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Franca R Guerini, Elisabetta Bolognesi, Stefano Sotgiu, Alessandra Carta, Claudia Clerici, Matteo Chiappedi, Alessandro Ghezzo, Michela Zanette, Maria Martina Mensi, Maria Paola Canevini, Milena Zanzottera, Cristina Agliardi, Andrea Saul Costa, Umberto Balottin, Mario Clerici
Recent results show that in mainland Italian children with Autism spectrum disorder (ASD), HLA-G coding alleles distribution is skewed and an association between HLA-G*01:05N and ASD is present. Herein, in an independent cohort of Sardinian ASD (sASD) children and their relatives, we verify whether HLA-G allele association with ASD could be confirmed in this genetically peculiar insular population. One hundred children with a diagnosis of ASD, born in Sardinia and of Sardinian descent, 91 of their mothers, and 40 of their healthy siblings were enrolled...
February 11, 2019: Brain, Behavior, and Immunity
Paola Aparecida Alves Azevedo, João Pedro Rueda Furlan, Guilherme Bartolomeu Gonçalves, Carolina Nogueira Gomes, Rafael da Silva Goulart, Eliana Guedes Stehling, André Pitondo-Silva
OBJECTIVES: The present study aimed to characterize 48 Klebsiella pneumoniae isolated from outpatients with urinary tract infections (UTIs) in the micro-region of Ribeirão Preto, located in the Southeastern of Brazil. METHODS: Thee isolates were identified by conventional biochemical and phenotypic tests and confirmed as K. pneumoniae using MALDI-TOF VITEK® MS. Antimicrobial susceptibility testing were performed by disk diffusion method as recommended by the Clinical Laboratory Standards Institute using thirty-eight different antibiotic discs...
February 11, 2019: Journal of Global Antimicrobial Resistance
Piero Ruscitti, Francesco Ursini, Paola Cipriani, Marta Greco, Saverio Alvaro, Liakouli Vasiliki, Paola Di Benedetto, Francesco Carubbi, Onorina Berardicurti, Elio Gulletta, Giovambattista De Sarro, Roberto Giacomelli
Recently, it has been shown that some well-known pathogenic mediators in rheumatoid arthritis (RA), such as interleukin-1β (IL-1β) and tumor necrosis factor (TNF), could play a pathogenic role in insulin resistance and (IR) and type 2 diabetes (T2D).In this 6-month longitudinal study, we aimed at investigating if the inhibition of IL-1 or TNF is associated with an improvement of IR in RA patients with comorbid T2D and the possible effects on selected serum adipokines. RA patients with comorbid T2D were recruited among those undergoing treatment with anakinra (ANA) or with TNF inhibitor (TNFi)...
February 2019: Medicine (Baltimore)
Pieter Vrijens, Sam Noppen, Talitha Boogaerts, Els Vanstreels, Roberto Ronca, Paola Chiodelli, Manon Laporte, Evelien Vanderlinden, Sandra Liekens, Annelies Stevaert, Lieve Naesens
The possible resistance of influenza virus against existing antiviral drugs calls for new therapeutic concepts. One appealing strategy is to inhibit virus entry, in particular at the stage of internalization. This requires a better understanding of virus-host interactions during the entry process, including the role of receptor tyrosine kinases (RTKs). To search for cellular targets, we evaluated a panel of 276 protein kinase inhibitors in a multicycle antiviral assay in Madin-Darby canine kidney cells. The RTK inhibitor Ki8751 displayed robust anti-influenza A and B virus activity and was selected for mechanistic investigations...
February 14, 2019: Journal of General Virology
Alfredo Bottone, Milena Masullo, Paola Montoro, Cosimo Pizza, Sonia Piacente
INTRODUCTION: Prunus dulcis Mill. is a plant cultivated for the production of its edible seeds, known as sweet almonds. In the last decades almond demand has highly increased due to their wide use in the industrial manufacturing of almond-based foods; this has led to a huge production of waste materials, mainly corresponding to shells and husks. OBJECTIVE: To achieve a deeper understanding of the chemical composition of almond husks with the aim of exploring these byproducts as a source of bioactives to be used in nutraceutical and cosmetic formulations...
February 14, 2019: Phytochemical Analysis: PCA
Vincenzo Piccolo, Paola Corneli, Gabriela de Castro, Teresa Russo, Iris Zalaudek, Roberto Alfano, Giuseppe Argenziano
No abstract text is available yet for this article.
February 14, 2019: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Elisa García, Roxana Rodríguez-Barrera, Vinnitsa Buzoianu-Anguiano, Adrian Flores-Romero, Emanuel Malagón-Axotla, Marco Guerrero-Godinez, Estefanía De la Cruz-Castillo, Laura Castillo-Carvajal, Monserrat Rivas-Gonzalez, Paola Santiago-Tovar, Ivis Morales, Cesar Borlongan, Antonio Ibarra
Spinal cord injury is a very common pathological event that has devastating functional consequences in patients. In recent years, several research groups are trying to find an effective therapy that could be applied in clinical practice. In this study, we analyzed the combination of different strategies as a potential therapy for spinal cord injury. Immunization with neural derived peptides (INDP), inhibition of glial scar formation (dipyridyl: DPY), as well as the use of biocompatible matrix (fibrin glue: FG) impregnated with bone marrow mesenchymal stem cells (MSCs) were combined and then its beneficial effects were evaluated in the induction of neuroprotection and neuroregeneration after acute SCI...
June 2019: Neural Regeneration Research
Cecilia Camarda, Paola Torelli, Carmela Pipia, Delia Azzarello, Iacopo Battaglini, Gianluca Sottile, Giovanna Cilluffo, Rosolino Camarda
BACKGROUND: To assess the prevalence of three nociceptive primitive reflexes (nPR), i.e., glabellar tap, snout reflex, and palmomental reflex, in neurologically and cognitively healthy (NCH) aging subjects. OBJECTIVE: To investigate whether nPR are cross-sectionally associated with white matter hyperintensities (WMH), lacunes, atrophy of the caudate nuclei, and global brain atrophy. METHODS: A total of 1246 NCH subjects aged 45-91 years were included in the study and underwent standard brain MRI...
February 14, 2019: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
Julia Menichetti, Letizia De Luca, Paola Dordoni, Simona Donegani, Cristina Marenghi, Riccardo Valdagni, Lara Bellardita
OBJECTIVE: Health promotion is a key aspect for health outcomes of prostate cancer (PCa) patients. However, it has been poorly explored among patients following monitoring programmes, for example Active Surveillance (AS). This study aimed to explore PCa patients' perceptions of health promotion during AS. METHODS: An explorative qualitative research design was adopted. Four focus groups were used to collected data from 24 men enrolled in the Prostate Cancer Research International: AS (PRIAS) protocol...
February 13, 2019: European Journal of Cancer Care
Gloria Dalla Costa, Vittorio Martinelli, Lucia Moiola, Francesca Sangalli, Bruno Colombo, Annamaria Finardi, Paola Cinque, Eva-Maria Kolb, Aiden Haghikia, Ralf Gold, Roberto Furlan, Giancarlo Comi
This study analyzed serum neurofilament light chains (NfL) in 2 European cohorts of 312 MS patients to investigate whether NfL are biomarkers of PML during natalizumab treatment. The cohort comprised 25 PML, 136 natalizumab-treated, and 151 untreated MS patients. Patients subsequently developing PML had similar NfL to other natalizumab-treated MS patients. At PML onset, NfL were 10-fold higher than in the pre-PML condition and in natalizumab-treated or untreated MS patients, and NfL continued to increase until onset of immune reconstitution inflammatory syndrome...
February 13, 2019: Annals of Neurology
Marilia Rita Pinzone, D Jake VanBelzen, Sam Weissman, Maria Paola Bertuccio, LaMont Cannon, Emmanuele Venanzi-Rullo, Stephen Migueles, R Brad Jones, Talia Mota, Sarah B Joseph, Kevin Groen, Alexander O Pasternak, Wei-Ting Hwang, Brad Sherman, Anastasios Vourekas, Giuseppe Nunnari, Una O'Doherty
After initiating antiretroviral therapy (ART), a rapid decline in HIV viral load is followed by a long period of undetectable viremia. Viral outgrowth assay suggests the reservoir continues to decline slowly. Here, we use full-length sequencing to longitudinally study the proviral landscape of four subjects on ART to investigate the selective pressures influencing the dynamics of the treatment-resistant HIV reservoir. We find intact and defective proviruses that contain genetic elements favoring efficient protein expression decrease over time...
February 13, 2019: Nature Communications
Marco Bonato, Paola Bagnoli, Cinzia Centelleghe, Mike Maric, Ginevra Brocca, Sandro Mazzariol, Bruno Cozzi
The retia mirabilia are vascular nets composed by small vessels dispersed among numerous veins, allowing blood storage, regulation of flow, and pressure damping effects. Here we investigated their potential role during the diving phase of the bottlenose dolphin ( Tursiops truncatus ). To this effect, the whole vertebral retia mirabilia of a series of dolphins were removed during post-mortem analysis and examined to assess vessel diameters, estimate vascular volume, and flow rate. Here we formulate a new hemodynamic model to help clarify vascular dynamics throughout the diving phase, based on the total blood volume of a bottlenose dolphin, and using data available about the perfusion of the main organs and body systems...
February 13, 2019: Journal of Experimental Biology
Francesca Gazzani, Chiara Pavoni, Paola Cozza, Roberta Lione
BACKGROUND: Maxillary protraction with facemask (FM) is an orthopedic approach for treatment of Class III growing patients. Aim of the present investigation was to analyze tension loads produced by two different facial mask (FM) designs on facial skin of subject with skeletal Class III. METHODS: A three-dimensional (3D) geometry of Delaire and Petit FM models were reconstructed from the original Computer Aided Design (CAD) 3D prototype using software package (ANSYS 5...
February 13, 2019: BMC Oral Health
Paola Guariglia, Flavio Giaimo, Massimiliano Palmiero, Laura Piccardi
Reliable and valid measures are necessary to assess subjective working memory complaints that can be distinct from objective memory performance. The Working Memory Questionnaire (WMQ) is a self-administered scale proposed by Vallat-Azouvi. It assesses the three different working memory domains (memory storage, attention, and executive functions) in accordance with Baddeley's working memory model. Our aim was to propose an Italian translation of the WMQ and provide normative data. We collected normative data from 697 healthy Italian participants aged between 18 and 88 years...
February 13, 2019: Applied Neuropsychology. Adult
Paola Bocanegra-Ibarias, Elvira Garza-González, Magaly Padilla-Orozco, Soraya Mendoza-Olazarán, Eduardo Pérez-Alba, Samantha Flores-Treviño, Ulises Garza-Ramos, Jesus Silva-Sánchez, Adrián Camacho-Ortiz
The worldwide dissemination of high-risk carbapenemase-producing Klebsiella pneumoniae clones has become a major threat to healthcare facilities. This study describes the successful containment of a hospital outbreak caused by NDM-1-producing K. pneumoniae Sequence Type (ST) 307 using active surveillance. The outbreak began when a patient was transferred from a local hospital. After 48 hours in our hospital, a tracheal aspirate was positive for a meropenem resistant and carbapenemase-producing K. pneumoniae...
2019: PloS One
Sabrina Buoro, Michela Seghezzi, Paola Dominoni, Valentina Moioli, Barbara Manenti, Giulia Previtali, Cosimo Ottomano, Giuseppe Lippi
INTRODUCTION: Cellular analysis in body fluids (BFs) provides important diagnostic information in various pathological settings. This study was hence aimed at comparing automated cell count obtained with Mindray BC-6800 (BC-BF) vs Sysmex XN-series (XN-BF) and evaluating other quantitative and qualitative information provided by these analyzers in ascitic (AF), pleural (PF), synovial (SF), and cerebrospinal (CSF) fluids. METHODS: Three hundred and fifty-one samples (99 AFs, 45 PFs, 75 SFs, and 132 CSFs) were analyzed in parallel with BC-BF, XN-BF, and optical microscopy (OM)...
February 13, 2019: International Journal of Laboratory Hematology
David Bennett, Rosa Metella Refini, Maria Lucia Valentini, Annalisa Fui, Antonella Fossi, Maria Pieroni, Maria Antonietta Mazzei, Paola Rottoli
INTRODUCTION: Familial pulmonary fibrosis (FPF) is defined as an idiopathic diffuse parenchymal lung disease affecting two or more members of the same primary biological family. The aim of this study was to compare disease progression and tolerance to pirfenidone in a population of FPF patients who presented with radiological and/or histological evidence of UIP, and a group of idiopathic pulmonary fibrosis (IPF) patients. METHODS: Seventy-three patients (19 with FPF and 54 with IPF) were enrolled and data were collected retrospectively at 6, 12 and 24 months follow-up...
February 13, 2019: Lung
Alexandre Turani-I-Belloto, Nathan Meunier, Paola Lopez, Jacques Leng
In the process of fabricating porous polymers, we use dispersed calcite as a sacrificial solid that generates porosity after dissolution. To do this, we trap calcite particles in a hydrogel, dissolve the particles and dry the hydrogel; here, we describe in detail the dissolution kinetics. We prepare PEGDA [poly(ethylene glycol)-diacrylate] water solutions loaded with micron-sized calcite particles (containing mostly calcium carbonate) up to about 30% volume fraction; these dispersions are photo-polymerized into hydrogels as flat and shallow monoliths with a typical thickness of ≈100 μm and a lateral extent on the order of 1 cm...
February 13, 2019: Soft Matter
Vincenzo Montinaro, Emanuela Cataldo, Francesca Cianciotta, Vincenza Colucci, Giuseppina D'Ettorre, Giulia Fontò, Davide Gianfreda, Marica Giliberti, Enrica Gintoli, Silvia Matino, Adriano Montinaro, Paolo Protopapa, Paola Suavo-Bulzis
No abstract text is available yet for this article.
February 2019: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Massimiliano Bergallo, Pier-Angelo Tovo, Enrico Bertino, Valentina Daprà, Alice Pirra, Paola Montanari, Ilaria Galliano, Cristina Calvi
No abstract text is available yet for this article.
February 12, 2019: Minerva Ginecologica
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