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JOURNAL ARTICLE
Chloe Dumot, Georgios Mantziaris, Sam Dayawansa, Selcuk Peker, Yavuz Samanci, Ahmed M Nabeel, Wael A Reda, Sameh R Tawadros, Khaled AbdelKarim, Amr M N El-Shehaby, Reem M Emad, Ahmed Ragab Abdelsalam, Roman Liscak, Jaromir May, Elad Mashiach, Fernando De Nigris Vasconcellos, Kenneth Bernstein, Douglas Kondziolka, Herwin Speckter, Ruben Mota, Anderson Brito, Shray Kumar Bindal, Ajay Niranjan, L Dade Lunsford, Carolina Gesteira Benjamin, Timoteo Abrantes de Lacerda Almeida, Jennifer Mao, David Mathieu, Jean-Nicolas Tourigny, Manjul Tripathi, Joshua David Palmer, Jennifer Matsui, Joe Crooks, Rodney E Wegner, Matthew J Shepard, Mary Lee Vance, Jason P Sheehan
BACKGROUND: Stereotactic radiosurgery (SRS) is used to treat recurrent or residual nonfunctioning pituitary neuroendocrine tumors (NFPA). The objective of the study was to assess imaging and development of new pituitary hormone deficiency. METHODS: Patients treated with single-session SRS for a NFPA were included in this retrospective, multicenter study. Tumor control and new pituitary dysfunction were evaluated using Cox analysis and Kaplan-Meier curves. RESULTS: 869 patients (male 476 [54...
December 14, 2023: Neuro-oncology
#22
JOURNAL ARTICLE
Rasha Aboelhassan, Mohamed Emam Sobeih, Mohamed Alm El-Din, Ramy R Ghali, Ibtessam Saad El-Din, Ola Khorshid, Mohsen Mokhtar, Ahmed Magdy Rabea, Abdelaziz Belal, Hamdy A Azim, Mohamed Abdullah, Tamer Elnahas, Hesham Tawfik, Sherif Abdelwahab, Amr Abdelaziz Elsaid, Tarek Hashem, Mohamed Mancy, Heba Farag
BACKGROUND: Stage III non-small cell lung cancer (NSCLC) being highly heterogeneous requires multimodal therapeutic strategies for optimal management. We present findings on treatment patterns and their associated survival outcomes in patients with stage III NSCLC from the Egypt subset of the KINDLE global real-world study conducted across countries from Asia, Middle East, Africa, and Latin America. METHOD: Retrospective data from the Egypt subset (21 centers) of adult patients diagnosed with stage III NSCLC between January 2013 and December 2017 were analyzed...
2023: Therapeutic Advances in Medical Oncology
#23
JOURNAL ARTICLE
Othman Bin-Alamer, Hussam Abou-Al-Shaar, Raj Singh, Arka N Mallela, Andrew Legarreta, Greg Bowden, David Mathieu, Haley K Perlow, Joshua D Palmer, Shahed Elhamdani, Matthew Shepard, Yun Liang, Ahmed M Nabeel, Wael A Reda, Sameh R Tawadros, Khaled Abdelkarim, Amr M N El-Shehaby, Reem Emad Eldin, Ahmed Hesham Elazzazi, Ronald E Warnick, Yair M Gozal, Megan Daly, Brendan McShane, Marcel Addis-Jackson, Gokul Karthikeyan, Sian Smith, Piero Picozzi, Andrea Franzini, Tehila Kaisman-Elbaz, Huai-Che Yang, Judith Hess, Kelsey Templeton, Xiaoran Zhang, Zhishuo Wei, Stylianos Pikis, Georgios Mantziaris, Gabriela Simonova, Roman Liscak, Selcuk Peker, Yavuz Samanci, Veronica Chiang, Charles R Kersh, Cheng-Chia Lee, Daniel M Trifiletti, Ajay Niranjan, Constantinos G Hadjipanayis, L Dade Lunsford, Jason P Sheehan
OBJECTIVE: The goal of this study was to characterize local tumor control (LC), overall survival (OS), and safety of stereotactic radiosurgery for colorectal brain metastasis (CRBM). METHODS: Ten international institutions participating in the International Radiosurgery Research Foundation provided data for this retrospective case series. This study included 187 patients with CRBM (281 tumors), with a median age of 62 years and 56.7% being male. Most patients (53...
November 10, 2023: Journal of Neurosurgery
#24
EDITORIAL
Emad Shash, Ghada A Soliman, Wahid Al-Kharusi, Maha Yahia, Julius Mwaiselage, Dewani Mesemo, Chacha Mwita, Samuel Gathere, Leo Masamba, Henda Rais, Mustafa Hussein, Victoria Ngo, Pedro Mateu Gelabert, Hany Hussein, Robert M Chamberlain, Amr S Soliman
No abstract text is available yet for this article.
November 6, 2023: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
#25
JOURNAL ARTICLE
By Amr Khalifa, Ana Guijarro, Silvia Ravera, Nadia Bertola, Maria Pia Adorni, Bianca Papotti, Lizzia Raffaghello, Roberto Benelli, Pamela Becherini, Asmaa Namatalla, Daniela Verzola, Daniele Reverberi, Fiammetta Monacelli, Michele Cea, Livia Pisciotta, Franco Bernini, Irene Caffa, Alessio Nencioni
Identifying oncological applications for drugs that are already approved for other medical indications is considered a possible solution for the increasing costs of cancer treatment. Under the hypothesis that nutritional stress through fasting might enhance the antitumour properties of at least some non-oncological agents, by screening drug libraries, we find that cholesterol biosynthesis inhibitors (CBIs), including simvastatin, have increased activity against cancers of different histology under fasting conditions...
October 31, 2023: Nature Communications
#26
Mohammed Abusuliman, Amr M Mohamed, Anas Mahmoud, Tala Beliani, Ibrahim M Ismail-Sayed
Malignant pericardial effusion (MPE) is a slowly progressive and potentially clinically silent condition. Pericardial effusion can arise in oncology patients due to several factors, including disease spreading directly or metastatically, anticancer therapy side effects, or both. Solid and hematological malignancy metastasis more frequently involves the pericardium than primary tumors, with lung cancer being the most common metastatic tumor to involve the pericardium. While 5%-20% of all patients with metastatic neoplasms have pericardial involvement, MPE rarely appears with hemodynamic instability...
September 2023: Curēus
#27
JOURNAL ARTICLE
Dmitry V Sverchinsky, Bashar A Alhasan, Marina A Mikeladze, Vladimir F Lazarev, Liubov S Kuznetcova, Alisa V Morshneva, Alina D Nikotina, Amr Ziewanah, Lidia V Koludarova, Tatiana Y Starkova, Boris A Margulis, Irina V Guzhova
BACKGROUND: Cancer recurrence is regulated by a variety of factors, among which is the material of dying tumor cells; it is suggested that remaining after anti-cancer therapy tumor cells receive a signal from proteins called damage-associated molecular patterns (DAMPs), one of which is heat shock protein 70 (Hsp70). METHODS: Two models of tumor repopulation were employed, based on minimal population of cancer cells and application of conditioned medium (CM). To deplete the CMs of Hsp70 affinity chromatography on ATP-agarose and immunoprecipitation were used...
October 25, 2023: Journal of Experimental & Clinical Cancer Research: CR
#28
JOURNAL ARTICLE
Junhyung Lee, Katrina Hueniken, Karl Cuddy, Jiajie Pu, Amr El Maghrabi, Andrew Hope, Ali Hosni, Michael Glogauer, Erin Watson
IMPORTANCE: Patients with head and neck cancer undergo extraction of teeth with poor prognoses to minimize post-radiation therapy (RT) extractions, which are known to cause osteoradionecrosis (ORN). However, many patients are required to start RT before the extraction sites are completely healed. The role of pre-RT extractions in the development of ORN has been disputed in literature. OBJECTIVE: To determine whether the timing of pre-RT dental extractions is associated with ORN development in patients with head and neck cancer...
December 1, 2023: JAMA Otolaryngology—Head & Neck Surgery
#29
REVIEW
Nikhil Singh, Karin Thursky, Gabriela Maron, Joshua Wolf
BACKGROUND: The use of fluoroquinolones to prevent infections in neutropenic patients with cancer or undergoing hematopoietic stem cell transplantation (HSCT) is a controversial issue, with international guidelines providing conflicting recommendations. Although potential benefits are clear, concerns revolve around efficacy, potential harms, and antimicrobial resistance (AMR) implications. DISCUSSION: Fluoroquinolone prophylaxis reduces neutropenic fever (NF) bloodstream infections and other serious bacterial infections, based on evidence from systematic reviews, randomized controlled trials, and observational studies in adults and children...
September 25, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
#30
JOURNAL ARTICLE
Abhishek Midya, Amogh Hiremath, Jacob Huber, Vidya Sankar Viswanathan, Danly Omil-Lima, Amr Mahran, Leonardo K Bittencourt, Sree Harsha Tirumani, Lee Ponsky, Rakesh Shiradkar, Anant Madabhushi
OBJECTIVE: The aim of this study was to quantify radiomic changes in prostate cancer (PCa) progression on serial MRI among patients on active surveillance (AS) and evaluate their association with pathologic progression on biopsy. METHODS: This retrospective study comprised N = 121 biopsy-proven PCa patients on AS at a single institution, of whom N = 50 at baseline conformed to the inclusion criteria. ISUP Gleason Grade Groups (GGG) were obtained from 12-core TRUS-guided systematic biopsies at baseline and follow-up...
2023: Frontiers in Oncology
#31
JOURNAL ARTICLE
Ahmed Elgendy, Amr Abdelhamid AbouZeid, Mohamed El-Debeiky, Mahmoud Mostafa, Mohammed Hamada Takrouney, Mohamed Abouheba, Ahmed Khairi, Sameh Shehata, Sherif M Shehata
OBJECTIVES: Nationwide criteria regarding patients with sacrococcygeal teratoma (SCT) are still lacking in Egypt. We aimed to present a multicenter study regarding the management and outcomes of this tumor to evaluate our national treatment strategy. METHODS: A retrospective analysis including all patients with SCT who were managed at four major Egyptian centers between 2013 and 2023. Clinical data, surgical approaches, and short- and long-term outcomes were discussed...
September 18, 2023: World Journal of Surgical Oncology
#32
EDITORIAL
Amr S Soliman
No abstract text is available yet for this article.
September 1, 2023: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
#33
JOURNAL ARTICLE
Amr Ahmed El-Arabey, Haiyan Zhang, Mohnad Abdalla, Samia T Al-Shouli, Samia S Alkhalil, Yi Liu
Metformin is a regularly prescribed and low-cost generic medication. Metformin has been proposed as a target for Dipeptidyl-peptidase 4 (DPP4) expression in various clinical disorders. We provide insilco investigations on molecular docking and dynamic modeling of metformin and DPP4 potential interactions. Moreover, we conducted bioinformatic studies to highlight the clinical significance of DPP4 expression and mutation in various types of malignancies, as well as the invasion of different immune cells into the tumor microenvironment...
August 25, 2023: Medical Oncology
#34
JOURNAL ARTICLE
Olga-Demetra Biziotis, Evangelia Evelyn Tsakiridis, Amr Ali, Elham Ahmadi, Jianhan Wu, Simon Wang, Bassem Mekhaeil, Kanwaldeep Singh, Gabe Menjolian, Thomas Farrell, Bassam Abdulkarim, Ranjan K Sur, Aruz Mesci, Peter Ellis, Tobias Berg, Jonathan L Bramson, Paola Muti, Gregory R Steinberg, Theodoros Tsakiridis
Non-small cell lung cancer (NSCLC) has a poor prognosis, and effective therapeutic strategies are lacking. The diabetes drug canagliflozin inhibits NSCLC cell proliferation and the mammalian target of rapamycin (mTOR) pathway, which mediates cell growth and survival, but it is unclear whether this drug can enhance response rates when combined with cytotoxic therapy. Here, we evaluated the effects of canagliflozin on human NSCLC response to cytotoxic therapy in tissue cultures and xenografts. Ribonucleic acid sequencing (RNA-seq), real-time quantitative PCR (RT-qPCR), metabolic function, small interfering ribonucleic acid (siRNA) knockdown, and protein expression assays were used in mechanistic analyses...
August 16, 2023: Molecular Oncology
#35
REVIEW
Erin H Yang, Ibrahim N Muhsen, Hadeel Samarkandi, Riad El Fakih, Mahmoud Aljurf, Amr Hanbali
Daratumumab is a first-in-class human anti-CD38 IgG1 monoclonal antibody approved for treating newly diagnosed and relapsed refractory multiple myeloma. Pre-clinical data supported daratumumab's ability to deplete autoantibodies producing plasma cells, B-cells, and NK cells. Those reports showed promising results on using daratumumab in autoimmune disorders that are refractory to multiple lines of therapies, which encouraged using daratumumab in various autoimmune conditions that are refractory to standard therapies...
July 20, 2023: Hematology/oncology and Stem Cell Therapy
#36
JOURNAL ARTICLE
Nitin Bansal, Pankaj Goyal, Dharmishtha Basu, Ullas Batra, Neelam Sachdeva, Srujana Joga, Arpit Jain, D C Doval
BACKGROUND: Improving basic infection control (IC) practices, diagnostics and anti-microbial stewardship (AMS) are key tools to handle antimicrobial resistance (AMR). MATERIALS AND METHODS: This is a retrospective study done over 6 years (2016-2021) in an oncology centre in North India with many on-going interventions to improve IC practices, diagnostics and AMS. This study looked into AMR patterns from clinical isolates, rates of hospital acquired infections (HAI) and clinical outcomes...
2023: Indian Journal of Medical Microbiology
#37
JOURNAL ARTICLE
Mennatallah Elnaggar, Hanafy Hafez, Amr Abdallah, Mahmoud Hamza, Marwa M Khalaf, Alaa El-Haddad
BACKGROUND/OBJECTIVES: Cyclosporine A (CSA) dosing has been complicated by considerable intra-patient and inter-patient variability in pharmacokinetics, which is affected by different factors. We aimed to assess the various factors that might affect the CSA dose and its plasma level. PATIENTS AND METHODS: This retrospective study included paediatric cancer patients who underwent allogeneic hematopoietic stem cell transplant at the Children's Cancer Hospital Egypt 57357 from matched related donors with CSA as graft versus host disease prophylaxis...
August 1, 2023: Journal of Oncology Pharmacy Practice
#38
JOURNAL ARTICLE
Erin Watson, Amr El Maghrabi, Jun Hyung Lee, Jiajie Pu, Wei Xu, Shahad Joudah, Violet D'Souza, Carlos Quiñonez, Zahra Dorna Mojdami, Shao Hui Huang, Brian O'Sullivan, Jolie Ringash, John Kim, John Cho, Scott Bratman, John Waldron, David Goldstein, Ali Hosni Abdalaty, Michael Glogauer, Andrew Hope
Oral toxicities such as osteoradionecrosis can be minimized by dental screening and prophylactic dental care prior to head and neck (HN) radiation therapy (RT). However, limited information is available about how dental insurance interacts with prophylactic dental care and osteoradionecrosis. To address this gap in knowledge, we conducted a cohort study of 2743 consecutive adult patients treated with curative radiation for HN malignancy who underwent pre-radiation dental assessment and where required, prophylactic dental treatment...
October 2023: Oral Oncology
#39
JOURNAL ARTICLE
Shadi Chamseddine, Yehia I Mohamed, Sunyoung S Lee, James C Yao, Zishuo Ian Hu, Hop S Tran Cao, Lianchun Xiao, Ryan Sun, Jeffrey S Morris, Rikita I Hatia, Manal Hassan, Dan G Duda, Maria Diab, Amr Mohamed, Ahmed Nassar, Saumil Datar, Hesham M Amin, Ahmed Omar Kaseb
Circulating inflammatory cytokines play critical roles in tumor-associated inflammation and immune responses. Recent data has suggested that several interleukins (ILs) mediate carcinogenesis in hepatocellular carcinoma (HCC). However, the predictive and prognostic value of circulating ILs has yet to be validated. Our study aimed to evaluate the association of the serum ILs with overall survival (OS) and clinicopathologic features in a large cohort of HCC patients. We prospectively collected data, and serum samples from 767 HCC patients treated at The University of Texas MD Anderson Cancer Center between 2001 and 2014, with a median follow-up of 67...
July 19, 2023: Oncology
#40
REVIEW
Walaa A El-Dakroury, Heba M Midan, Ahmed I Abulsoud, Shereen Saeid Elshaer, Ahmed A El-Husseiny, Doaa Fathi, Nourhan M Abdelmaksoud, Sherif S Abdel Mageed, Mohammed S Elballal, Mohamed Bakr Zaki, Mai A Abd-Elmawla, Tohada M Al-Noshokaty, Nehal I Rizk, Mahmoud A Elrebehy, Amr H Hashem, Yasser M Moustafa, Ahmed S Doghish
Adrenocortical carcinoma (ACC) is an uncommon aggressive endocrine malignancy that is nonetheless associated with significant mortality and morbidity rates because of endocrine and oncological consequences. Recent genome-wide investigations of ACC have advanced our understanding of the disease, but substantial obstacles remain to overcome regarding diagnosis and prognosis. MicroRNAs (miRNAs, miRs) play a crucial role in the development and metastasis of a wide range of carcinomas by regulating the expression of their target genes through various mechanisms causing translational repression or messenger RNA (mRNA) degradation...
July 4, 2023: Pathology, Research and Practice
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