Shun Hay Pun, Karla M O'Neill, Kevin S Edgar, Eleanor K Gill, Arya Moez, Hojjat Naderi-Meshkin, Sudhir B Malla, Michelle B Hookham, Mohammed Alsaggaf, Vinuthna Vani Madishetti, Bianca Botezatu, William King, Coy Brunssen, Henning Morawietz, Philip D Dunne, Derek P Brazil, Reinhold J Medina, Chris J Watson, David J Grieve
Ischaemic cardiovascular disease is associated with tissue hypoxia as a significant determinant of angiogenic dysfunction and adverse remodelling. While cord blood-derived endothelial colony-forming cells (CB-ECFCs) hold clear therapeutic potential due to their enhanced angiogenic and proliferative capacity, their impaired functionality within the disease microenvironment represents a major barrier to clinical translation. The aim of this study was to define the specific contribution of NOX4 NADPH oxidase, which we previously reported as a key CB-ECFC regulator, to hypoxia-induced dysfunction and its potential as a therapeutic target...
September 6, 2023: Cells