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diabetes aspirin

R Pop, I Zinchenko, V Quenardelle, D Mihoc, M Manisor, J S Richter, F Severac, M Simu, S Chibbaro, O Rouyer, V Wolff, R Beaujeux
BACKGROUND AND PURPOSE: There are very few published data on the patency of carotid stents implanted during thrombectomies for tandem lesions in the anterior circulation. We aimed to communicate our experience of stenting in the acute setting with systematic follow-up of stent patency and discuss predictors and clinical repercussions of delayed stent thrombosis. MATERIALS AND METHODS: We performed a retrospective study of stroke thrombectomies in a single center between January 2009 and April 2018...
February 14, 2019: AJNR. American Journal of Neuroradiology
Dong-Hwa Lee, Eun Ju Chun, Tae Jung Oh, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Kyong Soo Park, Hak Chul Jang, Soo Lim
AIM: Cilostazol is an antiplatelet agent with multiple beneficial metabolic effects via inhibition of phosphodiesterase-3 in vascular smooth muscle cells, cardiomyocytes, adipose tissue, and platelets. We performed a prospective study to evaluate the effect of cilostazol compared with aspirin in Korean diabetic patients with subclinical coronary atherosclerosis. MATERIALS AND METHODS: One hundred diabetic patients who had mild-to-moderate coronary atherosclerosis assessed by coronary computed tomographic angiography were randomly assigned to either 200 mg/day cilostazol(CTZ) or 100 mg/day aspirin(ASA) groups (n=50 each)...
February 13, 2019: Diabetes, Obesity & Metabolism
Julien Vouillarmet, Victor Aboyans
The effect of aspirin in primary cardiovascular (CV) prevention in people with diabetes is still a matter of debate. Recent results of ASCEND trial suggest that the absolute benefit on CV events is largely counter-balanced by the bleeding risk. However, one crucial question is whether aspirin should be maintained or withdrawn from the prescription list of those who are already under this therapy since a while ago. Indeed, large epidemiological data reported that the aspirin discontinuation was associated to an increased risk of CV events...
February 10, 2019: Diabetes Research and Clinical Practice
Stephanie R Reading, Mary Helen Black, Daniel E Singer, Alan S Go, Margaret C Fang, Natalia Udaltsova, Teresa N Harrison, Rong X Wei, In-Lu Amy Liu, Kristi Reynolds
BACKGROUND: Atrial fibrillation (AF) patients are routinely prescribed medications to prevent and treat complications, including those from common co-occurring comorbidities. However, adherence to such medications may be suboptimal. Therefore, we sought to identify risk factors for general medication non-adherence in a population of patients with atrial fibrillation. METHODS: Data were collected from a large, ethnically-diverse cohort of Kaiser Permanente Northern and Southern California adult members with incident diagnosed AF between January 1, 2006 and June 30, 2009...
February 11, 2019: BMC Cardiovascular Disorders
Federico Fortuni, Gabriele Crimi, Valeria Gritti, Alessandro Mandurino Mirizzi, Sergio Leonardi, Gaetano M De Ferrari
No abstract text is available yet for this article.
February 11, 2019: European Journal of Preventive Cardiology
Fatemeh Kazemi, Adeleh Divsalar, Ali Akbar Saboury, Arefeh Seyedarabi
Nowadays diabetes, as a metabolic disorder, is increasing at an alarming rate. Glycation and production of advanced glycation end products (AGEs) is the most important factor involved in diabetic complications. Due to the side effects of synthetic drugs, the demand for natural anti-diabetic herbal medicines has increased. Propolis is a natural and resinous material, which iscollected by honeybees. Due to the impact of nanotechnology in medicine and the advantageous role of nanoparticles in treatment, nano-propolis particles (PNP) were prepared...
January 23, 2019: Colloids and Surfaces. B, Biointerfaces
Gretchen A Benson, Abbey Sidebottom, Joy Hayes, Michael D Miedema, Jackie Boucher, Marc Vacquier, Arthur Sillah, Safa Gamam, Jeff J VanWormer
BACKGROUND: Clinical care for type 2 diabetes has improved but remains suboptimal. Collaborative, team-based models that maximize skills of different disciplines may improve care for individuals with diabetes, but few have been tested using rigorous research designs. OBJECTIVE: To investigate the efficacy of a registered dietitian nutritionist-led telemedicine program compared with that of a control group in terms of diabetes optimal care goals. DESIGN: A randomized controlled trial in which participants were assigned to a control or intervention group...
January 30, 2019: Journal of the Academy of Nutrition and Dietetics
Charles H Hennekens, Nicole Schuttenberg, Marc A Pfeffer
The increasing burden of cardiovascular disease worldwide, including the United States, underscores the need for the more widespread use of adjunctive drug therapies of proven net benefit in the primary prevention of cardiovascular disease. These include aspirin to reduce mortality from cardiovascular disease, statins to lower LDL-cholesterol levels, appropriate use of multiple antihypertensive drug therapies to lower blood pressure, and aggressive multifactorial management of diabetes. This article reviews randomized evidence to provide guidance to primary care providers regarding the use of adjunctive drug therapies...
March 2019: Primary Care
Safi U Khan, Zain Ul Abideen Asad, Muhammad U Khan, Swapna Talluri, Farman Ali, Muhammad Shahzeb Khan, Ahmad N Lone, Farouk Mookadam, Richard A Krasuski, Edo Kaluski
BACKGROUND: The safety and efficacy of aspirin for the primary prevention of cardiovascular disease in patients with diabetes mellitus remains controversial. DESIGN: A meta-analysis to investigate the effects of aspirin for the prevention of cardiovascular disease in diabetes mellitus. METHODS: Ten randomized controlled trials were selected using MEDLINE, EMBASE and CENTRAL databases until 27 September 2018. Risk ratios (RRs) with 95% confidence intervals (CIs) and risk differences (RDs) reported as incident events per 1000 person-years were calculated...
January 30, 2019: European Journal of Preventive Cardiology
Natasha Sobers, Angela M C Rose, T Alafia Samuels, Julia Critchley, Melissa Abed, Ian Hambleton, Arianne Harvey, Nigel Unwin
OBJECTIVES: In Barbados, high case fatality rates have been reported after myocardial infarction (MI) with higher rates in women than men. To explore this inequality, we examined documented pharmacological interventions for ST-segment elevated myocardial infarction (STEMI), non-STEMI (NSTEMI) and unstable and chronic angina in women and men. DESIGN: Prospective cohort registry data for STEMI and NSTEMI and retrospective chart review for unstable and chronic angina...
January 28, 2019: BMJ Open
Sean L Zheng, Alistair J Roddick
Importance: The role for aspirin in cardiovascular primary prevention remains controversial, with potential benefits limited by an increased bleeding risk. Objective: To assess the association of aspirin use for primary prevention with cardiovascular events and bleeding. Data Sources: PubMed and Embase were searched on Cochrane Library Central Register of Controlled Trials from the earliest available date through November 1, 2018. Study Selection: Randomized clinical trials enrolling at least 1000 participants with no known cardiovascular disease and a follow-up of at least 12 months were included...
January 22, 2019: JAMA: the Journal of the American Medical Association
Mukul Sharma, Robert G Hart, Stuart J Connolly, Jackie Bosch, Olga Shestakovska, Kelvin K H Ng, Luciana Catanese, Katalin Keltai, Victor Aboyans, Marco Alings, Jong-Won Ha, John Varigos, Andrew Tonkin, Martin O'Donnell, Deepak L Bhatt, Keith Fox, Aldo Maggioni, Scott D Berkowitz, Nancy Cook Bruns, Salim Yusuf, John W Eikelboom
BACKGROUND: Strokes were significantly reduced by the combination of rivaroxaban plus aspirin compared with aspirin in the COMPASS Trial. We present detailed analyses of stroke by type, predictors, and antithrombotic effects in key subgroups. METHODS: Participants had stable coronary artery or peripheral artery disease and were randomly assigned to receive aspirin 100 mg once daily (n=9126), rivaroxaban 5 mg twice daily (n=9117) or rivaroxaban 2.5 mg twice daily plus aspirin (n=9152)...
January 22, 2019: Circulation
Kevan R Polkinghorne, Rory Wolfe, Kim M Jachno, James B Wetmore, John J McNeil, Mark R Nelson, Christopher M Reid, Anne M Murray
The prevalence of chronic kidney disease (CKD) in the elderly is controversial because age-related decline in kidney function may not truly reflect underlying kidney disease. We estimate the baseline prevalence and predictors of CKD using the CKD Epidemiology Collaboration (CKD-EPIeGFR ) and Berlin Initiative Study 1 (BIS1eGFR ) eGFR equations in the ASPirin in Reducing Events in the Elderly (ASPREE) trial cohort of healthy older participants. GFR was estimated using CKD-EPI and BIS1 equations. CKD was defined as eGFR <60 mL/min/1...
January 20, 2019: Nephrology
Zi Hao Phang, Jun Jie Chew, Jayamalar A/P Thurairajasingam, Sa'adon B Ibrahim
Spontaneous spinal epidural hematoma is a rare condition defined by bleeding in the epidural space of the spine with no identifiable causes such as trauma, vascular malformation, or bleeding disorders. This is a case of a 79-year-old woman with a medical history of diabetes mellitus, dyslipidemia, and hypertension presented with the sudden onset of severe thoracolumbar back pain associated with weakness and numbness in her bilateral lower limb. Examination of the lower limb showed bilateral lower limb motor and sensory deficits...
October 2018: Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
Erin Carson, Alice N Hemenway
BACKGROUND: Data on aspirin for primary prevention of cardiovascular disease (CVD) are conflicting and changing as new trials are published on the subject. OBJECTIVE: To review recent data evaluating the efficacy and safety of aspirin for primary prevention of CVD. DATA SOURCES: Articles evaluating aspirin for primary prevention of CVD were gathered using a MEDLINE search with the keywords aspirin review, aspirin peripheral artery disease, aspirin stroke, aspirin coronary artery disease, aspirin diabetes, aspirin primary prophylaxis, and aspirin elderly...
January 17, 2019: Annals of Pharmacotherapy
Saher Zaidi, Jason Gandhi, Gunjan Joshi, Noel L Smith, Sardar Ali Khan
BACKGROUND: Prostate cancer (PCa) is characterized as the most frequent type of cancer in males. Recent research has suggested patients who have diabetes mellitus taking metformin (MF) have a lower risk of PCa. MF has antineoplastic effects such as adenosine monophosphate-activated protein kinase (AMPK)-dependent and independent mechanisms, suppression of androgen signaling pathway, and alterations of insulin-like growth factor-1 (IGF-1) signaling pathways that cause the growth and proliferation of PCa...
January 16, 2019: Prostate Cancer and Prostatic Diseases
Nicolas Geis, Philip Raake, Christina Kiriakou, Derliz Mereles, Lutz Frankenstein, Haitham Abu-Sharar, Emmanuel Chorianopoulos, Hugo A Katus, Raffi Bekeredjian, Sven T Pleger
BACKGROUND: Incidence of stroke within 30 days after percutaneous mitral valve repair using the MitraClip varies from 0.7% and 2.6% between registries. Standard medical treatment after the MitraClip procedure, in the absence of risk factors requiring antithrombotic therapy such as atrial fibrillation, is dual antiplatelet therapy using aspirin and clopidogrel. ESC/EACTS and ACC/AHA surgical guidelines show a Class IIa indication for temporary antithrombotic therapy after mitral valve repair/bioprosthetic valve replacement within the first three months even in patients with no additional risk factors...
January 16, 2019: Acta Cardiologica
Maurizio G Abrignani, Iris Parrini, Daniele Grosseto, Chiara Lestuzzi, Marinella Mistrangelo, Bruno Passaretti
Although commonly thought of as two separate disease entities, cardiovascular diseases and cancer, the leading causes of death, possess various possible interactions, including a number of similar risk factors (e.g. obesity, diabetes, chronic inflammation). Each cardiologist should provide counseling for a correct lifestyle (diet, physical exercise, avoiding smoking and alcohol abuse); doing so, not only cardiovascular diseases, but also cancer could be prevented. Besides, intervention on diet, physical activity and smoking has been shown to be effective even in patients with known cancers...
January 2019: Giornale Italiano di Cardiologia
Ying Xing, Kathryn Cb Tan
Cardiovascular disease (CVD) is a major cause of morbidity and mortality in people with diabetes. Aspirin is commonly used in the treatment and prevention of CVD, and the effectiveness of aspirin for the secondary prevention of CVD is well established in people with or without diabetes. In contrast, the role of aspirin in primary prevention is still controversial as the cardiovascular benefit of aspirin may not outweigh the risk of haemorrhage. Even though diabetes raises cardiovascular risk which would suggest that aspirin could have a greater benefit, it remains uncertain whether there is a clear net benefit of aspirin in primary prevention of CVD in people with diabetes...
January 13, 2019: Journal of Diabetes Investigation
Gijs F N Berkelmans, Soffia Gudbjörnsdottir, Frank L J Visseren, Sarah H Wild, Stefan Franzen, John Chalmers, Barry R Davis, Neil R Poulter, Annemieke M Spijkerman, Mark Woodward, Sara L Pressel, Ajay K Gupta, Yvonne T van der Schouw, Ann-Marie Svensson, Yolanda van der Graaf, Stephanie H Read, Bjorn Eliasson, Jannick A N Dorresteijn
Aims: Although group-level effectiveness of lipid, blood pressure, glucose, and aspirin treatment for prevention of cardiovascular disease (CVD) has been proven by trials, important differences in absolute effectiveness exist between individuals. We aim to develop and validate a prediction tool for individualizing lifelong CVD prevention in people with Type 2 diabetes mellitus (T2DM) predicting life-years gained without myocardial infarction or stroke. Methods and results: We developed and validated the Diabetes Lifetime-perspective prediction (DIAL) model, consisting of two complementary competing risk adjusted Cox proportional hazards functions using data from people with T2DM registered in the Swedish National Diabetes Registry (n = 389 366)...
January 9, 2019: European Heart Journal
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