Sajid Ali, Muhammad Umair Amin, Muhammad Yasir Ali, Imran Tariq, Shashank Reddy Pinnapireddy, Lili Duse, Nathalie Goergen, Christian Wölk, Gerd Hause, Jarmila Jedelská, Jens Schäfer, Udo Bakowsky
5,10,15,20-Tetrakis(3-hydroxyphenyl)chlorin (mTHPC; temoporfin) is one of the most potent second-generation photosensitizers available today for the treatment of a variety of clinical disorders and has a unique capability of being activated at different wavelengths. However, due to its highly lipophilic nature, poor solubility in the aqueous media and poor bioavailability limits its application in anticancer therapies. To overcome these potential issues, we developed three different liposomal formulations with mTHPC encapsulated in hydrophobic milieu thus increasing the bioavailability of the drug...
March 6, 2020: European Journal of Pharmaceutics and Biopharmaceutics