression to chronic kidney disease (CKD), administration of growth factors shows great potential in the treatment of renal repair and further fibrosis. At early phase of AKI, administration of exogenous fibroblast growth factor 2 (FGF2) protects against renal injury by inhibition of mitochondrial damage and inflammatory response. Here, we investigated whether this treatment attenuates the long-term renal interstitial fibrosis induced by I/R injury...
May 26, 2023: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/37159995/nephro-oncology-clinical-and-biochemical-aspects-of-kidney-disease-and-cancer
#29
JOURNAL ARTICLE
Slawomir Lizakowski, Alicja Dębska-Ślizień, Ilona Kurnatowska, Maciej Jan Zaucha, Marcin Matuszewski, Beata Naumnik, Marcin Adamczak, Jerzy Chudek, Magdalena Durlik, Carla Ferrándiz-Pulido, Bartosz Foroncewicz, Ryszard Gellert, Magdalena Krajewska, Michał Nowicki, Andrzej Więcek, Jolanta Małyszko
Onco-nephrology is a new field of medicine which combines many aspects of kidney injury in cancer patients and cancers in patients with kidney disease. This connection takes many forms and includes drug-induced nephrotoxicity, electrolyte disorders, numerous paraneoplastic syndromes and an increased rate cancers in dialysis and transplanted patients. The appropriate laboratory assessment of the kidney function allows to optimize chemotherapy and thus minimizes the risk of complications. This article focuses on acute kidney injury (AKI), chronic kidney disease (CKD), various electrolyte and acid-base disorders, the most common cancers after kidney transplantation and the kidney disorders associated with HSCT (hematopoietic stem cell transplantation)...
May 9, 2023: Acta Biochimica Polonica
https://read.qxmd.com/read/37145183/patient-level-factors-increase-risk-of-acute-kidney-disease-in-hospitalized-children-with-acute-kidney-injury
#30
JOURNAL ARTICLE
Mital Patel, Christoph Hornik, Clarissa Diamantidis, David T Selewski, Rasheed Gbadegesin
BACKGROUND: Studies in adults have shown that persistent kidney dysfunction ≥7-90 days following acute kidney injury (AKI), termed acute kidney disease (AKD), increases chronic kidney disease (CKD) and mortality risk. Little is known about the factors associated with the transition of AKI to AKD and the impact of AKD on outcomes in children. The aim of this study is to evaluate risk factors for progression of AKI to AKD in hospitalized children and to determine if AKD is a risk factor for CKD...
October 2023: Pediatric Nephrology
https://read.qxmd.com/read/36914214/tubulovascular-protection-from-protease-activated-receptor-1-depletion-during-aki-to-ckd-transition
#31
JOURNAL ARTICLE
Sarah W Y Lok, Wai Han Yiu, Yixin Zou, Rui Xue, Hongyu Li, Jingyuan Ma, Jiaoyi Chen, Loretta Y Y Chan, Kar Neng Lai, Sydney C W Tang
BACKGROUND: Thromboembolic events are prevalent in chronic kidney disease (CKD) patients due to increased thrombin generation leading to a hypercoagulable state. We previously demonstrated that inhibition of protease-activated receptor-1 (PAR-1) by vorapaxar reduces kidney fibrosis. METHODS: We used an animal model of unilateral ischemia-reperfusion (UIRI)-induced CKD to explore the tubulovascular crosstalk mechanisms of PAR-1 in AKI-to-CKD transition. RESULTS: During the early phase of AKI, PAR-1 deficient mice exhibited reduced kidney inflammation, vascular injury and preserved endothelial integrity and capillary permeability...
March 13, 2023: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/36882356/living-donor-liver-transplantation-alone-is-not-inferior-to-combined-kidney-liver-transplant-for-cirrhotic-patients-with-chronic-kidney-disease
#32
JOURNAL ARTICLE
Sapana Verma, Selva Kumar Naganathan, Lalit Kumar Das, Shaleen Agarwal, Subhash Gupta
BACKGROUND: Chronic kidney disease (CKD) is common in patients with chronic liver disease (CLD) as is acute kidney injury (AKI). The differentiation between CKD vs AKI is often difficult and sometimes the both may coexist. A combined kidney-liver transplant (CKLT) may result in a kidney transplant in patients whose renal function is likely to recover or at least who have stable renal function post-transplant. We retrospectively enrolled 2742 patients who underwent living donor liver transplant at our center from 2007 to 2019...
March 5, 2023: Transplantation Proceedings
https://read.qxmd.com/read/36865508/spectrum-outcomes-and-mortality-predictors-of-acute-kidney-injury-among-non-covid-19-patients-during-covid-19-pandemic-data-from-four-intensive-care-units
#33
JOURNAL ARTICLE
Bhupinder Singh, Pavitra Manu Dogra, Vivek Sood, Vishal Singh, Amit Katyal, Manish Dhawan, Shyam Madabhushi, Krishna M Kumar, Bhupendra Singh, Abhishek Sharma
INTRODUCTION: The data of acute kidney injury (AKI), that is, community-acquired AKI (CA-AKI) and hospital-acquired AKI (HA-AKI) among non-COVID patients from intensive care units (ICU) during the coronavirus disease-2019 (COVID-19) pandemic are scarce. We planned to study the change in the profile of such patients compared to the pre-pandemic era. MATERIALS AND METHODS: This prospective observational study was conducted at four ICUs dealing with non-COVID patients at a government hospital in North India, and was aimed at assessing outcomes, and mortality predictors of AKI among non-COVID patients during the COVID-19 pandemic...
February 2023: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/36754366/kidney-disease-and-stroke-epidemiology-and-potential-mechanisms-of-susceptibility
#34
JOURNAL ARTICLE
Mickaël Bobot, Laurent Suissa, Jean-François Hak, Stéphane Burtey, Benjamin Guillet, Guillaume Hache
Patients with Chronic Kidney Disease (CKD) have an increased risk of both ischemic and haemorrhagic stroke compared to the general population. Both acute and chronic kidney impairment are independently associated with poor outcome after the onset of a stroke, after adjustment on confounders. End-stage kidney disease (ESKD) is associated with a 7- and 9-fold increased incidence of both ischemic and haemorrhagic strokes, respectively, poorer neurological outcome and a 3-fold higher mortality. Acute kidney injury (AKI) occurs in 12% of patients with stroke and is associated with a 4-fold increased mortality and unfavourable functional outcome...
February 8, 2023: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/36746439/long-term-kidney-outcomes-after-leptospirosis-a-prospective-multicentre-cohort-study-in-thailand
#35
MULTICENTER STUDY
Jeerath Phannajit, Tanat Lertussavavivat, Umaporn Limothai, Sasipha Tachaboon, Yingyos Avihingsanon, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Kriang Tungsanga, Visith Sitprija, Nattachai Srisawat
BACKGROUND: Leptospirosis is one of the most important public-health zoonotic diseases in the tropics that can cause severe organ dysfunction and death. Currently there are insufficient data on long-term renal dysfunction in patients after leptospirosis infection. METHODS: A prospective multicentre cohort study was conducted at 15 hospitals in the Sisaket province of Thailand. Confirmed leptospirosis patients admitted from 1 December 2015 to 30 November 2018 were followed between 1 February 2020 and 31 October 2020 (median 4...
September 29, 2023: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/36702551/long-term-outcomes-of-covid-19-survivors-with-hospital-aki-association-with-time-to-recovery-from-aki
#36
JOURNAL ARTICLE
Justin Y Lu, Montek S Boparai, Caroline Shi, Erin M Henninger, Mahendranath Rangareddy, Sudhakar Veeraraghavan, Parsa Mirhaji, Molly C Fisher, Tim Q Duong
BACKGROUND: Although coronavirus disease 2019 (COVID-19) patients who develop in-hospital acute kidney injury (AKI) have worse short-term outcomes, their long-term outcomes have not been fully characterized. We investigated 90-day and 1-year outcomes after hospital AKI grouped by time to recovery from AKI. METHODS: This study consisted of 3296 COVID-19 patients with hospital AKI stratified by early recovery (<48 hours), delayed recovery (2-7 days) and prolonged recovery (>7-90 days)...
September 29, 2023: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/36651817/the-impact-of-acute-kidney-injury-with-or-without-recovery-on-long-term-kidney-outcome-in-patients-undergoing-living-liver-transplantation
#37
JOURNAL ARTICLE
Ping-Fang Chiu, Pei-Ru Lin, Chun-Chieh Tsai, Yao-Peng Hsieh
BACKGROUND: Acute kidney injury (AKI) is associated with an increased incidence of poor liver graft and renal outcomes in patients who underwent liver transplantation (LT). To date, no comprehensive study has compared patients with and without post-LT AKI and analyzed patients who recovered from AKI versus those who did not. METHODS: Patients who received living LT between January 2003 and January 2019 were enrolled. We diagnosed and classified AKI patients based on AKI-KDIGO guidelines by increment of creatinine after surgery when compared to serum creatinine on the day of surgery...
January 18, 2023: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/36450235/clinical-outcomes-of-persistent-severe-acute-kidney-injury-among-patients-with-kidney-disease-improving-global-outcomes-stage-2-or-3-acute-kidney-injury
#38
JOURNAL ARTICLE
Jay L Koyner, Rachel H Mackey, Ning A Rosenthal, Leslie Ann Carabuena, J Patrick Kampf, Toni Rodriguez, Aarti Sanghani, Jorge Echeverri, Paul McPherson, Michael J Blackowicz, Julien Textoris
INTRODUCTION: The burden of persistent (≥3 days) severe AKI (PS-AKI) is poorly described among inpatients with stage 2-3 AKI in the ward or ICU. Quantification could motivate targeted interventions to decrease duration of AKI in these high-risk patients. METHODS: This retrospective cohort study included adult patients discharged from January 1, 2017, to December 31, 2019, from US hospitals in the PINC AI Healthcare Database. Patients with KDIGO stage 2 or 3 AKI, length of stay ≥3 days, ≥3 serum creatinine measures, and no history of renal transplant, dialysis, or stage 5 chronic kidney disease were included...
2022: American Journal of Nephrology
https://read.qxmd.com/read/36411687/clinic-pathological-characteristics-of-rare-tubulointerstitial-diseases
#39
JOURNAL ARTICLE
Kewen Shi, Shuguang Yuan, Yao Huang, Zheng Li, Chang Wang, Hong Liu, Lin Sun, Fuyou Liu, Xuejing Zhu
OBJECTIVES: Tubulointerstitial diseases is one of the common causes of renal dysfunction. Some rare pathological types are easy to be misdiagnosed and missedly diagnosed because of their low prevalence and relatively insufficient understanding, which affects the treatment and prognosis of patients. This study aims to explore clinical manifestations and pathological characteristics of several rare tubulointerstitial diseases, and therefore to improve their diagnosis and treatment. METHODS: A total of 9 363 patients diagnosed by renal biopsy in the Department of Nephrology, Second Xiangya Hospital, Central South University from November 2011 to September 2021 were selected...
October 28, 2022: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://read.qxmd.com/read/36327038/sick-day-management-in-people-with-chronic-kidney-disease-a-scoping-review
#40
REVIEW
Henna Duong, Wubshet Tesfaye, Connie Van, Kamal Sud, Mimi Truong, Ines Krass, Ronald L Castelino
BACKGROUND: Use of certain medications during an acute illness may put patients at an increased risk of acute kidney injury (AKI). Patients with chronic kidney disease (CKD) are at higher risk of developing superimposed AKI. The aim of this scoping review is to collate and characterise existing evidence on sick day management considerations and practices during acute illness in people with CKD. METHODS: We searched Embase, CINAHL, MEDLINE, International Pharmaceutical Abstract, Scopus, Google Scholar and grey literature sources...
June 2023: Journal of Nephrology
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