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JOURNAL ARTICLE
Katerina Deike, Andreas Decker, Paul Scheyhing, Julia Harten, Nadine Zimmermann, Daniel Paech, Oliver Peters, Silka D Freiesleben, Luisa-Sophie Schneider, Lukas Preis, Josef Priller, Eike Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fliessbach, Okka Kimmich, Jens Wiltfang, Claudia Bartels, Niels Hansen, Frank Jessen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy, Michael Wagner, Sandra Roeske, Michael T Heneka, Frederic Brosseron, Alfredo Ramirez, Laura Dobisch, Steffen Wolfsgruber, Luca Kleineidam, Renat Yakupov, Melina Stark, Matthias C Schmid, Moritz Berger, Stefan Hetzer, Peter Dechent, Klaus Scheffler, Gabor C Petzold, Anja Schneider, Alexander Effland, Alexander Radbruch
OBJECTIVES: Impaired perivascular clearance has been suggested as a contributing factor to the pathogenesis of Alzheimer disease (AD). However, it remains unresolved when the anatomy of the perivascular space (PVS) is altered during AD progression. Therefore, this study investigates the association between PVS volume and AD progression in cognitively unimpaired (CU) individuals, both with and without subjective cognitive decline (SCD), and in those clinically diagnosed with mild cognitive impairment (MCI) or mild AD...
April 23, 2024: Investigative Radiology
#2
JOURNAL ARTICLE
Louise N Pivac, Belinda M Brown, Kelsey R Sewell, James D Doecke, Victor L Villemagne, Vincent Doré, Michael Weinborn, Hamid R Sohrabi, Samantha L Gardener, Romola S Bucks, Simon M Laws, Kevin Taddei, Paul Maruff, Colin L Masters, Christopher Rowe, Ralph N Martins, Stephanie R Rainey-Smith
INTRODUCTION: This study investigated whether self-reported sleep quality is associated with brain amyloid beta (Aβ) accumulation. METHODS: Linear mixed effect model analyses were conducted for 189 cognitively unimpaired (CU) older adults (mean ± standard deviation 74.0 ± 6.2; 53.2% female), with baseline self-reported sleep data, and positron emission tomography-determined brain Aβ measured over a minimum of three time points (range 33...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
#3
JOURNAL ARTICLE
Elizabeth Sugg, Elizabeth Gleeson, Sarah N Baker, Peng Li, Chenlu Gao, Ariel Mueller, Hao Deng, Shiqian Shen, Esteban Franco-Garcia, Richa Saxena, Erik S Musiek, Oluwaseun Akeju, Zhongcong Xie, Kun Hu, Lei Gao
INTRODUCTION: Surgical patients over 70 experience postoperative delirium (POD) complications in up to 50% of procedures. Sleep/circadian disruption has emerged as a potential risk factor for POD in epidemiological studies. This protocol presents a single-site, prospective observational study designed to examine the relationship between sleep/circadian regulation and POD and how this association could be moderated or mediated by Alzheimer's disease (AD) pathology and genetic risk for AD...
April 19, 2024: BMJ Open
#4
JOURNAL ARTICLE
Guilherme Moraes Balbim, Ryan S Falck, Nárlon Cássio Boa Sorte Silva, Arthur F Kramer, Michelle Voss, Teresa Liu-Ambrose
BACKGROUND: The relationship of cognition and the 24-hour activity cycles (24-HAC), encompassing physical activity, sedentary behaviour, and sleep, in older adults with mild cognitive impairment (MCI) remains uncertain. Distinct combinations of 24-HAC behaviours can characterize unique activity profiles and influence cognition. We aimed to characterize 24-HAC activity profiles in older adults with MCI and assess whether differences in cognition exist across profiles. METHODS: We conducted a cross-sectional analysis utilizing baseline data from three randomized controlled trials involving 253 community-dwelling older adults (55+ years) with MCI (no functional impairment, dementia diagnosis, and Montreal Cognitive Assessment score <26/30)...
April 20, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
#5
JOURNAL ARTICLE
Claire André, Marie-Ève Martineau-Dussault, Andrée-Ann Baril, Nicola Andrea Marchi, Véronique Daneault, Dominique Lorrain, Carol Hudon, Célyne H Bastien, Dominique Petit, Cynthia Thompson, Judes Poirier, Jacques Montplaisir, Nadia Gosselin, Julie Carrier
STUDY OBJECTIVES: Apolipoprotein E ɛ4 (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD). In addition, APOE4 carriers may exhibit sleep disturbances, but conflicting results have been reported, such that there is no clear consensus regarding which aspects of sleep are impacted. Our objective was to compare objective sleep architecture between APOE4 carriers and non-carriers, and to investigate the modulating impact of age, sex, cognitive status and obstructive sleep apnea...
April 18, 2024: Sleep
#6
REVIEW
Role of Serotonylation and SERT Posttranslational Modifications in Alzheimer's Disease Pathogenesis.
Arubala P Reddy, Priyanka Rawat, Nicholas Rohr, Razelle Alvir, Jasbir Bisht, Mst Anika Bushra, Jennifer Luong, Aananya P Reddy
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) is implicated mainly in Alzheimer's disease (AD) and reported to be responsible for several processes and roles in the human body, such as regulating sleep, food intake, sexual behavior, anxiety, and drug abuse. It is synthesized from the amino acid tryptophan. Serotonin also functions as a signal between neurons to mature, survive, and differentiate. It plays a crucial role in neuronal plasticity, including cell migration and cell contact formation...
April 4, 2024: Aging and Disease
#7
JOURNAL ARTICLE
Zarui A Melikyan, Claudia H Kawas, Annlia Paganini-Hill, Luohua Jiang, Syed Bukhari, Thomas J Montine, Bryce A Mander, María M Corrada
INTRODUCTION: We investigated the association between sleep duration and neuropathologic changes 19 to 40 years later in oldest-old (age 90+) participants of The 90+ Study. METHODS: Participants self-reported sleep duration and underwent neuropathologic evaluation. We categorized sleep duration as < 7, 7 to 8 = reference, > 8 hours and dichotomized neuropathologic changes as present/absent. We estimated odds ratio (OR) and 95% confidence intervals (CI) using logistic regression...
April 11, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#8
JOURNAL ARTICLE
Marijn Muurling, Casper de Boer, Chris Hinds, Alankar Atreya, Aiden Doherty, Vasilis Alepopoulos, Jelena Curcic, Anna-Katharine Brem, Pauline Conde, Sajini Kuruppu, Xavier Morató, Valentina Saletti, Samantha Galluzzi, Estefania Vilarino Luis, Sandra Cardoso, Tina Stukelj, Milica Gregorič Kramberger, Dora Roik, Ivan Koychev, Ann-Cecilie Hopøy, Emilia Schwertner, Mara Gkioka, Dag Aarsland, Pieter Jelle Visser
INTRODUCTION: Remote monitoring technologies (RMTs) can measure cognitive and functional decline objectively at-home, and offer opportunities to measure passively and continuously, possibly improving sensitivity and reducing participant burden in clinical trials. However, there is skepticism that age and cognitive or functional impairment may render participants unable or unwilling to comply with complex RMT protocols. We therefore assessed the feasibility and usability of a complex RMT protocol in all syndromic stages of Alzheimer's disease and in healthy control participants...
2024: Digital Health
#9
REVIEW
Amy Bedward, Jasmine Kaur, Sadiyah Seedat, Holly Donohue, Chia Siang Kow, Muhammad Kamran Rasheed, Amaan Javed, Syed Shahzad Hasan
INTRODUCTION: This systematic review and meta-analysis evaluates the evidence from randomized controlled trials (RCTs) involving pharmacological interventions for improving sleep in people with Alzheimer's disease (AD). METHODS: A systematic literature search in eight databases from January 2000 to July 2023 focusing on RCTs that compared a pharmacological intervention with a placebo for enhancing sleep in people with AD. The authors registered the study protocol at Prospero, followed the PRISMA guidelines, and produced the pooled estimates using random-effect or IVhet models...
April 10, 2024: Expert Review of Neurotherapeutics
#10
REVIEW
Geert Mayer, Helmut Frohnhofen, Martha Jokisch, Dirk M Hermann, Janine Gronewold
Due to worldwide demographic change, the number of older persons in the population is increasing. Aging is accompanied by changes of sleep structure, deposition of beta-amyloid (Aß) and tau proteins and vascular changes and can turn into mild cognitive impairment (MCI) as well as dementia. Sleep disorders are discussed both as a risk factor for and as a consequence of MCI/dementia. Cross-sectional and longitudinal population-based as well as case-control studies revealed sleep disorders, especially sleep-disorderded breathing (SDB) and excessive or insufficient sleep durations, as risk factors for all-cause MCI/dementia...
2024: Frontiers in Neuroscience
#11
JOURNAL ARTICLE
Nicola Luigi Bragazzi, Ayoub Boulares, Sergio Garbarino
In their article, Finch and Burstein explore the hypothesis that Alzheimer's disease and related dementias (ADRD) may predominantly be phenomena of the modern era. Through a review of classical Greek and Latin literature, they found minimal reference to conditions akin to ADRD, suggesting a historical rarity of severe cognitive decline. Instead, ancient texts focused on physical aspects of aging, with cognitive changes, when noted, not resembling modern-day dementia. Finch and Burstein further extend their analysis by drawing parallels with the Tsimane people of Bolivia, known for their low prevalence of dementia and cardiovascular diseases, attributed to lifestyle factors such as diet and physical activity...
March 30, 2024: Journal of Alzheimer's Disease: JAD
#12
Anh N Do, Muhammad Ali, Jigyasha Timsina, Lihua Wang, Daniel Western, Menghan Liu, Jessie Sanford, Matitee Rosende-Roca, Merce Boada, Raquel Puerta, Ted Wilson, Agustin Ruiz, Pau Pastor, Tony Wyss-Coray, Carlos Cruchaga, Yun Ju Sung
In Alzheimer's disease (AD), the most common cause of dementia, females have higher prevalence and faster progression, but sex-specific molecular findings in AD are limited. Here, we comprehensively examined and validated 7,006 aptamers targeting 6,162 proteins in cerebral spinal fluid (CSF) from 2,077 amyloid/tau positive cases and controls to identify sex-specific proteomic signatures of AD. In discovery (N=1,766), we identified 330 male-specific and 121 female-specific proteomic alternations in CSF (FDR <0...
March 16, 2024: medRxiv
#13
JOURNAL ARTICLE
Antoine R Trammell, Felicia C Goldstein, Monica W Parker, Ihab M Hajjar
BACKGROUND: "Super-agers" are adults aged ≥80 with cognitive performance similar to persons two to three decades younger. Characteristics such as larger hippocampal volume, APOE-ε4 allele absence, higher educational attainment, female sex, and lifelong cognitive stimulation are associated with cognitive performance compatible with super-aging. These findings are based on predominantly white research samples. Limited data are available on African-American super-agers. To fill this gap, we explored potential factors associated with super-aging in older African-American adults...
March 29, 2024: Journal of the American Geriatrics Society
#14
JOURNAL ARTICLE
Chase Irwin, Donna Tjandra, Chengcheng Hu, Vinod Aggarwal, Amanda Lienau, Bruno Giordani, Jenna Wiens, Raymond Q Migrino
INTRODUCTION: Identifying mild cognitive impairment (MCI) patients at risk for dementia could facilitate early interventions. Using electronic health records (EHRs), we developed a model to predict MCI to all-cause dementia (ACD) conversion at 5 years. METHODS: Cox proportional hazards model was used to identify predictors of ACD conversion from EHR data in veterans with MCI. Model performance (area under the receiver operating characteristic curve [AUC] and Brier score) was evaluated on a held-out data subset...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
#15
REVIEW
Vladimir Nikolaevich Nikolenko, Irina Dmitriyevna Borminskaya, Arina Timofeevna Nikitina, Maria Sergeevna Golyshkina, Negoriya Aliagayevna Rizaeva, Marine Valikovna Oganesyan
Locus coeruleus is a small bilateral nucleus in the brainstem. It is the main source of norepinephrine (noradrenaline) throughout the central nervous system (about 70% of all norepinephrine in the central nervous system), and, as shown in numerous studies, it is involved in regulating a significant number of functions. The detailed study of the functions of the Locus Coeruleus (LC) and its significance in human life became possible only after the development of histofluorescence methods for monoamines in the 1960s...
March 20, 2024: Frontiers in Bioscience (Landmark Edition)
#16
JOURNAL ARTICLE
Lisa Bransby, Nawaf Yassi, Emily Rosenich, Rachel Buckley, Qiao-Xin Li, Paul Maruff, Matthew Pase, Yen Ying Lim
This study aimed to determine associations between modifiable dementia risk factors (MDRF), across domains mood symptomatology, lifestyle behaviors, cardiovascular conditions, cognitive/social engagement, sleep disorders/symptomatology, with cognition, beta-amyloid (Aβ) and tau, and brain volume. Middle-aged/older adults (n=82) enrolled in a sub-study of the Healthy Brain Project completed self-report questionnaires and a neuropsychological battery. Cerebrospinal fluid levels of Aβ 1-42, total tau (t-tau), and phosphorylated tau (p-tau181 ) (Roche Elecsys), and MRI markers of hippocampal volume and total brain volume were obtained...
March 2, 2024: Neurobiology of Aging
#17
JOURNAL ARTICLE
Andrée-Ann Baril, Cynthia Picard, Anne Labonté, Erlan Sanchez, Catherine Duclos, Béry Mohammediyan, John C S Breitner, Sylvia Villeneuve, Judes Poirier
STUDY OBJECTIVES: While short sleep could promote neurodegeneration, long sleep may be a marker of ongoing neurodegeneration, potentially as a result of neuroinflammation. The objective was to evaluate sleep patterns with age of expected Alzheimer's disease (AD) onset and neuroinflammation. METHODS: We tested 203 dementia-free participants (68.5±5.4y/o, 78M). The PREVENT-AD cohort includes older persons with a parental history of AD whose age was nearing their expected AD onset...
March 25, 2024: Sleep
#18
JOURNAL ARTICLE
Jinmyoung Cho, Laura P Sands, Alan B Stevens, Heather G Allore, Molly J Horstman
BACKGROUND AND OBJECTIVES: This study aims to identify patterns of caregiving intensity and assess associations between caregiving intensity and multidimensional physical health indicators and health behaviors among spousal caregivers of persons with Alzheimer's disease and related dementia. RESEARCH DESIGN AND METHODS: Using data from 152 spousal caregivers aged 65 and older, the intensity of their caregiving experience was measured as the number and frequency of health- and medical-related helping activities for their care recipient...
2024: Innovation in Aging
#19
JOURNAL ARTICLE
Victoria Grace Gabb, Jonathan Blackman, Hamish Duncan Morrison, Bijetri Biswas, Haoxuan Li, Nicholas Turner, Georgina M Russell, Rosemary Greenwood, Amy Jolly, William Trender, Adam Hampshire, Alan Whone, Elizabeth Coulthard
BACKGROUND: Sleep disturbances are a potentially modifiable risk factor for neurodegenerative dementia secondary to Alzheimer disease (AD) and Lewy body disease (LBD). Therefore, we need to identify the best methods to study sleep in this population. OBJECTIVE: This study will assess the feasibility and acceptability of various wearable devices, smart devices, and remote study tasks in sleep and cognition research for people with AD and LBD. METHODS: We will deliver a feasibility and acceptability study alongside a prospective observational cohort study assessing sleep and cognition longitudinally in the home environment...
March 22, 2024: JMIR Research Protocols
#20
JOURNAL ARTICLE
Ada Wai Tung Fung, Allen Ting Chun Lee, Suk Ling Ma, Linda Chiu Wa Lam
BACKGROUND: Early cognitive deficits commonly seen in older people have not been well defined and managed in primary care. The objectives are (1) to develop and validate a new risk score to estimate the risk of dementia in Chinese older population; and (2) to evaluate the use of risk score in conjunction with cognitive screening in detecting early cognitive deficits in community older people. METHODS: A development cohort of 306 cognitive healthy older adults aged 60 or above were followed for 6 years...
March 21, 2024: BMC Geriatrics
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