keyword
https://read.qxmd.com/read/38641460/retraction-notice-to-in-vitro-anticholinergic-drugs-affect-cd8-peripheral-blood-t-cells-apoptosis-in-copd-immunobiology-217-3-2012-345-353
#21
Mirella Profita, Loredana Riccobono, Angela Marina Montalbano, Anna Bonanno, Maria Ferraro, Giusy Daniela Albano, Stefania Gerbino, Paola Casarosa, Michael Paul Pieper, Mark Gjomarkaj
No abstract text is available yet for this article.
April 18, 2024: Immunobiology
https://read.qxmd.com/read/38640887/oral-language-predictors-of-word-reading-and-spelling-a-cross-linguistic-comparison-in-bilingual-and-monolingual-children
#22
JOURNAL ARTICLE
Paola Bonifacci, Martina Cangelosi, Stéphanie Bellocchi
The current study investigated linguistic predictors of word reading and spelling skills in a cross-linguistic comparison (French vs. Italian) in heritage bilinguals (HBs) and their monolingual peers. The sample included 265 children (French: n = 113; 67 monolinguals and 46 HBs; Italian: n = 152; 82 monolinguals and 70 HBs) attending Grades 3, 4, and 5 while performing oral language, reading, and spelling tasks. The battery included verbal knowledge, morphosyntactic comprehension, nonword repetition, word reading (speed and accuracy), and spelling tasks...
April 18, 2024: Journal of Experimental Child Psychology
https://read.qxmd.com/read/38640845/breastfeeding-patterns-in-one-year-old-children-was-not-affected-by-a-breastfeeding-support-intervention
#23
JOURNAL ARTICLE
Eva-Lotta Funkquist, Paola Oras
BACKGROUND: Breastfeeding patterns in 12-month-old children play a central role in the mother-infant dyad, but studies describing the patterns are scarce. AIM: To investigate breastfeeding patterns in 12-month-old infants before and after a breastfeeding support programme. STUDY DESIGN: A baseline/intervention design as part of a larger implementation project aiming to revive the Ten Steps to Successful Breastfeeding programme. SUBJECTS: During a 24-h period, 28 mothers from a baseline group and 24 mothers from an intervention group recorded all breastfeeding sessions on a pen and paper form...
April 16, 2024: Early Human Development
https://read.qxmd.com/read/38640653/extracellular-vesicles-selective-capture-by-peptide-functionalized-hollow-fiber-membranes
#24
JOURNAL ARTICLE
Simona Salerno, Antonella Piscioneri, Sabrina Morelli, Alessandro Gori, Elena Provasi, Paola Gagni, Lucio Barile, Marina Cretich, Marcella Chiari, Loredana De Bartolo
Recently, membrane devices and processes have been applied for the separation and concentration of subcellular components such as extracellular vesicles (EVs), which play a diagnostic and therapeutic role in many pathological conditions. However, the separation and isolation of specific EV populations from other components found in biological fluids is still challenging. Here, we developed a peptide-functionalized hollow fiber (HF) membrane module to achieve the separation and enrichment of highly pure EVs derived from the culture media of human cardiac progenitor cells...
April 12, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38639092/increased-reports-of-measles-in-the-metropolitan-city-of-milan-northern-italy-september-2023-to-march-2024
#25
JOURNAL ARTICLE
Maria Gori, Clara Fappani, Silvia Bianchi, Sabrina Senatore, Daniela Colzani, Priscilla Pasutto, Melissa Baggieri, Silvia Gioacchini, Antonella Marchi, Paola Bucci, Emilio D'Ugo, Marino Faccini, Danilo Cereda, Luigi Vezzosi, Elisabetta Tanzi, Fabio Magurano, Antonella Amendola
Since late 2023, the Metropolitan City of Milan and surrounding areas (northern Italy) have been experiencing a resurgence of measles, with most cases detected starting from January 2024. During this brief period, we observed measles in travellers from endemic areas, participants in international events, vaccinees and healthcare workers. Indigenous cases have also been identified. Even though we have not yet identified large and disruptive outbreaks, strengthening surveillance and vaccination activities is pivotal to help limit the impact of measles spread...
April 2024: Euro Surveillance
https://read.qxmd.com/read/38638242/assessing-the-effectiveness-and-safety-of-lenvatinib-and-everolimus-in-advanced-renal-cell-carcinoma-insights-from-the-relieve-study-s-analysis-of-heavily-pretreated-patients
#26
JOURNAL ARTICLE
Sebastiano Buti, Alessandro Olivari, Cristina Masini, Davide Bimbatti, Donata Sartori, Paola Ermacora, Carlo Cattrini, Maria Giuseppa Vitale, Ernesto Rossi, Claudia Mucciarini, Mimma Rizzo, Michele Sisani, Matteo Santoni, Giandomenico Roviello, Veronica Mollica, Vincenza Conteduca, Francesco Grillone, Marika Cinausero, Giuseppe Prati, Francesco Atzori, Marco Stellato, Francesco Massari, Melissa Bersanelli
BACKGROUND: The treatment of heavily pretreated patients with metastatic renal cell carcinoma (mRCC) represents an unmet medical need and is still challenging. OBJECTIVES: The primary objective was to assess the effectiveness of the lenvatinib plus everolimus combination and the secondary objective was the toxicity profile of this combination. DESIGN: We conducted a longitudinal retrospective study examining mRCC patients pre-treated with one or more lines of therapy among different cancer centers in Italy...
2024: Therapeutic Advances in Urology
https://read.qxmd.com/read/38637923/autologous-pancreatic-islet-cell-transplantation-following-pancreatectomy-for-pancreas-diseases-other-than-chronic-pancreatitis-a-15-y-study-of-the-milan-protocol
#27
JOURNAL ARTICLE
Lorenzo Piemonti, Raffella Melzi, Francesca Aleotti, Giovanni Capretti, Rita Nano, Alessia Mercalli, Paola Magistretti, Rossana Caldara, Nicolò Pecorelli, Davide Catarinella, Chiara Gremizzi, Francesca Gavazzi, Francesco De Cobelli, Dario Poretti, Massimo Falconi, Alessandro Zerbi, Gianpaolo Balzano
BACKGROUND: Pancreatogenic diabetes, a consequence of pancreatic tissue loss following pancreatectomy, poses a significant challenge for patients undergoing pancreatic surgery. Islet autotransplantation (IAT) offers a promising approach to prevent or alleviate pancreatogenic diabetes, but its application has been limited to individuals with painful chronic pancreatitis. METHODS: This study presents a 15-y clinical experience with the Milan Protocol, which expands IAT after pancreatectomy to a broader spectrum of patients with malignant and nonmalignant pancreatic diseases...
April 19, 2024: Transplantation
https://read.qxmd.com/read/38637500/monkeypox-virus-genomic-accordion-strategies
#28
JOURNAL ARTICLE
Sara Monzón, Sarai Varona, Anabel Negredo, Santiago Vidal-Freire, Juan Angel Patiño-Galindo, Natalia Ferressini-Gerpe, Angel Zaballos, Eva Orviz, Oskar Ayerdi, Ana Muñoz-Gómez, Alberto Delgado-Iribarren, Vicente Estrada, Cristina García, Francisca Molero, Patricia Sánchez-Mora, Montserrat Torres, Ana Vázquez, Juan-Carlos Galán, Ignacio Torres, Manuel Causse Del Río, Laura Merino-Diaz, Marcos López, Alicia Galar, Laura Cardeñoso, Almudena Gutiérrez, Cristina Loras, Isabel Escribano, Marta E Alvarez-Argüelles, Leticia Del Río, María Simón, María Angeles Meléndez, Juan Camacho, Laura Herrero, Pilar Jiménez, María Luisa Navarro-Rico, Isabel Jado, Elaina Giannetti, Jens H Kuhn, Mariano Sanchez-Lockhart, Nicholas Di Paola, Jeffrey R Kugelman, Susana Guerra, Adolfo García-Sastre, Isabel Cuesta, Maripaz P Sánchez-Seco, Gustavo Palacios
The 2023 monkeypox (mpox) epidemic was caused by a subclade IIb descendant of a monkeypox virus (MPXV) lineage traced back to Nigeria in 1971. Person-to-person transmission appears higher than for clade I or subclade IIa MPXV, possibly caused by genomic changes in subclade IIb MPXV. Key genomic changes could occur in the genome's low-complexity regions (LCRs), which are challenging to sequence and are often dismissed as uninformative. Here, using a combination of highly sensitive techniques, we determine a high-quality MPXV genome sequence of a representative of the current epidemic with LCRs resolved at unprecedented accuracy...
April 18, 2024: Nature Communications
https://read.qxmd.com/read/38637439/diagnostic-performance-of-serum-ca-125-for-overall-and-complicated-acute-appendicitis-a-systematic-review-and-meta-analysis
#29
REVIEW
Javier Arredondo Montero, Blanca Paola Pérez Riveros, Oscar Emilio Bueso Asfura
This study aimed to analyze the diagnostic performance of serum CA-125 in acute appendicitis (AA). This review was registered in PROSPERO (CRD42023450988). We included prospective and retrospective original clinical studies evaluating the diagnostic performance of serum CA-125 in AA. A search was conducted in PubMed, Web of Science, Scopus, and OVID. Search terms and keywords were: (appendicitis OR appendectomy) AND (CA-125 OR CA125). Two independent reviewers selected the articles and extracted relevant data...
April 18, 2024: Updates in Surgery
https://read.qxmd.com/read/38636769/hysteroscopic-subchorionic-injection-of-methotrexate-followed-by-laparoscopic-excision-of-the-gestational-sac-for-the-management-of-cesarean-scar-ectopic-pregnancy-an-innovative-dual-approach-of-a-challenging-pathology
#30
JOURNAL ARTICLE
Maria Del Milagro Tejerizo Fe, Paola Elizabeth Benitez, Alejandro Martin Gonzalez, Kyara Marquez, Joelle Mouhanna, Jose Carugno
This innovative two-step therapeutic approach should be considered a compelling option for managing cesarean scar ectopic pregnancy.
April 16, 2024: Fertility and Sterility
https://read.qxmd.com/read/38635610/an-outbreak-of-covid-19-after-a-pilgrimage-to-medjugorje-due-to-delta-sub-lineages
#31
JOURNAL ARTICLE
Alessandra Lo Presti, Salvatore Rubino, Gabriele Ibba, Luigina Ambrosio, Angela Di Martino, Federica Ferraro, Alessia Rapiti, Francesco Maraglino, Emanuela Maria Frisicale, Giovanni Rezza, Flavia Angioj, Sergio Uzzau, Maria Luciana Contini, Stefania Manca, Ferdinando Coghe, Germano Orrù, Anna Teresa Palamara, Paola Stefanelli
INTRODUCTION: A COVID-19 outbreak occurred at the end of October 2021 among pilgrims returning from Medjugorje (Bosnia and Herzegovina). METHODOLOGY: Whole genome sequencing (WGS) of SARS-CoV-2, epidemiological data, and phylogenetic analysis were used to reconstruct outbreak dynamics. RESULTS: The results suggest that only in one case, associated with the SARS-CoV-2 sub-lineage AY.9.2, it is possible to trace back the place of contagion to Medjugorje, while the other cases were likely to be acquired in the country of origin...
March 31, 2024: Journal of Infection in Developing Countries
https://read.qxmd.com/read/38635454/imaging-assessment-of-nontraumatic-pathologic-conditions-at-the-craniovertebral-junction-a-comprehensive-review
#32
JOURNAL ARTICLE
Letícia R Morimoto, Daisy T Kase, Paola G Esmanhotto, Murilo A Maciel, Ana C L Augusto, Patrick F Catricala, Julia E C Anaya, Sugoto Mukherjee, Artur R C Fernandes, André Y Aihara
Nontraumatic pathologic conditions of the craniovertebral junction encompass a range of conditions affecting the complex anatomy of this region without direct physical injury. These conditions include congenital syndromes that predispose individuals to ligamentous laxity, potentially leading to instability. Additionally, rare but noteworthy cases such as Grisel syndrome, a cause of pediatric torticollis, may arise without a traumatic trigger. Inflammatory diseases, including rheumatoid arthritis, ankylosing spondylitis, and crystal deposition, can lead to cervical instability and spinal cord compression...
May 2024: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://read.qxmd.com/read/38634754/effects-of-focal-muscle-vibration-on-cervical-pain-in-parkinson-s-disease-patients-a-pilot-study
#33
JOURNAL ARTICLE
Gianpaolo Ronconi, Dario Mattia Gatto, Mariantonietta Ariani, Sefora Codazza, Maurizio Panunzio, Daniele Coraci, Paola Emilia Ferrara
Musculoskeletal pain is a common symptom of Parkinson's disease (PD) that is not adequately treated with current dopaminergic drugs. This pilot study sought to investigate the effect of focal muscle vibration (fMV) on a group of Parkinson's disease patients suffering from chronic cervical pain. In addition to conventional physiotherapy, twenty-two patients with idiopathic Parkinson's disease (Hoehn and Yahr stages II-III) received three weeks of bilateral focal musclevibration to the trapezius muscles. The Visual Analogue Scale (VAS), the Short-form McGill, and the Present PainIntensity scales were used to assess pain at baseline (T0), after three weeks of treatment (T1), one week after the last treatment session (T2), and three weeks after T2 (T3)...
April 18, 2024: European Journal of Translational Myology
https://read.qxmd.com/read/38634751/is-there-any-relationship-between-scoliosis-cervical-pain-and-postural-imbalance-in-parkinson-s-disease-a-cross-sectional-pilot-study
#34
JOURNAL ARTICLE
Gianpaolo Ronconi, Dario Mattia Gatto, Mariantonietta Ariani, Sefora Codazza, Fabio Ingravalle, Giorgio Ferriero, Daniele Coraci, Paola Emilia Ferrara
Parkinson's disease (PD) is defined by progressive worsening of gait, posture, and balance, as well as disability in daily life activities, and improvement in chronic musculoskeletal pain, particularly neck pain associated with worsening of balance. The study's goal is to look into the relationship between scoliosis, balance, and cervical pain in Parkinson's disease patients. Cross-sectional, pilot study. The study included 16 Parkinson's patients. Neck cervical pain was measured using the pain visual analogue scale and the short form McGill pain questionnaire, while dynamic balance was assessed using static balance, Tinetti, Berg Balance, and the Short Physical Performance Battery scales (SPPB)...
April 18, 2024: European Journal of Translational Myology
https://read.qxmd.com/read/38634611/school-racial-composition-effect-modification-by-caring-teacher-staff-presence-and-mid-late-life-depressive-symptoms-findings-from-the-study-of-healthy-aging-among-african-americans
#35
JOURNAL ARTICLE
Taylor M Mobley, Eleanor Hayes-Larson, Yingyan Wu, Rachel L Peterson, Kristen M George, Paola Gilsanz, M Maria Glymour, Marilyn D Thomas, Lisa L Barnes, Rachel A Whitmer, Elizabeth Rose Mayeda
For Black students in the United States, attending schools with a higher proportion of White students is associated with worse mental and physical health outcomes in adolescence/early adulthood. No prior studies evaluate K-12 school racial composition and later-life mental health. In a cohort of Black adults ages 50+ in Northern California who retrospectively self-reported school racial composition for grades 1, 6, 9, and 12, we assessed the association between attending a school with mostly Black students vs...
April 17, 2024: American Journal of Epidemiology
https://read.qxmd.com/read/38634243/structure-of-aspergillus-flavus-populations-associated-with-maize-in-greece-spain-and-serbia-implications-for-aflatoxin-biocontrol-on-a-regional-scale
#36
JOURNAL ARTICLE
Mohamed Ali Ouadhene, Kenneth A Callicott, Alejandro Ortega-Beltran, Hillary L Mehl, Peter J Cotty, Paola Battilani
Aspergillus flavus is the most frequently identified producer of aflatoxins. Non-aflatoxigenic members of the A. flavus L strains are used in various continents as active ingredients of bioprotectants directed at preventing aflatoxin contamination by competitive displacement of aflatoxin producers. The current research examined the genetic diversity of A. flavus L strain across southern Europe to gain insights into the population structure and evolution of this species and to evaluate the prevalence of genotypes closely related to MUCL54911, the active ingredient of AF-X1...
April 2024: Environmental Microbiology Reports
https://read.qxmd.com/read/38634012/safety-and-efficacy-of-a-feed-additive-consisting-of-vitamin-b-12-cyanocobalamin-produced-by-fermentation-with-ensifer-adhaerens-%C3%A2-cgmcc-21299-for-all-animal-species-nhu-europe-gmbh
#37
JOURNAL ARTICLE
Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Maryline Kouba, Marta López-Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Roberto Edoardo Villa, Ruud Woutersen, Pier Sandro Cocconcelli, Angelica Amaduzzi, Jaume Galobart, Orsolya Holcznecht, Paola Manini, Alberto Navarro Villa, Elisa Pettenati, Anita Radovnikovic, Barbara Rossi, Maria Vittoria Vettori, Fabiola Pizzo
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of vitamin B12 (cyanocobalamin) produced by fermentation with a non-genetically modified strain of Ensifer adhaerens (CGMCC 21299), when used as a nutritional additive for all animal species. No viable cells or DNA of the production strain were detected in the additive. Therefore, cyanocobalamin produced by fermentation with E. adhaerens CGMCC 21299 does not raise safety concerns as regards to the production strain...
April 2024: EFSA journal
https://read.qxmd.com/read/38633983/targeting-shared-pathways-in-tauopathies-and-age-related-macular-degeneration-implications-for-novel-therapies
#38
REVIEW
Michele Rinaldi, Antonio Pezone, Gaia Italia Quadrini, Gianmarco Abbadessa, Maria Paola Laezza, Maria Laura Passaro, Antonio Porcellini, Ciro Costagliola
The intricate parallels in structure and function between the human retina and the central nervous system designate the retina as a prospective avenue for understanding brain-related processes. This review extensively explores the shared physiopathological mechanisms connecting age-related macular degeneration (AMD) and proteinopathies, with a specific focus on tauopathies. The pivotal involvement of oxidative stress and cellular senescence emerges as key drivers of pathogenesis in both conditions. Uncovering these shared elements not only has the potential to enhance our understanding of intricate neurodegenerative diseases but also sets the stage for pioneering therapeutic approaches in AMD...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38633774/etiologies-of-bloody-diarrhea-in-children-presenting-with-acute-gastroenteritis-to-us-emergency-departments
#39
Paola Fonseca-Romero, Sharia M Ahmed, Ben J Brintz, D Matthew Vierkant, Jennifer Dien Bard, Daniel M Cohen, Ara Festekjian, Amy L Leber, Jami T Jackson, Neena Kanwar, Chari Larsen, Rangaraj Selvarangan, Kimberle C Chapin, Andrew T Pavia, Daniel T Leung
Among 111 children presenting with bloody diarrhea in a multicenter study of molecular testing in US emergency departments, we found viral pathogens in 18%, bacteria in 48%, protozoa in 2%, and no pathogens detected in 38%.
April 4, 2024: medRxiv
https://read.qxmd.com/read/38633362/assessment-of-acute-and-chronic-toxicity-in-wistar-rats-rattus-norvegicus-and-new-zealand-rabbits-oryctolagus-cuniculus-of-an-enriched-polyphenol-extract-obtained-from-caesalpinia-spinosa
#40
JOURNAL ARTICLE
Ricardo Ballesteros-Ramírez, Paola Lasso, Claudia Urueña, Jenny Saturno, Susana Fiorentino
Although herbal drugs are often considered safe for consumption, there is increasing evidence that some can generate undesirable health effects. However, polyphenols found in certain plants have been shown to provide a range of benefits for human health. In previous work, a standardized and quantified extract (P2Et) obtained from Caesalpinia spinosa (Dividivi) plant showed promising antioxidant, immunomodulatory, and anti-inflammatory properties in animal models of cancer and COVID-19 patients. The extract has also been subjected to genotoxicity, mutagenicity, and 28-day oral chronic toxicity evaluations, demonstrating a good safety profile...
2024: Journal of Toxicology
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