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Fikri Selcuk Simsek, Saadet Akarsu, Yavuz Narin
One of the most important benign tumors in neurofibromatosis type 1 (NF1) is plexiform neurofibroma, and there is a risk of developing malignant peripheral nerve sheath tumor (MPNST) throughout life approximately 10%. However lesion characterization by anatomical imaging methods are not possible. Because of that most of cases goes to biopsy. Using of fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) for lesion characterization can be helpful in NF1 patients. We aimed to present an example of the efficacy of FDG-PET/CT in distinguishing benign neurofibroma from MPNST...
January 2019: World Journal of Nuclear Medicine
X H Yi, H C Lai, J Z Liu, S C Lin, C Li, X Q Chen, D S Wang
Objective: To compare the performances of VCA-IgA, EA-IgA and Rta-IgG in the diagnosis of nasopharyngeal carcinoma, and find the most appropriate combined interpretation scheme. Method: The current study included a total of 346 subjects. Ninety-six subjects were nasopharyngeal carcinoma cases which were pathologically verified by the biopsy under electronic laryngoscope. The remaining 250 subjects, who received EBV tests at the same period, were normal healthy individuals without nasopharyngeal carcinoma. VCA-IgA, EA-IgA and Rta-IgG were detected in all cases...
November 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Kathleen M Mazor, Ann M King, Ruth B Hoppe, Annie O Kochersberger, Jie Yan, Jesse D Reim
BACKGROUND: Good clinician-patient communication is essential to provide quality health care and key to patient-centered care. However, individuals and organizations seeking to improve in this area face significant challenges. A major barrier is the absence of an efficient system for assessing clinicians' communication skills and providing meaningful, individual-level feedback. OBJECTIVE: The purpose of this paper is to describe the design and creation of the Video-Based Communication Assessment (VCA), an innovative, flexible system for assessing and ultimately enhancing clinicians' communication skills...
October 14, 2018: JMIR Medical Education
C Anton Fries, Shari D Lawson, Lin C Wang, Kai V Slaughter, Praveen K Vemula, Ashish Dhayani, Nitin Joshi, Jeffrey M Karp, Rory F Rickard, Vijay S Gorantla, Michael R Davis
BACKGROUND: Currently, patients receiving vascularized composite allotransplantation (VCA) grafts must take long-term systemic immunosuppressive therapy to prevent immunologic rejection. The morbidity and mortality associated with these medications is the single greatest barrier to more patients being able to receive these life-enhancing transplants. In contrast to solid organs, VCA, exemplified by hand or face transplants, allow visual diagnosis of clinical acute rejection (AR), directed biopsy and targeted graft therapies...
2019: PloS One
Nicholas L Robbins, Matthew J Wordsworth, Bijaya K Parida, Bruce Kaplan, Vijay S Gorantla, Col Erik K Weitzel, Warren C Breidenbach
BACKGROUND: From 1996 to 2000 Diefenbeck et al. carried out 6 knee vascularized composite allotransplants(VCA). The VCAs were composed of bone, soft tissue, and the femoral vascular pedicle (25-40 cm total length). All rejected between 14 to 56 months. The failures were attributed to chronic rejection (CR). In 2008 the Louisville team lost their fourth patient's hand transplant at 8 months. During the rejection workup the senior surgeon's intra-operative findings noted a thickened arterial pedicle attributed to intimal hyperplasia (IH) with significant fibrotic perivascular tissue and a near 'no flow phenomenon'...
December 28, 2018: Plastic and Reconstructive Surgery
Lu Zhang, Xiaoning Luo, Xiaokai Mo, Wenhui Huang, Changhong Liang, Shuixing Zhang
OBJECTIVE: To develop a model based on the clinical variables for evaluating the risk of distant metastasis in patients with advanced nasopharyngeal carcinoma (NPC). METHODS: From September,2007 to June,2015,a total of 238 consecutive patients with biopsy-proven NPC in stage Ⅲ-Ⅳ(M0) based on the AJCC TNM staging manual were enrolled in this study,including 106 male and 34 female patients with a median age of 45 years (range 18-68 years).In this cohort,126 patients received concurrent chemoradiotherapy,and 24 received chemotherapy and radiotherapy,and 40 had induction chemotherapy...
December 30, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Rikesh A Gandhi, Patrick J Hesketh, Evan R Bannister, Ronnie Sebro, Samir Mehta
BACKGROUND: The ideal volar locking plate for the treatment of distal radius fracture should anatomically fit the volar surface of the distal radius. The purpose of this study was to measure the volar cortical angle (VCA) of uninjured adult distal radii to determine how well the VCA matches that of modern volar locking plates and whether variations in the VCA are related to demographic factors. METHODS: A retrospective radiographic analysis of 273 uninjured adult distal radii was performed...
December 31, 2018: Hand: Official Journal of the American Association for Hand Surgery
Abdelaal Alsayed Alkhouly, Ali Mohammad Al-Amin, Moustafa Ibraheem Mukarrab
BACKGROUND: Percutaneous balloon mitral valvuloplasty (PBMV) can be complicated with significant mitral regurgitation (MR). We performed a pilot, prospective study to evaluate the role of three dimensional transesophageal echocardiography (3D-TEE) in the prediction of MR after PBMV through mitral valve quantification (MVQ). METHODS: Between October 2014 and October 2016, 37 patients with rheumatic, moderate-to-severe mitral stenosis, referred to the Cath lab of Bab Alshearia University hospitals for PBMV, were divided into two age and sex matched groups...
November 2018: Indian Heart Journal
Elie Deeba, Dana Koptides, Efthychia Gaglia, Astero Constantinou, Anastasia Lambrianides, Marios Pantzaris, Georges Krashias, Christina Christodoulou
Multiple Sclerosis (MS) is a chronic, demyelinating, inflammatory disease of the central nervous system (CNS) with a strong autoimmune component. Several genetic and environmental factors have been suggested to contribute in MS. The Epstein-Barr virus (EBV) is one pathogenic candidate proposed to be involved in the onset of MS and/or induction of subsequent exacerbations. The possible involvement of EBV in MS is highlighted by a number of national epidemiological studies showing a higher percentage of EBV seropositivity...
December 15, 2018: Molecular Immunology
Gülay Gök, Tufan Çınar, Nurten Sayar
INTRODUCTION: Rheumatic mitral stenosis (MS) is an important health issue in developing countries. Assessment of the correct mitral valve area (MVA) is essential for the timing of intervention. Most of the parameters for the assessment of rheumatic MS are derived from Two-dimensional (2D) echocardiography. Three-dimensional (3D) echocardiography is commonly used in our daily practice at the present time. The aim of this study was to assess the value of 3D echocardiography mitral valve vena contracta area (VCA) in predicting the severity of Rheumatic MS by comparing 3D planimetry...
December 11, 2018: Echocardiography
Branislav Kollar, Bohdan Pomahac, Leonardo V Riella
PURPOSE OF REVIEW: Vascularized composite allotransplantation (VCA) is a promising approach to restore the quality of life of carefully selected patients that suffered extensive injury. Although acute rejection occurs very frequently, still little is known about the specific characteristics of the VCA immune response. This review aims to highlight the current development in the field of VCA concerning the immunobiology and management of upper extremity and face transplant recipients. RECENT FINDINGS: T-cell mediated rejection is the predominant mechanism of allograft injury in VCA...
December 6, 2018: Current Opinion in Organ Transplantation
Gordana Halec, Tim Waterboer, Nicole Brenner, Julia Butt, David W Hardy, Gypsyamber D'Souza, Steven Wolinsky, Bernard J Macatangay, Michael Pawlita, Roger Detels, Otoniel Martínez-Maza, Shehnaz K Hussain
BACKGROUND: HIV infection is associated with increased susceptibility to common pathogens which may trigger chronic antigenic stimulation and hyperactivation of B-cells, events known to precede the development of AIDS-associated non-Hodgkin lymphoma (AIDS-NHL). METHODS: To explore whether cumulative exposure to infectious agents contributes to AIDS-NHL risk, we tested sera from 199 AIDS-NHL patients (pre-NHL, average lead-time 3.9 years) and 199 matched HIV-infected controls from the Multicenter AIDS Cohort Study (MACS), for anti-IgG responses to 18 pathogens using multiplex serology...
November 20, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Marialuigia Spinelli, Lavinia Di Meglio, Beatrice Mosimann, Edoardo Di Naro, Daniel Surbek, Luigi Raio
BACKGROUND: Normal morphometry of the vermis and its relation to the posterior fossa (PF) rule out most major anomalies of the cerebellum. However, accurate categorization of the position and size of the fetal vermis remains a challenge. OBJECTIVE: Our aim was to test a new method to assess the position and size of fetal vermis on 3-dimensional ultrasound (3D-US). METHODS: We measured the vermian-crest angle (VCA) in normal fetuses using multiplanar 3D-US...
December 5, 2018: Fetal Diagnosis and Therapy
Faith Dickerson, Lorraine Jones-Brando, Glen Ford, Giulio Genovese, Cassie Stallings, Andrea Origoni, Colm O'Dushlaine, Emily Katsafanas, Kevin Sweeney, Sunil Khushalani, Robert Yolken
Background: Epstein-Barr virus (EBV) is a highly prevalent human herpesvirus capable of infecting the central nervous system and establishing persistent infection. Methods: We employed solid phase immunoassay techniques to measure immunoglobulin G (IgG) class antibodies to EBV virions and defined proteins in 432 individuals with schizophrenia and 311 individuals without a history of a psychiatric disorder. Western blot testing was performed to document reactivity to specific EBV proteins...
November 20, 2018: Schizophrenia Bulletin
Jingchen Tian, Shusen Sun, Zhigang Zhao, Xingang Li
1. This study aimed to evaluate the pharmacokinetic interaction of shuanghuanglian (SHL) and azithromycin in rats, and to provide experimental support for rational drug use in clinics. 2. HPLC-UV and HPLC-MS/MS approaches were respectively developed to detect the forsythiaside (active component of SHL) and azithromycin concentrations. Both non-compartmental and compartmental analyses were employed to calculate pharmacokinetic parameters. A nonlinear mixed-effects modelling method was applied to fit the drug concentration-time data...
November 20, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Sohei Yamamoto, Yu Sakai
Herein, we describe an extremely rare case of gastritis due to concurrent infection with Epstein-Barr virus (EBV) and cytomegalovirus (CMV) occurring in an immunocompetent adult. The patient was a 35-year-old man who presented with slight fever, nausea, anorexia, weight loss for 3 weeks, mild transaminitis, and leukocytosis with atypical lymphocytes in peripheral blood. The clinical presentation and elevated IgM titers to both EBV-VCA and CMV strongly suggested infectious mononucleosis syndrome caused by co-infection with EBV and CMV...
November 16, 2018: Clinical Journal of Gastroenterology
Emilia Sforza, David Hupin, Frédéric Roche
Idiopathic hypersomnia (IH) is a rare central hypersomnia of unknown physiopathology. In this study, we determine if the presence of infectious mononucleosis evaluated by serological markers of Epstein Barr virus infection plays a role in this hypersomnia. Ten patients with a suspicion of IH underwent to clinical assessment, 24 h polysomnography, and serologic testing for mononucleosis including Viral Capside Antigen (VCA) IgG, the VCA IgM, and the EBV nuclear antigen (EBNA). None of the patients reported neurological inflammatory disease and viral infection prior the onset of the disease...
2018: Frontiers in Neurology
Anamaria Balić, Lucija Bartolić, Ivana Ilić, Jaka Radoš
Dear Editor,We present the case of a 40-year old male patient with lymphomatoid papulosis of a waxing and waning course on whom three biopsies were performed during a 14-year period with no change in histopathological or immunophenotypical characteristics. Lymphomatoid papulosis (LP) is a chronic, recurrent, self-healing papulonodular skin eruption with the histopathologic features of a cutaneous T-cell lymphoma but an often benign and indolent clinical course (1). It is designated as a primary, cutaneous, CD30+ lymphoproliferative disorder...
October 2018: Acta Dermatovenerologica Croatica: ADC
Yinmin Wang, Xiuxia Wang, Xianyu Zhou, Zhu Zhu, Jun Yang, Fei Liu
Adipose‑derived stem cells (ADSCs) have an immunomodulatory role in vascularized composite tissue allo‑transplantation (VCA). However, the specific effects of ADSCs on lymphocytes remain to be fully elucidated. The present study examined the changes in T cells co‑cultured with ADSCs in terms of the proliferation by Cell Counting Kit‑8 assay, cell cycle profile and apoptosis by flow cytometry, inflammatory cytokine production by polymerase chain reaction and ELISA, in addition to the expression of survival proteins by western blotting...
October 24, 2018: International Journal of Molecular Medicine
Zhao-Xia Li, Shan Zeng, Hui-Xia Wu, Yi Zhou
Previous systematic reviews have found a higher sero-prevalence of EBV antibodies in SLE patients compared with controls. Because many studies have been published, there is a need to apply more precise systematic review methods. We examined the association between EBV and SLE patients by conducting a systematic review and meta-analysis of case-control studies that examined the prevalence of EBV antibodies and the DNA-positive rate. We searched the MEDLINE and EMBASE databases from 1966 to 2018 with no language restrictions...
October 25, 2018: Clinical and Experimental Medicine
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