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Oncology, amr

Riccardo Bertolo, Jose Agudelo, Juan Garisto, Sherif Armanyous, Amr Fergany, Jihad Kaouk
OBJECTIVE: to compare perioperative and oncological outcomes of intracorporeal (ICUD) vs extracorporeal urinary diversion ECUD after robot-assisted radical cystectomy (RARC). METHODS: From January 2014 to December 2017, data of consecutive patients who underwent RARC performed by 2 institutional surgeons were prospectively collected in a dedicated database (IRB: 251647). Patients were divided in 2 groups according to the operating surgeon, one performing ECUD, the other ICUD...
January 29, 2019: Urology
Ercan Malkoç, Matthew J Maurice, Önder Kara, Daniel Ramirez, Ryan J Nelson, Julien Dagenais, Khaled Fareed, Amr Fergany, Robert J Stein, Pascal Mouracade, Jihad H Kaouk
OBJECTIVE: To identify preoperative factors that predict positive surgical margins in partial nephrectomy. MATERIAL AND METHODS: Using our institutional partial nephrectomy database, we investigated the patients who underwent partial nephrectomy for malignant tumors between January 2011 and December 2015. Patient, tumor, surgeon characteristics were compared by surgical margin status. Multivariable logistic regression was used to identify independent predictors of positive surgical margins...
January 1, 2019: Turkish Journal of Urology
L Mark Knab, Mazen S Zenati, Anton Khodakov, Maryjoe Rice, Amr Al-Abbas, David L Bartlett, Amer H Zureikat, Herbert J Zeh, Melissa E Hogg
In the XML of the original article, L. Mark Knab's first name was tagged incorrectly.
December 12, 2018: Annals of Surgical Oncology
Andy Wai Kan Yeung, Amr El-Demerdash, Ioana Berindan-Neagoe, Atanas G Atanasov, Yuh-Shan Ho
Although numerous bibliometric studies have examined various aspects of cancer research, the landscape of scientific studies focusing on natural products in cancer research has not been characterized. Using the Web of Science Core Collection online database, we identify and analyze scientific articles on natural products in cancer-related research. English is the language of publication for 99% of articles. In general, annual citation count of an article increases quickly after publication, reaches a plateau in the second year, stays in this plateau for 10 yr, and then begins to fall...
2018: Critical Reviews in Oncogenesis
Juan Garisto, Riccardo Bertolo, Julien Dagenais, Daniel Sagalovich, Khaled Fareed, Amr Fergany, Robert Stein, Jihad Kaouk
INTRODUCTION: We aimed to compare perioperative, functional and oncological outcomes between robot-assisted partial nephrectomy (RAPN) and open partial nephrectomy (OPN) for highly complex renal tumors (R.E.N.A.L. nephrometry Score > 9). METHODS: A retrospective review of 1,497 patients who consecutively underwent partial nephrectomy at a single academic tertiary center between 2008 and 2016 was performed to get data about patients who underwent RAPN and OPN for renal masses with RENAL score > 9...
October 2018: Urologic Oncology
L Mark Knab, Mazen S Zenati, Anton Khodakov, Maryjoe Rice, Amr Al-Abbas, David L Bartlett, Amer H Zureikat, Herbert J Zeh, Melissa E Hogg
BACKGROUND: Robotic surgery is increasingly being used for complex oncologic operations, although currently there is no standardized curriculum in place for surgical oncologists. We describe the evolution of a proficiency-based robotic training program implemented for surgical oncology fellows, and demonstrate the outcomes of the program. METHODS: A 5-step robotic curriculum began integration in July 2013. Fellows from July 2013 to August 2017 were included. An education portfolio was created for each fellow, including pre-fellowship experience, fellowship experience with data from robotic curriculum and operative experience, and post-fellowship practice information...
November 2018: Annals of Surgical Oncology
Amr Ahmed El-Arabey, Salama Abdu Salama, Adel Rashad Abd-Allah
In 2015, more than 1.6 million new cancer cases with 589,430 deaths were estimated over worldwide. Cancer is a complex disease with abnormal cell growth control which is hallmarked by chromosome misalignment and consequently genomic instability. Mitosis is a well-known target for chemotherapy as taxol and colchicines inhibit tumor cell division by inhibiting mitotic spindle plasticity. Accumulating evidence has revealed that the Centromere-associated Protein E (CENP-E) is expressed during mitosis and plays critical roles in inaccurate chromosome alignment...
September 1, 2018: Life Sciences
Ashraf Saad Zaghloul, Ahmed Mahmoud El-Minawi, Mohamed Atef ElKordy, Amr Kamal Younes, Ahmed Mostafa Mahmoud, Waleed Mohamed Fadlalla, Gamal Amira Mohamed
AIM OF WORK: Robotics in surgery led to an improvement of visualization, a better handling of tissues and better suturing. This study aimed to document the first experience of the Egyptian National Cancer Institute (NCI) using the robot-assisted laparoscopic approach in radical hysterectomies for cervical cancer and to highlight observed advantages, disadvantages, morbidity and oncological outcomes. PATIENTS AND METHODS: Data of cases that had either early cervical cancer (stage IB-IIA1 with a tumor ≥2 cm) or locally advanced cervical cancer (Stage IIA2-IIB after chemo-radiotherapy) were collected prospectively...
June 2018: Journal of the Egyptian National Cancer Institute
Ahmed El Kaffas, Mehrdad J Gangeh, Golnaz Farhat, William Tyler Tran, Amr Hashim, Anoja Giles, Gregory J Czarnota
High-dose radiotherapy effects are regulated by acute tumour endothelial cell death followed by rapid tumour cell death instead of canonical DNA break damage. Pre-treatment with ultrasound-stimulated microbubbles (USMB) has enabled higher-dose radiation effects with conventional radiation doses. This study aimed to confirm acute and longitudinal relationships between vascular shutdown and tumour cell death following radiation and USMB in a wild type murine fibrosarcoma model using in vivo imaging. Methods: Tumour xenografts were treated with single radiation doses of 2 or 8 Gy alone, or in combination with low-/high-concentration USMB...
2018: Theranostics
Aakash Pai, Muddassar Hussain, Richard Hindley, Amr Emara, Neil Barber
INTRODUCTION: When performing open or laparoscopic nephroureterectomy (LNU), the optimal way to excise the distal ureter remains controversial. There are concerns that primary endoscopic detachment of the intramural ureter is associated with adverse outcomes. Existing studies have limited number of patients and inadequate oncologic follow-up. We provide our institutions experience of this technique. MATERIALS AND METHODS: Data were collected prospectively on 59 patients (37 men) who underwent LNU for a 10-year period at a single center using a standardized technique: initial endoscopic circumferential release of the distal ureter and bladder cuff followed by retroperitoneal en bloc LNU...
July 2017: Journal of Endourology
Önder Kara, Matthew J Maurice, Pascal Mouracade, Ercan Malkoç, Julien Dagenais, Ryan J Nelson, Jaya Sai S Chavali, Robert J Stein, Amr Fergany, Jihad H Kaouk
PURPOSE: We sought to identify the preoperative factors associated with conversion from robotic partial nephrectomy to radical nephrectomy. We report the incidence of this event. MATERIALS AND METHODS: Using our institutional review board approved database, we abstracted data on 1,023 robotic partial nephrectomies performed at our center between 2010 and 2015. Standard and converted cases were compared in terms of patients and tumor characteristics, and perioperative, functional and oncologic outcomes...
July 2017: Journal of Urology
Amr S Abu Lila, Naoto Moriyoshi, Masakazu Fukushima, Cheng-Long Huang, Hiromi Wada, Tatsuhiro Ishida
Metronomic chemotherapy is currently considered an emerging therapeutic option in clinical oncology. S-1, an oral formulation of Tegafur (TF), a prodrug of 5-fluorouracil (5-FU), is designed to improve the antitumor activity of 5-FU in tandem with reducing its toxicity. Clinically, metronomic S-1 dosing has been approved for the standard first- and second-line treatment of metastatic or advanced stage of colorectal (CRC). However, expression of intratumor thymidylate synthase (TS), a significant gene in cellular proliferation, is associated with poor outcome to 5-FU-based chemotherapeutic regimens...
August 1, 2017: Cancer Letters
Salah Aref, Mohamed Sabry El-Ghonemy, Sherin Abd El-Aziz, Tarek Abouzeid, Mona Talaab, Amr El-Sabbagh
OBJECTIVES: Based on the concept of immune dysregulation in immune thrombocytopenic purpura (ITP) and that Interleukin-18 (IL-18) is an inflammatory cytokine that plays an important role in autoimmune disease by inducing interferon-γ secretion; this study aimed to assess a possible association between the IL-18 promoter polymorphisms (-607 C/A site) and genetic susceptibility to ITP and the impact of the immunoglobulins (Igs) concentrations level on disease severity and response to therapy...
March 2017: Hematology (Amsterdam, Netherlands)
Tommy K Nielsen, Brunolf W Lagerveld, Francis Keeley, Giovanni Lughezzani, Seshadri Sriprasad, Neil J Barber, Lars U Hansen, Nicole M Buffi, Giorgio Guazzoni, Johan A van der Zee, Mohamed Ismail, Khaled Farrag, Amr M Emara, Lars Lund, Øyvind Østraat, Michael Borre
OBJECTIVE: To assess complication rates and intermediate oncological outcomes of laparoscopic-assisted cryoablation (LCA) in patients with small renal masses (SRMs). PATIENTS AND METHODS: A retrospective review of 808 patients treated with LCA for T1a SRMs from 2005 to 2015 at eight European institutions. Complications were analysed according to the Clavien-Dindo classification. Kaplan-Meier analyses were used to estimate 5- and 10-year disease-free survival (DFS) and overall survival (OS)...
March 2017: BJU International
Amparo L Figueroa, Richard A P Takx, Megan H MacNabb, Amr Abdelbaky, Zachary R Lavender, Rebecca S Kaplan, Quynh A Truong, Janet Lo, Brian B Ghoshhajra, Steven K Grinspoon, Udo Hoffmann, Ahmed Tawakol
BACKGROUND: The objective of this study was to evaluate how different measures of adiposity are related to both arterial inflammation and the risk of subsequent cardiovascular events. METHODS AND RESULTS: We included individuals who underwent (18)F-fluorodeoxyglucose positron emission tomography/computed tomography imaging for oncological evaluation. Subcutaneous adipose tissue (SAT) volume, visceral adipose tissue (VAT) volume, and VAT/SAT ratio were determined...
April 2016: Circulation. Cardiovascular Imaging
Keith I Block, Charlotte Gyllenhaal, Leroy Lowe, Amedeo Amedei, A R M Ruhul Amin, Amr Amin, Katia Aquilano, Jack Arbiser, Alexandra Arreola, Alla Arzumanyan, S Salman Ashraf, Asfar S Azmi, Fabian Benencia, Dipita Bhakta, Alan Bilsland, Anupam Bishayee, Stacy W Blain, Penny B Block, Chandra S Boosani, Thomas E Carey, Amancio Carnero, Marianeve Carotenuto, Stephanie C Casey, Mrinmay Chakrabarti, Rupesh Chaturvedi, Georgia Zhuo Chen, Helen Chen, Sophie Chen, Yi Charlie Chen, Beom K Choi, Maria Rosa Ciriolo, Helen M Coley, Andrew R Collins, Marisa Connell, Sarah Crawford, Colleen S Curran, Charlotta Dabrosin, Giovanna Damia, Santanu Dasgupta, Ralph J DeBerardinis, William K Decker, Punita Dhawan, Anna Mae E Diehl, Jin-Tang Dong, Q Ping Dou, Janice E Drew, Eyad Elkord, Bassel El-Rayes, Mark A Feitelson, Dean W Felsher, Lynnette R Ferguson, Carmela Fimognari, Gary L Firestone, Christian Frezza, Hiromasa Fujii, Mark M Fuster, Daniele Generali, Alexandros G Georgakilas, Frank Gieseler, Michael Gilbertson, Michelle F Green, Brendan Grue, Gunjan Guha, Dorota Halicka, William G Helferich, Petr Heneberg, Patricia Hentosh, Matthew D Hirschey, Lorne J Hofseth, Randall F Holcombe, Kanya Honoki, Hsue-Yin Hsu, Gloria S Huang, Lasse D Jensen, Wen G Jiang, Lee W Jones, Phillip A Karpowicz, W Nicol Keith, Sid P Kerkar, Gazala N Khan, Mahin Khatami, Young H Ko, Omer Kucuk, Rob J Kulathinal, Nagi B Kumar, Byoung S Kwon, Anne Le, Michael A Lea, Ho-Young Lee, Terry Lichtor, Liang-Tzung Lin, Jason W Locasale, Bal L Lokeshwar, Valter D Longo, Costas A Lyssiotis, Karen L MacKenzie, Meenakshi Malhotra, Maria Marino, Maria L Martinez-Chantar, Ander Matheu, Christopher Maxwell, Eoin McDonnell, Alan K Meeker, Mahya Mehrmohamadi, Kapil Mehta, Gregory A Michelotti, Ramzi M Mohammad, Sulma I Mohammed, D James Morre, Vinayak Muralidhar, Irfana Muqbil, Michael P Murphy, Ganji Purnachandra Nagaraju, Rita Nahta, Elena Niccolai, Somaira Nowsheen, Carolina Panis, Francesco Pantano, Virginia R Parslow, Graham Pawelec, Peter L Pedersen, Brad Poore, Deepak Poudyal, Satya Prakash, Mark Prince, Lizzia Raffaghello, Jeffrey C Rathmell, W Kimryn Rathmell, Swapan K Ray, Jörg Reichrath, Sarallah Rezazadeh, Domenico Ribatti, Luigi Ricciardiello, R Brooks Robey, Francis Rodier, H P Vasantha Rupasinghe, Gian Luigi Russo, Elizabeth P Ryan, Abbas K Samadi, Isidro Sanchez-Garcia, Andrew J Sanders, Daniele Santini, Malancha Sarkar, Tetsuro Sasada, Neeraj K Saxena, Rodney E Shackelford, H M C Shantha Kumara, Dipali Sharma, Dong M Shin, David Sidransky, Markus David Siegelin, Emanuela Signori, Neetu Singh, Sharanya Sivanand, Daniel Sliva, Carl Smythe, Carmela Spagnuolo, Diana M Stafforini, John Stagg, Pochi R Subbarayan, Tabetha Sundin, Wamidh H Talib, Sarah K Thompson, Phuoc T Tran, Hendrik Ungefroren, Matthew G Vander Heiden, Vasundara Venkateswaran, Dass S Vinay, Panagiotis J Vlachostergios, Zongwei Wang, Kathryn E Wellen, Richard L Whelan, Eddy S Yang, Huanjie Yang, Xujuan Yang, Paul Yaswen, Clement Yedjou, Xin Yin, Jiyue Zhu, Massimo Zollo
Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted)...
December 2015: Seminars in Cancer Biology
Amr Fergany
OBJECTIVE: Laparoscopic radical cystectomy (LRC) has emerged as a minimally invasive alternative to open radical cystectomy (ORC). This review focuses on patient selection criteria, technical aspects and postoperative outcomes of LRC. METHODS: Material for the review was obtained by a PubMed search over the last 10 years, using the keywords 'laparoscopic radical cystectomy' and 'laparoscopic bladder cancer' in human subjects. RESULTS: Twenty-two publications selected for relevance and content were used for this review from the total search yield...
March 2012: Arab Journal of Urology
Rana Sayed, Amr S Saad, Lamia El Wakeel, Engi Elkholy, Osama Badary
PURPOSE: To evaluate effects of metformin on clinical outcome of non-diabetic patients with stage IV NSCLC. MATERIALS AND METHODS: A prospective, randomized, open-label, controlled pilot study was conducted on patients with stage IV NSCLC with an Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0-2, excluding patients with diabetes and lactic acidosis. Thirty chemo-naive, non-diabetic patients with stage IV NSCLC were enrolled. Fifteen patients received intravenous gemcitabine/cisplatin regimen alone (arm B) while fifteen patients received the same regimen plus daily oral metformin 500 mg (arm A)...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Brian R Lane, Sevag Demirjian, Ithaar H Derweesh, Toshio Takagi, Zhiling Zhang, Lily Velet, Cesar E Ercole, Amr F Fergany, Steven C Campbell
BACKGROUND: Chronic kidney disease (CKD) can be associated with a higher risk of progression to end-stage renal disease and mortality, but the etiology of nephron loss may modify this. Previous studies suggested that CKD primarily due to surgical removal of nephrons (CKD-S) may be more stable and associated with better survival than CKD due to medical causes (CKD-M). OBJECTIVE: We addressed limitations of our previous work with comprehensive control for confounding factors, differentiation of non-renal cancer-related mortality, and longer follow-up for more discriminatory assessment of the impact of CKD-S...
December 2015: European Urology
Amrallah A Mohammed, Abdullah S Al-Zahrani, Mohamed A Sherisher, Ahmad A Alnagar, Ayman El-Shentenawy, Amr T El-Kashif
BACKGROUND: Although cancer patients are susceptible to infection, there is no evidence-based published guideline on the appropriate use of antimicrobial treatment in this group of patients. METHODS: We retrospectively collected medical records of all terminal cancer patients who died in the oncology department over a 15-month period and were reviewed for the pattern of infection and causes of antimicrobial use during the patients' last admission of life. RESULTS: A total of 258 eligible patients were enrolled, there was an equal distribution of males and females (M/F: 129/129), and the mean age was 60...
September 2014: Journal of the Egyptian National Cancer Institute
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