Lewis C E Mason, David R Greig, Lauren A Cowley, Sally R Partridge, Elena Martinez, Grace A Blackwell, Charlotte E Chong, P Malaka De Silva, Rebecca J Bengtsson, Jenny L Draper, Andrew N Ginn, Indy Sandaradura, Eby M Sim, Jonathan R Iredell, Vitali Sintchenko, Danielle J Ingle, Benjamin P Howden, Sophie Lefèvre, Elisabeth Njampeko, François-Xavier Weill, Pieter-Jan Ceyssens, Claire Jenkins, Kate S Baker
Shigella sonnei causes shigellosis, a severe gastrointestinal illness that is sexually transmissible among men who have sex with men (MSM). Multidrug resistance in S. sonnei is common including against World Health Organisation recommended treatment options, azithromycin, and ciprofloxacin. Recently, an MSM-associated outbreak of extended-spectrum β-lactamase producing, extensively drug resistant S. sonnei was reported in the United Kingdom. Here, we aimed to identify the genetic basis, evolutionary history, and international dissemination of the outbreak strain...
April 8, 2023: Nature Communications