Omar Rossi, Francesco Citiulo, Carlo Giannelli, Emilia Cappelletti, Gianmarco Gasperini, Francesca Mancini, Alessandra Acquaviva, Maria Michelina Raso, Luigi Sollai, Renzo Alfini, Maria Grazia Aruta, Claudia Giorgina Vitali, Mariagrazia Pizza, Francesca Necchi, Rino Rappuoli, Laura B Martin, Francesco Berlanda Scorza, Anna Maria Colucci, Francesca Micoli
Shigellosis is a leading cause of diarrheal disease in low-middle-income countries (LMICs). Effective vaccines will help to reduce the disease burden, exacerbated by increasing antibiotic resistance, in the most susceptible population represented by young children. A challenge for a broadly protective vaccine against shigellosis is to cover the most epidemiologically relevant serotypes among >50 Shigella serotypes circulating worldwide. The GMMA platform has been proposed as an innovative delivery system for Shigella O-antigens, and we have developed a 4-component vaccine against S...
September 5, 2023: NPJ Vaccines