Hua Diao, Wen-Qiong Xue, Tong-Min Wang, Da-Wei Yang, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Yan-Xia Wu, Xue-Yin Chen, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Su-Mei Cao, Qing Liu, Wei-Min Ye, Yong-Qiao He, Wei-Hua Jia
Previous studies have demonstrated strong associations between host genetic factors and Epstein-Barr virus (EBV) VCA-IgA with the risk of nasopharyngeal carcinoma (NPC). However, the specific interplay between host genetics and EBV VCA-IgA on NPC risk is not well understood. In this two-stage case-control study (N = 4804), we utilized interaction and mediation analysis to investigate the interplay between host genetics (genome-wide association study-derived polygenic risk score [PRS]) and EBV VCA-IgA antibody level in the NPC risk...
November 2023: Journal of Medical Virology