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Kailin Zhang, Yan Tang, Li Meng, Liping Zhu, Xiaoting Zhou, Yuwen Zhao, Xinxiang Yan, Beisha Tang, Jifeng Guo
The pathogenesis of Parkinson's disease (PD) is not well established. The rs894278 polymorphism of SNCA has been associated with PD. We performed this study to investigate the relationship between rs894278 and PD status on resting-state brain activity, by analyzing the amplitude of low-frequency fluctuation (ALFF). A total of 81 PD patients and 64 healthy controls were recruited. Disease severity and PD stage were evaluated in PD patients using the unified Parkinson's disease rating scale (UPDRS) and the Hoehn and Yahr (HY) scale, while the cognitive function of all participants was assessed using the mini-mental state examination (MMSE)...
2019: Frontiers in Neuroscience
Maria Seidel, Viola Borchardt, Daniel Geisler, Joseph A King, Ilka Boehm, Sophie Pauligk, Fabio Bernardoni, Ronald Biemann, Veit Roessner, Martin Walter, Stefan Ehrlich
OBJECTIVE: Functional MRI studies have repeatedly shown alterations in patients with anorexia nervosa (AN). These alterations might be driven by baseline signal characteristics such as the (fractional) amplitude of low frequency fluctuations (fALFF/ALFF), as well as regional signal consistency [ie. regional homogeneity (ReHo)] within circumscribed brain regions. Previous studies have also demonstrated grey matter (pseudo-) atrophy in underweight AN. Here we study fALFF/ALFF and ReHo in predominantly adolescent patients with AN, while taking grey matter changes into consideration...
February 15, 2019: Journal of the American Academy of Child and Adolescent Psychiatry
Aamir Iqbal Waidha, Hongbin Zhang, Maren Lepple, Supratik Dasgupta, Lambert Alff, Peter Slater, A D Fortes, Oliver Clemens
A new highly oxygen deficient metastable modification of perovskite-related BaCoO2+δ (δ ∼ 0.01-0.02) has been prepared using high temperature reactions with short heating times. This defect rich compound has at least partially square planar coordination of the Co2+ ions, a highly unusual coordination environment for Co. Low temperature neutron powder diffraction showed a G-type antiferromagnetic ordering, confirmed by SQUID magnetic measurements, which indicate a high Néel temperature of 220 K. This work shows how novel defective phases can be synthesized by exploiting short reaction times in solid state synthesis, thus offering an alternative route for new materials synthesis...
February 14, 2019: Chemical Communications: Chem Comm
Hadeer Emam, David C Steffens, Godfrey Pearlson, Lihong Wang
OBJECTIVE: Previous studies of imaging predictors on acute treatment response in late life depression (LLD) demonstrated that poor response to selective serotonin reuptake inhibitors (SSRI) is associated with pre-treatment low functional connectivity (FC) within executive control network and high FC within default-mode network including the ventromedial prefrontal cortex (vmPFC). However, there is less research in regional resting-state functional activity that explains FC changes related to SSRI response...
February 13, 2019: International Journal of Geriatric Psychiatry
Long-Biao Cui, Min Cai, Xing-Rui Wang, Yuan-Qiang Zhu, Liu-Xian Wang, Yi-Bin Xi, Hua-Ning Wang, Xia Zhu, Hong Yin
INTRODUCTION: Treatment response at an early stage of schizophrenia is of considerable value with regard to future management of the disorder; however, there are currently no biomarkers that can inform physicians about the likelihood of response. OBJECTS: We aim to develop and validate regional brain activity derived from functional magnetic resonance imaging (fMRI) as a potential signature to predict early treatment response in schizophrenia. METHODS: Amplitude of low-frequency fluctuation (ALFF) was measured at the start of the first/single episode resulting in hospitalization...
January 30, 2019: Brain and Behavior
Yinghui Liang, Rongrong Shao, Zhiying Zhang, Xinmin Li, Longhao Zhou, Suqin Guo
Introduction: Childhood-onset schizophrenia with obsessive-compulsive symptoms (COSO) and without obsessive-compulsive symptoms (COS) share considerable overlap in clinical features and genetic risk factors. However, the extent of brain functional abnormalities in COSO and COS is poorly understood. Material and methods: A total of 51 first-episode childhood schizophrenic patients and 30 healthy age- and sex-matched controls were recruited. We used the Yale-Brown Obsessive Compulsive Scale to divide patients into COSO ( n = 21) and COS ( n = 30) groups...
January 2019: Archives of Medical Science: AMS
Jun Yang, Bin Li, Qiu-Yue Yu, Lei Ye, Pei-Wen Zhu, Wen-Qing Shi, Qing Yuan, You-Lan Min, Yu-Lin He, Yi Shao
Background: The results of previous studies have indicated that pain-associated diseases can result in marked functional and anatomical alterations in the brain. However, differences in spontaneous brain activity occurring in toothache (TA) patients remain unclear. Objective: This study investigated intrinsic brain activity changes in TA subjects using the amplitude of low-frequency fluctuation (ALFF) technique. Methods: A total of 18 patients with TA (eight males, and 10 females) and 18 healthy controls (HCs) who were matched for gender, age, and educational status were enrolled...
2019: Neuropsychiatric Disease and Treatment
Fei Jiang, Chen Yu, Min-Jing Zuo, Chun Zhang, Ying Wang, Fu-Qing Zhou, Xian-Jun Zeng
Objective: In this study, we aimed to investigate the frequency-dependent spontaneous neural activity in primary angle-closure glaucoma (PACG) using the amplitude of low-frequency fluctuations (ALFF) method. Patients and methods: In total, 52 PACG individuals (24 males and 28 females) and 52 normal-sighted controls (NS; 24 males and 28 females) who were closely matched in age, sex, and education underwent resting-state magnetic resonance imaging scans. A repeated-measures ANOVA and post hoc two-sample t -tests were conducted to analyze the different ALFF values in two different frequency bands (slow-4, 0...
2019: Neuropsychiatric Disease and Treatment
Delin Sun, Rachel D Phillips, Hannah L Mulready, Stephen T Zablonski, Jessica A Turner, Matthew D Turner, Kathryn McClymond, Jason A Nieuwsma, Rajendra A Morey
Moral injury is closely associated with posttraumatic stress disorder (PTSD) and characterized by disturbances in social and moral cognition. Little is known about the neural underpinnings of moral injury, and whether the neural correlates are different between moral injury and PTSD. A sample of 26 U.S. military veterans (two females: 28-55 years old) were investigated to determine how subjective appraisals of morally injurious events measured by Moral Injury Event Scale (MIES) and PTSD symptoms are differentially related to spontaneous fluctuations indexed by amplitude of low frequency fluctuation (ALFF) as well as functional connectivity during resting-state functional magnetic resonance imaging scanning...
January 28, 2019: Depression and Anxiety
Yanqing Tang, Qian Zhou, Miao Chang, Adam Chekroud, Ralitza Gueorguieva, Xiaowei Jiang, Yifang Zhou, George He, Margaret Rowland, Dahai Wang, Shinan Fu, Zhiyang Yin, Haixia Leng, Shengnan Wei, Ke Xu, Fei Wang, John H Krystal, Naomi R Driesen
Studying individuals at increased genetic risk for schizophrenia may generate important theories regarding the emergence of the illness. In this investigation, genetic high-risk individuals (GHR, n = 37) were assessed with functional magnetic resonance imaging and compared to individuals in the first episode of schizophrenia (FESZ, n = 42) and healthy comparison subjects (HCS, n = 59). Measures of functional connectivity and the amplitude of low-frequency fluctuation (ALFF) were obtained in a global, data-driven analysis...
January 23, 2019: Schizophrenia Research
Yu-Ting Shen, Jian-Wei Wang, Min Wang, Yan Zhi, Jun-Yi Li, Yong-Sheng Yuan, Xi-Xi Wang, Hui Zhang, Ke-Zhong Zhang
AIMS: We aimed to explore effects of bone marrow stromal cell antigen-1 (BST1) rs4698412 allelic variant on brain activation and associative clinical symptoms in Parkinson's disease (PD). METHODS: A total of 49 PD patients and 47 healthy control (HC) subjects were recruited for clinical evaluations, blood samples collection for genotypes, and resting-state functional MRI (rs-fMRI) scans. Based on BST1 rs4698412 allelic variant (G → A), participants were further divided into 18 PD-GG, 31 PD-GA/AA, 20 HC-GG, and 27 HC-GA/AA carriers, which respectively indicated subjects carrying ancestral or risk allele in that locus in PD or HC...
January 24, 2019: CNS Neuroscience & Therapeutics
Shuming Zhong, Guanmao Chen, Lianping Zhao, Yanbin Jia, Feng Chen, Zhangzhang Qi, Li Huang, Ying Wang
<br>Background/aims: Although abnormalities of amplitude of low-frequency fluctuations (ALFF) and hormone levels of hypothalamus-pituitary-thyroid (HPT) axis have been reported in patients with bipolar disorder (BD). However, the associations between abnormal ALFF and serum thyroid hormone levels remain unknown. METHOD: Ninety patients with unmedicated BD II depression and 100 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rs-fMRI), and then routine band (0...
January 23, 2019: Neuroendocrinology
Huiqing Hu, Jingwu Chen, Huiyuan Huang, Caihong Zhou, Shufei Zhang, Xian Liu, Lijuan Wang, Ping Chen, Kun Nie, Lixiang Chen, Shuai Wang, Biao Huang, Ruiwang Huang
Freezing of gait (FOG), a disabling symptom of Parkinson's disease (PD), severely affects PD patients' life quality. Previous studies found neuropathologies in functional connectivity related to FOG, but few studies detected abnormal regional activities related to FOG in PD patients. In the present study, we analyzed the amplitude of low-frequency fluctuations (ALFF) to detect brain regions showing abnormal activity in PD patients with FOG (PD-with-FOG) and without FOG (PD-without-FOG). As different frequencies of neural oscillations in brain may reflect distinct brain functional and physiological properties, we conducted this study in three frequency bands, slow-5 (0...
January 21, 2019: Brain Imaging and Behavior
Xuan Bu, Xinyu Hu, Lianqing Zhang, Bin Li, Ming Zhou, Lu Lu, Xiaoxiao Hu, Hailong Li, Yanchun Yang, Wanjie Tang, Qiyong Gong, Xiaoqi Huang
Previous resting-state functional magnetic resonance imaging (rs-fMRI) studies of obsessive-compulsive disorder (OCD) have facilitated our understanding of OCD pathophysiology based on its intrinsic activity. However, whether the group difference derived from univariate analysis could be useful for informing the diagnosis of individual OCD patients remains unclear. We aimed to apply multivariate pattern analysis of different rs-fMRI parameters to distinguish drug-naive patients with OCD from healthy control subjects (HCS)...
January 17, 2019: Translational Psychiatry
Pengshuo Wang, Jian Yang, Zhiyang Yin, Jia Duan, Ran Zhang, Jiaze Sun, Yixiao Xu, Luyu Liu, Xuemei Chen, Huizi Li, Jiahui Kang, Yue Zhu, Xin Deng, Miao Chang, Shengnan Wei, Yifang Zhou, Xiaowei Jiang, Fei Wang, Yanqing Tang
BACKGROUND: Cognitive impairments are prominent in schizophrenia (SZ). Imaging studies have demonstrated that functional changes of several areas of the brain exist in SZ patients. The relationships between these two indexes are largely unexplored in SZ. The MATRICS Consensus Cognitive Battery (MCCB) was used to measure cognitive impairment in multi-dimensional cognitive fields of SZ patients. This study was conducted to explore the relationship between cognitive functional impairment and the amplitude of low-frequency fluctuation (ALFF) in SZ patients...
January 17, 2019: BMC Psychiatry
Ming Qi, Yi Zhu, Ling Zhang, Ting Wu, Jie Wang
The current study aimed to evaluate the effect of a specially designed moderate-intensity aerobic dance (SDMIAD) on brain spontaneous activity in older adults with mild cognitive impairment (MCI) using resting-state functional magnetic resonance imaging (RS-fMRI). A total of 38 subjects with MCI were recruited to the current study and were randomized into two groups: Exercise (EG, n=19) and control (CG, n=19). The EG was treated with a SDMIAD and usual care for 3 months. The CG only received usual care. None of the patients were administered medicine that affected cognition during the intervention...
January 2019: Experimental and Therapeutic Medicine
Hong Yu, Xiang Qiu, Yu-Qing Zhang, Yan Deng, Mao-Yuan He, Yu-Ting Zhao, Zhao-Hua Zhai
PURPOSE: To explore the amplitude of low frequency fluctuation (ALFF) and functional connectivity (FC) disorders in non-neuropsychiatric systemic lupus erythematosus (non-NPSLE) patients by resting-state functional magnetic resonance imaging (rs-fMRI) and to study whether there are some clinical biomarkers that can be used to monitor the brain dysfunction. METHODS: Based on the rs-fMRI data of 36 non-NPSLE patients and 30 normal controls, we first obtained the regions with abnormal ALFF signals in non-NPSLE patients...
January 12, 2019: Neuroradiology
Limei Song, Qinmu Peng, Shuwei Liu, Jiaojian Wang
The hubs of the brain network play a key role in integrating and transferring information between different functional modules. However, the effects of long-term practice on functional network hubs in chess experts are largely undefined. Here, we investigated whether alterations of hubs can be detected in chess experts using resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory methods. We first mapped the whole-brain voxel-wise functional connectivity and calculated the functional connectivity strength (FCS) map in each of the 28 chess players and 27 gender- and age-matched healthy novice players...
January 5, 2019: Brain Imaging and Behavior
Lili Gu, Shunda Hong, Jian Jiang, Jiaqi Liu, Xintian Cao, Qing Huang, Xianjun Zeng, Fuqing Zhou, Daying Zhang
Purpose: Postherpetic neuralgia (PHN) detrimentally affects brain function. Recent studies have suggested that frequency-dependent changes in electroencephalography in chronic pain patients and blood oxygenation level dependent (BOLD) fluctuations can reflect neuronal activity in different frequencies. The current study aimed to investigate PHN-related brain oscillatory activity in a specific frequency band by using the amplitude of low-frequency fluctuation (ALFF) method. Materials and methods: ALFF changes were analyzed across different frequencies (slow-4 band: 0...
2019: Journal of Pain Research
Ilona Karpiel, Uwe Klose, Zofia Drzazga
There are a number of various methods of resting-state functional magnetic resonance imaging (rs-fMRI) analysis such as independent component analysis, multivariate autoregressive models, or seed correlation analysis however their results depend on arbitrary choice of parameters. Therefore, the aim of this work was to optimize the parameters in the seed correlation analysis using the Data Processing Assistant for Resting-State fMRI (DPARSF) toolbox for rs-fMRI data received from a Siemens Magnetom Skyra 3-Tesla scanner using a whole-brain, gradient-echo echo planar sequence with a 32-channel head coil...
December 21, 2018: Journal of Neuroscience Research
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