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Repeat decreased fetal movement

T Schmitz
OBJECTIVE: To evaluate short- and long-term benefits and risks associated with antenatal administration of a single course of corticosteroids and the related strategies: multiple and rescue courses. METHODS: The PubMed database, the Cochrane Library and the recommendations from the French and foreign obstetrical societies or colleges have been consulted. RESULTS: Antenatal administration of a single course of corticosteroids before 34 weeks of gestation is associated in the neonatal period with a significant reduction of respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC) and death (LE1), and in possibly childhood with a reduction of cerebral palsy and increased psychomotor development index and intact survival (LE3)...
December 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
J H Zhang, D X Zhang, L P Zhao, T T Yan, Q Zhang, J Z Jia, Y S Huang
OBJECTIVE: To explore the effects of rapamycin on the migration of human epidermal cell line HaCaT, and to analyze its molecular mechanism. METHODS: HaCaT cells were conventionally cultured with RPMI 1640 culture medium containing 10% fetal calf serum (hereinafter referred to as culture medium). (1) According to the random number table, HaCaT cells in logarithmic phase were divided into control group and 1, 5, 50, 100, 200 nmol/L rapamycin groups, with 6 wells in each group...
January 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Shamsi Abbasalizadeh, Zahra Neghadan Pharabar, Fatmeh Abbasalizadeh, Morteza Ghojazadeh, Mohamad Goldust
The term ofpreterm birth is used to define the premature neonates considering pregnancy age. In less than 34 week pregnancies, corticosteroids are prescribed to promote embryos' lung maturity. The presents study aimed at evaluating effects of betamethasone injection on feeling embryo motion by mother and index and biophysical profile in preterm pregnancies. In a descriptive-analytical study, 40 pregnant women with the pregnancy age of 30-34 weeks were evaluated. Embryo motion and index and biophysical profile of the amniotic fluid were checked before prescription of double dosage of muscular betamethasone (12 mg) at a 24 h time interval...
November 15, 2013: Pakistan Journal of Biological Sciences: PJBS
M Ząbek, W Mazurowski, J Dymecki, J Stelmachów, E Zawada
In three parkinsonian patients ages 48, 53, and 50, human fetal dopaminergic cells taken from the ventral part of mesencephalon of 11-12-week-old fetuses were implanted into the head of caudate nucleus. The operation was carried out with a specially designed device to enable safe and precise graft implantation. All patients had been suffering from severe Parkinson's disease for about 10-15 years (stage 4/5 according to Hoehn and Yahr scale) with bradykinesia, rigidity and tremor as the main symptoms. Long-lasting L-dopa therapy resulted in side effects with ON/OFF syndrome and dyskinesias...
January 1, 1994: Restorative Neurology and Neuroscience
Blair J Wylie, Mary E D'Alton
Fetomaternal hemorrhage refers to the entry of fetal blood into the maternal circulation before or during delivery. Antenatal fetomaternal hemorrhage is a pathological condition with a wide spectrum of clinical variation. Secondary to the resultant anemia, fetomaternal hemorrhage may have devastating consequences for the fetus such as neurologic injury, stillbirth, or neonatal death. Presentation is frequently without an evident precipitating factor. Recognition may become apparent only after injury has occurred, if at all...
May 2010: Obstetrics and Gynecology
S Cohen, E J H Mulder, H A van Oord, F H Jonker, N Parvizi, G C van der Weijden, M A M Taverne
Repeated ultrasonographic observation of fetal movements was used to distinguish movement patterns and to investigate the rate of occurrence and temporal organisation of these patterns (rest-activity cycles) during the last three weeks of gestation in the pig. By means of transabdominal ultrasonography with a 3.5MHz linear array transducer, motility in ten different fetuses (one per sow) was studied. Six (median; range 4-6) 1h recordings were made per fetus at 3-5 day intervals. Fifty-five 1h recordings were available for analysis...
July 1, 2010: Theriogenology
Julie Victoria Holm Tveit, Eli Saastad, Babill Stray-Pedersen, Per E Børdahl, J Frederik Frøen
OBJECTIVE: 'Normal' fetal activity is recognized as a sign of fetal well-being and concerns for decreased fetal movements is a frequent cause of non-scheduled antenatal visits. The aim of this study was to identify maternal characteristics in women presenting decreased fetal movements in a total population, to identify the risk of adverse outcomes and assess the management provided. DESIGN: Prospective population-based cohort. SETTING: Fourteen delivery units in Norway...
2009: Acta Obstetricia et Gynecologica Scandinavica
Mark Baguma-Nibasheka, Boris Kablar
Previous microarray analysis revealed beta-transducin repeat containing (Btrc) down-regulation in the retina of mouse embryos specifically lacking cholinergic amacrine cells (CACs) as a result of the absence of skeletal musculature and fetal ocular movements. To investigate the role of Btrc in the determination of retinal cell fate, the present study examined retinal morphology in Btrc-/- mouse fetuses. The Btrc-/- retina showed a normal number of cell layers and number of cells per layer with normal cell proliferation and apoptosis...
October 2009: Developmental Dynamics
D Wright, G M Chan
OBJECTIVE: Activity has been demonstrated in promoting bone mass in infants and adults. One of the major signs of fetal activity may be the length of the umbilical cord. We hypothesized that the fetus with a shortened umbilical cord may have low bone mineralization because of decreased movement or activity. STUDY DESIGN: We investigated eight healthy term infants with shortened umbilical cords and 15 control term infants. Mothers with pre-eclampsia or hypertension, chorioamnionitis or prolonged ruptured of membranes were excluded from the study...
September 2009: Journal of Perinatology: Official Journal of the California Perinatal Association
M Tshorny, F B Mimouni, Y Littner, A Alper, D Mandel
OBJECTIVE: Fetuses found to be in the breech presentation have limited motion of their lower limbs. The aim of this study was to test the hypothesis that bone speed of sound (SOS) would be lower in infants born after breech presentation than in those born after vertex presentation. STUDY DESIGN: We studied 127 singleton, appropriate for gestational age, term infants delivered by a scheduled cesarean delivery at approximately 38 weeks of gestation because of breech presentation or repeat elective cesarean section with vertex presentation...
November 2007: Journal of Perinatology: Official Journal of the California Perinatal Association
M Eichbaum, A S Gast, C Sohn
Massive fetomaternal hemorrhage (FMH) is a rare complication in pregnancy that may cause hydrops or can even be life-threatening for the fetus. We report on the case of a 19-year-old gravida I, para 0, who presented to our clinic at 32 weeks of gestation due to decreased fetal movements. The initial fetal heart rate tracing at admission showed a sinusoidal pattern without decelerations. The ultrasound examination performed immediately described a normally developed fetus with normal amounts of amniotic fluid and without abnormities of the placental structure...
2006: Fetal Diagnosis and Therapy
F Sergent, A Lefèvre, E Verspyck, L Marpeau
OBJECTIVE: To appreciate at the end of pregnancy, in a low-risk pregnant population, the interest of a screening for fetal well-being in case of decreased fetal movements. To define the most adapted screening. PATIENTS AND METHODS: Retrospective study over a complete year of the patients having consulted in the same center for decreased fetal movements and subjected to the same screening for fetal activity in hospitalization during 48 hours. This screening included a study of fetal heart rate repeated three times a day, a fetal biophysical profile scoring, an umbilical artery Doppler, a Kleihauer-Betke testing, and an amnioscopy...
November 2005: Gynécologie, Obstétrique & Fertilité
G Andrew Mickley, Cynthia L Kenmuir, Christine M Dengler-Crish, Colleen McMullen, Anna McConnell, Elizabeth Valentine
Adult rats exhibit a decrease in consummatory responses following repeated presentations of a taste (habituation) and an increase in consummatory responses if they experience an upward shift in the magnitude or intensity of a gustatory stimulus (e.g., sucrose or saccharin). These responses do not represent a direct sensorimotor reaction to a gustatory cue, but rather reflect a change in responding based on the memory of a previous taste. Here, we sought to determine if fetal rats could (like adults) adjust their orofacial motor responses based on a memory of recent gustatory experience...
April 2004: Developmental Psychobiology
Dubravko Habek, Jasna Cerkez Habek, Ante Barbir, Mira Barbir, Paula Granić
This study assessed perinatal outcome in pregnancies with accidentally diagnosed fetal grasping of the umbilical cord (FGUC) on ultrasonography (US) in late gestation as a possible cause of fetal hypoxia due to mechanical occlusion of umbilical circulation. In this retrospective clinical study, routine antenatal US examination revealed FGUC from 32 to 41 weeks of gestation in seven normal single pregnancies. Upon FGUC findings, fetal condition was followed up every second day by repeat US findings of FGUC, and then by Doppler parameters of fetoplacental circulation measurement of resistance index in umbilical artery (URI) and middle cerebral artery (CRI), and cardiotocography (CTG), and perinatal outcome (peripartal cardiotocography, 5-min Apgar score, umbilical arterial blood pH, occurrence of meconium amniotic fluid, need of additional treatment at neonatal intensive care unit (NICU), and mode of pregnancy termination (cesarean section, forceps or vacuum extraction-VE for hypoxia)...
October 2003: Archives of Gynecology and Obstetrics
Carole S Watson, Rachel Schaefer, Susan E White, Jacobus H Homan, Laurence Fraher, Richard Harding, Alan D Bocking
It was hypothesized that intermittent umbilical cord occlusion (UCO) would inhibit ovine fetal breathing movements (FBM) in association with increased cerebral adenosine levels. To test this hypothesis, on two successive days during late gestation (133-134 days; term = 146 days), microdialysis samples were collected from the brains of 10 chronically instrumented fetal sheep during 2-h periods of complete UCO induced every 30 min (Day 1: 2-min UCOs; Day 2: 4-min UCOs). Control fetuses (n = 10) underwent no UCO...
2002: Reproduction, Fertility, and Development
G H Visser
The administration of glucocorticosteroids to pregnant women results in a striking decrease of neonatal morbidity and mortality in premature infants. A single course of steroids--24 mg of betamethasone or dexamethasone, given in 2 to 4 doses--does not seem to result in long-term adverse effects, although relatively few follow-up studies have been carried out. However, betamethasone causes a temporary--yet considerable--reduction in fetal heart rate variation as well as in fetal breathing and body movements...
December 29, 2001: Nederlands Tijdschrift Voor Geneeskunde
C F van Heteren, P F Boekkooi, H W Jongsma, J G Nijhuis
OBJECTIVES: Fetal habituation to repeated stimulation has the potential to become a tool in the assessment of fetal condition and of the function of the fetal central nervous system (CNS). However, the influence of fetal quiescence and activity on habituation remains to be clarified. We studied habituation and the influence of fetal state and fetal heart rate (FHR) parameters on habituation in healthy term fetuses. SUBJECTS AND METHOD: We studied habituation in 37 healthy fetuses in two tests with an interval of 10 min...
March 2001: Early Human Development
R Bauer, M Schwab, R M Abrams, J Stein, K J Gerhardt
OBJECTIVE: Our purpose was to study effects of vibroacoustic stimuli on electrocortical activity and heart rate changes in fetal sheep in utero. STUDY DESIGN: Seven chronically instrumented near-term fetal sheep were repeatedly stimulated by an electronic artificial larynx for 32 seconds during periods of rapid-eye-movement and non-rapid-eye-movement sleep. Responses to vibroacoustic stimulation were obtained by spectral analysis of the electrocorticogram (fast Fourier transform) and by assessment of changes in fetal heart rate and fetal heart rate variability...
July 1997: American Journal of Obstetrics and Gynecology
S S Robertson, S L Johnson, L F Bacher, J R Wood, C H Wong, S R Robinson, W P Smotherman, P W Nathanielsz
Contractile activity of the uterus before the onset of labor (uterine contractures) has been described in a number of species and provides a powerful source of repeated stimulation for the fetus throughout much of gestation. To understand how fetal behavior responds to this dynamic aspect of the intrauterine environment, we investigated the effects of uterine contractures on the temporal organization of spontaneous motor activity in the fetal sheep during the last fifth of gestation. Eleven fetuses were instrumented on 113-116 days of gestation (dGA)...
December 1996: Developmental Psychobiology
A I Belich, N N Konstantinova, V V Natsvlishvili, N G Pavlova, N I Popova
The natural behavior of normal and anencephalic fetuses at 20 to 41 weeks of the development was studied by ultrasound monitoring and continuous recording of heart rate (HR) and motor activity (MA), followed by processing and presentation on [symbol: see text]CM computer. The statistical characteristics of HR and MA changes in the anencephalic fetuses were corrected by the degree of CNS deficiency. The comparative study of 20 normal and 34 anencephalic fetuses showed: 1) when the spinal cord was present, stable HR (about 150 bpm) seems to be due to cardiac automatism and sharp decelerations unaccompanied by MA were recorded; 2) in fetuses with the medulla oblongata present showed a decrease in baseline HR up to 140 bpm, repeated pronounced decelerations and spontaneous single motor acts dissociated with the latter; 3) when a rudiment of the midbrain was present, some reductions in the amplitude of decelerations and manifestation of weak accelerations, cluster motor acts, brief episodes of the active state were revealed; 4) the quiet state was observed in fetuses with the cerebral cortex; 5) the rest-activity cycle formed with further differentiation of the cerebral cortex...
1996: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
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