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Maya V Epifanova, Badri R Gvasalia, Maksim A Durashov, Sergey A Artemenko
INTRODUCTION: Platelet-rich plasma (PRP) found its use in treating different conditions and diseases, because concentrated plasma PRP consists of many growth factors. Their interaction with surrounding cells, intracellular matrix, and mediators at the site of injection leads to tissue regeneration. Angiogenic, vasculogenic, and regenerative effects of PRP may be used for erectile dysfunction (ED) and Peyronie's disease (PD) treatment. AIM: To present a current data review of preclinical and clinical trials on PRP use for treating ED and PD...
March 19, 2019: Sexual Medicine Reviews
Patrick G Rice, Bhaskar K Somani, Rowland W Rees
INTRODUCTION: Plaque incision and grafting (PIG) is indicated for men with complex or severe penile curvature and, despite a multitude of incision types and grafting materials having been used, no individual technique has proven superiority. AIM: To assess outcomes following PIG and to understand the operative technique. METHODS: A systematic review was performed to find all relevant studies reporting on use of the PIG technique to correct curvature resulting from Peyronie's disease...
March 16, 2019: Sexual Medicine
Allen D Seftel
No abstract text is available yet for this article.
March 19, 2019: Journal of Urology
Allen F Morey
No abstract text is available yet for this article.
March 13, 2019: Journal of Urology
Allen F Morey
No abstract text is available yet for this article.
March 13, 2019: Journal of Urology
Ishan Aditya, Ethan D Grober, Yonah Krakowsky
INTRODUCTION: Peyronie's disease (PD) and testosterone deficiency (TD) impact men at the same stage of life and can ultimately contribute to erectile dysfunction. There is speculation that low levels of testosterone (T) may predispose men to penile fibrosis; however, there is no published, up-to-date review summarizing the current evidence. Therefore, we conducted a narrative review of the literature exploring the relationship between PD and TD. METHODS: A comprehensive systematic search of existing literature of five online databases from June 1990 to June 2018 examining the relationship between PD and TD was conducted...
March 11, 2019: World Journal of Urology
Nikhil K Gupta, Randy Sulaver, Charles Welliver, Michael Kottwitz, Luke Frederick, Danuta Dynda, Tobias S Köhler
INTRODUCTION: Scrotoplasty has become a common practice during insertion of penile prosthesis, improving patient perception of penile length. Previous reports on scrotoplasty outcomes have only focused on the perceived benefits. The risk of wound complications after scrotoplasty is unknown. AIM: Identify wound complications and associated risk factors of scrotoplasty with insertion of penile prosthesis. METHODS: A retrospective review of a single-surgeon series (T...
March 6, 2019: Journal of Sexual Medicine
Matthew J Ziegelmann, Laurence A Levine
No abstract text is available yet for this article.
March 6, 2019: Journal of Sexual Medicine
U Milenkovic, M M Ilg, S Cellek, M Albersen
No abstract text is available yet for this article.
March 7, 2019: Expert Opinion on Emerging Drugs
Vassilis Protogerou, Efstathios Michalopoulos, Panagiotis Mallis, Ioanna Gontika, Zetta Dimou, Christos Liakouras, Catherine Stavropoulos-Giokas, Nikolaos Kostakopoulos, Michael Chrisofos, Charalampos Deliveliotis
Erectile dysfunction (ED) affects more than 30 million men; endothelial dysfunction plays a significant role in EDs pathogenesis. The aim of this study was to administer mesenchymal stem cells (MSC) derived from adipose tissue and platelet lysate (PL) into patients with erectile dysfunction. This pilot study enrolled eight patients with diagnosed ED. Patients enrolled were suffering from organic ED due to diabetes melitus, hypertension, hypercholesterolaemia, and Peyronie disease. The patients were distributed in 2 groups...
March 5, 2019: Bioengineering
Sune Møller Skov-Jeppesen, Ronja Niemann Lundrup, Peter Bille Juul Ladegaard, Jonas Mortensen, Mia Dahl Sørensen, Lars Lund
Extracorporeal shockwave therapy (ESWT) is a novel treatment modality to stimulate tissue regeneration and anti-fibrosis. In this review, we summarise the use of ESWT for erectile dysfunction (ED), diabetic foot ulcers (DFU), Peyronie's disease (PD), chronic kidney disease (CKD), and scleroderma. Several randomised clinical trials demonstrate the efficacy of ESWT for vasculogenic ED and DFU, and ESWT may also relieve pain in patients with PD. ESWT is still experimental for CKD and scleroderma. In general, ESWT is associated with few and mild adverse effects...
February 18, 2019: Ugeskrift for Laeger
Karen Randhawa, C J Shukla
Peyronies disease (PD) is estimated to affect approximately 3-9% of men worldwide and maybe associated with pain, erectile dysfunction and penile deformity including shortening. The condition has significant debilitating effects on quality of life, self-esteem and psychological wellbeing in addition to sexual function. Surgical results add further to this by patients having dissatisfaction with various aspects of outcomes. Non-surgical management may allow patients to avoid the morbidities associated with surgery and still achieve improved functional and aesthetic outcomes...
January 2019: Therapeutic Advances in Urology
Adam Wiggins, M Ryan Farrell, Peter Tsambarlis, Laurence A Levine
INTRODUCTION: Biothesiometry allows for evaluation of penile vibratory sensitivity and can be used as a non-invasive and rapid surrogate test of penile sexual sensitivity. However, no standardized measurement methodology currently exists. AIM: To describe and optimize a novel, standardized biothesiometry parameter-the penile sensitivity ratio (PSR). METHODS: We reviewed all biothesiometry data from men presenting to our institution from July 2013-May 2017...
February 14, 2019: Journal of Sexual Medicine
Esaú Fernández-Pascual, Francisco Javier Gonzalez-García, María Rodríguez-Monsalve, Jorge Turo, Claudio Martínez-Ballesteros, Joaquín Carballido, Juan Ignacio Martínez-Salamanca
INTRODUCTION: Patients with Peyronie's disease (PD) and erectile dysfunction (ED) concomitant with shortening or other malformations benefit from prosthesis implantation and penile lengthening procedures. AIM: To evaluate the safety and efficacy of a multi-incisional technique with penile prosthesis implantation with multiple corporeal incisions and collagen grafting for the surgical management of complex cases of PD with ED and severe penile shortening. METHODS: From February 2015-May 2018, 43 consecutive patients with complex PD were treated using this technique...
February 2019: Journal of Sexual Medicine
T A Masterson, A Galante, M Butaney, A Pastuszak, H Sadeghi-Nejad, R Ramasamy
Collagenase clostridium histolyticum (CCH, Xiaflex, Xiapex) is the only FDA-approved medication for treatment of Peyronie's disease. It is unclear how practitioners actually use CCH in their own practices. The objectives of the study were: (1) to identify variability in practice patterns for CCH among practitioners, (2) to assess adherence to the package insert instructions, and (3) to evaluate whether provider satisfaction was associated with adherence to instructions. A 30-question online survey was distributed to 1270 members of the International Society for Sexual Medicine (ISSM) from the EU, USA, Canada and Australia...
February 12, 2019: International Journal of Impotence Research
Thomas Masterson, Premal Patel, Ranjith Ramasamy
No abstract text is available yet for this article.
February 11, 2019: International Journal of Impotence Research
Patrick Whelan, Laurence A Levine
Penile prosthesis implantation for treatment of medical refractory erectile dysfunction remains the gold standard. However, some men have additional pathology present such as Peyronie's Disease, penile shortening, penoscrotal webbing, buried penis or other penoscrotal anatomical abnormalities that may be addressed at the time of prosthesis implantation. Although several techniques are described, there remains a lack of data regarding the outcomes. We sought to identify the results of available literature regarding the additional procedures performed at the time of penile prosthesis implantation that provide defined surgical outcomes rather than merely describe surgical techniques...
January 31, 2019: International Journal of Impotence Research
L Gallo, P Sarnacchiaro
OBJECTIVES: To present our experience with multimodal therapy for Peyronie's disease. METHODS: Retrospective data were collected since 2008 to 2017. The following features were evaluated at baseline and after treatment: age, duration of disease, erectile function, erected penile curvature, and stretched penile length. All patients were offered the same protocol including: 12 intralesional verapamil injections, oral therapy (OT) ?L-arginine 2g once and pentoxifylline 400mg 3 times a day for 6 months?, and penile traction therapy...
January 28, 2019: Actas Urologicas Españolas
Jonathan Nicholas Warner
PURPOSE OF REVIEW: The use of penile implant for the treatment of both erectile dysfunction and Peyronie's disease has changed little in the last 40 years, primarily limited to modeling and plaque incision. In the current review, I explore the history of Peyronie's treatment at the time of penile prosthesis placement and explore new surgical options that help resolve several of the issues that were not treated with the traditional approaches. RECENT FINDINGS: Advancements have been made in the area of graft material, lengthening procedures, and transcorporal techniques...
January 30, 2019: Current Urology Reports
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