Cong Ma, Yan Xu, Huilei Chen, Yue Huang, Shanshan Wang, Pin Zhang, Guojing Li, Zuying Xu, Xiaofeng Xu, Zhiming Ding, Huifen Xiang, Yunxia Cao
The use of bisphenol A (BPA) has been restricted due to its endocrine-disrupting effects. As a widely used alternative to BPA today, environmental levels of bisphenol Z (BPZ) continue to rise and accumulate in humans. Oocyte quality is critical for a successful pregnancy. Nevertheless, the toxic impacts of BPZ on the maturation of mammalian oocytes remain unexplored. Therefore, the impacts of BPZ and BPA on oocyte meiotic maturation were compared in an in vitro mouse oocyte culture model. Exposure to 150 μM of both BPZ and BPA disrupted the assembly of the meiotic spindle and the alignment of chromosomes, and BPZ exerted stronger toxicological effects than BPA...
April 11, 2024: Ecotoxicology and Environmental Safety