Mengmeng Sun, Liling Wang, Yong Zhuo, Shengyu Xu, Hehe Liu, Xuemei Jiang, Zhiwei Lu, Xianxiang Wang, Yanying Wang, Guizhou Yue, Bin Feng, Hanbing Rao, De Wu
The clinical application of oncology therapy is hampered by high glutathione concentrations, hypoxia, and inefficient activation of cell death mechanisms in cancer cells. In this study, Fe and Mo bimetallic sulfide nanomaterial (FeS2 @MoS2 ) based on metal-organic framework structure is rationally prepared with peroxidase (POD)-, catalase (CAT)-, superoxide dismutase (SOD)-like activities and glutathione depletion ability, which can confer versatility for treating tumors and mending wounds. In the lesion area, FeS2 @MoS2 with SOD-like activity can facilitate the transformation of superoxide anions (O2 - ) to hydrogen peroxide (H2 O2 ), and then the resulting H2 O2 serves as a substrate for the Fenton reaction with FMS to produce highly toxic hydroxyl radicals (∙OH)...
December 21, 2023: Small