Read by QxMD icon Read

Phototherapy in Neonatal Jaundice

Cecily M Begley, Gillian Ml Gyte, Declan Devane, William McGuire, Andrew Weeks, Linda M Biesty
BACKGROUND: Active management of the third stage of labour involves giving a prophylactic uterotonic, early cord clamping and controlled cord traction to deliver the placenta. With expectant management, signs of placental separation are awaited and the placenta is delivered spontaneously. Active management was introduced to try to reduce haemorrhage, a major contributor to maternal mortality in low-income countries. This is an update of a review last published in 2015. OBJECTIVES: To compare the effects of active versus expectant management of the third stage of labour on severe primary postpartum haemorrhage (PPH) and other maternal and infant outcomes...
February 13, 2019: Cochrane Database of Systematic Reviews
Nathalie Auger, Caroline Laverdière, Aimina Ayoub, Ernest Lo, Thuy Mai Luu
We sought to determine if neonatal phototherapy is associated with a greater risk of childhood cancer. We conducted a retrospective cohort study of 786,998 infants born in hospitals of Quebec, Canada between 2006 and 2016, with 4,660,868 person-years of follow-up over an 11-year period. The exposures were neonatal phototherapy (32,314 or 4.1% of infants) and untreated jaundice (91,855 or 11.7% of infants). The outcome was hospitalization for solid or hematopoietic childhood tumours between 2 months and 11 years of age...
January 26, 2019: International Journal of Cancer. Journal International du Cancer
Animesh Halder, Mukut Banerjee, Soumendra Singh, Aniruddha Adhikari, Probir Kumar Sarkar, Arnab Madhab Bhattacharya, Prantar Chakrabarti, Debasis Bhattacharyya, Asim Kumar Mallick, Samir Kumar Pal
OBJECTIVE: Careful screening of bilirubin level in newborns is mandatory as per American Academy of Pediatrics (2004), to reduce incidents of kernicterus and acute bilirubin encephalopathy. Although invasive capillary collection of blood and subsequent biochemical test is considered a gold standard for jaundice detection in neonates, transcutaneous bilirubin (TcB) measurement using various non-invasive instruments is also used sporadically across the globe. The major aim of this study was to develop a non-invasive spectrometry-based technique for measurement of neonatal bilirubin level as an alternative of total serum bilirubin (TSB) test without limitations of other available bilirubinometers...
January 14, 2019: IEEE Journal of Biomedical and Health Informatics
Patcharee Komvilaisak, Arunee Jetsrisuparb, Goonnapa Fucharoen, Ratana Komwilaisak, Junya Jirapradittha, Pakaphan Kiatchoosakun
BACKGROUND: Mutations causing α thalassemia are divided into deletion and nondeletion groups. In the nondeletion group, hemoglobin constant spring (Hb CS) and hemoglobin Pakse (Hb Pakse) are both caused by a termination codon mutation leading to elongation of the α2 globin gene. In the case of Hb CS, the mutation is TAA→CAA, whereas the mutation causing Hb Pakse is TAA→TAT. Clinical hematologic phenotypes are not significantly different. It is important to identify compound heterozygotes for purposes of genetic counseling...
January 5, 2019: Journal of Pediatric Hematology/oncology
Eric Herschel Fein, Scott Friedlander, Yang Lu, Youngju Pak, Rie Sakai-Bizmark, Lynne M Smith, Caroline J Chantry, Paul J Chung
OBJECTIVES: Newborns hospitalized with unconjugated hyperbilirubinemia without critical comorbidities may receive intensive phototherapy (IP) in non-ICU levels of care, such as a mother-newborn unit, or ICU levels of care. Our aim was to compare outcomes between each level. METHODS: Using hospital discharge data from 2005 to 2011 in New York's State Inpatient Database, we performed multivariate analyses to compare outcomes that included total cost of hospitalization, length of stay, 30-day readmission rate after IP, and the number of cases of death, exchange transfusion, and γ globulin infusion...
January 3, 2019: Hospital Pediatrics
Soheila Nouraie, Sedigheh AMIRALIl Akbari, Roshanak Vameghi, Alireza Akbarzade Baghban
Objectives: Delayed umbilical cord clamping (DCC) increases blood transfer to newborns. Hence we investigated the effect of the timing of DCC on hemoglobin levels, neonatal outcomes and developmental status in infants at four months old. Materials & Methods: This clinical trial examined infants born to 400 pregnant women immediately upon birth and at the age of four months in Isfahan, central Iran in 2016. A table of random numbers was used to randomly allocate the newborns to intervention group with a 90-120-sec delay in umbilical cord clamping and the control group with a clamping delay of below 60 sec, and blood samples were taken from their umbilical cords...
2019: Iranian Journal of Child Neurology
Ibinabo Ibiebele, Jennifer R Bowen, Tanya A Nippita, Jonathan M Morris, Jane B Ford
INTRODUCTION: There is debate about optimal management of pregnancies with a large-for-gestational age baby. A recent randomized controlled trial reported that early term induction of labor reduced cesarean section rates and infant morbidity. However, long term childhood outcomes have not been assessed. The aim of this study was to assess maternal, neonatal and child health and education outcomes for large-for-gestational age babies induced at 37-38 weeks gestation. MATERIAL AND METHODS: Population-based record linkage study of term (37+ weeks), cephalic-presenting singleton pregnancies with a large-for-gestational age baby in New South Wales, Australia, 2002-2006...
December 4, 2018: Acta Obstetricia et Gynecologica Scandinavica
Hare Krishna, Asha Changil, M Srinivas, Tara Sankar Roy, Tony George Jacob
Introduction: Phototherapy is the most common treatment for neonatal jaundice. This study sought to determine ultrastructural changes in testis, at different time-points, after 48 hours of conventional phototherapy was given to newborn rats. Methods: Newborn male Wistar rats ( n = 36) were divided into two groups as follows - group 1 (G1), control (without phototherapy) and group 2 (G2), exposure to conventional phototherapy for 48 h. Six animals from each group were sacrificed on postnatal days (PND) 70, 100 and 130...
October 2018: Journal of microscopy and ultrastructure
Francesco Cavallin, Daniele Trevisanuto, Aye Thein, Amanda Booth, Gaston Arnolda, Danica Kumara, Phyu U, Sandar Myint, Luciano Moccia
AIM: To evaluate the role of pathway to admission for jaundice among the risk factors for exchange transfusion in outborn infants in a low resource setting. METHODS: This retrospective case-control study (1:1 ratio) was carried out at the Yankin Children's Hospital in Yangon (Myanmar). All cases were neonates admitted for treatment of jaundice between March 2013 and February 2014 and who required exchange transfusion. Each control was the next noncase neonate admitted for treatment of jaundice and treated with phototherapy...
November 8, 2018: Journal of Maternal-fetal & Neonatal Medicine
Gaston Arnolda, Tran Dinh Chien, Andrew Hayen, Nguyen Thi Xuan Hoi, Katherine Maningas, Priscilla Joe, Francesco Cavallin, Daniele Trevisanuto, Luciano Moccia
INTRODUCTION: Neonatal jaundice is one of the most common reasons for hospital admission in low resource settings. Treatment is frequently inadequate as conventional phototherapy requires frequent bulb changes. LED phototherapy has comparable efficacy to conventional phototherapy, and the bulbs last over 40,000 hours. This observational study compares the effectiveness of three LED machines, two single-sided and one double-sided in routine use in Vietnam. METHODS: We included all infants weighting ≥1500g and with jaundice diagnosed visually or by Total Serum Bilirubin (TSB) measurement at The Da Nang Hospital for Women and Children (Da Nang, Vietnam)...
2018: PloS One
Jinfu Zhou, Changyi Yang, Wenbin Zhu, Shuwei Chen, Yinglin Zeng, Jing Wang, Hong Zhao, Yao Chen, Feng Lin
To date, the genetic risk factors for neonatal hyperbilirubinemia remain unknown in Southeastern China. This case-control study aimed to identify the genetic risk factors for neonatal hyperbilirubinemia in Fujian, Southeastern China. A total of 286 hyperbilirubinemic newborns were enrolled as a case group, and 250 randomly selected newborns without jaundice or with a bilirubin level that was lower than the threshold required for phototherapy served as controls. The serum levels of total bilirubin, unconjugated bilirubin, and direct bilirubin were measured, and the common genetic loci in UGT1A1, OATP1B1, and HO-1 genes were genotyped...
2018: BioMed Research International
Fabrízia Rennó Sodero Faulhaber, Gustavo Adolpho Moreira Faulhaber, Natália Aydos Marcondes, Renato Soibelmann Procianoy, Rita C Silveira
BACKGROUND: Jaundice due to indirect hyperbilirubinemia affects more than 60% of neonates and phototherapy is the treatment for severe types. There are no previous studies evaluating the effect of phototherapy on the function of neonates neutrophils. The aim of this study was to assess and compare the function of neutrophils by measuring the expression of neutrophils main surface markers in icteric neonates before and after phototherapy. METHODS: Neonates at a gestational age ≥35 weeks and birth weight ≥2,000 g who met the American Academy of Pediatrics criteria for phototherapy were included...
November 2018: Cytometry. Part B, Clinical Cytometry
T M Slusher, L T Day, T Ogundele, N Woolfield, J A Owa
No abstract text is available yet for this article.
October 3, 2018: Early Human Development
Ridhimaa Jain, Ashish Jain, Veena Devgan, Jerin Sekhar
OBJECTIVE: To determine the effect of alternative positions (relative to placenta) of normal term neonates, prior to the recommended delayed cord clamping, on placental transfusion and short-term neonatal outcome. METHODS: Normal term neonates born vaginally were randomly assigned to be placed either on mother's abdomen (Group AL, n = 97) or 20 cm below the introitus (Group BL, n = 102) for 90 seconds after delivery. Subsequently the cord was clamped...
September 26, 2018: Journal of Maternal-fetal & Neonatal Medicine
Shalin Lee Wan Fei, Keng Sheng Chew, Saloma Pawi, Li Tsu Chong, Khatijah Lim Abdullah, Lik Thai Lim, Feryante Rintika
OBJECTIVE: To identify the efficacy and safety of the use of various cost-effective reflective materials around phototherapy units to reduce the duration of phototherapy and hasten the reduction of bilirubin among neonates with physiologic jaundice. DATA SOURCES: A systematic review of randomized controlled trials identified from searches in the Cumulative Index to Nursing and Allied Health Literature, ScienceDirect, Embase, and the Cochrane Library with the use of keywords, MeSH terms, operators, and the review of reference lists of retrieved articles...
November 2018: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
Tim Colbourn, Charles Mwansambo
No abstract text is available yet for this article.
October 2018: Lancet Global Health
Masayoshi Zaitsu, Tatsuya Yoshihara, Hiromitsu Nakai, Shiro Kubota
BACKGROUND: Neonatal jaundice is strongly attributable to excess body-weight loss as a result of insufficient calorific intake. OBJECTIVES: To examine the incidence of neonatal jaundice (defined by use of phototherapy) and body-weight loss, as well as their association, among neonates under optimal thermal control with sufficient nutrition, a local protocol for temperature and nutritional regulation. METHODS: We retrospectively identified a cohort of 10,544 neonates (birth weight ≥2,500 g) placed in thermo-controlled incubators for 2 h immediately after birth...
2018: Neonatology
Yan Jiao, Yuting Jin, Huanhuan Meng, Meizhang Wen
This study aimed to discuss and evaluate the clinical effect of blue light phototherapy combined with bifico in treating neonatal hemolytic jaundice. One hundred and twenty cases with neonatal hemolytic jaundice were randomly divided into treatment group and control group, 60 cases in each group. Neonatal patients in the control group were treated with traditional treatment, including administration of enzyme inducer phenobarbital and blue light phototherapy for 8 consecutive hours every day. Neonatal patients in the treatment group received bifico orally based on traditional treatment...
August 2018: Experimental and Therapeutic Medicine
Fabrízia R S Faulhaber, Renato S Procianoy, Rita C Silveira
Phototherapy in neonates for treatment of pathological jaundice is an effective therapeutic tool that is widely used in neonatal units. Over the past years, a greater concern has emerged about the effects on the immune and inflammatory system and its potential genotoxic and side effects, especially the late ones, possibly associated with childhood diseases, showing that this treatment is not as harmless as previously believed. Numerous studies assessing these possible adverse effects of phototherapy on neonates have been published over the past years...
August 6, 2018: American Journal of Perinatology
Ruo-Han Wu, Shuo Feng, Mei Han, Patrina Caldwell, Shi-Gang Liu, Jing Zhang, Jian-Ping Liu
BACKGROUND: Neonatal jaundice affects at least 481,000 newborns every year. Phototherapy is recommended but it's effects are limited and adverse reactions can occur. In China, phototherapy combined with Yinzhihuang oral liquid is also used for this condition. This systematic review evaluated the effectiveness and safety of combination therapy with Yinzhihuang oral liquid and phototherapy compared to phototherapy alone for treating neonatal jaundice. METHOD: A comprehensive literature search was performed in four Chinese databases, two English language databases and two trial registries from inception to June 2017...
July 28, 2018: BMC Complementary and Alternative Medicine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"