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JOURNAL ARTICLE
Mohamed Fawzy, Gehad Ahmed, Yasser Youssef, Naglaa Elkinaai, Amal Refaat, Mai Amr Elahmadawy, Fadwa Said, Salma Elmenawi
BACKGROUND: Bilateral suprarenal neuroblastoma (BSN) is a rare presentation. Few previously published literature showed BSN patients to have favorable pattern and prognosis. This study aim was to evaluate clinical and biological features in relation to outcome of Egyptian patients with BSN. METHODS: Included patients were diagnosed from 2007 to 2017, retrospectively. Tissue biopsy, imaging and bone marrow were evaluated at presentation. Clinical, demographic, biological variables and risk group were determined and analyzed in relation to overall (OS) and event-free-survival (EFS)...
April 12, 2024: Discover. Oncology
#2
JOURNAL ARTICLE
Nicolas Soputro, Ethan Ferguson, Roxana Ramos-Carpinteyro, Jaya Sai Chavali, Albert Geskin, Khaled Fareed, Ryan Berglund, Amr Fergany, Robert J Stein, Georges Pascal Haber, Steven Campbell, Christopher J Weight, Jihad Kaouk
OBJECTIVE: To evaluate the long-term functional and oncological outcomes following robotic partial (RAPN) and radical nephrectomy (RARN). MATERIALS AND METHODS: A retrospective review was performed on 1816 patients who underwent RAPN and RARN at our institution between January 2006 and January 2018. Patients with long-term follow-ups of at least 5 years were selected. Exclusion criteria included patients with a previous history of partial or radical nephrectomy, known genetic mutations, and whose procedures were performed for benign indications Statistical analysis was performed with results as presented...
April 3, 2024: Journal of Endourology
#3
JOURNAL ARTICLE
Othman M Solaiman, Tusneem Elhassan, Riad E Fakih, Abdul Mannan, Zainab Alduhailib, Ashwaq A Mahdali, Hazzaa Alzahrani, Mouhamad Jamil, Naeem Chaudhri, Alyaa Elhazmi, Mohammad Kolko, Fahad Z Al-Sharif, Abdullah Alrbiaan, Mohammed Shaban, Marwan Shaheen, Nawal Salahuddin, Feras A Alfraih, Ashraf S Altarifi, Mona Hassanein, Sulaiman Hosaini, Noura Alhashim, Alaa A Mohamed, Amr Hanbali, Ali H Aljanoubi, Nadia R Al-Obaidi, Walid Rasheed, Khalid Maghrabi, Fahad Almohareb, Ayman Soubani, Mahmoud Aljurf, Syed O Ahmed
BACKGROUND AND OBJECTIVES: Prognostic factors reliably predicting outcomes for critically ill adolescent and young adult (AYA) patients undergoing allogeneic hematopoietic cell transplantation (allo-HSCT) are lacking. We assessed transplant and intensive care unit (ICU)-related factors impacting patient outcomes. PATIENTS AND METHODS: AYA patients who underwent allo-HSCT and required ICU admission at a Tertiary care Centre, during the period of 2003-2013, were included in this retrospective review...
March 22, 2024: Hematology/oncology and Stem Cell Therapy
#4
JOURNAL ARTICLE
Noha Rashad, Salem Eid Salem, Mohamed A M Meheissen, Ghada Refaat, Heba Mahmoud Sami, Abdelsalam Temerik, Nashwa Kordy, Mina A Daniel, Mohamed El-Kaffas, Mohamed Esam, Hazem El Mansy, Yasser Elkerm, Amr Abdelaziz Elsaid, Abdelsalam Attia Ismail, Mohyeldin Saber Abdelhalim, Lamiaa Moustafa Ahmad, Mai Akram Mahmoud, Eman D El Desouky
PURPOSE: Early-onset colorectal cancer (EOCRC) is a rising health problem. The incidence of EOCRC has increased over the past 2 decades all over the world. Reports from Egypt since the 1990s have reported a higher incidence among young populations with no identifiable risk factors. The aim of this study was to assess EOCRC in Egypt regarding incidence, characteristics, treatment pattern, and survival compared with average age onset and elderly patients. MATERIALS AND METHODS: This was a retrospective, record-based, cohort study combining data from four different cancer centers in Egypt...
March 2024: JCO global oncology
#5
JOURNAL ARTICLE
Kavin Sugumar, Henry Stitzel, Victoria Wu, David Bajor, Sakti Chakrabarti, Madison Conces, Lauren Henke, Melissa Lumish, Amit Mahipal, Amr Mohamed, Jordan M Winter, Jeffrey M Hardacre, John B Ammori, Jennifer E Selfridge, Lee M Ocuin
BACKGROUND: Treatment of unresectable colorectal liver metastases (UCRLM) includes locoregional and systemic therapy. A comprehensive analysis capturing long-term outcomes of these treatment options has not been performed. OBJECTIVE: A systematic review and meta-analysis was performed to calculate pooled outcomes of hepatic artery infusion with systemic chemotherapy (HAI-S), transarterial chemoembolization with systemic chemotherapy (TACE-S), transarterial radioembolization with systemic chemotherapy (TARE-S), doublet (FOLFOX, FOLFIRI), and triplet chemotherapy (FOLFOXIRI)...
March 19, 2024: Annals of Surgical Oncology
#6
REVIEW
A Dawoud, R A Elmasri, A H Mohamed, A Mahmoud, M M Rostom, R A Youness
The concept of 'Hallmarks of Cancer' is an approach of reducing the enormous complexity of cancer to a set of guiding principles. As the underlying mechanism of cancer are portrayed, we find that we gain insight and additional aspects of the disease arise. The understanding of the tumor microenvironment (TME) brought a new dimension and led to the discovery of novel hallmarks such as senescent cells, non-mutational epigenetic reprogramming, polymorphic microbiomes and unlocked phenotypic plasticity. Circular RNAs (circRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across all species...
April 2024: Critical Reviews in Oncology/hematology
#7
JOURNAL ARTICLE
Amr A Alnemr, Ola A Harb, Hytham Atia
OBJECTIVE: To compare the efficacy of the levonorgestrel intrauterine system (LNG-IUS) versus megestrol acetate (MA) in inducing complete regression among women with atypical endometrial hyperplasia (AEH) who declined hysterectomy. METHODS: In this single-center, open-label randomized controlled trial, we included 148 women with AEH who declined hysterectomy. We randomized participants to receive either daily oral MA 160 mg (n=74) or apply LNG-IUS (n=74) and scheduled their follow-up by endometrial sampling at 3, 6, 9, 12, 18, and 24 months...
February 22, 2024: Journal of Gynecologic Oncology
#8
JOURNAL ARTICLE
Nora Alkhudair, Jude Howaidi, Mohammed Alnuhait, Majed Alshamrani, Mansour Khan, Atika Alharbi, Fouad Alnajjar, Eshtyag Bajnaid, Hajer Almodaheem, Mansour Alhowimel, Ali Alzahrani, Amr Khardaly, Mohammed Alnahedh, Hamdi Elsoudi, Hana Alabdulkareem, Ahmed Alrashidan, Musa Alzahrani, Abdullah Alrajhi
BACKGROUND: Cancer care is posing immense challenges to healthcare systems globally. Advances in screening, monitoring, and treating cancer improved patient outcomes and survival rates yet amplified the disease burden. Multiple barriers might impede early access to innovative therapies. We thoroughly examined the current challenges in oncology medication access in Saudi Arabia and provided consensus recommendations to revitalize the process. METHODS: A focus group discussion was conducted...
February 20, 2024: Journal of Oncology Pharmacy Practice
#9
REVIEW
Anas Dabsha, Ismail A M H Elkharbotly, Mohammad Yaghmour, Amr Badr, Fady Badie, Sherif Khairallah, Yomna M Esmail, Mohamed Hossny, Amr Rizk, Amr El-Demiry, Galal Ghaly, Shaikha Al-Thani, Michelle Demetres, Abdelrahman Mohamed, Jonathan Villena-Vargas, Mona Kamal, Mohamed Rahouma
BACKGROUND: Mediastinal Yolk sac tumors (YST) are rare and highly malignant extragonadal germ cell tumors with rapid growth and early metastases. We sought to conduct a meta-analysis of published case reports/case series to compare differences in survival, demographics, and treatment modalities between adult and pediatric patients with YST. METHODS: Ovid Embase, Cochrane, and Ovid Medline databases were searched for primary mediastinal pure YST cases. The primary outcome was overall survival (OS)...
March 2024: European Journal of Surgical Oncology
#10
JOURNAL ARTICLE
Ali Almajid, Ali Bazroon, Hassan Albarbari, Hashim M Al-Awami, Alzahraa AlAhmed, Omar M Bakhurji, Ghadah Alharbi, Fatemah Aldawood, Zainab AlKhamis, Mohammed Alqarni, Mohammed Alabdullah, Raghad Almutairi
Background Antimicrobial resistance (AMR) has been designated a public health crisis by the World Health Organization. AMR can lead to escalated healthcare costs, higher mortality rates, increased morbidity, and more frequent hospitalizations. This study aimed to retrospectively evaluate the appropriateness of Tazocin prescription for community-acquired pneumonia (CAP). Methodology We conducted a retrospective analysis of patients aged ≥18 years who were admitted with a diagnosis of CAP and administered intravenous Tazocin between November 2021 and October 2022...
December 2023: Curēus
#11
JOURNAL ARTICLE
Rushmin Khazanchi, Khizar R Nandoliya, Maryam N Shahin, Ali I Rae, Rahul K Chaliparambil, Stephen G Bowden, Amr Alwakeal, Christian G Lopez Ramos, Brittany Stedelin, Mark W Youngblood, James P Chandler, Rimas V Lukas, Olabisi R Sanusi, Aclan Dogan, Matthew D Wood, Seunggu J Han, Stephen T Magill
OBJECTIVE: Whether obesity is associated with meningioma and the impact of obesity by gender has been debated. The primary objective of this study was to investigate differences in BMI between male and female patients undergoing craniotomy for meningioma and compare those with patients undergoing craniotomy for other intracranial tumors. The secondary objective was to compare meningioma location and progression-free survival (PFS) between obese and nonobese patients in a multi-institutional cohort...
January 19, 2024: Journal of Neurosurgery
#12
JOURNAL ARTICLE
Han Choi, Amr S Soliman, Randa Al Mousa, Jennifer Yeh, Jamal Khader, Iyad Sultan, Ahmad Kh Ibrahimi
BACKGROUND: The number of cancer survivors and survivorship are increasing. Health-related quality of life (HRQOL) has not been widely studied in low-and-middle-income countries (LMICs). The aim of this study is to explore HRQOL of childhood brain tumor survivors and its determinants in Jordan. METHODS: Health-related quality of life information was collected from 80 patients treated at the King Hussein Cancer Center and their parents using the Pediatric Quality of Life Inventory (PedsQL) Generic Core Scales questionnaire in Arabic...
February 2024: Neuro-oncology Practice
#13
JOURNAL ARTICLE
Yamu Li, Sulin Wu, Yiqing Zhao, Trang Dinh, Dongxu Jiang, J Eva Selfridge, George Myers, Yuxiang Wang, Xuan Zhao, Suzanne L Tomchuck, George Dubyak, Richard T Lee, Bassam Estfan, Marc Shapiro, Suneel D Kamath, Amr Mohamed, Stanley C-C Huang, Alex Y Huang, Ronald A Conlon, Smitha S Krishnamurthi, Jennifer R Eads, Joseph E Willis, Alok A Khorana, David L Bajor, Zhenghe Wang
Neutrophil Extracellular Traps (NETs), a web-like structure of cytosolic and granule proteins assembled on decondensed chromatin, kill pathogens and causes tissue damage in diseases. Whether NETs can kill cancer cells is unexplored. Here, we report that a combination of glutaminase inhibitor CB-839 and 5-FU inhibits the growth of PIK3CA mutant colorectal cancers (CRCs) in xenograft, syngeneic, and genetically engineered mouse models in part through NETs. Disruption of NETs by either DNase I treatment or depletion of neutrophils in CRCs attenuated the efficacy of the drug combination...
January 9, 2024: Journal of Clinical Investigation
#14
REVIEW
Vikash Kumar, Mrunanjali Gaddam, Amr Moustafa, Rabia Iqbal, Dhir Gala, Mili Shah, Vijay Reddy Gayam, Praneeth Bandaru, Madhavi Reddy, Vinaya Gadaputi
Artificial intelligence (AI) has made significant advancements in the medical domain in recent years. AI, an expansive field comprising Machine Learning (ML) and, within it, Deep Learning (DL), seeks to emulate the intricate operations of the human brain. It examines vast amounts of data and plays a crucial role in decision-making, overcoming limitations related to human evaluation. DL utilizes complex algorithms to analyze data. ML and DL are subsets of AI that utilize hard statistical techniques that help machines consistently improve at tasks with experience...
November 2023: Curēus
#15
JOURNAL ARTICLE
Chloe Dumot, Georgios Mantziaris, Sam Dayawansa, Selcuk Peker, Yavuz Samanci, Ahmed M Nabeel, Wael A Reda, Sameh R Tawadros, Khaled AbdelKarim, Amr M N El-Shehaby, Reem M Emad, Ahmed Ragab Abdelsalam, Roman Liscak, Jaromir May, Elad Mashiach, Fernando De Nigris Vasconcellos, Kenneth Bernstein, Douglas Kondziolka, Herwin Speckter, Ruben Mota, Anderson Brito, Shray Kumar Bindal, Ajay Niranjan, L Dade Lunsford, Carolina Gesteira Benjamin, Timoteo Abrantes de Lacerda Almeida, Jennifer Mao, David Mathieu, Jean-Nicolas Tourigny, Manjul Tripathi, Joshua David Palmer, Jennifer Matsui, Joe Crooks, Rodney E Wegner, Matthew J Shepard, Mary Lee Vance, Jason P Sheehan
BACKGROUND: Stereotactic radiosurgery (SRS) is used to treat recurrent or residual nonfunctioning pituitary neuroendocrine tumors (NFPA). The objective of the study was to assess imaging and development of new pituitary hormone deficiency. METHODS: Patients treated with single-session SRS for a NFPA were included in this retrospective, multicenter study. Tumor control and new pituitary dysfunction were evaluated using Cox analysis and Kaplan-Meier curves. RESULTS: 869 patients (male 476 [54...
December 14, 2023: Neuro-oncology
#16
JOURNAL ARTICLE
Rasha Aboelhassan, Mohamed Emam Sobeih, Mohamed Alm El-Din, Ramy R Ghali, Ibtessam Saad El-Din, Ola Khorshid, Mohsen Mokhtar, Ahmed Magdy Rabea, Abdelaziz Belal, Hamdy A Azim, Mohamed Abdullah, Tamer Elnahas, Hesham Tawfik, Sherif Abdelwahab, Amr Abdelaziz Elsaid, Tarek Hashem, Mohamed Mancy, Heba Farag
BACKGROUND: Stage III non-small cell lung cancer (NSCLC) being highly heterogeneous requires multimodal therapeutic strategies for optimal management. We present findings on treatment patterns and their associated survival outcomes in patients with stage III NSCLC from the Egypt subset of the KINDLE global real-world study conducted across countries from Asia, Middle East, Africa, and Latin America. METHOD: Retrospective data from the Egypt subset (21 centers) of adult patients diagnosed with stage III NSCLC between January 2013 and December 2017 were analyzed...
2023: Therapeutic Advances in Medical Oncology
#17
JOURNAL ARTICLE
Othman Bin-Alamer, Hussam Abou-Al-Shaar, Raj Singh, Arka N Mallela, Andrew Legarreta, Greg Bowden, David Mathieu, Haley K Perlow, Joshua D Palmer, Shahed Elhamdani, Matthew Shepard, Yun Liang, Ahmed M Nabeel, Wael A Reda, Sameh R Tawadros, Khaled Abdelkarim, Amr M N El-Shehaby, Reem Emad Eldin, Ahmed Hesham Elazzazi, Ronald E Warnick, Yair M Gozal, Megan Daly, Brendan McShane, Marcel Addis-Jackson, Gokul Karthikeyan, Sian Smith, Piero Picozzi, Andrea Franzini, Tehila Kaisman-Elbaz, Huai-Che Yang, Judith Hess, Kelsey Templeton, Xiaoran Zhang, Zhishuo Wei, Stylianos Pikis, Georgios Mantziaris, Gabriela Simonova, Roman Liscak, Selcuk Peker, Yavuz Samanci, Veronica Chiang, Charles R Kersh, Cheng-Chia Lee, Daniel M Trifiletti, Ajay Niranjan, Constantinos G Hadjipanayis, L Dade Lunsford, Jason P Sheehan
OBJECTIVE: The goal of this study was to characterize local tumor control (LC), overall survival (OS), and safety of stereotactic radiosurgery for colorectal brain metastasis (CRBM). METHODS: Ten international institutions participating in the International Radiosurgery Research Foundation provided data for this retrospective case series. This study included 187 patients with CRBM (281 tumors), with a median age of 62 years and 56.7% being male. Most patients (53...
November 10, 2023: Journal of Neurosurgery
#18
EDITORIAL
Emad Shash, Ghada A Soliman, Wahid Al-Kharusi, Maha Yahia, Julius Mwaiselage, Dewani Mesemo, Chacha Mwita, Samuel Gathere, Leo Masamba, Henda Rais, Mustafa Hussein, Victoria Ngo, Pedro Mateu Gelabert, Hany Hussein, Robert M Chamberlain, Amr S Soliman
No abstract text is available yet for this article.
November 6, 2023: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
#19
JOURNAL ARTICLE
By Amr Khalifa, Ana Guijarro, Silvia Ravera, Nadia Bertola, Maria Pia Adorni, Bianca Papotti, Lizzia Raffaghello, Roberto Benelli, Pamela Becherini, Asmaa Namatalla, Daniela Verzola, Daniele Reverberi, Fiammetta Monacelli, Michele Cea, Livia Pisciotta, Franco Bernini, Irene Caffa, Alessio Nencioni
Identifying oncological applications for drugs that are already approved for other medical indications is considered a possible solution for the increasing costs of cancer treatment. Under the hypothesis that nutritional stress through fasting might enhance the antitumour properties of at least some non-oncological agents, by screening drug libraries, we find that cholesterol biosynthesis inhibitors (CBIs), including simvastatin, have increased activity against cancers of different histology under fasting conditions...
October 31, 2023: Nature Communications
#20
Mohammed Abusuliman, Amr M Mohamed, Anas Mahmoud, Tala Beliani, Ibrahim M Ismail-Sayed
Malignant pericardial effusion (MPE) is a slowly progressive and potentially clinically silent condition. Pericardial effusion can arise in oncology patients due to several factors, including disease spreading directly or metastatically, anticancer therapy side effects, or both. Solid and hematological malignancy metastasis more frequently involves the pericardium than primary tumors, with lung cancer being the most common metastatic tumor to involve the pericardium. While 5%-20% of all patients with metastatic neoplasms have pericardial involvement, MPE rarely appears with hemodynamic instability...
September 2023: Curēus
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