Jun Li, Yinghui Hong, Yinsheng Zhong, Shujun Yang, Liying Pei, Zijie Huang, Huibao Long, Xuxiang Chen, Changqing Zhou, Guanghui Zheng, Chaotao Zeng, Haidong Wu, Tong Wang
Hypertension, a prevalent cardiovascular ailment globally, can precipitate numerous complications, notably hypertensive cardiomyopathy. Meteorin-like (METRNL) is demonstrated to possess potential protective properties on cardiovascular diseases. However, its specific role and underlying mechanism in hypertensive myocardial hypertrophy remain elusive. Spontaneously hypertensive rats (SHRs) served as hypertensive models to explore the effects of METRNL on hypertension and its induced myocardial hypertrophy. The research results indicate that, in contrast to Wistar-Kyoto (WKY) rats, SHRs exhibit significant symptoms of hypertension and myocardial hypertrophy, but cardiac-specific overexpression (OE) of METRNL can partially ameliorate these symptoms...
March 7, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease