keyword
https://read.qxmd.com/read/38521069/nanodrug-bacteria-conjugates-mediated-oncogenic-collagen-depletion-enhances-immune-checkpoint-blockade-therapy-against-pancreatic-cancer
#1
JOURNAL ARTICLE
Zhaoting Li, Fanyi Mo, Kai Guo, Shuai Ren, Yixin Wang, Yu Chen, Patrick B Schwartz, Nathaniel Richmond, Fengyuan Liu, Sean M Ronnekleiv-Kelly, Quanyin Hu
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) cancer cells specifically produce abnormal oncogenic collagen to bind with integrin α3β1 receptor and activate the downstream focal adhesion kinase (FAK), protein kinase B (AKT), and mitogen-activated protein kinase (MAPK) signaling pathway. Collectively, this promotes immunosuppression and tumor proliferation and restricts the response rate of clinical cancer immunotherapies. METHODS: Here, by leveraging the hypoxia tropism and excellent motility of the probiotic Escherichia coli strain Nissle 1917 (ECN), we developed nanodrug-bacteria conjugates to penetrate the extracellular matrix (ECM) and shuttle the surface-conjugated protein cages composed of collagenases and anti-programmed death-ligand 1 (PD-L1) antibodies to PDAC tumor parenchyma...
March 21, 2024: Med
https://read.qxmd.com/read/38507590/breaking-physical-barrier-of-fibrotic-breast-cancer-for-photodynamic-immunotherapy-by-remodeling-tumor-extracellular-matrix-and-reprogramming-cancer-associated-fibroblasts
#2
JOURNAL ARTICLE
Zi-Wen Qiu, Ying-Tao Zhong, Zhen-Ming Lu, Ni Yan, Ren-Jiang Kong, Jia-Qi Huang, Zhuo-Feng Li, Jun-Mei Nie, Runqing Li, Hong Cheng
Cancer-associated fibroblasts (CAFs) assist in breast cancer (BRCA) invasion and immune resistance by overproduction of extracellular matrix (ECM). Herein, we develop FPC@S, a photodynamic immunomodulator that targets the ECM, to improve the photodynamic immunotherapy for fibrotic BRCA. FPC@S combines a tumor ECM-targeting peptide, a photosensitizer (protoporphyrin IX) and an antifibrotic drug (SIS3). After anchoring to the ECM, FPC@S causes ECM remodeling and BRCA cell death by generating reactive oxygen species (ROS) in situ ...
March 20, 2024: ACS Nano
https://read.qxmd.com/read/38478356/lactate-in-breast-cancer-cells-is-associated-with-evasion-of-hypoxia-induced-cell-cycle-arrest-and-adverse-patient-outcome
#3
JOURNAL ARTICLE
Yamin Liu, Yasir Suhail, Ashkan Novin, Junaid Afzal, Aditya Pant, Kshitiz
Tumor hypoxia is a common microenvironmental factor in breast cancers, resulting in stabilization of Hypoxia-Inducible Factor 1 (HIF-1), the master regulator of hypoxic response in cells. Metabolic adaptation by HIF-1 results in inhibition of citric acid cycle, causing accumulation of lactate in large concentrations in hypoxic cancers. Lactate can therefore serve as a secondary microenvironmental factor influencing cellular response to hypoxia. Presence of lactate can alter the hypoxic response of breast cancers in many ways, sometimes in opposite manners...
March 13, 2024: Human Cell
https://read.qxmd.com/read/38477714/-in-situ-formed-microalgae-integrated-living-hydrogel-for-enhanced-tumor-starvation-therapy-and-immunotherapy-through-photosynthetic-oxygenation
#4
JOURNAL ARTICLE
Cheng Zhang, Zi-Yi Han, Ke-Wei Chen, Yu-Zhang Wang, Peng Bao, Ping Ji, Xiao Yan, Zhi-Yong Rao, Xuan Zeng, Xian-Zheng Zhang
The effectiveness of various cancer therapies for solid tumors is substantially limited by the highly hypoxic tumor microenvironment (TME). Here, a microalgae-integrated living hydrogel (ACG gel) is developed to concurrently enhance hypoxia-constrained tumor starvation therapy and immunotherapy. The ACG gel is formed in situ following intratumoral injection of a biohybrid fluid composed of alginate, Chlorella sorokiniana , and glucose oxidase, facilitated by the crossing-linking between divalent ions within tumors and alginate...
March 13, 2024: Nano Letters
https://read.qxmd.com/read/38456744/bimetallic-ptpd-atomic-clusters-as-apoptosis-ferroptosis-inducers-for-antineoplastic-therapy-through-heterogeneous-catalytic-processes
#5
JOURNAL ARTICLE
Xiaoqin Wang, Mengting He, Yinmin Zhao, Jie He, Jiansen Huang, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue
Active polymetallic atomic clusters can initiate heterogeneous catalytic reactions in the tumor microenvironment, and the products tend to cause manifold damage to cell metabolic functions. Herein, bimetallic PtPd atomic clusters (BAC) are constructed by the stripping of Pt and Pd nanoparticles on nitrogen-doped carbon and follow-up surface PEGylation, aiming at efficacious antineoplastic therapy through heterogeneous catalytic processes. After endocytosed by tumor cells, BAC with catalase-mimic activity can facilitate the decomposition of endogenous H2 O2 into O2 ...
March 8, 2024: ACS Nano
https://read.qxmd.com/read/38429826/promoting-collateral-formation-in-type-2-diabetes-mellitus-using-ultra-small-nanodots-with-autophagy-activation-and-ros-scavenging
#6
JOURNAL ARTICLE
Yixuan Wang, Feifei Li, Linshuang Mao, Yu Liu, Shuai Chen, Jingmeng Liu, Ke Huang, Qiujing Chen, Jianrong Wu, Lin Lu, Yuanyi Zheng, Weifeng Shen, Tao Ying, Yang Dai, Ying Shen
BACKGROUND: Impaired collateral formation is a major factor contributing to poor prognosis in type 2 diabetes mellitus (T2DM) patients with atherosclerotic cardiovascular disease. However, the current pharmacological treatments for improving collateral formation remain unsatisfactory. The induction of endothelial autophagy and the elimination of reactive oxygen species (ROS) represent potential therapeutic targets for enhancing endothelial angiogenesis and facilitating collateral formation...
March 1, 2024: Journal of Nanobiotechnology
https://read.qxmd.com/read/38412500/active-anchoring-stimuli-responsive-nano-craft-to-relieve-pulmonary-vasoconstriction-by-targeting-smooth-muscle-cell-for-hypoxic-pulmonary-hypertension-treatment
#7
JOURNAL ARTICLE
Mingxing Li, Xuwei Shang, Haiya Lou, Zixu Wang, Shanshan Xiang, Yihe Qiu, Fuqiang Hu, Fangying Yu, Hong Yuan
Recently, nanotechnology-based drug delivery platforms in treating pulmonary arterial hypertension (PAH) have gradually emerged. However, large mechanical stress and shear stress in blood vessels greatly affect the retention of nanopreparative materials at lesion sites, severely limiting nanotechnology-based drug delivery. Herein, a stimuli-responsive nanocraft was rationally designed by actively anchoring E-selectin overexpressed on pulmonary arterial endothelial cells (PAECs), under hypoxic conditions, allowing effective accumulation and retention of the drug at the lesion site...
February 27, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38312517/nano-oxygen-chamber-by-cascade-reaction-for-hypoxia-mitigation-and-reactive-oxygen-species-scavenging-in-wound-healing
#8
JOURNAL ARTICLE
Xiaoxue Han, Leah Ju, Chai Saengow, Wen Ren, Randy Ewoldt, Timothy Fan, Joseph Irudayaraj
Hypoxia, excessive reactive oxygen species (ROS), and impaired angiogenesis are prominent obstacles to wound healing following trauma and surgical procedures, often leading to the development of keloids and hypertrophic scars. To address these challenges, a novel approach has been proposed, involving the development of a cascade enzymatic reaction-based nanocarriers-laden wound dressing. This advanced technology incorporates superoxide dismutase modified oxygen nanobubbles and catalase modified oxygen nanobubbles within an alginate hydrogel matrix...
May 2024: Bioactive Materials
https://read.qxmd.com/read/38307478/dumbbell-shaped-bimetallic-aupd-nanoenzymes-for-nir-ii-cascade-catalysis-photothermal-synergistic-therapy
#9
JOURNAL ARTICLE
Zhe Tang, Yike Hou, Shuqi Huang, Narayan S Hosmane, Mingyue Cui, Xianan Li, Muhammad Suhail, Han Zhang, Jian Ge, M Zubair Iqbal, Xiangdong Kong
The noble metal NPs that are currently applied to photothermal therapy (PTT) have their photoexcitation location mainly in the NIR-I range, and the low tissue penetration limits their therapeutic effect. The complexity of the tumor microenvironment (TME) makes it difficult to inhibit tumor growth completely with a single therapy. Although TME has a high level of H2 O2 , the intratumor H2 O2 content is still insufficient to catalyze the generation of sufficient hydroxide radicals (‧OH) to achieve satisfactory therapeutic effects...
January 31, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38301048/whole-body-and-whole-organ-3d-imaging-of-hypoxia-using-an-activatable-covalent-fluorescent-probe-compatible-with-tissue-clearing
#10
JOURNAL ARTICLE
Daichi M Sakamoto, Iori Tamura, Bo Yi, Sho Hasegawa, Yutaro Saito, Naoki Yamada, Yoichi Takakusagi, Shimpei I Kubota, Minoru Kobayashi, Hiroshi Harada, Kenjiro Hanaoka, Masayasu Taki, Masaomi Nangaku, Kazuki Tainaka, Shinsuke Sando
Elucidation of biological phenomena requires imaging of microenvironments in vivo . Although the seamless visualization of in vivo hypoxia from the level of whole-body to single-cell has great potential to discover unknown phenomena in biological and medical fields, no methodology for achieving it has been established thus far. Here, we report the whole-body and whole-organ imaging of hypoxia, an important microenvironment, at single-cell resolution using activatable covalent fluorescent probes compatible with tissue clearing...
February 1, 2024: ACS Nano
https://read.qxmd.com/read/38298935/fe-doped-nanodiamond-based-photo-fenton-catalyst-for-dual-modal-fluorescence-imaging-and-improved-chemotherapeutic-efficacy-against-tumor-hypoxia
#11
JOURNAL ARTICLE
Rajakar Selvam, Wrenit Gem Pearl, Elena Perevedentseva, Artashes Karmenyan, Chia-Liang Cheng
The deficiency of oxygen in most solid tumors plays a profound role in their proliferation, metastasis, and invasion and contributes to their resistance to treatments such as radiation, chemotherapy, and photodynamic therapy (PDT). A therapeutic approach based on the Fenton reaction has received considerable interest as a means of treating cancer with ROS-based nano catalytic medicine, referred to as chemodynamic therapy (CDT). A range of modified treatment strategies are being explored to enhance both CDT and conventional methods of therapy...
January 23, 2024: RSC Advances
https://read.qxmd.com/read/38293152/a-cytological-f1-rnai-screen-for-defects-in-drosophila-melanogaster-female-meiosis
#12
William D Gilliland, Dennis P May, Amelia O Bowen, Kelly O Conger, Doreen Elrad, Marcin Marciniak, Sarah A Mashburn, Gabrielle Presbitero, Lucas F Welk
Genetic screens for recessive alleles induce mutations, make the mutated chromosomes homozygous, and then assay those homozygotes for the phenotype of interest. When screening for genes required for female meiosis, the phenotype of interest has typically been nondisjunction from chromosome segregation errors. As this requires that mutant females be viable and fertile, any mutants that are lethal or sterile when homozygous cannot be recovered by this approach. To overcome these limitations, our lab has screened the VALIUM22 collection produced by the Harvard TRiP Project, which contains RNAi constructs targeting genes known to be expressed in the germline in a vector optimized for germline expression...
January 15, 2024: bioRxiv
https://read.qxmd.com/read/38286966/fabrication-of-a-novel%C3%A2-tantalum-boride-vanadium-carbide%C3%A2-modified-screen-printed-carbon-electrode-for-voltammetric-determination-of-pimonidazole-in-bio-fluids
#13
JOURNAL ARTICLE
Umamaheswari Rajaji, S Saisree, K Y Sandhya, Razan A Alshgari, Ruey-Shin Juang, Ting-Yu Liu
For the first time, a tumour hypoxia marker detection has been developed using two-dimensional layered composite modified electrodes in biological and environmental samples. The concept of TaB2 and V4 C3 -based MXene composite materials is not reported hitherto using ball-milling and thermal methods and it remains the potentiality of the present work. The successful formation is confirmed through various characterisation techniques like X-ray crystallography, scanning electron microscopy photoelectron, and impedance spectroscopy...
January 29, 2024: Mikrochimica Acta
https://read.qxmd.com/read/38277483/biomimetic-nanomedicine-targeting-orchestrated-metabolism-coupled-with-regulatory-factors-to-disrupt-the-metabolic-plasticity-of-breast-cancer
#14
JOURNAL ARTICLE
Lingtong Meng, Jingpeng Yang, Yang Gao, Qinyan Cao, Shunjie Jiang, Yuyang Xiao, Haoran Wang, Wenzheng Liu, Ahu Yuan, Yanan Li, He Huang
Targeting nutrient metabolism has been proposed as an effective therapeutic strategy to combat breast cancer because of its high nutrient requirements. However, metabolic plasticity enables breast cancer cells to survive under unfavorable starvation conditions. The key mammalian target regulators rapamycin (mTOR) and hypoxia-inducible-factor-1 (HIF-1) tightly link the dynamic metabolism of glutamine and glucose to maintain nutrient flux. Blocking nutrient flow also induces autophagy to recycle nutrients in the autophagosome, which exacerbates metastasis and tumor progression...
January 26, 2024: ACS Nano
https://read.qxmd.com/read/38259153/red-cell-membrane-coating-prussian-blue-for-combined-photothermal-and-no-gas-therapy-for-nasopharyngeal-carcinoma
#15
JOURNAL ARTICLE
Wenbo Wang, Zhaoyi Cheng, Hui Xing, Shihao Zhou, Qiaozhang Ye, Gaofei Xiong, Guanhai Wang, Dong Ma
Nitric oxide (NO) gas molecules have demonstrated remarkable anti-tumor effects and minimal susceptibility to drug resistance, establishing as a promising modality for effective tumor treatment. However, how to realize its stable and efficient delivery in vivo is still a challenge. In this study, we have developed a heat-responsive biomimetic nano erythrocyte (M/B@R) by loading a NO donor (BNN6) onto mesoporous Prussian blue (M-PB) and subsequently enveloping them with red blood cell membranes. The preserved integrity of the red blood cell membrane (RBCm) structure could ensure its excellent biosafety, prolong its circulation time within the bloodstream and then enhance the accumulation of BNN6 at tumor sites...
January 23, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38258800/activatable-probes-for-ratiometric-imaging-of-endogenous-biomarkers-in-vivo
#16
REVIEW
Qinrui Fu, Xiao Yang, Mengzhen Wang, Kang Zhu, Yin Wang, Jibin Song
Dynamic variations in the concentration and abnormal distribution of endogenous biomarkers are strongly associated with multiple physiological and pathological states. Therefore, it is crucial to design imaging systems capable of real-time detection of dynamic changes in biomarkers for the accurate diagnosis and effective treatment of diseases. Recently, ratiometric imaging has emerged as a widely used technique for sensing and imaging of biomarkers due to its advantage of circumventing the limitations inherent to conventional intensity-dependent signal readout methods while also providing built-in self-calibration for signal correction...
January 23, 2024: ACS Nano
https://read.qxmd.com/read/38251656/nano-medicine-therapy-reprogramming-metabolic-network-of-tumor-microenvironment-new-opportunity-for-cancer-therapies
#17
REVIEW
Xiaojie Zhang, Min An, Juntao Zhang, Yumeng Zhao, Yanhua Liu
Metabolic heterogeneity is one of the characteristics of tumor cells. In order to adapt to the tumor microenvironment of hypoxia, acidity and nutritional deficiency, tumor cells have undergone extensive metabolic reprogramming. Metabolites involved in tumor cell metabolism are also very different from normal cells, such as a large number of lactate and adenosine. Metabolites play an important role in regulating the whole tumor microenvironment. Taking metabolites as the target, it aims to change the metabolic pattern of tumor cells again, destroy the energy balance it maintains, activate the immune system, and finally kill tumor cells...
January 22, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38235677/quantum-sensing-of-free-radical-generation-in-mitochondria-of-single-heart-muscle-cells-during-hypoxia-and-reoxygenation
#18
JOURNAL ARTICLE
Siyu Fan, Han Gao, Yue Zhang, Linyan Nie, Raquel Bártolo, Reinier Bron, Hélder A Santos, Romana Schirhagl
Cells are damaged during hypoxia (blood supply deprivation) and reoxygenation (oxygen return). This damage occurs in conditions such as cardiovascular diseases, cancer, and organ transplantation, potentially harming the tissue and organs. The role of free radicals in cellular metabolic reprogramming under hypoxia is under debate, but their measurement is challenging due to their short lifespan and limited diffusion range. In this study, we employed a quantum sensing technique to measure the real-time production of free radicals at the subcellular level...
January 18, 2024: ACS Nano
https://read.qxmd.com/read/38229704/hypoxia-and-singlet-oxygen-dual-responsive-micelles-for-photodynamic-and-chemotherapy-therapy-featured-with-enhanced-cellular-uptake-and-triggered-cargo-delivery
#19
JOURNAL ARTICLE
Xuliang Guo, Lefei Han, Wenyu Chen, Huixin He, Weijin Zhang, Chaoqi Huang, Xiu Wang
INTRODUCTION: Combination therapy provides better outcomes than a single therapy and becomes an efficient strategy for cancer treatment. In this study, we designed a hypoxia- and singlet oxygen-responsive polymeric micelles which contain azo and nitroimidazole groups for enhanced cellular uptake, repaid cargo release, and codelivery of photosensitizer Ce6 and hypoxia-activated prodrug tirapazamine TPZ (DHM-Ce6@TPZ), which could be used for combining Ce6-mediated photodynamic therapy (PDT) and PDT-activated chemotherapy to enhance the therapy effect of cancer...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38227812/mitochondrial-disruption-nanosystem-simultaneously-depressed-programmed-death-ligand-1-and-transforming-growth-factor-%C3%AE-to-overcome-photodynamic-immunotherapy-resistance
#20
JOURNAL ARTICLE
Xin Jiang, Lei Yi, Cheng Li, Haoxiang Wang, Wei Xiong, Yuan Li, Zaigang Zhou, Jianliang Shen
Currently, limited photosensitizers possess the capacity to reverse tumor hypoxia and reduce programmed death ligand-1 (PD-L1) and transforming growth factor-β (TGF-β) expression simultaneously, hindering the perfect photodynamic therapy (PDT) effect due to acquired immune resistance and the tumor hypoxic microenvironment. To tackle these challenges, in this research, we demonstrated that mitochondrial energy metabolism depression can be utilized as an innovative and efficient approach for reducing the expression of PD-L1 and TGF-β simultaneously, which may offer a design strategy for a more ideal PDT nanosystem...
January 16, 2024: ACS Nano
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