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Weidong Wu, Lin Huang, Bing Ye, Bin Zheng, Chun Chen, Jingyu Chen
Abnormalities in pulmonary vasculature or technical issues during lung procurement can lead to an insufficient left atrial (LA) cuff in donors. However, surgeons frequently need to reconfigure these less-than-ideal lungs for transplantation. This case report introduces a novel technique for such reconstruction. The patient was a 35-year-old male diagnosed with pneumoconiosis for over a year. Due to progressive worsening dyspnoea leading to respiratory failure on multiple occasions, he was deemed a candidate for lung transplantation...
May 15, 2024: Heliyon
#2
JOURNAL ARTICLE
(no author information available yet)
The methacholine challenge test (MCT) is a standard evaluation method of assessing airway hyperresponsiveness (AHR) and its severity, and has significant clinical value in the diagnosis and treatment of bronchial asthma. A consensus working group consisting of experts from the Pulmonary Function and Clinical Respiratory Physiology Committee of the Chinese Association of Chest Physicians, the Task Force for Pulmonary Function of the Chinese Thoracic Society, and the Pulmonary Function Group of Respiratory Branch of the Chinese Geriatric Society jointly developed this consensus...
February 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
#3
JOURNAL ARTICLE
Jiaoyu Ai, Wanlin Zhang, Wensheng Deng, Likun Yan, Lidong Zhang, Zongjing Huang, Ziyi Wu, Junhua Ai, Hai Jiang
BACKGROUND: CircRNAs participate in the development of hepatocellular carcinoma (HCC). This work aims to explore the key tumor promoting circRNA as a gene therapy target. METHODS: The differentially expressed gene circRNAs in HCC tumor tissues was identified by mining GSE121714 dataset. EdU staining, wound healing, transwell invasion assay, TUNEL staining and western blotting examined proliferation, migration, invasion, apoptosis and epithelial mesenchymal transition (EMT)...
January 2, 2024: BMC Cancer
#4
JOURNAL ARTICLE
Yu Zhang, Yanhong Wang, Mei Liu
BACKGROUND: Lung cancer is a major threat to human health. The molecular mechanisms related to the occurrence and development of lung cancer are complex and poorly known. Exploring molecular markers related to the development of lung cancer is helpful to improve the effect of early diagnosis and treatment. Long non-coding RNA (lncRNA) THAP7-AS1 is known to be highly expressed in gastric cancer, but has been less studied in other cancers. The aim of the study is to explore the role and mechanism of methyltransferase-like 3 (METTL3) mediated up-regulation of N6-methyladenosine (m6A) modified lncRNA THAP7-AS1 expression in promoting the development of lung cancer...
January 2, 2024: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
#5
JOURNAL ARTICLE
Arpit Tiwari, Sayali Mukherjee
BACKGROUND: Solid organ transplantation is a life-saving medical operation that has progressed greatly because of developments in diagnostic tools and histocompatibility tests. Crossmatching for complement-dependent cytotoxicity (CDC) and human leukocyte antigen (HLA) typing are two important methods for checking graft compatibility and reducing the risk of graft rejection. HLA typing and CDC crossmatching are critical in kidney, heart, lung, liver, pancreas, intestine, and multi-organ transplantation...
December 28, 2023: Reviews on Recent Clinical Trials
#6
JOURNAL ARTICLE
Michelle N Bremer, Garrick J Gama, Sarah Golts, Christine M Lin, Aarya Kafi, Gordon Yung, Eugene Golts, Kamyar Afshar
Limited data is available for American Indians /Alaska Natives (AI/AN) undergoing lung transplant. The goal of our study was to assess outcomes for AI/AN lung transplant recipients (LTR). A retrospective review of data from the Organ Procurement and Transplant Network was performed comparing AI/AN (n=88) and Caucasian (n=22,767) LTRs between May 4, 2005 and October 31, 2019. AI/AN LTRs had worse functional parameters prior to transplantation but had similar post-transplant outcomes compared to Caucasians LTRs...
November 14, 2023: Journal of Heart and Lung Transplantation
#7
JOURNAL ARTICLE
Zhaojia Wang, Min Liu, Ying Ai, Shaoqin Zheng, Yingyi Chen, Hujun Du, Shijia Yuan, Xueying Guo, Yueming Yuan, Guoming Li, Jianping Song, Changsheng Deng
Pulmonary fibrosis (PF) is a lethal disease characterized by a progressive decline in lung function. Currently, lung transplantation remains the only available treatment for PF. However, both artemisinin (ART) and hydroxychloroquine (HCQ) possess potential antifibrotic properties. This study aimed to investigate the effects and mechanisms of a compound known as Artemisinin-Hydroxychloroquine (AH) in treating PF, specifically by targeting the TGF-β1/Smad2/3 pathway. To do this, we utilized an animal model of PF induced by a single tracheal drip of bleomycin (BLM) in Sprague-Dawley (SD) rats...
November 13, 2023: Pulmonary Pharmacology & Therapeutics
#8
Besart Cuko, Massimo Baudo, Antoine Beurton, Olivier Busuttil, Mathieu Pernot
In the current era of improved survival after orthotopic heart transplantation, post-transplant valve dysfunction is not an uncommon occurrence. The first treatment is medical management, but when it fails, surgery, possibly as retransplantation, may be needed. However, due to the scarcity of donor hearts, efforts are being made on the preservation of the cardiac allograft function by conventional operations in lieu of retransplantation. In this case report, we present a patient developing severe aortic valve insufficiency and moderate-to-severe functional tricuspid valve insufficiency five years after cardiac transplant, leading to progressive clinical deterioration and heart failure symptoms...
September 2023: Curēus
#9
JOURNAL ARTICLE
Zheng Liu, Jixin Zhang, Ningyu Wang, Yun'ai Feng, Fei Tang, Tingyu Li, Liping Lv, Haichao Li, Wei Wang, Yaoping Liu
Liquid biopsy of cancers, detecting tumor-related information from liquid samples, has attracted wide attentions as an emerging technology. Our previously reported large-area PERFECT ( P recise- E fficient- R obust- F lexible- E asy- C ontrollable- T hin) filter has demonstrated competitive sensitivity in recovering rare tumor cells from clinical samples. However, it is time-consuming and easily biased to manually inspect rare target cells among numerous background cells distributed in a large area ( Φ ≥ 13 mm)...
2023: Microsystems & Nanoengineering
#10
JOURNAL ARTICLE
Wang Rui, Shang Yuhang, Li Yang, Yang Yue, Tang Ze, Zhao Yujie, Ma Xiaochao, Qin Da, Cui Youbin, Lu Tianyu
Objective: This study aims to explore the clinical application of an AI-3D reconstruction system in measuring lung volume and analyze its practical value in donor-recipient size matching in lung transplantation. Methods: The study retrospectively collected data from 75 subjects who underwent a plethysmography examination and lung CT at the First Hospital of Jilin University. General data and information related to lung function, and imaging results were collected. The correlation between actual total lung volume (aTLV), predicted total lung volume (pTLV), and artificial intelligence three-dimensional reconstruction CT lung volume (AI-3DCTVol) was analyzed for the overall, male, and female groups...
2023: Frontiers in Physiology
#11
REVIEW
Md Arafatur Rahman, Ibrahim Yilmaz, Sam T Albadri, Fadi E Salem, Bryan J Dangott, C Burcin Taner, Aziza Nassar, Zeynettin Akkus
Transplant pathology plays a critical role in ensuring that transplanted organs function properly and the immune systems of the recipients do not reject them. To improve outcomes for transplant recipients, accurate diagnosis and timely treatment are essential. Recent advances in artificial intelligence (AI)-empowered digital pathology could help monitor allograft rejection and weaning of immunosuppressive drugs. To explore the role of AI in transplant pathology, we conducted a systematic search of electronic databases from January 2010 to April 2023...
September 4, 2023: Bioengineering
#12
JOURNAL ARTICLE
Matthew R Carey, Dylan Marshall, Kevin Clerkin, Ronald Laracuente, Joseph Sanchez, Sneha S Jain, Jayant K Raikhelkar, Jay S Leb, Yuji Kaku, Melana Yuzefpolskaya, Yoshifumi Naka, Paolo C Colombo, Gabriel T Sayer, Koji Takeda, Nir Uriel, Veli K Topkara, Justin A Fried
BACKGROUND: Aortic root thrombosis(ART) is a complication of continuous-flow left ventricular assist device therapy. However, the incidence and related complications of ART in HeartMate 3 (HM3) patients remain unknown. METHODS: Patients who underwent HM3 implantation from November 2014 to August 2020 at a quaternary academic medical center were included. Demographics and outcomes were abstracted from the medical record. Echocardiograms and contrast-enhanced computed tomography studies were reviewed to identify patients who developed ART and/or moderate or greater aortic insufficiency (AI) on HM3 support...
September 20, 2023: Journal of Heart and Lung Transplantation
#13
RANDOMIZED CONTROLLED TRIAL
So Yoon Ahn, Yun Sil Chang, Myung Hee Lee, Sein Sung, Ai-Rhan Kim, Won Soon Park
BACKGROUND: We previously performed a phase II randomised double-blind clinical trial of mesenchymal stromal cell (MSCs) transplantation to prevent bronchopulmonary dysplasia in extremely premature infants. Subsequently, we followed the infants enrolled in this clinical trial to determine the safety and effectiveness of MSCs against bronchopulmonary dysplasia at 5-year follow-up. METHODS: We evaluated infants at 5 years of age receiving placebo or MSCs in a prospective follow-up study...
November 2023: Thorax
#14
JOURNAL ARTICLE
Marine Fidelle, Conrad Rauber, Carolina Alves Costa Silva, Ai-Ling Tian, Imran Lahmar, Anne-Laure Mallard de La Varende, Liwei Zhao, Cassandra Thelemaque, Isabelle Lebhar, Meriem Messaoudene, Eugenie Pizzato, Roxanne Birebent, Maxime Descartes Mbogning Fonkou, Silvia Zoppi, Anna Reni, Cécile Dalban, Marion Leduc, Gladys Ferrere, Sylvère Durand, Pierre Ly, Aymeric Silvin, Kevin Mulder, Charles-Antoine Dutertre, Florent Ginhoux, Satoru Yonekura, Maria Paula Roberti, Maryam Tidjani-Alou, Safae Terrisse, Jianzhou Chen, Oliver Kepp, Angela Schippers, Norbert Wagner, Javier Suárez-Gosálvez, Sebastian Kobold, Jean-Eudes Fahrner, Corentin Richard, Jacques Bosq, Leonardo Lordello, Giacomo Vitali, Nathalie Galleron, Benoît Quinquis, Emmanuelle Le Chatelier, Lucas Blanchard, Jean-Philippe Girard, Anne Jarry, Nadine Gervois, Emmanuelle Godefroy, Nathalie Labarrière, Ronald Koschny, Romain Daillère, Benjamin Besse, Caroline Truntzer, François Ghiringhelli, Nicolas Coatnoan, Vanessa Mhanna, David Klatzmann, Damien Drubay, Laurence Albiges, Andrew Maltez Thomas, Nicola Segata, François-Xavier Danlos, Aurélien Marabelle, Bertrand Routy, Lisa Derosa, Guido Kroemer, Laurence Zitvogel
Antibiotics (ABX) compromise the efficacy of programmed cell death protein 1 (PD-1) blockade in cancer patients, but the mechanisms underlying their immunosuppressive effects remain unknown. By inducing the down-regulation of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) in the ileum, post-ABX gut recolonization by Enterocloster species drove the emigration of enterotropic α4β7+ CD4+ regulatory T 17 cells into the tumor. These deleterious ABX effects were mimicked by oral gavage of Enterocloster species, by genetic deficiency, or by antibody-mediated neutralization of MAdCAM-1 and its receptor, α4β7 integrin...
June 9, 2023: Science
#15
JOURNAL ARTICLE
Melissa Pitton, Luca G Valente, Simone Oberhaensli, Carlo Casanova, Parham Sendi, Bruno Schnegg, Stephan M Jakob, David R Cameron, Yok-Ai Que, Monika Fürholz
BACKGROUND: Driveline infections (DLIs) at the exit site are frequent in patients with left ventricular assist devices (LVADs). The dynamics from colonization to infection are yet to be investigated. We combined systematic swabbing at the driveline exit site and genomic analyses to study the dynamics of bacterial pathogens and get insights into DLIs pathogenesis. METHODS: A prospective, observational, single-centre cohort study at the University Hospital of Bern, Switzerland was performed...
May 26, 2023: Journal of Heart and Lung Transplantation
#16
JOURNAL ARTICLE
Demilade Adedinsewo, Heather D Hardway, Andrea Carolina Morales-Lara, Mikolaj A Wieczorek, Patrick W Johnson, Erika J Douglass, Bryan J Dangott, Raouf E Nakhleh, Tathagat Narula, Parag C Patel, Rohan M Goswami, Melissa A Lyle, Alexander J Heckman, Juan C Leoni-Moreno, D Eric Steidley, Reza Arsanjani, Brian Hardaway, Mohsin Abbas, Atta Behfar, Zachi I Attia, Francisco Lopez-Jimenez, Peter A Noseworthy, Paul Friedman, Rickey E Carter, Mohamad Yamani
AIMS: Current non-invasive screening methods for cardiac allograft rejection have shown limited discrimination and are yet to be broadly integrated into heart transplant care. Given electrocardiogram (ECG) changes have been reported with severe cardiac allograft rejection, this study aimed to develop a deep-learning model, a form of artificial intelligence, to detect allograft rejection using the 12-lead ECG (AI-ECG). METHODS AND RESULTS: Heart transplant recipients were identified across three Mayo Clinic sites between 1998 and 2021...
March 2023: European heart journal. Digital health
#17
JOURNAL ARTICLE
Serge Kobsa, Koichi Akiyama, Samantha K Nemeth, Paul A Kurlansky, Yoshifumi Naka, Koji Takeda, Keiichi Itatani, Emily G Werth, Lewis M Brown, Giovanni Ferrari, Hiroo Takayama
BACKGROUND: Continuous-flow left ventricular assist devices commonly lead to aortic regurgitation, which results in decreased pump efficiency and worsening heart failure. We hypothesized that non-physiological wall shear stress and oscillatory shear index alter the abundance of structural proteins in aortic valves of left ventricular assist device (LVAD) patients. METHODS: Doppler images of aortic valves of patients undergoing heart transplants were obtained. Eight patients had been supported with LVADs, whereas 10 were not...
October 1, 2022: Journal of Heart and Lung Transplantation
#18
JOURNAL ARTICLE
Chenlong Li, Hongshan Zheng, Jinsheng Xiong, Yuxin Huang, Haoyang Li, Hua Jin, Siqi Ai, Yingjie Wang, Tianqi Su, Guiyin Sun, Xu Xiao, Tianjiao Fu, Yujie Wang, Xin Gao, Peng Liang
Brain metastasis (BM) frequently occurs in advanced non-small cell lung cancer (NSCLC) and is associated with poor clinical prognosis. Due to the location of metastatic lesions, the surgical resection is limited and the chemotherapy is ineffective because of the existence of the blood brain barrier (BBB). Therefore, it is essential to enhance our understanding about the underlying mechanisms associated with brain metastasis in NSCLC. In the present study, we explored the RNA-Seq data of brain metastasis cells from the GEO database, and extracted RNA collected from primary NSCLC tumors as well as paired brain metastatic lesions followed by microRNA PCR array...
August 12, 2022: Cell Death & Disease
#19
JOURNAL ARTICLE
Xiang Qian, Hong-Yan Zhang, Qing-Lin Li, Guan-Jun Ma, Zhuo Chen, Xu-Ming Ji, Chang-Yu Li, Ai-Qin Zhang
BACKGROUND: Accumulation of evidence suggests that the gut microbiome, its specific metabolites, and differentially expressed proteins (DEPs) are related to non-small cell lung cancer (NSCLC) pathogenesis. We now report the influences of the gut microbiota, metabolites, and DEPs on the mediation of NSCLC's chronic inflammation and immune dysregulation. METHODS: We conducted 16S ribosomal RNA sequencing for the gut microbiome in healthy volunteers and NSCLC patients...
June 2022: Clinical and Translational Medicine
#20
JOURNAL ARTICLE
Quanyu Du, Xuanyu Wu, Liping An, Rui Zhou, Xiang Xiao, Cheng Wu, Fei Wang, Han Yang
Pulmonary fibrosis is a serious disease for which effective drugs are unavailable. Here, we treated rat models of bleomycin (BLM)-induced pulmonary fibrosis with Astragali Radix extract injection (AI) combined with or without bone marrow mesenchymal stem cells (BMSCs). We injected rats intratracheally with BLM and transplanted BMSCs via tail vein injection 15 days later. We also intraperitoneally injected AI daily from days 15 to 28. Changes in lung pathology and function, as well as the levels of matrix metalloproteinases, collagen, C-X-C motif chemokine ligand 12 (CXCL12), and cluster of differentiation 90 (CD90) were assessed...
2022: Evidence-based Complementary and Alternative Medicine: ECAM
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